Umberto Hospital

Castell'Umberto, Italy

Umberto Hospital

Castell'Umberto, Italy

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Gebbia V.,University of Palermo | Bellavia M.,University of Palermo | Banna G.L.,Cannizzaro Hospital | Russo P.,University of Palermo | And 3 more authors.
Clinical Lung Cancer | Year: 2013

Background: Adherence to erlotinib could be a determinant for clinical outcome and treatment toxicity in patients with advanced non-small-cell lung cancer (A-NSCLC). Patients and Methods: In an observational study, the Basel Assessment of Adherence Scale (BAAS), a visual analogue scale (VAS), pill counting, and missed appointment rate were used to evaluate adherence in a first cohort of patients who was prescribed erlotinib without a specifically designed management strategy and in a second cohort of patients followed by an oral treatment monitoring program. Results: Adherence > 95% by BAAS at 2 months of treatment in the first and second cohorts was 72% and 84%, respectively (P =.042). Adherence by pill counting was 78% and 87% in the first and second cohorts, respectively (P =.0021). Disease control rate (DCR) (complete response [CR] + partial response [PR] + stable disease [SD]) was significantly higher in all patients whose adherence by BAAS at 2 months was ≥ 95% (P =.0266). DCR was higher in the second cohort compared with the first, being 63% (95% confidence interval [CI], 53%-72%) and 44% (95% CI, 30%-58%) in the second and the first cohort, respectively (P =.0368). A significant correlation between the number of adverse events and patient-reported adherence was observed (r = 0.105; P =.0001). Conclusion: Nonadherence may be related to poorer rates of response to erlotinib. Effective interventions to reduce nonadherence need to be implemented. © 2013 Elsevier Inc.

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