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News Article | May 10, 2017
Site: www.eurekalert.org

From diagnosis of HIV to successful viral suppression: this new ECDC report summarises key findings concerning and the Continuum of HIV Care in Europe based on data reported by countries in Europe and Central Asia. In the 37 countries reporting data, an estimated 1.2 million people are living with HIV, 898 000 of whom (75%) have been diagnosed; 88% of these are estimated to be virally suppressed. The continuum of HIV care is a framework that enables countries to monitor the effectiveness of their HIV response - from diagnosis towards viral suppression (which means that the virus is no longer detectable in the blood). This report provides a snapshot of the status of the continuum of care for the whole region as well as each of the 48 countries reporting at least some continuum data. Based on the findings of the ECDC Dublin Declaration report on the continuum in 2015, ECDC now monitors a four-stage continuum that is directly relevant in the European region: Between 2014 and 2016, there was a substantial increase in the proportion of countries able to report on all four stages of the continuum, from 40% of all reporting countries to 66%. In the 37 countries reporting data within Europe and Central Asia for both Stage 1 and Stage 2, an estimated 1 199 000 people are living with HIV, 898 000 of whom (75%) have been diagnosed. This also means that almost one in four people with diagnosed HIV infection are still not on treatment. In the 31 countries in Europe and Central Asia that reported data for both Stage 3 and Stage 4, 599 500 PLHIV are on treatment and 526 000 of these (88%) are virally suppressed. Despite this improvement, Stage 1 and Stage 4 remain the two stages where countries in Europe and Central Asia are least likely to have data available. To help address this issue, ECDC is supporting countries in the use of the ECDC HIV modelling tool to generate robust estimates of the number of people living with HIV and facilitating collaboration between public health and clinical experts to improve estimates of viral suppression. Overall, European and Central Asian countries need to improve the availability of continuum data, use the continuum of HIV care framework to monitor progress and identify areas for improvement, and take country-specific measures to strengthen HIV testing, treatment and care in order to accelerate progress towards achieving the UNAIDS 90-90-90 targets. Following previous progress reports, ECDC presents a new series of thematic reports and evidence briefs with the main findings from the 2016 Dublin Declaration monitoring process, discussing key issues and assessing the progress made since 2014 in Europe's response to HIV. Read the full ECDC thematic report "Continuum of HIV care - Monitoring implementation of the Dublin Declaration on partnership to fight HIV/HIDS in Europe and Central Asia - 2016 progress report Progress reports and evidence briefs: Monitoring the implementation of the Dublin Declaration Dublin


NEW YORK, May 09, 2017 (GLOBE NEWSWIRE) -- Blake Insomnia Therapeutics Inc. (OTCQB:BKIT) a New York based pharmaceutical company is pleased to announce the appointment of Dr. Eric Leire to join CEO Birger Jan Olsen on its Board of Directors. Dr. Leire has currently been the CEO of DanDrit Biotech (OTCQB:DDRT) which is developing a dendritic cell-based immunotherapy for the treatment of advanced colorectal cancer (Phase III clinical trials). He also serves on the Board of Novicol International Holding Inc., a Canadian company with a microbicide commercially available in China. Dr. Leire brings to Blake Insomnia Therapeutics a valued combination of medical professionalism with business acumen spanning over 30 years encompassing: - Biotech - held executive positions with Paringenix, APT Therapeutics, and Biostrategies Group; - Pharmaceutical - served in senior management at Pfizer, Boots Pharma, Schering Plough Pharmacia; - Private Equity - partner at Biofund Venture and Medwell Capital; - Non-Profit - HIV/AIDS Project Manager with Doctors of the World, establishing educational programs and coordinating with United Nations organization such as UNHCR, UNAIDS, UNICEF and UNDP; and - Academia - Research Associate at the Harvard University AIDS Institute. Dr. Eric Leire earned his MD from Grenoble University Medical School in Grenoble, France, and also holds an MBA with a Finance specialization from Institute Superieure des Affaires in Paris, France and a MBA with a Health Care Management specialization from the Kellogg Graduate School of Management, Northwestern University in Chicago, IL. “We are very happy Dr. Leire has accepted an appointment to our Board of Directors,” said Birger Jan Olsen, President and CEO of Blake Insomnia Therapeutics. “Dr. Leire is a highly accomplished doctor and executive with an international mindset and a demonstrated ability to creatively produce tangible results in the pharmaceutical and biotech industries. We are fully assured he has the qualifications and range of experience to advance the company to the position of being the premier quality of life provider though sleep enhancement.” Dr. Leire’s experience in the biotech industry, brings strong merit and expertise to Blake Insomnia’s future plans to engage drug regulatory agencies and conduct clinical trials. It is important to note that the Biotech industry possess the most stringent regulatory procedures that need to be fulfilled in order to achieve market approval. Given the strategic position of ZLX-1 compound and the large unmet clinical need for insomnia sufferers, Dr. Leire welcomes the opportunity to improve patient access to much needed treatment and will start working on the board as soon as the Company has obtained Director’s and Officer’s Insurance. Blake Insomnia Therapeutics Inc. Blake is a New York-based pharmaceutical company devoted to improving night-time and daytime quality of life for people with insomnia. The company’s patent-pending ZLX-1 compound has demonstrated efficacy without producing the side effects identified as the No. 1 problem with current sleep medication. The ZLX-1 compound is marketed under the brand name, Zleepax™. Please visit www.blakeinsomnia.com to learn more about the company, management and the ZLX-1 compound.


NEW YORK, May 09, 2017 (GLOBE NEWSWIRE) -- Blake Insomnia Therapeutics Inc. (OTCQB:BKIT) a New York based pharmaceutical company is pleased to announce the appointment of Dr. Eric Leire to join CEO Birger Jan Olsen on its Board of Directors. Dr. Leire has currently been the CEO of DanDrit Biotech (OTCQB:DDRT) which is developing a dendritic cell-based immunotherapy for the treatment of advanced colorectal cancer (Phase III clinical trials). He also serves on the Board of Novicol International Holding Inc., a Canadian company with a microbicide commercially available in China. Dr. Leire brings to Blake Insomnia Therapeutics a valued combination of medical professionalism with business acumen spanning over 30 years encompassing: - Biotech - held executive positions with Paringenix, APT Therapeutics, and Biostrategies Group; - Pharmaceutical - served in senior management at Pfizer, Boots Pharma, Schering Plough Pharmacia; - Private Equity - partner at Biofund Venture and Medwell Capital; - Non-Profit - HIV/AIDS Project Manager with Doctors of the World, establishing educational programs and coordinating with United Nations organization such as UNHCR, UNAIDS, UNICEF and UNDP; and - Academia - Research Associate at the Harvard University AIDS Institute. Dr. Eric Leire earned his MD from Grenoble University Medical School in Grenoble, France, and also holds an MBA with a Finance specialization from Institute Superieure des Affaires in Paris, France and a MBA with a Health Care Management specialization from the Kellogg Graduate School of Management, Northwestern University in Chicago, IL. “We are very happy Dr. Leire has accepted an appointment to our Board of Directors,” said Birger Jan Olsen, President and CEO of Blake Insomnia Therapeutics. “Dr. Leire is a highly accomplished doctor and executive with an international mindset and a demonstrated ability to creatively produce tangible results in the pharmaceutical and biotech industries. We are fully assured he has the qualifications and range of experience to advance the company to the position of being the premier quality of life provider though sleep enhancement.” Dr. Leire’s experience in the biotech industry, brings strong merit and expertise to Blake Insomnia’s future plans to engage drug regulatory agencies and conduct clinical trials. It is important to note that the Biotech industry possess the most stringent regulatory procedures that need to be fulfilled in order to achieve market approval. Given the strategic position of ZLX-1 compound and the large unmet clinical need for insomnia sufferers, Dr. Leire welcomes the opportunity to improve patient access to much needed treatment and will start working on the board as soon as the Company has obtained Director’s and Officer’s Insurance. Blake Insomnia Therapeutics Inc. Blake is a New York-based pharmaceutical company devoted to improving night-time and daytime quality of life for people with insomnia. The company’s patent-pending ZLX-1 compound has demonstrated efficacy without producing the side effects identified as the No. 1 problem with current sleep medication. The ZLX-1 compound is marketed under the brand name, Zleepax™. Please visit www.blakeinsomnia.com to learn more about the company, management and the ZLX-1 compound.


NEW YORK, May 09, 2017 (GLOBE NEWSWIRE) -- Blake Insomnia Therapeutics Inc. (OTCQB:BKIT) a New York based pharmaceutical company is pleased to announce the appointment of Dr. Eric Leire to join CEO Birger Jan Olsen on its Board of Directors. Dr. Leire has currently been the CEO of DanDrit Biotech (OTCQB:DDRT) which is developing a dendritic cell-based immunotherapy for the treatment of advanced colorectal cancer (Phase III clinical trials). He also serves on the Board of Novicol International Holding Inc., a Canadian company with a microbicide commercially available in China. Dr. Leire brings to Blake Insomnia Therapeutics a valued combination of medical professionalism with business acumen spanning over 30 years encompassing: - Biotech - held executive positions with Paringenix, APT Therapeutics, and Biostrategies Group; - Pharmaceutical - served in senior management at Pfizer, Boots Pharma, Schering Plough Pharmacia; - Private Equity - partner at Biofund Venture and Medwell Capital; - Non-Profit - HIV/AIDS Project Manager with Doctors of the World, establishing educational programs and coordinating with United Nations organization such as UNHCR, UNAIDS, UNICEF and UNDP; and - Academia - Research Associate at the Harvard University AIDS Institute. Dr. Eric Leire earned his MD from Grenoble University Medical School in Grenoble, France, and also holds an MBA with a Finance specialization from Institute Superieure des Affaires in Paris, France and a MBA with a Health Care Management specialization from the Kellogg Graduate School of Management, Northwestern University in Chicago, IL. “We are very happy Dr. Leire has accepted an appointment to our Board of Directors,” said Birger Jan Olsen, President and CEO of Blake Insomnia Therapeutics. “Dr. Leire is a highly accomplished doctor and executive with an international mindset and a demonstrated ability to creatively produce tangible results in the pharmaceutical and biotech industries. We are fully assured he has the qualifications and range of experience to advance the company to the position of being the premier quality of life provider though sleep enhancement.” Dr. Leire’s experience in the biotech industry, brings strong merit and expertise to Blake Insomnia’s future plans to engage drug regulatory agencies and conduct clinical trials. It is important to note that the Biotech industry possess the most stringent regulatory procedures that need to be fulfilled in order to achieve market approval. Given the strategic position of ZLX-1 compound and the large unmet clinical need for insomnia sufferers, Dr. Leire welcomes the opportunity to improve patient access to much needed treatment and will start working on the board as soon as the Company has obtained Director’s and Officer’s Insurance. Blake Insomnia Therapeutics Inc. Blake is a New York-based pharmaceutical company devoted to improving night-time and daytime quality of life for people with insomnia. The company’s patent-pending ZLX-1 compound has demonstrated efficacy without producing the side effects identified as the No. 1 problem with current sleep medication. The ZLX-1 compound is marketed under the brand name, Zleepax™. Please visit www.blakeinsomnia.com to learn more about the company, management and the ZLX-1 compound.


NEW YORK, May 09, 2017 (GLOBE NEWSWIRE) -- Blake Insomnia Therapeutics Inc. (OTCQB:BKIT) a New York based pharmaceutical company is pleased to announce the appointment of Dr. Eric Leire to join CEO Birger Jan Olsen on its Board of Directors. Dr. Leire has currently been the CEO of DanDrit Biotech (OTCQB:DDRT) which is developing a dendritic cell-based immunotherapy for the treatment of advanced colorectal cancer (Phase III clinical trials). He also serves on the Board of Novicol International Holding Inc., a Canadian company with a microbicide commercially available in China. Dr. Leire brings to Blake Insomnia Therapeutics a valued combination of medical professionalism with business acumen spanning over 30 years encompassing: - Biotech - held executive positions with Paringenix, APT Therapeutics, and Biostrategies Group; - Pharmaceutical - served in senior management at Pfizer, Boots Pharma, Schering Plough Pharmacia; - Private Equity - partner at Biofund Venture and Medwell Capital; - Non-Profit - HIV/AIDS Project Manager with Doctors of the World, establishing educational programs and coordinating with United Nations organization such as UNHCR, UNAIDS, UNICEF and UNDP; and - Academia - Research Associate at the Harvard University AIDS Institute. Dr. Eric Leire earned his MD from Grenoble University Medical School in Grenoble, France, and also holds an MBA with a Finance specialization from Institute Superieure des Affaires in Paris, France and a MBA with a Health Care Management specialization from the Kellogg Graduate School of Management, Northwestern University in Chicago, IL. “We are very happy Dr. Leire has accepted an appointment to our Board of Directors,” said Birger Jan Olsen, President and CEO of Blake Insomnia Therapeutics. “Dr. Leire is a highly accomplished doctor and executive with an international mindset and a demonstrated ability to creatively produce tangible results in the pharmaceutical and biotech industries. We are fully assured he has the qualifications and range of experience to advance the company to the position of being the premier quality of life provider though sleep enhancement.” Dr. Leire’s experience in the biotech industry, brings strong merit and expertise to Blake Insomnia’s future plans to engage drug regulatory agencies and conduct clinical trials. It is important to note that the Biotech industry possess the most stringent regulatory procedures that need to be fulfilled in order to achieve market approval. Given the strategic position of ZLX-1 compound and the large unmet clinical need for insomnia sufferers, Dr. Leire welcomes the opportunity to improve patient access to much needed treatment and will start working on the board as soon as the Company has obtained Director’s and Officer’s Insurance. Blake Insomnia Therapeutics Inc. Blake is a New York-based pharmaceutical company devoted to improving night-time and daytime quality of life for people with insomnia. The company’s patent-pending ZLX-1 compound has demonstrated efficacy without producing the side effects identified as the No. 1 problem with current sleep medication. The ZLX-1 compound is marketed under the brand name, Zleepax™. Please visit www.blakeinsomnia.com to learn more about the company, management and the ZLX-1 compound.


News Article | May 23, 2017
Site: www.scientificamerican.com

Having witnessed the success of combination therapy in HIV, cancer and heart disease, the time has come for Alzheimer’s disease. At meetings convened by the Alzheimer’s Association and others, a consensus is emerging that the most effective Alzheimer’s treatments may be those that attack the disease on multiple fronts. Looking back for a moment… In the 1980s, the world faced a new, unknown virus. HIV/AIDS was spreading virtually unchecked, devastating millions of lives and spurring lively scientific debate. Today, an HIV diagnosis is no longer a death sentence. AIDS-related deaths have fallen by 45 percent since their peak in 2005 according to UNAIDS, a United Nations program for global action against the spread of the virus. As researchers learned more about HIV, they developed new classes of antiviral medications—each attacking the virus in a unique way. Physicians eventually began prescribing two or more of these drugs together and emerging scientific evidence started revealing the most effective combinations. Today, a powerful three-drug antiviral “cocktail” is allowing people with HIV to live long lives. Advances in understanding the progression of Alzheimer’s point to a number of underlying biological processes involved in the development of the disease. By leveraging this knowledge, we now have a singular opportunity to pioneer new approaches against Alzheimer’s, including combination therapies. The Alzheimer’s Association has partnered with the Alzheimer’s Drug Discovery Foundation (ADDF) to challenge the research community to propose promising drug combinations to find more-effective treatments. The joint effort, known as the Alzheimer's Combination Therapy Opportunities (ACTO) grant initiative, will provide $2 million this year for testing approaches that simultaneously target two or more processes believed to underlie, exacerbate, or occur in the disease. An ACTO-funded study must involve repurposed drugs—those that have been determined safe for use in treating other conditions. With some information about safety already available, there is the potential to deliver new treatments more quickly than testing novel drugs, which take an average of 12 years to make it to pharmacy. ACTO will announce its initial award the first half of 2017. The predominant theory of how Alzheimer’s develops is that buildup of two characteristic lesions in the brain—amyloid plaques and tau tangles—leads to the death of nerve cells. Plaques are deposits of a protein fragment called beta-amyloid that build up in the spaces between nerve cells; tangles are twisted fibers of another protein called tau that build up inside the cells. The majority of Alzheimer's drug candidates currently being tested in clinical trials target species of amyloid and/or the plaques. Numerous other studies suggest brain inflammation and problems with blood circulation in the brain play a role in the disease’s progression. Other studies have identified an additional abnormal protein in the brains of people with the disease—and that this protein may explain why some people have Alzheimer’s changes in their brain but do not experience dementia. Because of the complexity of Alzheimer’s and its multiple causal factors, it may not only be preferable to use combination therapy, but necessary. Research on potential Alzheimer’s combination therapies in mouse models is showing promise. One study in mice found that using a combination of experimental anti-amyloid drugs could more effectively reduce amyloid plaque buildup and prevent new plaques from forming than either candidate alone. A second study in mice found that using leptin, a hormone that inhibits hunger, in combination with pioglitazone, an approved diabetes drug, could reduce both amyloid plaque accumulation and brain inflammation. Our hope is that testing multi-drug approaches is just the initial stirring of the innovation pot for Alzheimer’s combination therapy. Currently, the best evidence for reducing the risk for cognitive decline as we age through lifestyle is also a combination approach, including regular physical activity, mental stimulation, and a brain/heart-healthy diet. [alz.org/10ways] This begs the question, could Alzheimer’s combination therapy also take the form of drug therapy plus lifestyle changes? A combined lifestyle-drug approach is now common for lowering risk of heart disease; many people pair healthy diet and exercise with cholesterol and/or blood pressure medications. While combination therapy for Alzheimer’s is a promising strategy, studying it presents unique challenges. These include both science- and business-related obstacles. For example, few companies have a diverse enough pipeline of Alzheimer’s therapeutic agents in development to carry out combination therapy trials alone. Most would need to collaborate with another company or research center while protecting their intellectual property. Fortunately, partnership models exist in ongoing Alzheimer’s prevention trials where companies, academic researchers, government, non-profits and private charities have joined forces to test potential Alzheimer’s drug therapies. This approach makes it possible for companies to negotiate intellectual property concerns and spread the risk of therapy development across multiple stakeholders. Nonetheless, there remain many issues to untangle in this area. Another challenge is determining which treatment combinations to test. In April 2015, the Alzheimer’s Association convened an expert workgroup of leaders from academia and industry, and a former member of the U.S. Food and Drug Administration, to identify challenges and solutions to developing Alzheimer’s combination therapies. The group recommended that researchers collaborate to bring forward combinations of drug candidates previously tested in Alzheimer’s animal models and with known safety in humans. These candidates, they said, would yield the best chances for success and ensure speedier clinical trials. At the same time, we need more basic research to better understand how Alzheimer’s develops and progresses. Calling on lawmakers to increase federal Alzheimer’s research funding is something virtually anyone can do. Those who want to get involved can visit alz.org/advocacy. We are at a juncture of unprecedented promise in Alzheimer’s research. A few decades ago, we knew virtually nothing about how Alzheimer’s develops or progresses. Today we are looking at the possibility of combination therapies that attack the disease in multiple ways. With continued commitment from government, companies, academic researchers, and nonprofit research funders, we can unlock the combination to better Alzheimer’s therapy. This post includes excerpts from “Challenges, solutions, and recommendations for Alzheimer’s disease combination therapy,” a review article published in March 2016 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

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