Rossi G.,Section of Pathologic Anatomy |
Cavazza A.,Operative Unit of Pathologic Anatomy |
Gennari W.,Laboratory of Virology |
Marchioni A.,Respiratory Diseases Clinic |
And 4 more authors.
American Journal of Surgical Pathology | Year: 2012
Pulmonary granulomas represent a common inflammatory reaction to several lung infective or noninfective diseases. However, little is known about the histology and clinical presentation of chickenpox-related granulomas in immunocompetent subjects. We collected a series of 8 adult patients (mean age, 40 y; range, 33 to 53 y) with several bilateral pulmonary granulomas incidentally discovered after imaging studies. All patients were asymptomatic and had experienced a varicella-zoster virus (VZV) infection as adults but were clinically suspected to have a metastatic neoplasm of unknown origin. Chest computed tomography scan revealed numerous, tiny (few millimeters to 1 cm in size) nodules randomly dispersed through the lungs. Positron emission tomography scan performed in 4 patients was negative. All patients underwent video-assisted thoracoscopic surgical resection and were still alive and well. At histology, granulomas consisted of well-defined, rounded, small nodules centered by a deeply eosinophilic, acellular necrosis rimmed by lamellar dense collagen and a chronic inflammatory infiltrate with or without multinucleated giant cells. Chickenpox-related granulomas were included in the differential diagnosis along with several other granulomatous diseases. Polymerase chain reaction-based molecular analysis for VZV performed on paraffin sections detected VZV DNA in all 8 cases. By contrast, 85 cases of pulmonary granulomas of different etiologies were simultaneously studied by molecular analysis with negative results. Pathologists should be familiar with the peculiar morphologic appearance of chickenpox-related granulomas. A careful search for a history of VZV infection in adulthood and molecular studies may be very helpful in confirming the diagnosis. Copyright © 2012 by Lippincott Williams &Wilkins.
Cama E.,University of Padua |
Santarelli R.,University of Padua |
Muzzi E.,University of Padua |
Inches I.,Operative Unit of Neuroradiology |
And 4 more authors.
Acta Otorhinolaryngologica Italica | Year: 2011
Sarcoidosis is an inflammatory multisystem disorder of unknown cause. Approximately 5-7% of patients manifest symptoms of central nervous system involvement, or neurosarcoidosis. Cranial neuropathy usually entails facial nerve palsy and optic neuritis. Sudden hearing loss has been reported in fewer than 20 cases. Herewith, two new cases of sudden hearing loss due to probable neurosarcoidosis are reported, each having a quite different clinical course. In one case, unilateral sudden hearing loss and facial palsy were the presenting symptoms of systemic sarcoidosis, while in the second, unilateral sudden deafness occurred despite ongoing immunosuppressive treatment for systemic sarcoidosis.
Lamberti V.,Instituto Of Medicina Dello Sport E Dellattivita Motoria Ims |
Nardini S.,Operative Unit of Pneumology |
Romano P.,Instituto Of Medicina Dello Sport E Dellattivita Motoria Ims |
Menegon T.,Servizio per la Promozione della Salute e Tutela Nelle Attivita Sportive
Medicina dello Sport | Year: 2015
Aim. With this study we wanted to investigate how exercise programs can be customized and adapted to improve the clinical condition of the patients with chronic degenerative diseases stabilized and non-communicable diseases, affecting the health care cost containment. Methods. In 2009/2010, after appropriate medical screening, we selected a sample of 178 subjects aged between 35 and 85 years old, who had carried out a cycle of sport-therapy in medical gym with AMPA method (Personalized and Adapted Motor Activity). The subjects were then subjected to a new screening, useful for the comparison of clinical and functional parameters collected during pre-and postintervention. Were then identified five specific groups of patients: elevated blood pressure group, elevated blood glucose group, high cholesterol group, high BMI (Body Mass Index) group and reduced TI (Tiffeneau Index) group. For each group, we performed a comparison between the values of "baseline" and "end of cycle sport-therapy" of the parameters investigated. The modified questionnaire QUALEFFO-41 was used to evaluate the perception of health status and quality of life pre-and postintervention. Results. The effectiveness of sport-therapy is demonstrated by the improvement in the perception of health status, quality of life, cardiorespiratory functional capacity, cardiovascular and metabolic parameters considered. This is closely correlated with the reduction in the risk of cardiovascular events and with better management of chronic disease, which is likely to result in the reduction of hospital admissions and complaints to the general practitioner and / or specialist visits.Conclusion. We validate the sports therapy as an effective tool for the prevention and treatment of chronic stabilized diseases, that nowadays have become a health and social problem due to significant implications for welfare and economic development. In response to the new demand for health and care of citizens suffering from chronic disease and the reduction of health care costs, the Institute of Sports Medicine of Vittorio Veneto and the Health Units 7 of Pieve di Soligo (TV) have made available a sport-therapy service (AMPA system) on the territory.