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Nikou G.C.,Laiko University Hospital | Pazaitou-Panayiotou K.,Unit of Endocrinology and Endocrine Oncology | Dimitroulopoulos D.,Agios Savas Cancer Hospital | Alexandrakis G.,NIMTS Hospital | And 5 more authors.
BMC Endocrine Disorders

Background: The rare incidence of neuroendocrine neoplasms (NENs) has contributed to a paucity of large epidemiologic studies of patients with this condition. We investigated the occurrence and clinicopathologic features of NENs in Greece. Methods: Between October 2010 and November 2012 we collected data on 246 newly diagnosed patients from a broad-based multi-institutional registry that comprises eight academic and hospital sites in Greece. The WHO 2010 pathologic classification and the 7th AJCC Staging system was applied in all cases. Results: Of all patients 94 % had a sporadic and 6 % a multiple endocrine neoplasia tumor; 63.4 % were gastroenteropancreatic-(GEP)-NENs, 17.9 % Head & Neck NENs, 9.8 % NENs of Unknown Primary, 6.5 % Lung NENs and 2.4 % Pheochromocytomas. Gastric and pancreatic NENs were the most common primary sites. Poorly differentiated neuroendocrine carcinomas (NEC) were 9.3 %, all sporadic. Fifteen percent of patients were asymptomatic at presentation, 24 % had a first symptom of the disease related to endocrine syndrome and 61 % had symptoms related to locally advanced or metastatic disease. Metastatic disease was established in 25 % of tumors most frequently in the GEP NEN group. Findings are presented according to Ki-67 distribution. MRI had a higher diagnostic positive yield than Octreoscan. Somatostatin analogs, lanreotide and octreotide acetate, were prescribed at 38.5 & 61.5 % of NEN patients respectively and were found to be equally effective at providing symptomatic relief. Conclusions: This is to our knowledge the first study of a Greek tumor registry and one of the few European Registries providing information regarding clinicopathologic characteristics and therapies in patients with neuroendocrine tumors of various origin sites, beyond GEP NENs. © 2016 Nikou et al. Source

Kaltsas G.,National and Kapodistrian University of Athens | Chrisoulidou A.,Unit of Endocrinology and Endocrine Oncology | Piaditis G.,George Genimatas Hospital | Kassi E.,National and Kapodistrian University of Athens | Chrousos G.,National and Kapodistrian University of Athens
Trends in Endocrinology and Metabolism

Adrenal incidentalomas (AI) are serendipitously discovered lesions during abdominal imaging studies that need to be investigated for evidence of hormonal hypersecretion and/or malignancy. Because imaging modalities can reliably identify lesions that carry a high risk of malignancy, we focus on the identification of hypersecretory lesions and those with subclinical activity, particularly Cushing syndrome. Because diverse diagnostic tests and cut-offs are employed, the prevalence of hypersecretory AI varies widely, and there is controversy regarding their long-term sequelae. In this article we provide information regarding current radiological means to define the nature of AI, and the most appropriate biochemical tests for delineating hypersecretory states. We also discuss the duration and intensity of AI follow-up as well as the identification of AI that require specific therapeutic intervention. © 2012 Elsevier Ltd. Source

Chrisoulidou A.,Unit of Endocrinology and Endocrine Oncology | Goulis D.G.,Aristotle University of Thessaloniki | Iliadou P.K.,Unit of Endocrinology and Endocrine Oncology | Dave J.R.,Virology Immunology Section | And 4 more authors.
Hypertension in Pregnancy

Objective. To investigate whether Chlamydia pneumoniae (Cp) infection is more common in women whose current pregnancy is complicated with preeclampsia (PE) as compared to pregnant women without PE. Methods. Thirty pregnant women with PE and 30 pregnant women without PE were studied between 29 and 30 weeks of gestation. The presence of an acute or chronic Cp infection was determined by the estimations of serum IgG, IgM, and IgA Cp antibodies. Results. None of the women were diagnosed as having acute Cp infection. Prevalence of chronic Cp infection was 53 and 66% in the PE and control groups, respectively (X 2, p = 0.068). Conclusion. Chronic Cp infection is not more common in women whose pregnancy is complicated with PE as compared to pregnant women without PE. Therefore, no association between Cp infection and PE can be established. © 2011 Informa Healthcare USA, Inc. Source

Chrisoulidou A.,Unit of Endocrinology and Endocrine Oncology | Pazaitou-Panayiotou K.,Unit of Endocrinology and Endocrine Oncology | Georgiou E.,Unit of Endocrinology and Endocrine Oncology | Boudina M.,Unit of Endocrinology and Endocrine Oncology | And 4 more authors.
Endocrine Research

Introduction. We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk. Methods and Results. Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls. Conclusion. Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls. © 2010 Informa UK, Ltd. Source

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