Underground Coal Gasification Project Thar

Islāmkot, Pakistan

Underground Coal Gasification Project Thar

Islāmkot, Pakistan

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Mahmood S.,University of Education of Pakistan | Ahmad Z.,University of Wah | Aslam M.,University of Education of Pakistan | Hussain S.,University of Education of Pakistan | And 2 more authors.
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

Fixed dose Albendazole is an anthelmintic or anti-worm medication. A simple, precise and specific spectrophotometric method was developed and validated for the estimation of Albendazole in tablet dosage form. Albendazole showed maximum absorbance i.e.; λmax at 308 nm. The drug was derivatized in ethanolic HCl diluents solution. Beer Lambert’s law was obeyed at concentration range of 4-10 ppm. A linearity curve was calibrated by concentration versus absorbance. The regression equation of curve was calculated as Y = 0.0813 x + 0.0065, with correlation coefficient r = 0.9993. The accuracy was determined by recovery study and the overall percentage recovery was found to be 99.29% ± 0.943. Precision of the method was found to be 99.53% ± 0.853. SD and % RSD values were less than 1. The LOD and LOQ were calculated as 1.051 ppm, 3.185 ppm respectively. The developed method was validated in terms of linearity, accuracy, precision, limit of detection and quantification, robustness as per ICH guidelines. The method can be successfully applied for quality control analysis of Albendazole in pharmaceutical formulation. © 2015, Global Research Online. All rights reserved.


Mahmood S.,University of Education of Pakistan | Ahmad Z.,University of Wah | Aslam M.,University of Education of Pakistan | Naeem F.,University of Education of Pakistan | And 2 more authors.
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

The goal of the present study was to develop and validate of an analytical method for the evaluation of Clotrimazole in bulk and tablet dosage form. UV-VIS spectroscopic technique was used for the estimation of Clotrimazole. Organic solvents and chemicals were used as trial diluents. The selection of the diluents was carried out on the basis of solubility and stability factors upon which drug was fully solubilised and stable for sufficient time. The drug was finally soluble in 1NH 2 SO4. Beer Lambert’s law obeyed over a concentration range 4-12 ppm. Clotrimazole showed absorption maxima (λ max) at 263 nm. The recovery studies were established the accuracy of the proposed method and the results were validated as per ICH guidelines. Linearity was obtained by concentration versus absorbance for Clotrimazole with correlation coefficient r꞊0.999. Robustness of the method was calculated at two different wavelengths and was found to be 100.2% and 100.4% which was very close to the proposed assay value i.e., 100.4%. The LOD and LOQ were calculated as 0.353 ppm, 1.07 ppm respectively. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed method. The developed method can effectively be applied for the quality control analysis and determination of Clotrimazole in tablet dosage form. © 2015, Global Research Online. All rights reserved.


Imran M.,Underground Coal Gasification Project Thar | Kumar D.,Underground Coal Gasification Project Thar | Kumar N.,University of Sao Paulo | Qayyum A.,Underground Coal Gasification Project Thar | And 2 more authors.
Renewable and Sustainable Energy Reviews | Year: 2014

Underground Coal Gasification is the conversion of solid Coal to gas in-situ by heating the coal and injecting oxidants air/oxygen to cause the gasification by partial combustion instead of complete combustion of coal. UCG is the promising technology having a lot of health, safety and environmental advantages over the conventional mining techniques; the major motivational aspects of UCG involves increased worker health and safety by using no man underground, no surface disposal of ash and coal tailings, low dust and noise pollution, low water consumption, larger coal reserves exploitation, and low volatile organic components, methane and green house gases emission to atmosphere. UCG is an inherently clean coal technology as it reduces deadly sulfur and nitrogen oxide emissions to very low levels. Total solid waste from UCG is typically half the volume generated by conventional coal plants and water use is substantially lower as well. © 2014 Elsevier Ltd.

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