Unit of Epileptology and Experimental Neurophysiology and Fondazione Instituto Neurologico Carlo Besta

Milano, Italy

Unit of Epileptology and Experimental Neurophysiology and Fondazione Instituto Neurologico Carlo Besta

Milano, Italy
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PubMed | Unit of Epileptology and Experimental Neurophysiology and Fondazione Instituto Neurologico Carlo Besta and University of Rome La Sapienza
Type: Journal Article | Journal: Cold Spring Harbor perspectives in medicine | Year: 2015

The neurophysiological patterns that correlate with partial (focal) seizures are well defined in humans by standard electroencephalogram (EEG) and presurgical depth electrode recordings. Seizure patterns with similar features are reproduced in animal models of partial seizures and epilepsy. However, the network determinants that support interictal spikes, as well as the initiation, progression, and termination of seizures, are still elusive. Recent findings show that inhibitory networks are prominently involved at the onset of these seizures, and that extracellular changes in potassium contribute to initiate and sustain seizure progression. The end of a partial seizure correlates with an increase in network synchronization, which possibly involves both excitatory and inhibitory mechanisms.

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