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Bucharest, Romania

Nicolae C.,UMF Carol Davila Pharmacology | Nicolac I.,Dermatovenereological Research Center Biochemistry
Acta Endocrinologica | Year: 2012

Background: Gangliosidcs are N-acetyl - neuraminic - acid containing glycosphyngolipids that modulate several cellular functions. Objective: The present study confirmed the presence of cellular gangliosidcs in melanocytic tumors with neuroectodermal origin. These molecules showed large quantitative and structural vaiiabilily in melanocytic cells. Methods: The spectrum and levels of gangliosidcs were performed from 1991 until 2010, in 411 specimens of melanoma, 108 cutaneous metastases of melanoma, 206 ncvocellular and dysplastic nevus and 130 specimens of normal skin. Results: Melanoma showed aberrant gangliosides expression. This included overexpression of normal ganglioside constituents (GM2, GM3, GD2, GD3), which also appear in melanocytic nevus and epidermis tissues, and expression of gangliosides (O-Acctyl-Ganglioside) not found in normal adult tissue. The ganglioside composition of melanoma is: GM1 (1,29±0,87%), GM2 (10,32±4,1 1%), GM3 (22,23±11,30%), GD2 (16,03±9,13%), GD3 (39,06± 14,25%), GD1 a (2,!6±0,77%), GDlb (1,74±1,01%), GTlb (1,82±1,11 %), GQIb (1,34±1,07%), O-Acetyl-GD3 (4,01±2,81%). Conclusions: The overexpression and variability of gangliosidcs in melanoma and the low expression of them in normal tissue was correlated with oncogenic process and metastatic potential. Source

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