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Guadalajara, Mexico

Guevara-Gutierrez E.,Instituto Dermatologico Of Jalisco Dr Jose Barba Rubio | Yinh-Lao J.,Tufts University | Garcia-Gutierrez P.,Instituto Dermatologico Of Jalisco Dr Jose Barba Rubio | Tlacuilo-Parra A.,UMAE Hospital de Pediatria | Tlacuilo-Parra A.,Medical Research Division
Clinical Rheumatology | Year: 2010

Morphea is a disease that affects connective tissue and microvessels. Its pathogenesis is unknown, but several autoimmune factors participate. Our objective was to determine the frequency of antinuclear antibodies (ANAs) in pediatric patients with morphea and to establish their relation with the clinical variants and disease activity. A cross-sectional study was carried out from January 1999 to January 2008 in patients with morphea seen at the Instituto Dermatologico de Jalisco. ANAs were determined through an indirect immunoflourescent method, and the immunospecificity was done with a double immunodiffusion technique in agarose gel. A total of 34 children were included in the study, 74% of the female gender. Plaque morphea was the most common variant, present in 44% of the cases, followed by linear morphea in 38%, and generalized morphea in 18%. ANAs were positive in 29%, with homogenous immunoflourescense as the most frequent pattern (70%). Of the ANA-positive patients, 83% had generalized morphea, and in 70% of the cases the disease were considered as active. The frequency of ANA-positive children with morphea was 29%, and seems to be related to more extensive disease. No previous studies exist on this topic in the mestizo Mexican population. © 2010 Clinical Rheumatology. Source


Lopez-Aguilar E.,Laboratorio Of Investigacion En Tumores Cerebrales | Rioscovian-Soto A.P.,Laboratorio Of Investigacion En Tumores Cerebrales | Sepulveda-Vildosola A.C.,Direccion de Educacion e Investigacion | Siordia G.,UMAE Hospital de Pediatria | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2011

Introduction: Survival in children with astrocytomas is poor, fewer than 60% at five years. The identifications of molecular parameters could help us to better treatments. Bcl-2 inhibits the apoptosis and the sobre expression has been associated a poor prognosis. Objective: To identificate the Bcl-2 association with survival and histological grade in pediatric patients with astrocytomas. Methods: Between 1995 and 2009 all the patients with disgnosis of astrocytomas were includen. Inmunochemistry was realized to determinate Bcl-2 over expression. Kaplan-Meier and Log Rank test were calculated. Results: 38 patients were included; 13 (34.2%) over expressed Bcl-2 with five years survival of 29% compared with 64% at 5 years in .the group of patients which not sobreexpresed Bcl-2 gen Discussion: The Bcl-2 over expression in children with astrocytomas could be important in the treatment strategy and we think must be considered as a prognostic factor. Source


De-la-Llata M.,Direccion General de Coordinacion de Los Hospitales Regionales de Alta Especialidad | Vizcaino A.,Hospital Infantil de Mexico Federico Gomez | Bolio A.,Hospital Infantil de Mexico Federico Gomez | Alva C.,Hospital de Cardiologia CMN Siglo XXI | And 26 more authors.
Revista de Investigacion Clinica | Year: 2011

Introduction. The only way to characterize the Mexican problem related to congenital heart disease care is promoting the creation of a national database for registering the organization, resources, and related activities. Material and methods. The Health Secretary of Mexico adopted a Spanish registration model to design a survey for obtaining a national Mexican reference in congenital heart disease. This survey was distributed to all directors of medical and/or surgical health care centers for congenital heart disease in Mexico. This communication presents the results obtained in relation to organization, resources and activities performed during the last year 2009. Results. From the 22 health care centers which answered the survey 10 were reference centers (45%) and 12 were assistant centers (55%). All of them are provided with cardiologic auxiliary diagnostic methods. Except one, all centers have al least one bidimentional echocardiography apparatus. There is a general deficit between material and human resources detected in our study. Therapeutic actions for congenital heart disease (70% surgical and 30% therapeutical interventionism) show a clear centralization tendency for this kind of health care in Mexico City, Monterrey and finally Guadalajara. Conclusions. Due to the participation of almost all cardiac health centers in Mexico, our study provides an important information related to organization, resources, and medical and/or surgical activities for congenital heart disease. The data presented not only show Mexican reality, but allows us to identify better the national problematic for establishing priorities and propose solution alternatives. Source


Lopez-Aguilar E.,UMAE Hospital de Pediatria | Gascon-Lastiri G.,Servicio de Oncologia | Sepulveda-Vildosola A.C.,UMAE Hospital de Pediatria | Ramirez G.,Servicio de Neurocirugia | De La Cruz-Yanez H.,UMAE Hospital de Pediatria
Gaceta Mexicana de Oncologia | Year: 2011

Background: Astrocytomas are the most common brain tumor in children. There are many prognostic factors in these patients included histology, location, neurosurgery resection and treatment received. However new molecular markers are important in the survival. Apoptosis alteration could be related to survival in this group of patients. Intrinsic and extrinsic pathways were studied. Methods: Ten subsequent patients with astrocytoma were included. All patients were typified clinical characteristics, histological subtype, neurosurgery procedure and gene related to apoptosis included intrinsic and extrinsic pathway. Results: Ten patients were included, six male and four female (M:F 1.5:1), the age average 7.8 years. Location four patients supratentorial, four patients brain tumor and two located in cerebellum: Histological subtype low grade astrocytoma in seven patients, two multiform glioblastoma and one patient anaplastic astrocytoma. All patients presented intrinsic or extrinsic pathway alteration; must common alteration were observed on the caspasas pathway Discussion: We are not found a constant gene alteration, because both pathways were altered in intrinsic or extrinsic pathway. This is the first reports which integrate gene apoptosis expression and clinical follow up. Source

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