Chirila M.,UMF Iuliu Hatieganu ENT |
Bolboaca S.D.,UMF Iuliu Hatieganu |
Muresan M.,Emergency County Hospital |
Tomescu E.,UMF Iuliu Hatieganu ENT |
Cosgarea M.,UMF Iuliu Hatieganu ENT
Laryngo- Rhino- Otologie | Year: 2011
Lymphatic and Vascular Invasion in Laryngeal and Pyriform Sinus Carcinomas Background: To investigate prognostic significance of the lymphatic and vascular invasion in patients with squamous cell carcinoma of the larynx and pyriform sinus. Material and Methods: Patients with squamous cell carcinoma of the larynx and pyriform sinus who underwent laryngectomies between 2002 and 2006 in the ENT Clinic of Cluj-Napoca were investigated for lymphatic and vascular invasion and their effect on disease-free survival and recurrence rates. Results: The present study included 396 patients. The mean disease-free survival of patients with or without lymphatic invasion was statistically significant (p=0.000000). The mean disease-free survival of patients with or without vascular invasion was statistically significant (p=0.000021). In multivariant analysis, the lymphatic invasion was significantly correlated only with surgical resection borders (p=0.0004), while vascular invasion was significantly correlated with surgical resection borders (p=0.0000), nodes diameter (p=0.0075) and postoperative radiotherapy and/or chemotherapy (p=0.0002). Conclusion: Lymphatic and vascular invasion have a significant prognostic value and influence the disease-free survival, regional and distant metastasis rates significantly. © Georg Thieme Verlag KG Stuttgart - New York.