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Lopez Aguilar J.E.,UMAE Centro Medico Nacional Siglo XXI | Sepulveda-Vildosola A.C.,UMAE Centro Medico Nacional Siglo XXI | Boehler-Reyes A.,UMAE Centro Medico Nacional Siglo XXI | Rioscovian-Soto A.P.,UMAE Centro Medico Nacional Siglo XXI | Yanez-de La Cruz H.,UMAE Centro Medico Nacional Siglo XXI
Gaceta Mexicana de Oncologia | Year: 2011

Background: Clinical, histological and molecular factors have been describes as important in the survival of meduloblastoma patients. AKT is a biological marker associated to bad prognosis and malignancy in adults. In children, it is unknown if its expression is associated to survival. Objective: To determine if the over-expression for the protein AKT is associated to the prognosis of pediatric patients with meduloblastoma. Methods: Retrospective cohort. We included all patients diagnosed since January 1995 to December 2008. Clinical data was obtained from each patient's record. AKT was analyzed by inmunohistochemistry study of the tissue samples at diagnosis. Results: We included 21 patients, 76.2% were boys. Median age was 72 months (12-180 months). Classic histology was more frequent (10 patients), 7 were desmoplassic and 4 anaplasic. Five patients over-expressed AKT protein. Survival of these patients was 75%, at 18 months, and those who did not over-express AKT had a survival of 38.8% at 18 months (p = 0.258). Anaplasic histology and over-expression of AKT was present in 2 patients; Classic histology and over-espression of AKT was present in 3 patients. Conclusions: Although we did not find a significant association between survival and over-expression of AKT, those patients who over-expressed the protein had a 50% less survival. There seems to be an association between the over-expression of AKT and more aggressive histology. A larger sample of patients is required to obtain solid conclusions. Source

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