Uka Tarsadia University BardoliGujarat

Uka, India

Uka Tarsadia University BardoliGujarat

Uka, India
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Gupta A.,Uka Tarsadia University BardoliGujarat | Sheth N.R.,Saurashtra University | Pandey S.,Uka Tarsadia University BardoliGujarat | Joshi S.V.,Uka Tarsadia University BardoliGujarat
Brazilian Journal of Pharmacognosy | Year: 2015

The decoctions of the Butea monosperma (Lam.) Taub., Fabaceae, Bauhinia variegata L., Fabaceae, and Ocimum gratissimum L., Lamiaceae, are traditionally used for the treatment of various types of hepaticdisorder. Phytochemical studies have shown that total flavonoids from these plants were the majorconstituents of the picked out part of each plant. The present study was planned to investigate the hep-atoprotective effect of flavonoid rich fractions of the B. monosperma, B. variegata and O. gratissimumagainst paracetamol induced liver damage. Flavonoid rich fractions were isolated by solvent fractionation from each plant. Each fraction was subjected to various qualitative chemical tests to find out the metabolites. Flavonoid fractions of each plant were subjected for pharmacological screening. The rats were monitored for change in liver morphology, biochemical parameters like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase and total bilirubin for the groups receiving the flavonoid-rich fractions. All flavonoid rich fractions showed significant hepatoprotective activity. The histological studies supported the biochemical parameters. From the results of biochemical analysis and histopathological studies, it can be accomplished that in the ethyl acetate fraction of O. gratissimum showed highest hepatoprotective activity as compared to other fractions. The present study was the first evidence of flavonoid-rich fractions of each plant have a remarkable hepato-protective effect. All fractions contain a potent hepatoprotective agent suggested to be a flavone, which may find clinical application in amelioration of paracetamol-induced liver damage. © 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

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