Union University at Jackson

Jackson, TN, United States

Union University at Jackson

Jackson, TN, United States
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Guilaran I.J.,Union University at Jackson
Physics Teacher | Year: 2012

When I was an undergraduate physics major, I would often stay up late with my physics major roommate as we would digest the physics content we were learning in our courses and explore our respective imaginations armed with our new knowledge. Such activity during my undergraduate years was confined to informal settings, and the first formal creativity assignment in my physics education did not come until well into my graduate years when my graduate advisor demanded that I write a prospectus for my dissertation. I have often lamented the fact that the first formal assignment in which I was required to be creative, take responsibility for my own learning and research objectives, and see them to completion during my physics education came so late, considering the degree to which creative attributes are celebrated in the personalities of great physicists. In this essay I will apply some of the basic concepts as defined by creativity-related psychology literature to physics pedagogy, relate these concepts to the exchanges in this journal concerning Michael Sobel's paper1 "Physics for the Non-Scientist: A Middle Way," and provide the framework for a low-overhead creativity assignment that can easily be implemented at all levels of physics education. © American Association of Physics Teachers.

Mondal A.,Union University at Jackson | Mondal A.,Florida A&M University | Bennett L.L.,Union University at Jackson
Biomedicine and Pharmacotherapy | Year: 2016

Despite advances in diagnosis and treatment options, breast cancer is one of the main causes of cancer related death among women worldwide. Present study is aimed to preliminarily evaluate our hypothesis that the combination of resveratrol (RSV), a natural antioxidant, and lower dose of sorafenib (SF), a multi-kinase inhibitor and a component of ERK1/2 (extracellular signal-regulated kinase 1/2) pathway, would augment apoptosis in human breast cancer MCF7 cells. MCF7 cellexpressions s were treated with RSV, SF and their combination. MTT (3-[4,5-dimethylthiazol-2-yl] −2, 5-diphenyl-tetrazolium bromide) assay, DNA fragmentation assay, Hoechst33342, H2DCFDA (2', 7'-Dichlorodihydrofluorescein diacetate), Rhodamine123 staining, and Western Blot to detect different signaling protein expressions, were conducted to test the hypothesis. Combination of RSV and SF showed higher cytotoxicity on MCF7 cells than their individual treatment. Results from morphology change, Hoechst33342 staining, and DNA fragmentation suggested higher apoptosis data in the combinational treatment. Intracellular ROS (reactive oxygen species) levels, p53 and Bax/Bcl2 expressions, and decrease in mitochondrial membrane potential were also higher in the combinational treatment. Up-regulation of apaf-1, cl. caspase 9, cl. caspase 3 and cl. PARP (poly (ADP-Ribose) polymerase) were also noticed, while the expressions of cyclinD1 and cyclinB1 were decreased in the combinational group. The increase in apoptosis and signaling protein expressions with RSV and SF combinational treatment were increased over time. The combination of RSV and lower dose of SF at 6 μM showed enhanced apoptotic activity than SF alone. Therefore, RSV can be considered as a neo-adjuvant to improve SF efficacy in breast cancer treatment. © 2016 Elsevier Masson SAS

Jones K.M.,Union University at Jackson
American journal of pharmaceutical education | Year: 2012

To assess the extent to which US colleges and schools of pharmacy are incorporating interprofessional education into their introductory pharmacy practice experiences (IPPEs), and to identify barriers to implementation; characterize the format, structure, and assessment; and identify factors associated with incorporating interprofessional education in IPPEs. An electronic survey of 116 US colleges and schools of pharmacy was conducted from March 2011 through May 2011. Interprofessional education is a stated curricular goal in 78% of colleges and schools and consistently occurred in IPPEs in 55%. Most colleges and schools that included interprofessional education in IPPEs (70%) used subjective measures to assess competencies, while 17.5% used standardized outcomes assessment instruments. Barriers cited by respondents from colleges and schools that had not implemented interprofessional education in IPPEs included a lack of access to sufficient healthcare facilities with interprofessional education opportunities (57%) and a lack of required personnel resources (52%). Many US colleges and schools of pharmacy have incorporated interprofessional education into their IPPEs, but there is a need for further expansion of interprofessional education and better assessment related to achievement of interprofessional education competencies in IPPEs.

To evaluate first-year doctor of pharmacy (PharmD) students' communication apprehension, outcome expectations, and self-efficacy for communication over the duration of a 15-week patient-counseling course. First-year PharmD students (n=94) were asked to complete a 47-item, self-administered questionnaire on 3 occasions over the duration of the Nonprescription Drugs/Patient-Counseling course during the fall 2009 and 2010 semesters. Eighty-seven of 94 students completed the survey instrument across data collection periods. There were significant reductions in total communication apprehension scores and in the communication apprehension subscores for meetings and public speaking, and significant increases in self-efficacy over time. No differences were found for outcome expectations of communication scores or the subscores for interpersonal conversations and group discussion. Communication apprehension may be decreased and self-efficacy for communication increased in first-year PharmD students through a 15-week Nonprescription Drugs/Patient-Counseling course using small-group practice sessions, case studies, and role-play exercises in conjunction with classroom lectures.

Bennett L.L.,Union University at Jackson | Ingason A.,Union University at Jackson
Annals of Pharmacotherapy | Year: 2014

Objective: To review the pharmacology and pharmacokinetics, and to evaluate the clinical efficacy, safety, and place in therapy of enzalutamide for the treatment of castration-resistant prostate cancer (CRPC). Data Sources: A literature search through PubMed (1984 to November 2013; English language) was performed using the following keywords: MDV3100, androgen deprivation therapy, enzalutamide, CRPC, and androgen receptor antagonist. Searches were limited to published studies in humans. Study Selection and Data Extraction: All articles in English identified from reviews, abstracts, presentations, and clinical trials of enzalutamide in humans were selected and included. Data Synthesis: Enzalutamide is an oral, nonsteroidal second-generation androgen receptor antagonist that is Food and Drug Administration-approved for the treatment of metastatic CRPC in men who were previously treated with docetaxel. Enzalutamide was superior to placebo for increasing median survival from 13.6 months to 18.4 months. Enzalutamide was well tolerated at a dose of 160 mg, with minor adverse events such as fatigue, diarrhea, musculoskeletal pain, and hot flashes. Patients with increased risk of seizure should not take enzalutamide. Conclusions: Enzalutamide is effective to slow progression of metastatic CRPC, to reduce prostate-specific antigen (PSA) levels, to decrease time to progression of PSA, to increase time to first skeletal-related events, and to increase quality of response rate. Enzalutamide was given at 160 mg/d for a median of 8 cycles of administration. Clinical trials are currently being conducted to observe if enzalutamide will be useful for treatment of other cancers and for early administration in prostate cancer. © The Author(s) 2014.

Poore G.M.,Union University at Jackson
Computational Science and Discovery | Year: 2015

PythonTeX is a LaTeX package that allows Python code in LaTeX documents to be executed and provides access to the output. This makes possible reproducible documents that combine results with the code required to generate them. Calculations and figures may be next to the code that created them. Since code is adjacent to its output in the document, editing may be more efficient. Since code output may be accessed programmatically in the document, copy-and-paste errors are avoided and output is always guaranteed to be in sync with the code that generated it. This paper provides an introduction to PythonTeX and an overview of major features, including performance optimizations, debugging tools, and dependency tracking. Several complete examples are presented. Finally, advanced features are summarized. Though PythonTeX was designed for Python, it may be extended to support additional languages; support for the Ruby and Julia languages is already included. PythonTeX contains a utility for converting documents into plain LaTeX, suitable for format conversion, sharing, and journal submission. © 2015 IOP Publishing Ltd.

Kreissl S.,University of Colorado at Boulder | Pingen G.,Union University at Jackson | Maute K.,University of Colorado at Boulder
International Journal for Numerical Methods in Engineering | Year: 2011

A computational methodology for optimizing the conceptual layout of unsteady flow problems at low Reynolds numbers is presented. The geometry of the design is described by the spatial distribution of a fictitious material with continuously varying porosity. The flow is predicted by a stabilized finite element formulation of the incompressible Navier-Stokes equations. A Brinkman penalization is used to enforce zero-velocities in solid material. The resulting parameter optimization problem is solved by a non-linear programming method. The paper studies the feasibility of the material interpolation approach for optimizing the topology of unsteady flow problems. The derivation of the governing equations and the adjoint sensitivity analysis are presented. A design-dependent stabilization scheme is introduced to mitigate numerical instabilities in porous material. The emergence of non-physical artifacts in the optimized material distribution is observed and linked to an insufficient resolution of the flow field and an improper representation of the pressure field within solid material by the Brinkman penalization. Two numerical examples demonstrate that the designs optimized for unsteady flow differ significantly from their steady-state counterparts. © 2011 John Wiley & Sons, Ltd.

Bennett L.L.,Union University at Jackson | Mohan D.,Union University at Jackson
Annals of Pharmacotherapy | Year: 2013

Objective: To review the epidemiology, pathophysiology, and treatments of Gaucher disease (GD), focusing on the role of enzyme replacement therapy (ERT), andsubstrate reduction therapy (SRT). Data Sources: A literature search through PubMed (1984-May 2013) of English language articles was performed with terms: Gaucher's disease, lysosomal storage disease. Secondary and tertiary references were obtained by reviewing related articles. Study Selection and Data Extraction: All articles in English identified from the data sources, clinical studies using ERT, SRT and articles containing other interesting aspects were included. Data Synthesis: GD is the most common inherited LSD, characterized by a deficiency in the activity of the enzyme acid β-glucosidase, which leads to accumulation of glucocerebroside within lysosomes of macrophages, leading to hepatosplenomegaly, bone marrow suppression, and bone lesions. GD is classified into 3 types: type 1 GD (GD1) is chronic and non-neuronopathic, accounting for 95% of GDs, and types 2 and 3 (GD2, GD3) cause nerve cell destruction. Regular monitoring of enzyme chitotriosidase and pulmonary and activation-regulated chemokines are useful to confirm the diagnosis and effectiveness of GD treatment. Conclusions: There are 4 treatments available for GD1: 3 ERTs and 1 SRT. Miglustat, an SRT, is approved for mild to moderate GD1. ERTs are available for moderate to severe GD1 and can improve quality of life within the first year of treatment. The newest ERT, taliglucerase alfa, is plant-cell derived that can be produced on a large scale at lower cost. Eliglustat tartrate, another SRT, is under phase 3 clinical trials. No drugs have been approved for GD2 or GD3. © The Author(s) 2013.

Makhija D.,University of Colorado at Boulder | Pingen G.,Union University at Jackson | Maute K.,University of Colorado at Boulder
Computer Methods in Applied Mechanics and Engineering | Year: 2014

This paper presents a stabilized finite element formulation of the hydrodynamic Boltzmann transport equation (HBTE) to predict nearly incompressible fluid flow. The HBTE is discretized with Hermite polynomials in the velocity variable, and a streamline upwind Petrov-Galerkin formulation is used to discretize the spatial variable. A nonlinear stabilization scheme is presented, from which a simple linear stabilization scheme is constructed. In contrast to the Navier-Stokes (NS) equations, the HBTE is a first order equation and allows for conveniently enforcing Dirichlet conditions along immersed boundaries. A simple and efficient formulation for enforcing Dirichlet boundary conditions is presented and its accuracy is studied for immersed boundaries captured by the extended finite element method (XFEM). Numerical experiments indicate that both the linear and non-linear stabilization methods are sufficiently accurate and stable, but the linear formulation reduces the computational cost significantly. The accuracy of enforcing boundary conditions is satisfactory and shows second order convergence as the mesh is refined. Augmenting the boundary condition formulation with a penalty term increases the accuracy of enforcing the boundary condition constraints, but may degrade the accuracy of the global solution. Comparisons with results of a single relaxation time lattice Boltzmann method show that the proposed finite element method features greater robustness and lesser dependence of the computational costs on the level of mesh refinement. © 2014 Elsevier B.V.

Martin A.C.,Union University at Jackson
Journal of Pharmacy Practice | Year: 2011

The prevalence of osteoporosis is estimated to be 18% in men, but 30% of all fractures occur in men. With age, men experience a gradual decline in testosterone production and bone density. The rate of trabecular bone loss in the lumbar spine in men over age 50 can be double the rate of loss in men under age 50. Endogenous testosterone, estradiol, and their metabolites play a role in maintaining bone health, but their specific effects on bone turnover have been difficult to elucidate. Recently, large cohort studies have provided more detailed information confirming estrogen's associations and further characterizing the effect of endogenous testosterone and its metabolites on bone mineral density and fractures. Very few clinical trials have assessed the impact of testosterone replacement therapy (TRT) on bone density and fractures in men. The few studies that have been conducted are generally small and not robust enough to show the true treatment effect of TRT and adequately determine its safety. In the absence of data on patient outcomes, it is important for pharmacists to understand the impact of drug therapy on biomarkers and surrogate markers of disease for optimal pharmacotherapy selection and monitoring. © The Author(s) 2011.

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