Canoas, Brazil
Canoas, Brazil

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Monachese M.,Lawson Health Research Institute | Cunningham-Rundles S.,Cornell University | Diaz M.A.,Baylor College of Medicine | Guerrant R.,University of Virginia | And 10 more authors.
Gut Microbes | Year: 2011

Infectious disease in the developing world continues to represent one of the greatest challenges facing humanity. Every year over a million children suffer and die from the sequela of enteric infections, and in 2008 was estimated almost 2.7 million (UNAIDS 2009 update) adults and children became infected with human immunodeficiency virus (HIV). While oral rehydration therapy for diarrhea and antiretrovirals (ARV) for HIV are critical, there is a place for adjunctive therapies to improve quality of life. The importance of the human microbiota in retaining health is now recognized, as is the concept of replenishing beneficial microbes through probiotic treatments. Studies have shown that probiotics can reduce the duration of diarrhea, improve gut barrier function, help prevent bacterial vaginosis (BV) and enhance immunity even in HIV-infected subjects. However, many issues remain before the extent of probiotic benefits can be verified, and their application to the developing world realized. This consensus report outlines the potential probiotic, and to a lesser extent prebiotic, applications in resource disadvantaged settings, and recommends steps that could bring tangible relief to millions of people. The challenges to both efficacy and effectiveness studies in these settings include a lack of infrastructure and funding for scientists, students and research projects in developing countries; making available clinically proven probiotic and prebiotic products at affordable prices; and undertaking appropriately designed clinical trials. We present a roadmap on how efficacy studies may be conducted in a resource disadvantaged setting among persons with chronic diarrhea and HIV. These examples and the translation of efficacy into effectiveness are described. © 2011 Landes Bioscience.


Schuch F.B.,Unilasalle | Schuch F.B.,Hospital Of Clinicas Of Porto Alegre | Vancampfort D.,Catholic University of Leuven | Sui X.,University of South Carolina | And 6 more authors.
Preventive Medicine | Year: 2016

Physical activity (PA) is protective from future depression, however, the potential impact of cardiorespiratory fitness (CRF) on the development of depression is less clear. We aimed to investigate if lower levels of CRF are associated with a higher risk for depression onset. Major electronic databases were searched, from inception to January 2016 for prospective cohort studies evaluating the association between CRF and incident depression. Pooled hazard ratio (HR) with 95% confidence intervals (CIs) were calculated. Methodological quality was evaluated using the Newcastle-Ottawa scale (NOS). Three prospective studies were identified and data from two studies were pooled. Our data provide preliminary evidence found that people with low CRF and medium CRF were at increased risk of developing depression (n = 1,128,290, HR = 1.76, 95% CI 1.61–1.91, p < 0.001, I2 = 11.88, and HR = 1.23, 95% CI 1.20–1.38, p < 0.001, I2 = 0, respectively). Considered alongside the wider benefits of higher levels of CRF, these findings further support the rationale for interventions specifically targeting fitness, in order to reduce the significant burden associated with depression. © 2016 Elsevier Inc.


Barros F.M.C.,Federal University of Rio Grande do Sul | Ccana-Ccapatinta G.V.,Federal University of Rio Grande do Sul | Meirelles G.C.,Federal University of Rio Grande do Sul | Nunes J.M.,Federal University of Rio Grande do Sul | And 6 more authors.
Plant Systematics and Evolution | Year: 2013

The flowers constitute one of the main sites of accumulation of phenolic compounds in plants of the Hypericum genus. In addition to their important pharmacological activities, some metabolites found in species from the section Brathys and Trigynobrathys appear to have chemotaxonomic significance according to the literature. HPLC analyses were carried out to assess the pattern and accumulation of the dimeric phloroglucinols, benzophenones, benzopyrans, flavonoids and a phenolic acid in flowers of Hypericum species native to southern Brazil and Peruvian Páramos. Qualitative and quantitative differences are reported. Uliginosin B and hyperoside were the main components detected in all species and with maximum concentrations up to 0.188 % in H. caprifoliatum and 5.987 % in H. andinum, respectively. The content of japonicin A varied from 0.003 to 0.087 % in H. myrianthum, while the yield of hyperbrasilol B ranged from 0.006 % in H. laricifolium to 0.011 % in H. caprifoliatum. The major compounds in H. polyanthemum and H. carinatum were the benzopyrans 6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran (HP1 = 0.200 %), 7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran (HP2 = 0.225 %) and 5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethyl-benzopyran (HP3 = 0.327 %) and benzophenones cariphenone A (0.309 %) and cariphenone B (0.062 %), respectively. Maximum amounts of chlorogenic acid, isoquercitrin, quercitrin and guaijaverin were observed, respectively, in H. campestre (1.458 %), H. andinum (1.161 %), H. carinatum (0.231 %) and H. laricifolium (0.404 %). The results obtained support the taxonomic evidence of the dimeric phloroglucinol derivatives at the section level. © 2013 Springer-Verlag Wien.


Da Silva E.,Unilasalle | Pinto R.S.,Federal University of Rio Grande do Sul | Cadore E.L.,Federal University of Rio Grande do Sul | Kruel L.F.,Federal University of Rio Grande do Sul
Journal of Athletic Training | Year: 2015

Context: The effect of ibuprofen on pain tolerance during exercise is controversial, and its effects on endurance performance have been poorly investigated. Objective: To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue (tlim) in runners with exercise-induced muscle damage. Design: Randomized controlled clinical trial. Setting: Laboratory. Patients or Other Participants: Twenty healthy male long-distance runners (age = 18.8 ± 0.4 years, maximal oxygen consumption = 55.5 ± 5.9 mL·kg-1·min-1). Intervention(s): Participants were assigned to 2 groups (ibuprofen group = 10, placebo group = 10) to perform tlim trials (speed corresponded to their previously determined secondventilatory thresholds) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol (isokinetic dynamometry). One hour before the second tlim trial, the ibuprofen group received 1.2 g ibuprofen, and the placebo group received lactose orally. Main Outcome Measure(s): Time until self-reported fatigue, heart rate, respiratory quotient, oxygen consumption, and perceived exertion were recorded during each tlim test. Results: Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscledamage protocol. We observed a reduction in the endurance performance of both groups (P < .01) but no difference between groups (P = .55). Conclusions: Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners. © by the National Athletic Trainers' Association, Inc.


Oliveira C.,Unilasalle | Rodrigues R.T.,Federal University of Rio Grande do Sul | Rubio J.,Federal University of Rio Grande do Sul
Clean - Soil, Air, Water | Year: 2014

The formation of aerated flocs (aeroflocs) and the main operating parameters involved were studied to improve the rapid solid/liquid separation by flocculation-flotation. A continuous flow system at the laboratory scale was used that coupled micro-bubbles dissolved air flotation and a flocs generator reactor (FGR). The aerated floc characterization technique was employed to characterize the aggregates obtained using a non-ionic polymer (920SH SNF-Floerger®). Flocculation-flotation studies evaluated the effect of the suspension flow rates (Qs: 0.12, 0.24, 0.36, and 0.48m3/h, the air/solid rates (A/S: 0.01, 0.02, 0.03, and 0.04mg/mg) and the forms of flocculation (flocculation form I: a primary flocculation after coagulation inside a stirred tank, followed by mixture with air bubbles into the FGR and flocculation form II: full flocculation in the FGR). The main results demonstrated that the mixture of particles, air micro-bubbles and polymeric macromolecules in a proper turbulent flow inside the FGR was the key to the effective generation of very light aerated flocs. These aggregates had higher uprising rates, which ranged between 70 and 150m/h and represented 83% of the flocs population at an air/solid rate of 0.02mg/mg and a flow rate of 0.24m3/h. It is believed that, by maximizing operating parameters, improvements are achieved, mainly, both increasing the removal efficiencies and the design of the equipment that can be more compact requiring fewer areas than conventional units. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Lazzarotto A.R.,Unilasalle | Harthmann A.D.,Centro Universitario Metodista | Vicenzi F.L.,University of Porto | Sprinz E.,Federal University of Rio Grande do Sul
Revista Brasileira de Medicina do Esporte | Year: 2014

Introduction: Highly active antiretroviral therapy (HAART) was introduced to Brazil in 1996, as part of the national policy of free access to health services and drugs. Unfortunately, its continued use has been associated with changes in the redistribution of body fat, and metabolic changes which can increase morbidity and mortality in this population. Physical training has been studied as an effective strategy of non-pharmacological intervention to improve physical fitness parameters related to health and to minimize the undesirable effects of HIV infection and/or prolonged use of HAART. However, there are few studies on physical training, lipodystrophy syndrome and cardiology. Objective: To assess the risk of ischemic heart disease in HIV/AIDS subjects on HAART and in concurrent training with single sets. Methods: Fourteen subjects were assessed by waist circumference, systolic (SBP) and diastolic (DBP) blood pressure, lipid profile, total cholesterol (TC), HDL, LDL, triglycerides (TG) and glucose. The Framingham score was used to estimate the 10-year risk for coronary heart disease. Results: Except for LDL and TG values, most subjects were within the reference limits for the analyzed variables. Thirteen subjects (92.7%) were below the range of 10% for the 10-year risk for coronary heart disease, while only one subject (7.3%) showed a moderate risk. There was a significant correlation between training time and the SBP variable. Conclusion: We suggest conducting randomized trials to assess the same outcomes of this study.


Lazzarotto A.R.,Unilasalle | Lazzarotto A.R.,Federal University of Rio Grande do Sul | Bazzo K.O.,Faculdade da Serra Gaucha FSG
Revista Brasileira de Medicina do Esporte | Year: 2016

Introduction: Investigations of physical training with people living with HIV/Aids emphasize the aerobic, strength and concurrent components in multiple sets. Objective: To evaluate the concurrent training with single sets in immune, virological, cardiorespiratory, and muscular parameters in patients with HIV/Aids. Methods: Time series, with the participation of six men and one woman who used HAART. The immune parameter was assessed by flow cytometry, the virological, by the HIV-1 RNA 3.0 (bDNA) assay, the cardiopulmonary through the ramp protocol and the muscular parameter by the 15-repetition maximum and the maximum number of abdominal exercises within 1 minute. The training was performed three times a week for 12 weeks with monthly increments and reevaluations. The statistics included absolute value, median and range and the Wilcoxon t test using SPSS, version 20.0 (p<0.05). Results: In the immunological parameter, the number of CD4+ T lymphocytes increased (p=0.034). In the virological parameter, the viral load decreased in 2 participants (495 for 51 copies/ml and 72 non-detectable [<50 copies/ml]) and 5 maintained a non-detectable viral load. In the cardiorespiratory parameter there was an increase in the absolute VO2max (p=0.028) and maximum workload (Watt) in the cycloergometer (p=0.015). The workload increased in muscular function of all exercises assessed: peck deck (p=0.018), latissimus dorsi pull down (p=0.017), leg press (p=0.018), arm curl (p=0.016) and triceps extension (p=0.017) and maximum number of abdominal exercises in 1 minute (p=0.018). Conclusion: The training improved cardiopulmonary and muscular parameters and caused no deleterious effects on immune parameter or increase in viral load. © 2016, Redprint Editora Ltda. All rights reserved.


Grings M.,Federal University of Rio Grande do Sul | Boldrini I.I.,Federal University of Rio Grande do Sul | Knob A.,Herbario do Centro Universitario La Salle | De Loreto Bordignon S.A.,UNILASALLE
Phytotaxa | Year: 2014

Calyculogyas serrana (Malvaceae), a new species endemic to the highland slopes of “Serra Geral” plateau, in the Brazilian state of Rio Grande do Sul, is described and illustrated and we also provide information regarding its habitat and conservation status. The genus Calyculogygas has now two species, of which Calyculogygas uruguayensis is the type species. The two species are differentiated with a key, a table and illustrations, and we also provide a map of their distributions. © 2014 Magnolia Press. All rights reserved.


Oliveira C.,Unilasalle | Rodrigues R.T.,Federal University of Rio Grande do Sul | Rubio J.,Federal University of Rio Grande do Sul
Bubble Science, Engineering and Technology | Year: 2014

Understanding the generation and behaviour of air bubbles in the presence of different reagents is important in the solid/liquid separation processes used to treat mineral and water and wastewater by flocculation-flotation. The presence of large air bubbles in aerated flocs, which have higher up-rising rates, can lead to the development of higher capacity units. The present work evaluated the generation and behaviour of air bubbles on hydrophilic particles of quartz in water and other aqueous solutions (10 mg L-1 920SH non-ionic polymer, 30 mg L-1 DF250 surfactant and 50 mg L-1 Flotigan EDA amine). The operating parameters were the air bubble growth time, contact angle, adhesion, attachment and detachment. The main results showed that the air bubbles grew more readily in the presence of non-ionic polymers and after adhesion in non-ionic polymer and water. The formation of large bubbles in aerated flocs in an effort to develop industrial flocculation-flotation operations with higher throughputs units is discussed. © 2014 W. S. Maney & Son Ltd.


PubMed | UniLasalle and CNRS Integrated Transformations of Renewable Matter
Type: | Journal: Bioprocess and biosystems engineering | Year: 2016

The chemical oxygen demand (COD) is an essential parameter in waste management, particularly when monitoring wet anaerobic digestion processes. An adapted method to determine COD was developed for solid waste (total solids >15%). This method used commercial COD tubes and did not require sample dilution. A homemade plastic weighing support was used to transfer the solid sample into COD tubes. Potassium hydrogen phthalate and glucose used as standards showed an excellent repeatability. A small underestimation of the theoretical COD value (standard values around 5% lower than theoretical values) was also observed, mainly due to the intrinsic COD of the weighing support and to measurement uncertainties. The adapted COD method was tested using various solid wastes in the range of 1-8mg

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