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Denisov V.M.,Siberian Federal University | Zhereb V.P.,Siberian Federal University | Denisova L.T.,Siberian Federal University | El'Berg M.S.,Siberian State Aerospace University | Storozhenko V.A.,Ukrainian Medical Stomatological Academy
Inorganic Materials | Year: 2011

A literature review on phase equilibria in the PbO-GeO 2 system is reported and the main sources of discrepancies in the results of different authors are considered. Uncontrolled metastable phase formation is shown to be the most probable cause for disagreements about composition and structures of phases formed in the system. The authors' results of investigations of physicochemical properties for stable and metastable phases obtained by various routes, including mechanochemical and thermal (crystallization of a metastable melt) activation, are presented. Similar phenomena are shown to take place in the binary PbO-SiO 2 system and under partial substitution Ge → Si in the ternary oxide system PbO-GeO 2-SiO 2. The particular role played by the 6s 2 electron pair a Pb 2+ ion in stabilization of intermediate energy-saturated states and meta-stable phase formation is discussed. © 2011 Pleiades Publishing, Ltd. Source


Vazhnichaya Ye.M.,Ukrainian Medical Stomatological Academy | Mokliak Ye.V.,Ukrainian Medical Stomatological Academy | Kurapov Yu.A.,Ukrainian Academy of Sciences | Zabozlaev A.A.,Company PHARMASOFT
Biomeditsinskaya Khimiya | Year: 2015

Magnetite nanoparticles (NPs) are studied as agents for magnetic resonance imaging, hyperthermia of malignant tumors, targeted drug delivery as well as anti-anemic action. One of the main problems of such NPs is their aggregation that requires creation of methods for magnetite NPs stabilization during preparation of liquid medicinal forms on their basis. The present work is devoted to the possibility of mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) use for solubilization of magnetite NPs in hydrophilic medium. For this purpose, the condensate produced by electron-beam evaporation and condensation, with magnetite particles of size 5-8 nm deposited into the crystals of sodium chloride were used in conjunction with substance of mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate), and low molecular weight polyvinylpyrrolidone (PVP). The NP condensate was dispersed in distilled water or PVP or mexidol solutions. NPs size distribution in the liquid phase of the systems was determined by photon correlation spectroscopy, iron (Fe) concentration was evaluated by atomic emission spectrometry. It is shown that in the dispersion prepared in distilled water, the major amount of NPs was of 13-120 nm in size, in mexidol solution - 270-1700 nm, in PVP solution - 30-900 nm. In the fluid containing magnetite NPs together with mexidol and PVP, the main fraction (99.9%) was characterized by the NPs size of 14-75 nm with maximum of 25 nm. This system had the highest iron concentration: it was similar to that in the sample with mexidol solution and 6.6-7.3 times higher than the concentration in the samples with distilled water or PVP. Thus, in the preparation of aqueous dispersions based on magnetite NPs condensate, mexidol provides a transition of Fe to the liquid phase in amount necessary to achieve its biological activity, and PVP stabilizes such modified NPs. Source


Manko A.,Ukrainian Medical Stomatological Academy | Ghasemzadeh J.,Ukrainian Medical Stomatological Academy
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia | Year: 2010

Under the long-term administration of omeprazole pathological changes appear in soft periodontium tissues, namely: disbalance of NO-ergic system, activation of free-radical oxidation, increase of MMM concentration, activation of MMP-1 and, consequently, intensification of collagen proteins destruction and increase of catabolism of connective tissue amorphous phase components of periodontium. Source


Sukhomlyn A.,Ukrainian Medical Stomatological Academy | Neporada K.,Ukrainian Medical Stomatological Academy
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia | Year: 2010

Under conditions of long omeprazole introduction pathological changes in salivary glands tissues appear: intensification of free-radical oxidation, disbalance of proteolysis by decompensated type, increased activity of 6-amilase, disbalance of polyammes and NO-ergic systems. Experimental correction by multiprobiotic Symbiter ® Acidophilus promotes normalisation of pathological changes in salivary glands of rats during long introduction of proton pomp inhibitor because free-radical oxidation and proteolytic processes are depressed, normalises balance of the polyammes and NO-ergic systems. Source


Vazhnichaya Y.M.,Ukrainian Medical Stomatological Academy | Mokliak Y.V.,Ukrainian Medical Stomatological Academy | Zabozlaev A.A.,Russian Federation Ltd
Sovremennye Tehnologii v Medicine | Year: 2015

One of the preconditions of biomedical use of iron oxide nanoparticles including magnetite is their stabilization in liquid medium, wherein the covering substances largely determine pharmacological activity and toxicity of such nanoparticles. We obtained nanofluid that contains magnetite nanoparticles stabilized with 2-ethyl-6-methyl-3-hydroxypyridine succinate (Mexidol) and polyvinyl pyrrolidone (PVP). Its anti-anemic properties have not been studied previously. The aim of the investigation was to study the effect of magnetite nanoparticles stabilized with Mexidol and PVP on hematological parameters of laboratory animals in the norm and after acute blood loss. Materials and Methods. Experiments were performed on 109 albino male rats. The liquid containing magnetite nanoparticles stabilized with Mexidol and PVP was administered to intact animals and rats after blood loss in the dose of 1.35 mg Fe/kg. Its effects were compared with the action of standard iron preparation Ferrum Lek (1.25 mg Fe/kg) as a reference drug. We determined red blood cells count, total hemoglobin, hematocrit, erythrocyte indices as well as reticulocytes content in blood 3 and 72 h after the administration of the nanofluid and the reference preparation. Results. Nanofluid stimulates erythropoiesis in intact animals that is characterized by the increase in red blood cells count, total hemoglobin and hematocrit, which, however, are within the normal range. In anemia induced by acute blood loss, the nanofluid helps to restore these parameters and increases significantly the number of reticulocytes in blood. In both cases, the effects of the nanofluid are more pronounced than those of the reference preparation that can be due to better bioavailability of iron in the nanofluid, with Mexidol being used as one of stabilizing agents. Conclusion. Magnetite nanoparticles stabilized with Mexidol and PVP stimulate erythropoiesis in the norm and in acute blood loss that is potentiated by the presence of succinate-containing 3-hyroxypyridine derivative as their constituent. The efficiency of magnetite nanoparticles and the possibility to use them as nanofluid offer the prospect of developing a new pharmaceutical form to correct anemic conditions based on these nanoparticles. © 2015, Sovremennye Tehnologii v Medicine. All rights reserved. Source

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