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Berlin, Germany
Berlin, Germany

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Battmer R.-D.,UKB | Borel S.,Beaujon | Brendel M.,Advanced Bionics | Buchner A.,MHH | And 13 more authors.
Cochlear Implants International | Year: 2015

Objective: To compare the fitting time requirements and the efficiency in achieving improvements in speech perception during the first 6 months after initial stimulation of computer-assisted fitting with the Fitting to Outcome eXpert’ (FOX) and a standard clinical fitting procedure. Method: Twenty-seven post-lingually deafened adults, newly implanted recipients of the Advanced Bionics HiRes 90K™ cochlear implant from Germany, the UK, and France took part in a controlled, randomized, clinical study. Speech perception was measured for all participants and fitting times were compared across groups programmed using FOX and conventional programming methods. Results: The fitting time for FOX was significantly reduced at 14 days (P< 0.001) but equivalent over the 6- month period. The groups were not well matched for duration of deafness; therefore, speech perception could not be compared across groups. Discussion: Despite including more objective measures of performance than a standard fitting approach and the adjustment of a greater range of parameters during initial fitting, FOX did not add to the overall fitting time when compared to the conventional approach. FOX significantly reduced the fitting time in the first 2 weeks and by providing a standard fitting protocol, reduced variability across centres. Conclusions: FOX computer-assisted fitting can be successfully used at switch on, in different clinical environments, reducing fitting time in the first 2 weeks and is efficient at providing a usable program. © W. S. Maney & Son Ltd 2015.


van den Abbeele T.,Hopital Robert Debre | Noel-Petroff N.,Hopital Robert Debre | Akin I.,SB Ankara Diskapi Yildirim Beyazit Education and Research Hospital | Caner G.,SB | And 21 more authors.
Cochlear Implants International | Year: 2012

Objectives: The aims of this study were to collect data on electrically evoked compound action potential (eCAP) and electrically evoked stapedius reflex thresholds (eSRT) in HiResolution TM cochlear implant (CI) users, and to explore the relationships between these objective measures and behavioural measures of comfort levels (M-levels). Methods: A prospective study on newly implanted subjects was designed. The eCAP was measured intraoperatively and at first fitting through neural response imaging (NRI), using the SoundWave TM fitting software. The eSRT was measured intra-operatively by visual monitoring of the stapes, using both singleelectrode stimulation and speech bursts (four electrodes stimulated at the same time). Measures of M-levels were performed according to standard clinical practice and collected at first fitting, 3 and 6 months of CI use. Results: One hundred seventeen subjects from 14 centres, all implanted unilaterally with a HiResolution CII Bionic Ear ® or HiRes 90K ®, were included in the study. Speech burst stimulation elicited a significantly higher eSRT success rate than single-electrode stimulation, 84 vs. 64% respectively. The NRI success rate was 81% intra-operatively, significantly increasing to 96% after 6 months. Fitting guidelines were defined on the basis of a single NRI measurement. Correlations, analysis of variance, and multiple regression analysis were applied to generate a predictive model for the M-levels. Discussion: Useful insights were produced into the behaviour of objective measures according to time, electrode location, and fitting parameters. They may usefully assist in programming the CI when no reliable feedback is obtained through standard behavioural procedures. © W.S. Maney & Son Ltd 2012.


Mittmann P.,Ukb | Rademacher G.,Ukb | Mutze S.,Ukb | Hassepass F.,Albert Ludwigs University of Freiburg | And 2 more authors.
BioMed Research International | Year: 2015

The position of the cochlear implant electrode array within the scala tympani is essential for an optimal postoperative hearing benefit. If the electrode array changes in between the scalae intracochlearly (i.e., from scala tympani to scala vestibuli), a reduced auditory performance can be assumed. We established a neural response telemetry-ratio (NRT-ratio) which corresponds with the scalar position of the electrodes but shows within its limits a variability. The aim of this study was to determine if insertion depth angle or cochlea size influences the NRT-ratio. The intraoperative electrophysiological NRT data of 26 patients were evaluated. Using a flat panel tomography system, the position of the electrode array was evaluated radiologically. The insertion depth angle of the electrode, the cochlea size, and the NRT-ratio were calculated postoperatively. The radiological results were compared with the intraoperatively obtained electrophysiological data (NRT-ratio) and statistically evaluated. In all patients the NRT-ratio, the insertion depth angle, and the cochlea size could be determined. A significant correlation between insertional depth, cochlear size, and the NRT-ratio was not found. The NRT-ratio is a reliable electrophysiological tool to determine the scalar position of a perimodiolar electrode array. The NRT-ratio can be applied independent from insertion depth and cochlear size. © 2015 Philipp Mittmann et al.


PubMed | ukb and Albert Ludwigs University of Freiburg
Type: | Journal: BioMed research international | Year: 2016

The position of the cochlear implant electrode array within the scala tympani is essential for an optimal postoperative hearing benefit. If the electrode array changes in between the scalae intracochlearly (i.e., from scala tympani to scala vestibuli), a reduced auditory performance can be assumed. We established a neural response telemetry-ratio (NRT-ratio) which corresponds with the scalar position of the electrodes but shows within its limits a variability. The aim of this study was to determine if insertion depth angle or cochlea size influences the NRT-ratio. The intraoperative electrophysiological NRT data of 26 patients were evaluated. Using a flat panel tomography system, the position of the electrode array was evaluated radiologically. The insertion depth angle of the electrode, the cochlea size, and the NRT-ratio were calculated postoperatively. The radiological results were compared with the intraoperatively obtained electrophysiological data (NRT-ratio) and statistically evaluated. In all patients the NRT-ratio, the insertion depth angle, and the cochlea size could be determined. A significant correlation between insertional depth, cochlear size, and the NRT-ratio was not found. The NRT-ratio is a reliable electrophysiological tool to determine the scalar position of a perimodiolar electrode array. The NRT-ratio can be applied independent from insertion depth and cochlear size.


Schmitt I.,UKB | Schmitt I.,German Center for Neurodegenerative Diseases | Kaut O.,UKB | Khazneh H.,UKB | And 8 more authors.
Movement Disorders | Year: 2015

Background: Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker. Methods: We performed a thorough analysis of α-synuclein methylation in bisulfite-treated DNA from peripheral blood of 490 sporadic PD patients and 485 healthy controls and in addition analyzed the effect of levodopa (l-dopa) on α-synuclein methylation and expression in cultured mononuclear cells. Results: α-Synuclein was hypomethylated in sporadic PD patients, correlated with sex, age, and a polymorphism in the analyzed sequence stretch (rs3756063). α-Synuclein methylation separated healthy individuals from sporadic PD with a specificity of 74% (male) and 78% (female), respectively. α-Synuclein methylation was increased in sporadic PD patients with higher l-dopa dosage, and l-dopa specifically induced methylation of α-synuclein intron 1 in cultured mononuclear cells. Conclusions: α-Synuclein methylation levels depended on disease status, sex, age, and the genotype of rs3756063. The pharmacological action of l-dopa was not limited to the dopamine precursor function but included epigenetic off-target effects. The hypomethylation of α-synuclein in sporadic PD patients' blood already observed in previous studies was probably underestimated because of effect of l-dopa, which was not known previously. The analysis of α-synuclein methylation can help to identify nonparkinsonian individuals with reasonable specificity, which offers a valuable tool for researchers and clinicians. © 2015 International Parkinson and Movement Disorder Society. © 2015 International Parkinson and Movement Disorder Society


PubMed | University of Bonn, University of Lübeck, UKB and German Center for Neurodegenerative Diseases
Type: Journal Article | Journal: Movement disorders : official journal of the Movement Disorder Society | Year: 2016

Increasing gene dosages of -synuclein induce familial Parkinsons disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered -synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker.We performed a thorough analysis of -synuclein methylation in bisulfite-treated DNA from peripheral blood of 490 sporadic PD patients and 485 healthy controls and in addition analyzed the effect of levodopa (L-dopa) on -synuclein methylation and expression in cultured mononuclear cells.-Synuclein was hypomethylated in sporadic PD patients, correlated with sex, age, and a polymorphism in the analyzed sequence stretch (rs3756063). -Synuclein methylation separated healthy individuals from sporadic PD with a specificity of 74% (male) and 78% (female), respectively. -Synuclein methylation was increased in sporadic PD patients with higher l-dopa dosage, and L-dopa specifically induced methylation of -synuclein intron 1 in cultured mononuclear cells.-Synuclein methylation levels depended on disease status, sex, age, and the genotype of rs3756063. The pharmacological action of L-dopa was not limited to the dopamine precursor function but included epigenetic off-target effects. The hypomethylation of -synuclein in sporadic PD patients blood already observed in previous studies was probably underestimated because of effect of L-dopa, which was not known previously. The analysis of -synuclein methylation can help to identify nonparkinsonian individuals with reasonable specificity, which offers a valuable tool for researchers and clinicians.


Schultheiss C.,UKB | Nusser-Muller-Busch R.,UKB | Seidl R.O.,UKB
European Archives of Oto-Rhino-Laryngology | Year: 2011

Contrary to clinical experience, clinical swallow tests are predominantly performed using water (water swallow tests, WST). In this study, we examine whether swallow tests performed using a bolus of semisolid food (bolus swallow test, BST) offer benefits. In a prospective, randomised, blind study, the results of a standardised saliva swallow test (SST), WST, BST, combinations of these tests and an endoscopic swallow test (FEES) in patients with oropharyngeal swallowing disorders of neurological (NEU) and non-neurological (NNEU) origin were compared. Sensitivity, specificity, test accuracy and inter-rater reliability were analysed. 62 patients (mean age = 64.68; range = 22-84) were included in the study (NEU = 40; NNEU = 22). A sensitivity of 70.7% (NEU = 70.3%, NNEU = 71.4%) and specificity of 82.5% (NEU = 92.3%; NNEU = 100%) were determined for the WST. The BST + SST was found to have a sensitivity of 89.6% (NEU = 66.7%; NNEU = 90.9%) and a specificity of 72.7% (NEU = 87.5%; NNEU = 90.9%). Analysis of test accuracy showed a statistically significant correlation between FEES and BST + SST. Only BST + SST exhibited statistically significant inter-rater reliability. BST in combination with SST was the sensitive clinical instrument for detecting aspiration both over the patient population as a whole and over the two sub-populations. Inter-rater reliability was found to be statistically significant. The results presented here demonstrate the benefit of semisolid food in investigating clinical dysphagia. © 2011 The Author(s).


Knopke S.,UKB | Todt I.,UKB | Ernst A.,UKB | Seidl R.O.,UKB
Otolaryngology - Head and Neck Surgery | Year: 2010

Objective: Injuries to the cartilaginous larynx are rare disorders that usually undergo good spontaneous healing and rarely require surgery. Study Design: Case series with chart review from patients with pseudarthrosis of the cornu of the thyroid cartilage. Setting: ENT department of a level I trauma center. Subjects and Methods: We examined the medical records of seven patients treated for impaired healing of the cornu of the thyroid cartilage at a level I trauma center between 1997 and 2009. Results: Seven patients were treated as a result of impaired healing of injuries to the cornu of the thyroid cartilage caused by trivial trauma (e.g., car accidents). The principal symptom was odynophagia. Computed tomography was used to confirm the diagnosis. Treatment involved resecting the cornu of the thyroid cartilage. Histology showed a hypertrophic pseudarthrosis at the base of the cornu. All patients were free of symptoms 10 days after resection. Conclusion: Pseudarthrosis of the cornu of the thyroid cartilage is a previously undescribed condition. Pseudarthrosis of the laryngeal skeleton should be excluded in patients with odynophagia. © 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation.

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