UKK Institute

Tampere, Finland

UKK Institute

Tampere, Finland
Time filter
Source Type

Yli-Kuha A.-N.,University of Tampere | Gissler M.,Finnish National Institute for Health and Welfare | Klemetti R.,Finnish National Institute for Health and Welfare | Luoto R.,UKK Institute | Hemminki E.,Finnish National Institute for Health and Welfare
Human Reproduction | Year: 2012

Background Results of earlier studies on cancer risk in infertile women are inconsistent for many cancer types. Our goal was to study cancer incidence among a cohort of women treated with IVF, including ICSI and frozen embryo transfer (FET), compared with that of a control population.Methods A cohort of women who purchased drugs for IVF (including ICSI and FET treatments, n = 9175) in the period 19961998 in Finland (later called IVF women) and their age and residence-matched controls further adjusted for socio-economic position and marital status were linked to the Finnish Cancer Registry 19962004. Results The overall cancer incidence and combined incidence of hormonal-related breast, uterine and invasive ovarian cancers were similar among IVF women and controls. IVF women had statistically significantly less cervical cancer [odds ratio (OR): 0.51, 95 confidence interval (CI): 0.300.85], but more skin cancers other than melanoma (OR: 3.11, 95 CI: 1.029.6). IVF women had three times more invasive ovarian cancers than controls, but this difference was not statistically significant, possibly due to the small number of cases. IVF women had slightly fewer breast cancers but difference was likewise not statistically significant. All cases of pulmonary cancer were diagnosed among controls (P = 0.03). Conclusion s General cancer risk or risk of hormonal-related cancers in women was not increased by IVF. The differences in certain cancers suggest a healthy patient effect or may be partly caused by residual socio-economic differences. More large studies and reanalysis of existing studies are needed to evaluate cancer risk among infertile women by subgroups regarding the cause of infertility. When evaluating risk of cancer after drug exposure, dosage and the use of different medicaments should be taken into consideration. © 2012 The Author.

Krenn P.J.,University of Graz | Titze S.,University of Graz | Oja P.,UKK Institute | Jones A.,University of East Anglia | And 2 more authors.
American Journal of Preventive Medicine | Year: 2011

Context: The GPS represents an innovative way to objectively assess the spatial locations of physical activity behavior. The aim of this systematic review was to determine the capability of GPS to collect high-quality data on the location of activities in research on the relationship between physical activity and the environment. Evidence acquisition: Published and unpublished articles identified from seven electronic databases, reference lists, bibliographies, and websites up to March 2010 were systematically searched for, appraised, and analyzed in summer 2010. Included studies used GPS to measure the spatial locations of physical activity and some form of environmental analysis related to the GPS data. The capability of GPS was expressed in terms of data quality, which in turn was defined as the proportion of GPS data lost in each study. Evidence synthesis: 24 studies met the inclusion criteria. Data loss was positively correlated with the measurement period for which participants were asked to wear the GPS device (r=0.81, p<0.001). Major reasons for data loss included signal drop-outs, loss of device battery power, and poor adherence of participants to measurement protocols. Data loss did not differ significantly between children and adults or by study sample size, year of publication, or GPS device manufacturer. Conclusions: GPS is a promising tool for improving understanding of the spatial context of physical activity. The current findings suggest that the choice of an appropriate device and efforts to maximize participant adherence are key to improving data quality, especially over longer study periods. © 2011 American Journal of Preventive Medicine.

Leppanen M.,UKK Institute | Aaltonen S.,University of Jyväskylä | Parkkari J.,UKK Institute | Heinonen A.,University of Jyväskylä | Kujala U.M.,University of Jyväskylä
Sports Medicine | Year: 2014

Background: The effects of methods to prevent injuries have been studied in several systematic reviews. However, no meta-analysis taking into account all randomised controlled intervention trials aiming at the prevention of sports injuries has been published. Objective: To summarise the effects of sports injury prevention interventions. Design: Systematic review and meta-analysis of randomised controlled trials. Data Sources: PubMed, MEDLINE, SPORTDiscus, the Cochrane Central Register of Controlled Trials, CINAHL, PEDro, and Web of Science, searched in September 2013. The reference lists of retrieved articles and reviews were hand searched. Eligibility Criteria for Selecting Studies: To be selected articles had to examine the effects of any preventive intervention on sports injuries, be randomised/quasi-randomised and controlled trials, published in a peer-reviewed journal. The outcome of the trial had to be injury rate or the number of injured individuals. Results: Of the 5580 articles retrieved after a search of databases and the relevant bibliography, 68 randomised controlled trials were included in the systematic review and 60 trials were included in the meta-analysis. Insoles (OR 0.51, 95 % CI 0.32-0.81), external joint supports (OR 0.40, 95 % CI 0.30-0.53), and specific training programmes (OR 0.55, 95 % CI 0.46-0.66) appeared to be effective in reducing the risk of sports injuries. Stretching (OR 0.92, 95 % CI 0.80-1.06), modified shoes (OR 1.23, 95 % CI 0.81-1.87), and preventive videos (OR 0.86, 95 % CI 0.44-1.68) seemed not to be effective. Conclusions: This meta-analysis showed that certain interventions can reduce the risk of sports injuries. There were limitations regarding the quality of the trials, generalisability of the results, and heterogeneity of the study designs. In future, the mechanisms behind effective methods and the most beneficial elements of preventive training programmes need to be clarified. © 2013 Springer International Publishing Switzerland.

Suomalainen P.,University of Tampere | Moisala A.-S.,Hatanpaa Hospital | Paakkala A.,University of Tampere | Kannus P.,UKK Institute | Jarvela T.,Hatanpaa Hospital
American Journal of Sports Medicine | Year: 2011

Background: One aspect of the debate over the reconstruction of the anterior cruciate ligament is whether it should be carried out with the single-bundle or double-bundle technique. Hypothesis: The double-bundle technique results in fewer graft failures than the single-bundle technique in anterior cruciate ligament reconstruction. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 153 patients were prospectively randomized into 2 groups of anterior cruciate ligament reconstruction with hamstring autografts using aperture interference screw fixation: single-bundle technique (SB group, n = 78) and double-bundle technique (DB group, n = 75). The evaluation methods were clinical examination, KT-1000 arthrometric measurement, the International Knee Documentation Committee (IKDC) and the Lysholm knee scores, and magnetic resonance imaging (MRI) evaluation. All of the operations were performed by 1 experienced orthopaedic surgeon, and all clinical assessments were made by 2 blinded and independent examiners. A musculoskeletal radiologist blinded to the clinical data made the MRI interpretation. Results: There were no differences between the study groups preoperatively. Ninety percent of patients (n = 138) were available at a minimum 2-year follow-up (range, 24-37 months). Eight patients (7 in the SB group and 1 in the DB group) had graft failure during the follow-up and had anterior cruciate ligament revision surgery (P = .04). In addition, 7 patients (5 in the SB group and 2 in the DB group) had an invisible graft on the MRI assessment at the 2-year follow-up. Also, the anteromedial bundle was partially invisible in 2 patients and the posterolateral bundle in 9 patients. Together, the total number of failures and invisible grafts were significantly higher in the SB group (12 patients, 15%) than the DB group (3 patients, 4%) (P = .024). No significant group differences were found in the knee scores or stability evaluations at the follow-up. Conclusion: This 2-year randomized trial showed that the revision rate of the anterior cruciate ligament reconstruction was significantly lower with the double-bundle technique than that with the single-bundle technique. However, additional years of followup are needed to reveal the long-term results. © 2011 The Author(s).

Stronegger W.J.,Medical University of Graz | Titze S.,University of Graz | Oja P.,UKK Institute
Health and Place | Year: 2010

The aim of our study was to identify perceptions of the residential environment and their association with physical activity for specific purposes and with self-rated health in an urban context. A representative survey of inhabitants of Graz (a mid-sized Austrian city) aged 15-60 years (n=997) was conducted. We found a perceived high social-environmental quality of the residential environment to be associated with higher levels of self-rated health and leisure time physical activity. Both leisure time physical activity and satisfaction with environmental quality were independently linked with self-rated health. Furthermore, a high level of satisfaction with the individual's local infrastructure may support the residents to engage in higher levels of physical activity for transportation, whereas the preferred mode of transportation may be gender-specific: men tend to use the bicycle while women walk. Our results suggest that local infrastructure facilities should be designed so as to ensure accessibility by both walking and cycling. © 2010 Elsevier Ltd.

Kurppa K.,University of Tampere | Paavola A.,University of Tampere | Collin P.,University of Tampere | Sievanen H.,UKK Institute | And 6 more authors.
Gastroenterology | Year: 2014

Background & Aims We investigated whether screen-detected and apparently asymptomatic adults with endomysial antibodies (EmA) benefit from a gluten-free diet (GFD). Methods We performed a prospective trial of 3031 individuals at risk for celiac disease based on screens for EmA. Of 148 seropositive individuals, 40 fulfilled inclusion criteria and were assigned randomly to groups placed on a GFD or gluten-containing diets. We evaluated ratios of small-bowel mucosal villous height:crypt depth, serology and laboratory test results, gastrointestinal symptom scores, physiologic well-being, perception of health by a visual analog scale, bone mineral density, and body composition at baseline and after 1 year. Thereafter, the group on the gluten-containing diet started a GFD and was evaluated a third time; subjects in the GFD group remained on this diet. Results After 1 year on the GFD, the mean mucosal villous height:crypt depth values increased (P <.001), levels of celiac-associated antibodies decreased (P <.003), and gastrointestinal symptoms improved to a greater extent than in patients on gluten-containing diets (P =.003). The GFD group also had reduced indigestion (P =.006), reflux (P =.05), and anxiety (P =.025), and better health, based on the visual analog scale (P =.017), than the gluten-containing diet group. Only social function scores improved more in the gluten-containing diet group than in the GFD group (P =.031). There were no differences between groups in laboratory test results, bone mineral density, or body composition. Most measured parameters improved when patients in the gluten-containing diet group were placed on GFDs. No subjects considered their experience to be negative and most expected to remain on GFDs. Conclusions GFDs benefit asymptomatic EmA-positive patients. The results support active screening of patients at risk for celiac disease. no: NCT01116505. © 2014 by the AGA Institute.

Krenn P.J.,University of Graz | Oja P.,UKK Institute | Titze S.,University of Graz
International Journal of Behavioral Nutrition and Physical Activity | Year: 2014

Background: Despite evidence that environmental features are related to physical activity, the association between the built environment and bicycling for transportation remains a poorly investigated subject. The aim of the study was to improve our understanding of the environmental determinants of bicycling as a means of transportation in urban European settings by comparing the spatial differences between the routes actually used by bicyclists and the shortest possible routes.Methods: In the present study we examined differences in the currently used and the shortest possible bicycling routes, with respect to distance, type of street, and environmental characteristics, in the city of Graz, Austria. The objective measurement methods of a Global Positioning System (GPS) and a Geographic Information System (GIS) were used.Results: Bicycling routes actually used were significantly longer than the shortest possible routes. Furthermore, the following attributes were also significantly different between the used route compared to the shortest possible route: Bicyclists often used bicycle lanes and pathways, flat and green areas, and they rarely used main roads and crossings.Conclusion: The results of the study support our hypothesis that bicyclists prefer bicycle pathways and lanes instead of the shortest possible routes. This underlines the importance of a well-developed bicycling infrastructure in urban communities. © 2014 Krenn et al.; licensee BioMed Central Ltd.

Suomalainen P.,University of Tampere | Jarvela T.,Sports Clinic and Hospital Mehilainen | Paakkala A.,University of Tampere | Kannus P.,UKK Institute | Jarvinen M.,University of Tampere
American Journal of Sports Medicine | Year: 2012

Background: Surgical technique is essential in anterior cruciate ligament (ACL) reconstruction. Purpose: This randomized 5-year study tested the hypothesis that double-bundle ACL reconstruction with hamstring autografts and aperture screw fixation has fewer graft ruptures and rates of osteoarthritis (OA) and better stability than single-bundle reconstruction. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Ninety patients were randomized: double-bundle ACL reconstruction with bioabsorbable screw fixation (DB group; n = 30), single-bundle ACL reconstruction with bioabsorbable screw fixation (SBB group; n = 30), and single-bundle ACL reconstruction with metallic screw fixation (SBM group; n = 30). The following evaluation methods were used: clinical examination, KT-1000 arthrometer measurement, and International Knee Documentation Committee (IKDC) and Lysholm knee scores. Additionally, radiographic evaluation was made by a musculoskeletal radiologist who was unaware of the patients clinical and surgical data. A single orthopaedic surgeon performed all the operations, and clinical follow-up assessments were made in a blinded manner by an independent examiner. Results: Preoperatively, there were no differences between the groups. Eleven patients (7 in the SBB group, 3 in the SBM group, and 1 in the DB group) had a graft failure during the follow-up and went on to ACL revision surgery (P≤.043). Of the remaining 79 patients, a 5-year follow-up was performed for 65 patients (20 in the DB group, 21 in the SBB group, and 24 in the SBM group) who had their grafts intact. At 5 years, there was no statistically significant difference in the pivot-shift or KT-1000 arthrometer tests. In the DB group, 20% of the patients had OA in the medial femorotibial compartment and 10% in the lateral compartment, while the corresponding figures were 33% and 18% in the single-bundle groups, again an insignificant finding. Further, no significant group differences were found in the knee scores. Conclusion: The double-bundle surgery resulted in significantly fewer graft failures and subsequent revision ACL surgery than the single-bundle surgeries during the 5-year follow-up. Knee stability and OA rates were similar at 5 years. In view of the size of the groups, some caution should be exercised when interpreting the lack of difference in the secondary outcomes. © 2012 The Author(s).

Suomalainen P.,University of Tampere | Kannus P.,UKK Institute | Jarvela T.,Hospital Mehilainen
International Orthopaedics | Year: 2013

Purpose: Anterior cruciate ligament (ACL) reconstruction has been under intensive discussion and debate, although the anatomy of this ligament was resolved thoroughly almost 200 years ago. The ACL consist of two bundles, anteromedial (AM) and posterolateral (PL). The conventional single-bundle method reconstructs the AM bundle only, while the modern double-bundle technique recreates both bundles for their anatomical sites. Methods: An English language literature search was undertaken over the years 2000-2012 for ACL reconstruction, double-bundle versus single bundle technique. The search found 14 RCTs and two meta-analyses published to date. Results: Two of the 14 studies (14 %) showed no difference between the two reconstruction methods while the remaining majority (12 trials, 86 %) concluded that the DB technique was better than the SB method. After the DB reconstruction, rotational stability of the knee was better in seven studies (50 %) and anteroposterior stability in six (43 %). No study spoke for the single-bundle technique. In addition, with the double-bundle technique knee scores were reported to be better in five (36 %) studies, and three trials (21 %) revealed less reoperations in the double-bundle group. Conclusions: The double-bundle ACL reconstruction technique was reported to have better or at least the same results as the conventional single-bundle method - even at a five-year follow-up. However, the majority of these studies had a rather short follow-up, and thus, longer studies are needed to confirm the true long-term results of ACL surgery. Long follow-up periods are also needed to find out whether double-bundle ACL reconstruction can eventually prevent knee osteoarthritis. © 2012 Springer-Verlag Berlin Heidelberg.

News Article | November 29, 2016

An international research collaboration, led by University of Sydney, has found that cycling, swimming, aerobics and racquet sports offer life saving benefits compared to running and football. Published today in the British Journal of Sports Medicine, the study also found that death from cardiovascular disease (CVD) was reduced in people who participated in swimming, racquet sports and aerobics. The study examined 80,000 adults over 30 years of age to investigate the link between participation in six different 'exercise disciplines' and death, including cycling, swimming, racquet sports, aerobics, football and running. The researchers drew on responses from 11 nationally representative annual health surveys for England and Scotland, carried out between 1994 and 2008. Compared with study participants who did not participate in the corresponding sport, risk of death from any cause was: Compared with study participants who did not participate in the corresponding sport, risk of death from cardiovascular disease was: "Our findings indicate that it's not only how much and how often, but also what type of exercise you do that seems to make the difference," said senior author Associate Professor Emmanuel Stamatakis from the Charles Perkins Centre, Faculty of Health Sciences and School of Public Health at the University of Sydney. "Participation in specific sports may have various benefits for health. These observations with the existing evidence should support the sport community together with other sectors to design and implement effective health enhancing exercise programs and physical activity in general," he said. Future research should aim to further strengthen the sport-specific evidence base and understanding of how to enable greater sports participation for people from all age groups and walks of life. This research was a large scale collaboration between University of Sydney, University of Oxford, UKK Institute (Finland), University of Edinburgh, and four other international universities. The researchers drew on responses from eleven nationally representative baseline health examination surveys carried out in the United Kingdom between 1994 and 2006 which looked at the association between participation in six different sport/exercise disciplines and mortality. In all, the analysis included 80,306 adults with an average age of 52. In each of the surveys, participants were quizzed about how much physical activity they had done in the preceding 4 weeks, and whether it had been enough to make them breathless and sweaty.

Loading UKK Institute collaborators
Loading UKK Institute collaborators