Jeonju, South Korea
Jeonju, South Korea

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The present invention relates to plant cells that express a target protein, a production method thereof, and a method of producing a target protein using the same. The plant cells have introduced therein a recombinant vector containing gene(s) encoding a target protein, and the plant cells include plant cambial meristematic cells (CMC) or callus. The cambial meristematic cells (CMCs) are a cell line containing innately undifferentiated cells isolated from a plant, wherein the cell line is a cell line isolated from the cambial tissue of the plant and has meristematic continuity without going through dedifferentiation into callus. A system of expressing a target protein using the recombinant plant cells according to the present invention can overcome the problems of conventional plant cell culture. In addition, it shows significantly high transformation efficiency, and thus can produce large amounts of target proteins, including biopharmaceutical proteins. Accordingly, it enables the commercialization of biopharmaceutical drugs, including protein products of plant origin.


The present invention relates to a composition for preventing or treating acquired immunodeficiency syndrome (AIDS), comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof, which are derived from a natural product, minimize adverse side effects of prior therapeutic agents and safe for the human body. Further, they effectively increase the count of T cells such as CD4+ T cells and decrease the number of HIVs, thereby preventing opportunistic infection, dysneuria, and neoplaia caused by immune incompetence, and ultimately the risk of death. Therefore, they are useful in preventing and treating AIDS, and relieving symptoms of AIDS.


The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.


The present invention relates to a stem cell derived from a cambium of the family Asteraceae and a method of isolating and culturing the same. The inventive stem cell derived from the cambium of the family Asteraceae is isolated in an undifferentiated state without undergoing a dedifferentiation process, such that it can be stably maintained without variations in the growth rate and growth pattern thereof even during long-term culture, and thus can be cultured in large amounts. In addition, the disclosed stem cell and a culture thereof have not only the effect of inhibiting the effect of inhibiting NO production caused by treatment with LPS (lipopolysaccharide), but also the effect of inhibiting the expression COX-2 gene (proinflammatory cytokine), and are thus useful as an effective anti-inflammatory composition.


The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.


The present invention relates to a stem cell derived from a cambium of family Ginkgoaceae and a method of isolating the same. The stem cell derived from the cambium of the family Ginkgoaceae is isolated in an undifferentiated state without undergoing a dedifferentiation process, such that it can be stably maintained without variations in the growth rate and growth pattern thereof even during long-term culture, and thus can be cultured in large amounts. In addition, the disclosed stem cell line has an antioxidant effect which is similar to or higher than that of an existing antioxidant, as demonstrated by measuring the ability to eliminate radicals caused by oxidants. Thus, the disclosed stem cell line is useful as an effective antioxidant composition.


The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.


The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has an active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time.


The present invention relates to a stem cell derived from a cambium of family Solanaceae and a method of isolating and culturing the same. The stem cell derived from the cambium of the family Solanaceae is isolated in an undifferentiated state without undergoing a dedifferentiation process, such that it can be stably maintained without variations in the growth rate and growth pattern thereof even during long-term culture, and thus can be cultured in large amounts. In addition, the disclosed stem cell and a culture medium thereof more efficiently inhibit the production of enzyme associated with the progression of aging compared to retinoic acid known to have a strong effect of reducing wrinkles, and they have the effect of inducing procollagen biosynthesis, and thus are useful for preventing and delaying aging.


Plant cells express a target protein, a production method thereof, and a method of producing a target protein using the same are disclosed. The plant cells have introduced therein a recombinant vector containing gene(s) encoding a target protein, and the plant cells include plant cambial meristematic cells (CMC) or callus. The cambial meristematic cells (CMCs) are a cell line containing innately undifferentiated cells isolated from a plant, wherein the cell line is a cell line isolated from the cambial tissue of the plant and has meristematic continuity without going through dedifferentiation into callus. A system of expressing a target protein using the recombinant plant cells according to the present invention can overcome the problems of conventional plant cell culture. In addition, it shows significantly high transformation efficiency, and thus can produce large amounts of target proteins, including biopharmaceutical proteins.

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