Uniformed Services University of the Health Sciences

Bryans Road, MD, United States

The Uniformed Services University of the Health science is a health science university run by the U.S. federal government. The primary mission of the school is to prepare graduates for service to the U.S. at home and abroad in the medical corps.The university consists of the F. Edward Hébert School of Medicine, a medical school, which includes a full health science graduate education program, the Graduate School of Nursing, a nursing school, and a postgraduate dental college. The university's campus is located in Bethesda, Maryland. USU was established in 1972 under legislation sponsored by U.S. Representative Felix Edward Hébert of Louisiana. It graduated its first class in 1980.USU falls under the office of the Assistant Secretary of Defense for Health Affairs. Formerly known by the acronym USUHS, it has officially adopted the abbreviated acronym USU. Wikipedia.

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News Article | May 6, 2017
Site: www.prnewswire.com

New anatomically accurate features make it easier than ever to treat Victoria as if she were a real expectant mom. Her eyes, for example, can focus on and interact with her care-giver, enabling users to conduct a neurological-assessment that evaluates impaired eye motion for warning signs of a stroke, head trauma, drug use, cranial nerve impairment and other conditions. From early pregnancy complications, high-risk deliveries, and postpartum emergencies to non-gravid scenarios for general nursing care, Victoria simulates a full range of obstetrical events to facilitate teamwork and deepen critical thinking skills in learners of all levels. More than a childbirth simulator, Victoria is a complete simulation solution developed from decades of obstetrical experience -- a comprehensive package of tools and support to help improve patient safety in women's health through education and training. Super Tory, the world's most advanced neonatal patient simulator, gasps for breath as if he were a real newborn in respiratory distress. The new manikin's tablet-controlled dynamic lungs are so realistic that they accurately respond to real mechanical ventilation. At the touch of a button, Super Tory's respiratory system goes into acute distress and his entire body reacts. There's no mistaking when Super Tory is very sick – and that every member of the respiratory care team will need to work together to revive him. "Every specialist gets to participate in Super Tory's treatment," Gaumard executive vice president John Eggert says. Respiratory therapists, for example, can stabilize Super Tory with ACV, SIMV, CPAP, PCV, PSV or NIPPV, using real equipment in the NICU. "Super Tory allows healthcare providers to prepare for high risk/low frequency complications with anatomical and physiological accuracy never before seen in neonatal simulation," Mr. Eggert adds. "It's the first neonatal simulator to offer heart and lung interaction as well as motion in a mobile platform." "Super Tory can be assessed for early onset sepsis, hyperbilirubinemia, pneumonia with pneumothorax and other conditions using real vital signs monitors.  Critical metrics such as ECG-derived respiration rate, pre- and post-ductal SpO2, and NIBP can be evaluated in real time.  And Super Tory can be paced and defibrillated using real energy, just as in a clinical live situation. His facial expressions change and you can track his chest wall motion and programmable arm and leg movements." Super Tory is wireless and tetherless to ensure continuity of care as he is moved from the labor and delivery room to the NICU. Super Tory can be treated anytime, anywhere and remains fully functional in transit due to an internal, rechargeable battery that provides up to eight hours of wireless, tetherless operation -- an unprecedented technological feat in a simulator that is just eight pounds and 21 inches. Super Tory further expands the Gaumard neonatal high fidelity product line, which already includes Newborn Hal® and Newborn Tory® for those who demand an even higher level of fidelity including physical movement and actual mechanical ventilation. These features enable learners to experience advanced-level scenarios as in actual clinical practice. For in-depth training at the ACOG annual meeting, Colonel Shad Deering, Assistant Dean for Simulation Education at Uniformed Services University of the Health Sciences, leads a six-hour course on emergencies in clinical obstetrics on Tuesday, May 9 (details at http://bit.ly/2oYz756). Gaumard® Scientific Company has designed, manufactured and marketed simulators for health care education for more than 60 years. Users worldwide recognize Gaumard products for their innovation in simulation. In 2000, Gaumard launched the revolutionary family of NOELLE® maternal and neonatal care simulators that changed the way training is conducted. In 2004, Gaumard pioneered the use of fully tetherless technology with the introduction of the family of HAL® simulators. In 2014, the company introduced Victoria®, its most advanced, mobile maternal/fetal simulator as part of the NOELLE family. Gaumard manufactures its products at its world headquarters in Miami. The company sells simulators through its own representatives in North America and through 200 distributors in 70 countries. For more information, visit www.gaumard.com. Follow Gaumard on Twitter at http://www.twitter.com/GaumardInFocus on Facebook at www.facebook.com/gaumardsimulators and on YouTube at https://www.youtube.com/user/gaumardmedsimulators. View a video of Gaumard customer testimonials at http://bit.ly/1Oqhwcl. To view a video demonstration of Victoria, see http://bit.ly/1OSPBNd. Click here to see a schedule of all upcoming events at which Gaumard will demonstrate its patient simulators. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/gaumard-simulators-train-physicians-at-acog-2017-300452699.html

Riley E.M.,London School of Hygiene and Tropical Medicine | Stewart V.A.,Uniformed Services University of the Health Sciences
Nature Medicine | Year: 2013

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a licensed vaccine will soon be available for use in endemic countries, but given the relatively low efficacy of the vaccine, this needs to be seen as a major step forward on the road to a malaria vaccine rather than as arrival at the final destination. The focus for vaccine developers now moves to the next generation of malaria vaccines, but it is not yet clear what characteristics these new vaccines should have or how they can be evaluated. Here we briefly review the epidemiological and immunological requirements for malaria vaccines and the recent history of malaria vaccine development and then put forward a manifesto for future research in this area. We argue that rational design of more effective malaria vaccines will be accelerated by a better understanding of the immune effector mechanisms involved in parasite regulation, control and elimination. © 2013 Nature America, Inc. All rights reserved.

Halstead S.B.,Uniformed Services University of the Health Sciences
Emerging Infectious Diseases | Year: 2015

After an absence of ≈200 years, chikungunya returned to the American tropics in 2013. The virus is maintained in a complex African zoonotic cycle but escapes into an urban cycle at 40- to 50-year intervals, causing global pandemics. In 1823, classical chikungunya, a viral exanthem in humans, occurred on Zanzibar, and in 1827, it arrived in the Caribbean and spread to North and South America. In Zanzibar, the disease was known as kidenga pepo, Swahili for a sudden cramp-like seizure caused by an evil spirit; in Cuba, it was known as dengue, a Spanish homonym of denga. During the eighteenth century, dengue (present-day chikungunya) was distinguished from breakbone fever (present-day dengue), another febrile exanthem. In the twentieth century, experiments resulted in the recovery and naming of present-day dengue viruses. In 1952, chikungunya virus was recovered during an outbreak in Tanzania, but by then, the virus had lost its original name to present-day dengue viruses. © 2014, Emerging Infectious Diseases. All rights reserved.

Via C.S.,Uniformed Services University of the Health Sciences
Trends in Immunology | Year: 2010

The parent-into-F1 model has led to important advances in our understanding of lupus. Here, we review the work in murine lupus that elucidated the role of T cells and supported the conclusion that the parent-into-F1 model of induced lupus compares favorably with de facto gold standard spontaneous models of lupus. Then we focus on recent work in parent-into-F1 mice, which has yielded novel insights into unresolved controversies, such as the role of apoptosis in the pathogenesis of lupus and lupus in patients receiving TNF blockade. Finally, the review considers the evidence that supports a potential role for CD8 T cells, both cytotoxic and memory cells, in mediating disease remission.

Gaidamakova E.K.,Uniformed Services University of the Health Sciences
Cell host & microbe | Year: 2012

Although pathogen inactivation by γ-radiation is an attractive approach for whole-organism vaccine development, radiation doses required to ensure sterility also destroy immunogenic protein epitopes needed to mount protective immune responses. We demonstrate the use of a reconstituted manganous peptide complex from the radiation-resistant bacterium Deinococcus radiodurans to protect protein epitopes from radiation-induced damage and uncouple it from genome damage and organism killing. The Mn(2+) complex preserved antigenic structures in aqueous preparations of bacteriophage lambda, Venezuelan equine encephalitis virus, and Staphylococcus aureus during supralethal irradiation (25-40 kGy). An irradiated vaccine elicited both antibody and Th17 responses, and induced B and T cell-dependent protection against methicillin-resistant S. aureus (MRSA) in mice. Structural integrity of viruses and bacteria are shown to be preserved at radiation doses far above those which abolish infectivity. This approach could expedite vaccine production for emerging and established pathogens for which no protective vaccines exist. Copyright © 2012 Elsevier Inc. All rights reserved.

Scott D.W.,Uniformed Services University of the Health Sciences
Blood | Year: 2013

A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed "inhibitors." The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring intensive FVIII treatment until inhibitor titers drop. Although often successful, ITI is extremely costly and is less likely to succeed in patients with high-titer inhibitors. During the past decade, significant progress has been made in clarifying mechanisms of allo- and autoimmune responses to FVIII and in suppression of these responses. Animal model studies are suggesting novel, less costly methods to induce tolerance to FVIII. Complementary studies of anti-FVIII T-cell responses using blood samples from human donors are identifying immunodominant T-cell epitopes in FVIII and possible targets for tolerogenic efforts. Mechanistic experiments using human T-cell clones and lines are providing a clinically relevant counterpoint to the animal model studies. This review highlights recent progress toward the related goals of lowering the incidence of anti-FVIII immune responses and promoting durable, functional immune tolerance to FVIII in patients with an existing inhibitor.

Flagg T.P.,Uniformed Services University of the Health Sciences | Enkvetchakul D.,Washington University in St. Louis
Physiological Reviews | Year: 2010

ATP-sensitive potassium (KATP) channels are present in the surface and internal membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback between muscle cell metabolism and electrical activity. In so doing, they can play an important role in the control of contractility, particularly when cellular energetics are compromised, protecting the tissue against calcium overload and fiber damage, but the cost of this protection may be enhanced arrhythmic activity. Generated as complexes of Kir6.1 or Kir6.2 pore-forming subunits with regulatory sulfonylurea receptor subunits, SUR1 or SUR2, the differential assembly of KATP channels in different tissues gives rise to tissue-specific physiological and pharmacological regulation, and hence to the tissue-specific pharmacological control of contractility. The last 10 years have provided insights into the regulation and role of muscle KATP channels, in large part driven by studies of mice in which the protein determinants of channel activity have been deleted or modified. As yet, few human diseases have been correlated with altered muscle KATP activity, but genetically modified animals give important insights to likely pathological roles of aberrant channel activity in different muscle types. © 2010 the American Physiological Society.

Vannucci A.,Uniformed Services University of the Health Sciences
Journal of consulting and clinical psychology | Year: 2013

We used latent profile analysis (LPA) to classify children and adolescents into subtypes based on the overlap of disinhibited eating behaviors-eating in the absence of hunger, emotional eating, and subjective and objective binge eating. Participants were 411 youths (8-18 years) from the community who reported on their disinhibited eating patterns. A subset (n = 223) ate ad libitum from two test meals. LPA produced five subtypes that were most prominently distinguished by objective binge eating (OBE; n = 53), subjective binge eating (SBE; n = 59), emotional eating (EE; n = 62), a mix of emotional eating and eating in the absence of hunger (EE-EAH; n = 172), and no disinhibited eating (No-DE; n = 64). Accounting for age, sex, race, and body mass index z score (BMI-z), the four disinhibited eating groups had more problem behaviors than the no disinhibited eating group (p = .001). OBE and SBE subtypes had greater BMI-z, percent fat mass, disordered eating attitudes, and trait anxiety than EE, EE-EAH, and No-DE subtypes (ps < .01). However, the OBE subtype reported the highest eating concern (p < .001), and the OBE, SBE, and EE subtypes reported higher depressive symptoms than the EE-EAH and No-DE subtypes. Across both test meals, OBE and SBE subtypes consumed a lesser percentage of protein and a higher percentage of carbohydrate than the other subtypes (ps < .02), adjusting for age, sex, race, height, lean mass, percent fat mass, and total intake. EE subtypes also consumed a greater percentage of carbohydrate and a lower percentage of fat than the EE-EAH and No-DE subtypes (ps < .03). The SBE subtype consumed the least total calories (p = .01). We conclude that behavioral subtypes of disinhibited eating may be distinguished by psychological characteristics and objective eating behavior. Prospective data are required to determine whether subtypes predict the onset of eating disorders and obesity.

Cox B.M.,Uniformed Services University of the Health Sciences
Molecular Pharmacology | Year: 2013

It is now about 40 years since Avram Goldstein proposed the use of the stereoselectivity of opioid receptors to identify these receptors in neural membranes. In 2012, the crystal structures of the four members of the opioid receptor family were reported, providing a structural basis for understanding of critical features affecting the actions of opiate drugs. This minireview summarizes these recent developments in our understanding of opiate receptors. Receptor function is also influenced by amino acid substitutions in the protein sequence. Among opioid receptor genes, one polymorphism is much more frequent in human populations than the many others that have been found, but the functional significance of this single nucleotide polymorphism (SNP) has been unclear. Recent studies have shed new light on how this SNP might influence opioid receptor function. In this minireview, the functional significance of the most prevalent genetic polymorphism among the opioid receptor genes is also considered. Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics.

Daly M.J.,Uniformed Services University of the Health Sciences
DNA Repair | Year: 2012

A founding concept of radiobiology that deals with X-rays, γ-rays and ultraviolet light is that radiation indiscriminately damages cellular macromolecules. Mounting experimental evidence does not fit into this theoretical framework. Whereas DNA lesion-yields in cells exposed to a given dose and type of radiation appear to be fixed, protein lesion-yields are highly variable. Extremely radiation resistant bacteria such as Deinococcus radiodurans have evolved extraordinarily efficient antioxidant chemical defenses which specifically protect proteins and the functions they catalyze. In diverse prokaryotes, the lethal effects of radiation appear to be governed by oxidative protein damage, which inactivates enzymes including those needed to repair and replicate DNA. These findings offer fresh insight into the molecular mechanisms of radiation resistance and present themselves as new opportunities to study and control oxidative stress in eukaryotes, including mammalian cells and their cancer cell counterparts. © 2011.

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