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In 2006, the Ministry of Health created the National Policy on Integrative and Complementary Therapies in the Unified Health System. This study aimed to investigate the knowledge and acceptance of complementary and integrative therapies and pharmaceutical care by SUS users. The study was conducted in the pharmacy of a primary healthcare unit in São João da Mata city, Minas Gerais state, Brazil. A cross sectional study was performed qualitatively and quantitatively with three doctors and 35 service users. Of these, 100% did not know the complementary and integrative therapies. After clear and simple explanation by the researcher, 31.42% said they would accept the use of herbal medicine, 51.42% accepted acupuncture, 37.14% would use homeopathy and none would use crenotherapy. When asked about the pharmaceutical care, 45.71% said they had heard of this matter, 22.85% know what it is and 31.42% had never heard of it. When the three doctors who at the clinic were questioned, there was indifference, non-acceptance and acceptance, respectively. In conclusion, this study showed that the vast majority of respondents would accept the complementary and integrative therapies if they were offered by the health unit. In addition, users find important a greater role of the pharmacist. One need to implement outreach programs for patients and especially for prescribers of complementary and integrative practices.


Damiao B.,Unifal MG | de Souza G.G.,Unifal MG | Nogueira D.A.,Unifal MG | Junior W.C.R.,Unifal MG | And 2 more authors.
Revista Neurociencias | Year: 2012

Objective. Investigate quantitative changes in cerebral cortex neurons bodies caused by the use of anabolic steroids. Method. Thirty mice were used, which received treatment with steroids (group 1- Deca Durabolin®; group 2- Potenay®; group 3- Saline) once a week and submitted to swimming three times a week, taking total treatment duration one month. After euthanasia, the brains were removed, fixed and histological processed and cresyl violet was used for staining. The slices were analyzed by light microscope and software to count the neurons bodies. Results. The results shows that there was a significant decrease of neurons bodies number in treated groups (P<0.01) when compared with the control group, but was not significant (P>0.05) when both genders were compared. In Potenay ® group, the animals showed 23.36 neurons bodies while the animals in Deca-durabolin® group had 23.40. The average values of neuron bodies were equal and lower than of control group, which was 31.70. Conclusion. The neuronal bodies density in cerebral cortex decreased significantly in mice undergoing treatment with steroids in relation to control group.


Amorim I.S.,Federal University of Lavras | Ferreira E.B.,Unifal MG | Lima R.R.,Unifal MG | Pereira R.G.F.A.,Federal University of Lavras
Food Quality and Preference | Year: 2010

Sensory science uses the human senses as instruments of measurement. Sensory analysis makes it possible to study organoleptic properties of products using a panel of assessors. Kermit and Lengard (2006) say that a good sensory panel should provide results that are accurate, discriminating and precise. Thus, in a successful analysis, it is key to have a set of robust tools for monitoring individual assessor's performances as well as the performance of the panel as a whole. The success of using a sensory panel depends on its performance, i.e., its ability to identify small differences between products in certain attributes with statistical significance. A good panel performance is achieved when each panelist discriminates between products (large product variability), repeats the assessments (small within-assessor variability) and agrees with all other panelists on the sensory sensation that is described by a particular attribute with certain strength (small between-assessor variability) (Derndorfer, Baierl, Nimmervoll, & Sinkovits, 2005). Evaluating unidimensionality of panel is essential for the efficient use of the sensory analysis. For such purpose, the Monte Carlo based test revealed to be powerful for large panel and sample sizes. It can be adopted as a tool for checking the efficiency of the training process of a panel. © 2009 Elsevier Ltd. All rights reserved.


Zavan B.,UNIFAL MG | Paffaro A.M.A.,UNIFAL MG | Joazeiro P.P.,University of Campinas | Yamada A.T.,University of Campinas | Paffaro Jr. V.A.,UNIFAL MG
Anatomical Record | Year: 2010

Uterine natural killer (uNK) cells are the dominant lymphocytes of pregnant mammals' uterus. Studies have identified four differentiation stage of mouse uNK cells based on Dolichos biflorus lectin cytochemistry, and their distribution showed preferential domain in the uterus through out the pregnancy. This work was done to investigate the expression of α5, α6, and β7 integrins on uNK cells and their ligands distribution. Section of mouse uterus from sixth to seventeenth gestational days were submitted to immunocytochemistry and positive reactions for α5, α6, and β7 integrins were found on uNK from eighth to tenth gestational days but not after twelfth gestational days. Fibronectin reactions were seemed from sixth to tenth gestational days around uNK from the myometrium and endometrium close to the myometrium. No reaction for fibronectin was seen in the decidualized and nondecidualized endometrium near the placenta. Laminin reaction was seen just in the antimesometrial side. β7 integrin seems to be the active receptor to bind with VCAM-1 or MAdCAM-1 of endothelial cells, promoting the uNK cross through the vessels. The absence of laminin in an uNK domain suggests these cells are not dependent of laminin and α6 integrin for their establishment. However, fibronectin seems to support uNK migration, proliferation, differentiation, and survival in the uterus by binding with α5 integrin. The loss of α5 integrin ligation by the down regulation of fibronectin could inhibits these events and further studies are need to investigate whether unligated α5 can actively and initiate apoptosis, maybe in a caspase 8-dependent way that has been called integrin-mediated death. © 2010 Wiley-Liss, Inc.


Incerpi E.K.,UNIFAL MG | Oliveira L.M.,University of Sao Paulo | Pereira E.M.,UNIFAL MG | Soncini R.,UNIFAL MG
International Journal of Experimental Pathology | Year: 2015

The aim of this study was to determine the effects of previous administration of metyrapone (met) on the acute lung injury (ALI) induced by caecal ligation and puncture (CLP) and to explore met's relationship with endogenous glucocorticoids (GCs) as measured by inflammatory, oxidative and functional parameters. One hundred and thirty-five Wistar rats were divided into three main groups: Control (Naïve), Sham and CLP. The animals received pretreatment one hour before surgery. The Naïve group did not undergo any procedure or pretreatment. The Sham group only had the caecum exposed and was pretreated with saline. The CLP group was divided into three pretreatments: metyrapone (CLP met 50 mg/kg i.p.), dexamethasone (CLP dex 0.5 mg/kg i.p.) or saline (CLP sal equivalent volume of 0.9% NaCl). Analyses were performed after 6 and 24 h of sepsis. Previous administration of met significantly increased inflammatory cells, as well as myeloperoxidase (MPO) activity in the lung tissue and alveolar collapsed area, with consequent impairment of respiratory mechanics being observed compared to Sham and Naïve; CLP sal exhibited similar results to those of met. The met reduced corticosterone (CCT) levels and dramatically increased hydrogen peroxide (H2O2) levels in the lung tissue compared to CLP sal. Our results suggest that previous administration of met may have contributed to increased pulmonary oxidative stress and increased mortality by mechanisms dependent of endogenous GC. © 2015 International Journal of Experimental Pathology.


Poirier G.,UNIFAL MG | Cassanjes F.C.,UNIFAL MG
Materials Chemistry and Physics | Year: 2010

Glasses were prepared in the binary system (100 - x)NaPO3-xMoO3 with x varying from 0 to 50 mol%. An increase in the MoO3 concentration promotes a strong absorption in the visible and near infrared attributed to Mo reduction during glass synthesis. X-ray absorption measurements were performed at the Mo K and L3 edges to investigate both the coordination number and oxidation state of Mo in these glasses. The evolution of the pre-peak observed at the K edge suggests that Mo atoms are six-fold coordinated in these glasses. This hypothesis was confirmed by data obtained at the Mo-L3-absorption edge. Since the final electronic states at the L3-absorption edge are mostly orbitals of d-character which are splitted by the ligand field, the amplitude of the d-orbital splitting could be estimated and the related coordination number of Mo obtained. Finally, the oxidation state of Mo could be related with a change of the white line intensity at the Mo-L3 edge. These results confirm that the optical absorption in the visible is due to Mo reduction and that transparent samples prepared by slow cooling contain less reduced Mo species. © 2009 Elsevier B.V. All rights reserved.


Ribeiro C.M.,Unifal MG | Silva D.K.,Unifal MG | Damiao B.,Unifal MG | Alves D.M.,Unifal MG | And 3 more authors.
Revista Neurociencias | Year: 2014

Introduction. In the last decades anabolic-androgenic steroids (AAS) use has increased and remains a high risk to customer’s health, mainly in the neurologic aspect. This article seeks to elucidate mechanisms by which AAS act in the cerebellum, by quantitative analyzing of Purkinje cells. Method. Sixty Swiss mice were divided into 6 experimental groups (n=10): G1 - males and female control; G2 – males and females treated with Deposteron®; G3 – males and females treated with Winstrol Depot®. The treatment lasts 30 days and consisted of intraperitoneal (IP) injection of 0.8 mg/kg of Deposteron® and 1.8 mg/kg of Winstrol Depot®. The animals were also submitted to swimming thrice a week during 30 days. Euthanasia was performed by Halothane inhalation and the cerebellums were fixed in a 4% formaldehyde solution in phosphate buffer solution (pH 7.4 O.1M). Fragments were processed and stained with Cresil-Violet and put to Purkinje cells counting. Results. After analyzing the samples, we could observe that there were no differences among females. However, among males treated with Deposteron® under the use of this specific AAS presented a decrease in the number of Purkinje cells (p<0.05). Conclusion. Therefore concluded that AAS is associated with the decrease in Purkinje cells in male animals treated with Deposteron®. © 2015 Universidade Federal de Sao Paulo. All rights reserved.


Sampaio M.T.F.,UNIFAL MG | Polo M.,Institute Ciencias da Natureza | Barbosa W.,Instituto Agronomico Of Campinas
Revista Arvore | Year: 2012

The objective of this study was to evaluate the species growing, to identify their growth pattern and to discuss the method quality in relation to plant reforestation. The survey was conducted after 32 months of planting seedlings, through sampling of fixed area by using plots, in which five sampling areas, selected to cover the entire length reforested, containing 200 individuals/sample area was used. Height and diameter were measured in all sampled plants, with a height greater than 1 (one) meter. Data were analyzed as a randomized block lineation (RBL), subjected to analysis of variance followed by Scott & Knott test at 5% of significance level, using the program SISVAR. Finally, it was concluded that pioneer species or those that have a short life cycle are considered ideal for deployment in early of reforestation due to fast growth; however they should have their management associated with not pioneer species or perennials species.


Gorini L.S.,Unifal MG | Silva D.K.,Unifal MG | Alves D.M.,Unifal MG | Rossi Junior W.C.,Unifal MG | Esteves A.,Unifal MG
Revista Neurociencias | Year: 2015

Introduction. The androgenic anabolic steroids (AAS) are a group of natural and synthetic compounds formed by the hormone testosterone and its derivatives. The purpose of this study is analyzing the density of nerve cells in the mouse cerebellum. Method. The male mice strain were divided into 4 groups: G1: Control (N=10), G2: Deca Durabolin® (N=10), G3: Durateston® (N=10) and G4: They were treated with both anabolic (N=10) simultaneously. Those mice were treated for two months and received doses of AAS and were submitted to swimming three times a week. After euthanasia the animals the cerebellums were removed, fixed and processed histologically. The cut samples were taken with 7μm then stained with cresyl violet and after, analyzed by a microscopic coupled to a camera and analysis software to count the neurons bodies. Results. Differences were observed in the results among the control group (8.41) and the groups that were treated with steroid Deca Durabolin® (5.10≅39%), Durateston® (5.60≅33%), and the group treated with both Anabolic (5.22≅38%). Conclusions. Thus, it is possible to observe through the results obtained that there was a decrease, the average from treatment groups AAS was 37%, in the density of neuron bodies in the cerebellar cortex. © 2015, Universidade Federal de Sao Paulo. All rights reserved.


PubMed | UNIFAL MG and University of Sao Paulo
Type: Journal Article | Journal: International journal of experimental pathology | Year: 2015

The aim of this study was to determine the effects of previous administration of metyrapone (met) on the acute lung injury (ALI) induced by caecal ligation and puncture (CLP) and to explore mets relationship with endogenous glucocorticoids (GCs) as measured by inflammatory, oxidative and functional parameters. One hundred and thirty-five Wistar rats were divided into three main groups: Control (Nave), Sham and CLP. The animals received pretreatment one hour before surgery. The Nave group did not undergo any procedure or pretreatment. The Sham group only had the caecum exposed and was pretreated with saline. The CLP group was divided into three pretreatments: metyrapone (CLP met 50mg/kg i.p.), dexamethasone (CLP dex 0.5mg/kg i.p.) or saline (CLP sal equivalent volume of 0.9% NaCl). Analyses were performed after 6 and 24h of sepsis. Previous administration of met significantly increased inflammatory cells, as well as myeloperoxidase (MPO) activity in the lung tissue and alveolar collapsed area, with consequent impairment of respiratory mechanics being observed compared to Sham and Nave; CLP sal exhibited similar results to those of met. The met reduced corticosterone (CCT) levels and dramatically increased hydrogen peroxide (H2 O2 ) levels in the lung tissue compared to CLP sal. Our results suggest that previous administration of met may have contributed to increased pulmonary oxidative stress and increased mortality by mechanisms dependent of endogenous GC.

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