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Saiz-Poseu J.,Unidad University | Sedo J.,Catalan Institute of Nanoscience and Nanotechnology | Garcia B.,Unidad University | Benaiges C.,Autonomous University of Barcelona | And 5 more authors.
Advanced Materials | Year: 2013

A facile one-step polymerization strategy is explored to achieve novel catechol-based materials. Depending on the functionality of the catechol, the as-prepared product can be used to modify at will the surface tension of nano and bulk structures, from oleo-/hydrophobic to highly hydrophilic. A hydrophobic catechol prepared thus polymerized shows the ability to self-assemble as solid nanoparticles with sticky properties in polar solvent media. Such a versatile concept is ideal for the development of catechol-based multifunctional materials. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Moragues M.E.,Unidad University | Moragues M.E.,Polytechnic University of Valencia | Moragues M.E.,CIBER ISCIII | Martinez-Manez R.,Unidad University | And 5 more authors.
Chemical Society Reviews | Year: 2011

This critical review is focused on examples reported in the year 2009 dealing with the design of chromogenic and fluorogenic chemosensors or reagents for anions (264 references). © 2011 The Royal Society of Chemistry.

Yin C.,Shanxi University | Huo F.,Shanxi University | Zhang J.,Shanxi University | Martinez-Manez R.,Unidad University | And 4 more authors.
Chemical Society Reviews | Year: 2013

Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes. This journal is © 2013 The Royal Society of Chemistry.

Coll C.,Unidad University | Coll C.,Polytechnic University of Valencia | Coll C.,CIBER ISCIII | Bernardos A.,Unidad University | And 7 more authors.
Accounts of Chemical Research | Year: 2013

Blending molecular and supramolecular advances with materials science has resulted in recent years in the development of new organic-inorganic hybrid materials displaying innovative functionalities. One appealing concept in this field is the development of gated nanodevices. These materials are prepared by grafting molecular or supramolecular caps onto the external surface of mesoporous inorganic scaffolds loaded with a particular cargo. The caps or "gates" can then be opened and the cargo delivered at will upon the application of a given stimulus.In this Account, we report some of the recent advances we have made in designing such materials for drug delivery and as new chromo-fluorogenic probes. For controlled release applications, we have prepared capped hybrid mesoporous supports capable of being selectively opened by applying certain physical and chemical stimuli. We report examples of gated materials opened by changes in pH (using polyamines as caps), light (employing spiropyran derivatives or gold nanoparticles), and temperature (using selected paraffins). We also report gated materials opened by enzymes that cleave capping molecules based on lactose, hydrolyzed starch, and peptides. The use of enzymes is especially appealing because molecular caps built of enzyme-specific sequences made of peptides or other cleavable molecules could allow on-command delivery of drugs and biomolecules in specialized contexts.In the second part of the manuscript, we revisit the possibility of using hybrid gated nanomaterials as sensory systems. In such systems, when target analytes interact with the cap, their presence triggers the transport of a dye from pores to the solution, resulting in a chromo-fluorogenic signal that allows their detection. Two approaches are possible. In the first one, pores remain open and the dye can diffuse into the solution, until the presence of a target analyte binds to receptors in the caps and closes the gate. In the second approach, the caps are closed and the presence of a target analyte induces pore opening and dye delivery. One of the most interesting properties of these sensory hybrid materials is their inherent amplification features, because few target analyte molecules can modulate the transport of a significant amount of dye molecules within the porous network. We describe such systems for the recognition and sensing of anionic (ATP, long-chain carboxylates, anionic surfactants, borate, and oligonucleotides), cationic (methylmercury), and neutral (nerve agent simulants and sulfathiazole) species. © 2012 American Chemical Society.

Escuder-Gilabert L.,University of Valencia | Martin-Biosca Y.,University of Valencia | Medina-Hernandez M.J.,University of Valencia | Sagrado S.,University of Valencia | Sagrado S.,Unidad University
Journal of Chromatography A | Year: 2014

Despite the fact that extensive research in the field of separations by capillary electrophoresis (CE) has been carried out and many reviews have been published in the last years, a specific review on the use and future potential of cyclodextrins (CDs) in CE is not available. This review focuses the attention in the CD-CE topic over the January 2013-February 2014 period (not covered by previous more general CE-reviews). Recent contributions (reviews and research articles) including practical uses (e.g. solute-CD binding constant estimation and further potentials; 19% of publications), developments and applications (mainly chiral and achiral analysis; 38 and 24% of publications, respectively) are summarized in nine comprehensive tables and are commented. Statistics and predictions related to the CD-CE publications are highlighted in order to infer the current and expected research interests. Finally, trends and initiatives on CD-CE attending to real needs or practical criteria are outlined. © 2014 Elsevier B.V.

Via-Sosa M.A.,Unidad University | Lopes N.,University of Barcelone | March M.,Unidad University
BMC Family Practice | Year: 2013

Background: Drug dosing errors are common in renal-impaired patients. Appropriate dosing adjustment and drug selection is important to ensure patients' safety and to avoid adverse drug effects and poor outcomes. There are few studies on this issue in community pharmacies. The aims of this study were, firstly, to determine the prevalence of dosing inadequacy as a consequence of renal impairment in patients over 65 taking 3 or more drug products who were being attended in community pharmacies and, secondly, to evaluate the effectiveness of the community pharmacist's intervention in improving dosing inadequacy in these patients when compared with usual care. Methods. The study was carried out in 40 Spanish community pharmacies. The study had two phases: the first, with an observational, multicentre, cross sectional design, served to determine the dosing inadequacy, the drug-related problems per patient and to obtain the control group. The second phase, with a controlled study with historical control group, was the intervention phase. When dosing adjustments were needed, the pharmacists made recommendations to the physicians. A comparison was made between the control and the intervention group regarding the prevalence of drug dosing inadequacy and the mean number of drug-related problems per patient. Results: The mean of the prevalence of drug dosing inadequacy was 17.5% [95% CI 14.6-21.5] in phase 1 and 15.5% [95% CI 14.5-16.6] in phase 2. The mean number of drug-related problems per patient was 0.7 [95% CI 0.5-0.8] in phase 1 and 0.50 [95% CI 0.4-0.6] in phase 2. The difference in the prevalence of dosing inadequacy between the control and intervention group before the pharmacists' intervention was 0.73% [95% CI (-6.0) - 7.5] and after the pharmacists' intervention it was 13.5% [95% CI 8.0 - 19.5] (p < 0.001) while the difference in the mean of drug-related problems per patient before the pharmacists' intervention was 0.05 [95% CI(-0.2) - 0.3] and following the intervention it was 0.5 [95% CI 0.3 - 0.7] (p < 0.001). Conclusion: A drug dosing adjustment service for elderly patients with renal impairment in community pharmacies can increase the proportion of adequate drug dosing, and improve the drug-related problems per patient. Collaborative practice with physicians can improve these results. © 2013 Via-Sosa et al.; licensee BioMed Central Ltd.

Medina C.,Unidad University | Frias M.,CSIC - Eduardo Torroja Institute for Construction Science | Sanchez De Rojas M.I.,CSIC - Eduardo Torroja Institute for Construction Science
Journal of Cleaner Production | Year: 2014

The re-use of construction and demolition, ceramic and similar waste in the construction industry has aroused considerable interest in recent years, as an avenue for furthering the sustainable use of resources and reducing the volume of waste dumped in landfills. Recycling materials as components in the manufacture of cement-based products, however, calls for an understanding of the leachability of the elements present in the new materials that may be harmful to human health or the respective ecosystems. The present study addresses the effect of including recycled ceramic sanitary ware waste as a partial substitute (25%) for natural coarse aggregate in the manufacture of recycled concrete in direct contact with water intended for human consumption. The findings show that the inclusion of ceramic aggregate raises the alkali concentration (Na and K) slightly and lowers the concentration of other elements (B, Si, Cl and Mg) in the water. The levels of all the leached elements were observed to be lower than the limits specified in the legislation in effect on water for human consumption. Consequently, these new concretes are apt for use in such applications, for they ensure water quality. © 2013 Elsevier Ltd. All rights reserved.

Frias M.,CSIC - Eduardo Torroja Institute for Construction Science | Garcia R.,Unidad University | De La Villa R.V.,Unidad University | Villar E.,University "Marta Abreu" of Las Villas
Construction and Building Materials | Year: 2013

This paper presents for the first time the influence of mixing different thermally activated paper sludges (APS) and fly ash (FA) on the pozzolanic reaction kinetics in APS-FA-Ca(OH)2 systems as a previous step to manufacture the future commercial ternary blended cements. In this study, two paper sludge wastes from different origins and activation conditions (laboratory (LS) and industrial (IS) scale) have been investigated, once mixed with fly ash at a ratio of 1:1 by weight. The results indicated that binary blends of pozzolans exhibited a high pozzolanic activity, showing that the hydrated phases produced during the pozzolanic reaction depend on the origin and activation conditions of clay wastes. At all times of reaction, the predominant phase turn out to be the LDH structures when LS pozzolan was used; meanwhile for the IS pozzolan the C4ACH12 along with the LDH were the main phases during the first 28 days. © 2012 Elsevier Ltd. All rights reserved.

Salcedo G.,Unidad University | Quirce S.,Hospital Universitario La Paz | Diaz-Perales A.,Unidad University
Journal of Investigational Allergology and Clinical Immunology | Year: 2011

Baker's asthma is a frequent occupational allergic disease caused mainly by inhalation of cereal flour, particularly wheat flour. This review deals with the current diagnosis and immunomodulatory treatments, as well as the role of wheat allergens as molecular tools to enhance management and knowledge of this disease. The review also discusses the current status of several salt-soluble proteins (albumins and globulins)-cereal α-amylase/trypsin inhibitors, peroxidase, thioredoxin, nonspecific lipid transfer protein, serine proteinase inhibitor, and thaumatin-like protein-as well as salt-insoluble storage proteins (prolamins, namely, gliadins and glutenins) as allergens associated with baker's asthma. Finally, current limitations to using these proteins as molecular tools for diagnosis and immunotherapy are highlighted. © 2011 Esmon Publicidad.

Poyato-Ariza F.J.,Unidad University
Journal of Vertebrate Paleontology | Year: 2010

Polazzodus coronatus, gen. et sp. nov., is a pycnodontiform fish from two proximate Late Cretaceous fossil sites near Polazzo, in northeastern Italy, where it is relatively abundant. Its autapomorphic characters are the presence of a distinctively shaped second dorsal ridge scale with an anterior projection; the presence of an olfactory fenestra on the premaxilla; an axe blade-like morphology of the maxilla; and the presence of a conspicuous posterodorsal process on the cleithrum. Polazzodus coronatus, gen. et sp. nov., is closely related to the pycnodontids Oropycnodus, Pycnodus, and probably 'Coelodus' gridelli and Tergestinia. Although their phylogenetic interrelationships will be tested when the last two forms are revised, Polazzodus coronatus is assigned to the subfamily Pycnodontinae within the Family Pycnodontidae, because it possesses the autapomorphies of both latter groups; for instance, the presence of an exposed part of the endocranium, without overlying dermal bones, which is an autapomorphy of the Pycnodontinae. The shape and large size of the supraoccipital bone in Polazzodus, together with the arrangement of the other occipital bones, indicates that this exposed portion of the endocranium is most likely formed by the endochondral supraoccipital bone. © 2010 by the Society of Vertebrate Paleontology.

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