News Article | December 13, 2016
The International Association of HealthCare Professionals is pleased to welcome Arup Maitra, MD, Nephrologist, to their prestigious organization with his upcoming publication in The Leading Physicians of the World. Dr. Maitra is a highly-trained and qualified Nephrologist with an extensive expertise in all facets of his work, especially internal medicine and nephrology. He has been in practice for more than 20 years and is currently serving patients at Renal Consultants Inc. in Canton, Ohio. Furthermore, Dr. Maitra is affiliated with Aultman Hospital, Mercy Medical Center, Union Hospital, and Affinity Medical Center. Dr. Arup Maitra’s career in medicine began in 1982 when he graduated his Medical Degree from the Armed Forces Medical College of the University of Pune in India. After moving to the United States, Dr. Maitra completed his internship at the Lincoln Hospital, followed by his residency at New York Medical College. Dr. Maitra is certified in Nephrology by the American Board of Internal Medicine, and has also earned the coveted title of Fellow of the American College of Physicians. In addition to his busy practice, Dr. Maitra serves as a Clinical Assistant Professor at Northeast Ohio Medical University. He attributes his great success in his field to his compassion for his patients, as well as his commitment to providing them with the best treatment available. When he is not assisting patients, Dr. Maitra likes to relax by reading. Learn more about Dr. Maitra by reading his upcoming publication in the Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics. Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise. A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life. For more information about FindaTopDoc, visit http://www.findatopdoc.com
Tsang J.Y.S.,Chinese University of Hong Kong |
Ni Y.-B.,Chinese University of Hong Kong |
Chan S.-K.,Kwong Wah Hospital |
Shao M.-M.,Guangzhou University |
And 3 more authors.
Annals of Surgical Oncology | Year: 2014
Background: Androgen receptor (AR), a nuclear steroid hormone receptor, is differentially expressed in breast cancer subgroups with distinct clinical implications. Methods: To investigate the clinical significance of AR in breast cancers more precisely, the expression of AR in a large cohort of breast cancer was correlated with clinicopathological features, biomarker expression, and patients' survival according to different molecular groupings in this study. Results: Higher AR expression was found in ER+ (57.8 %) than in ER- (24.7 %) cancers. In the ER+ cancers, AR expression was associated with favorable clinicopathological features, including lower grade (p <.001), lower pT stage (p <.001), and positivity for PR (p <.001). It was an independent prognostic factor for longer disease-free survival, mainly in the HER2+ luminal B cancers (hazard ratio [HR] = 0.251, 95 % CI 0.065-0.972, p =.045). In ER- cancers, AR expression was associated with features distinct from basal-like breast cancer, and such features were found in molecular apocrine (MA) cancers. AR correlated with presence of extensive in situ component (p =.006) and apocrine phenotype (p <.001), HER2 (p =.026), and EGFR (p =.048), but negatively with c-kit (p =.041), CK5/6 (p <.001), CK14 (p =.002), and αB-crystallin (p =.038). However, AR expression was found only in 37.8 % of immunohistochemically defined MA. Of note, AR-MA appeared to have a trend of worse overall survival than AR+MA. Conclusions: AR expression was different in ER+ and ER- cancers and had different clinical implications. AR alone may not be a good marker for MA subtype. Its expression in MA may have substantial prognostic implication and as such warrants further validation. © 2014 Society of Surgical Oncology.
Gou S.,Union Hospital |
Cui P.,Union Hospital |
Li X.,Union Hospital |
Shi P.,Union Hospital |
And 2 more authors.
PLoS ONE | Year: 2013
Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States. The prognosis remains dismal with little advance in treatment. Metformin is a drug widely used for the treatment of type II diabetes. Recent epidemiologic data revealed that oral administration of metformin is associated with a reduced risk of pancreatic cancer, suggesting its potential as a novel drug for this disease. Many studies have demonstrated the in vitro anticancer action of metformin, but the typically used concentrations were much higher than the in vivo plasma and tissue concentrations achieved with recommended therapeutic doses of metformin, and low concentrations of metformin had little effect on the proliferation of pancreatic cancer cells. We examined the effect of low concentrations of metformin on different subpopulations of pancreatic cancer cells and found that these selectively inhibited the proliferation of CD133+ but not CD24+CD44+ESA+ cells. We also examined the effect of low concentrations of metformin on cell invasion and in vivo tumor formation, demonstrating in vitro and in vivo anticancer action. Metformin was associated with a reduction of phospho-Erk and phospho-mTOR independent of Akt and AMPK phosphorylation. CD133+ pancreatic cancer cells are considered to be cancer stem cells that contribute to recurrence, metastasis and resistance to adjuvant therapies in pancreatic cancer. Our results provide a basis for combination of metformin with current therapies to improve the prognosis of this disease. © 2013 Gou et al.
Mak S.T.,United Christian Hospital |
Io I.Y.-F.,Caritas Medical Center |
Wong A.C.-M.,Union Hospital
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2013
Purpose To evaluate the prognostic factors for outcome of endoscopic dacryocystorhinostomy (DCR) in patients with primary acquired nasolacrimal duct obstruction. Materials and Methods Eighty-three consecutive cases of endoscopic DCR performed for primary acquired nasolacrimalduct obstruction by a single surgeon were included in a retrospective, noncomparative case series. The outcome was assessed at aminimumof 5months after surgery, being at least 3 months after removal of stents. Surgical success was defined both subjectively and objectively. Subjective success was defined as absence of epiphora. Objective anatomical success was defined as patency on syringing, and presence of a functioning rhinostomy evaluated using the functional endoscopic dye test. Variables assessed included age at surgery, gender,side, duration of intraoperative mitomycin C application, and duration of stent left in-situ. The prognostic factors for outcome were analyzed by the logistic regression test. Results Of the 79 analyzed cases, 74 (93.7 %) had successful surgical outcomes. The mean age at time of surgery was 55.5±13.3 years, and the majority of patients were female (85 %). The mean follow-up period was 23.3±16.8 months. Age at surgery is a significant factor influencing the surgical outcome (P<0.05). Gender, side, duration of intraoperativemitomycin C application, and duration of stent left in-situ had no significant association with the outcome (P>0.05). Conclusion In endoscopic DCR for primary acquired nasolacrimal duct obstruction, younger patient age at time of surgerywas associated with a higher rate of failure. © Springer-Verlag Berlin Heidelberg 2012.
Wong A.C.-M.,Union Hospital |
Mak S.T.,Caritas Medical Center
Journal of Cataract and Refractive Surgery | Year: 2011
A 47-year-old man who had been using finasteride for male pattern alopecia for 4 years complained of progressive bilateral blurring of vision. His general health had been good, and he was not on any other long-term medication. Examination showed bilateral anterior subcapsular cataracts. Phacoemulsification and insertion of intraocular lenses were performed, and both eyes showed features of intraoperative floppy-iris syndrome (IFIS), including undulation and billowing of the iris, iris prolapse, and pupil constriction. We believe the use of finasteride can be associated with cataract formation and IFIS. Ophthalmologists and physicians prescribing finasteride should be aware of this possible association. © 2011 ASCRS and ESCRS.
Lau P.P.L.,Queen Elizabeth Hospital |
Lui P.C.W.,Union Hospital |
Lau G.T.C.,Queen Elizabeth Hospital |
Yau D.T.W.,Queen Elizabeth Hospital |
And 2 more authors.
American Journal of Surgical Pathology | Year: 2013
Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon sarcoma with a deceptively bland-looking morphology that disguises its malignant clinical behavior. It shows distinctive chromosomal translocations resulting in fusion of FUS with the CREB3L2 gene in most cases and CREB3L1 in rare cases. Thus molecular studies are particularly helpful in the diagnosis of this bland-looking sarcoma. We report 2 cases of LGFMS serendipitously found to harbor a novel alternative EWSR1-CREB3L1 gene fusion, as confirmed by DNA sequencing of reverse transcriptase-polymerase chain reaction products and fluorescence in situ hybridization. One patient was a child who presented with a subcutaneous nodule on the lower leg, and the other was a middle-aged woman who had a mass lesion over the proximal thigh. Morphologically, one case showed a spindle cell tumor with hyalinization and giant rosettes, whereas the other showed classical histology of LGFMS with focal metaplastic bone formation. Immunostaining for MUC4 showed extensive positive staining. Our findings therefore expand the spectrum of gene fusions that characterize LGFMS and suggest that the EWSR1 gene may substitute for the function of FUS in gene fusions of sarcoma. Copyright © 2013 by Lippincott Williams &Wilkins.
Poudyal S.,Union Hospital
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences | Year: 2012
FOR smear layer removal from root canal walls, ethylenediaminetetraacetic acid (EDTA) is an effective chelating agent and its efficiency depends upon a lot of factors such as concentration, pH, duration of application, the type of the solution, the root canal length, penetration depth of the material, and hardness of the dentin.The aim of this scanning electron microscopic study was to evaluate the effectiveness of 19% EDTA gel on smear layer removal at different time periods when used as a final step in the irrigation regime.
Mak S.T.,Caritas Medical Center |
Wong A.C.-M.,Union Hospital
Eye (Basingstoke) | Year: 2012
AimsTo assess the vision-related quality of life of corneal transplant recipients using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25), and to identify the socio-demographic factors that associate with patients self-assessment of perceived visual function.MethodsThirty patients who received corneal transplants were included in this prospective observational, cross-sectional study. Socio-demographic and clinical data, including age, sex, systemic health status, employment status, visual acuity, reason of corneal transplantation, laterality of corneal graft, and follow-up period were collected. NEI VFQ-25 was scored using Rasch analysis. Subgroup analyses were also performed.ResultsAge, sex, visual acuity, and health status had no significant correlation or association with the Rasch-transformed score. Patients who received bilateral corneal grafts were significantly less able socioemotionally than those with unilateral graft. Patients who became unemployed or retired after transplantation were also significantly less able in both visual functioning and socioemotional status.ConclusionCorneal transplant recipients had a decreased vision-related quality of life as demonstrated by the NEI VFQ-25. Apart from anatomical success and visual acuity, ophthalmologists should also consider other aspects of visual outcome. In particular, those who received bilateral grafts require more attention. Employment programmes should be part of corneal transplantation rehabilitation planning. © 2012 Macmillan Publishers Limited All rights reserved.
Shuai X.-X.,Union Hospital |
Chen Y.-Y.,Huazhong University of Science and Technology |
Lu Y.-X.,Union Hospital |
Su G.-H.,Union Hospital |
And 3 more authors.
European Journal of Heart Failure | Year: 2011
AimsThere are no unified criteria for diagnosing heart failure with preserved ejection fraction (HFpEF). The aim of this study was to evaluate the present main diagnostic criteria and to discover which parameters and strategies are more valuable.Methods and resultsEchocardiographic data and plasma N-terminal pro-brain natriuretic peptide levels were assessed in a derivation cohort (n 236) and a validation cohort (n 98). Both cohorts included normal controls, patients with hypertensive heart disease without heart failure and patients with HFpEF. In the derivation cohort, the ratio of early mitral inflow velocity to tissue Doppler velocity at lateral mitral annulus (lateral E/e<12), left atrial volume index (LAVI<34 mL/m2), and the difference between duration of reversed pulmonary vein atrial systole flow and duration of mitral A wave flow (ArdAd>30 ms) had the greatest diagnostic value among all the single parameters. A brief strategy that consisted of either: (i) lateral E/e<12; or (ii) 12>lateral E/e<8, with either LAVI<34 mL/m2 or ArdAd>30 ms, provided good diagnostic accuracy for identifying diastolic dysfunction in HFpEF, with a sensitivity of 77 and specificity of 81. These observations were confirmed in the validation cohort.ConclusionEchocardiographic parameters including lateral E/e, LAVI, and ArdAd have the greatest value in diagnosing HFpEF. A brief strategy that included these three parameters had great diagnostic value and would be simple to use in clinic practice. © 2011 The Author.
Wong A.C.M.,Union Hospital |
Mak S.T.,Tuen Mun Hospital
Journal of AAPOS | Year: 2012
Preseptal cellulitis in children can be caused by a reaction to embedded insects, their body parts, or secretions. We report the case of a 2-year-old girl who presented with preseptal cellulitis caused by an insect identified as Megacopta centrosignatum in her superior fornix. Copyright © 2012 by the American Association for Pediatric Ophthalmology and Strabismus.