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Chaban O.,Bogomolets National Medical University | Chaban O.,Ukrainian Research Institute of Social
Psychiatry, Psychotherapy and Clinical Psychology | Year: 2016

Main clinical characteristics of atypical antipsychotics reviewed. Main advantages and disadvantages of atypical antipsychotics were determined. We created "Ordinary portrait" of a patient with schizophrenia - for atypical antipsychotics selection targets were determined based on diff erent symptoms of schizophrenia.


Steinberg S.,DeCODE Genetics Inc. | De Jong S.,University of California at Los Angeles | Mattheisen M.,Harvard University | Mattheisen M.,University of Bonn | And 169 more authors.
Molecular Psychiatry | Year: 2014

Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255T; odds ratio=1.08; P=6.6 × 10 -11). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255T is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders). © 2014 Macmillan Publishers Limited.


PubMed | University of Frankfurt am Main, Karolinska Institutet, Semmelweis University, Eli Lilly and Company and 51 more.
Type: Journal Article | Journal: Molecular psychiatry | Year: 2013

Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18206 cases and 42536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22651 additional Icelanders).

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