Mokale V.,UICT |
Khatumaria B.,UICT |
Verma U.,UICT |
Shimpi N.,UICT |
And 2 more authors.
Micro and Nanosystems | Year: 2014
The aim and objective of the present work was to prepare and develop hydrochlorothiazide (HCTZ) nanoparti-cles for quick and complete release by nanonization technique to overcome the poor water solubility and bioavailability problems. The poor solubility of many drugs along with a slow dissolution rate is a major research and industrial problems for pharmaceutical scientists and industries who are included in pill disclosure and medication improvement. It has been accounted for that something like 40% of the mixes are defectively water dissolvable or basically insoluble in water. HCTZ nanoparticles were prepared by solvent evaporation method under ultra-sonication process. Prepared nanoparticles were evaluated for the yield, drug loading and entrapment efficiency studies. HCTZ nanoparticles were also characterized for drug and polymer interaction by using FT-IR and DSC. Morphological characteristics of the formulation were studied by particle size analysis and surface charge, XRD, and FE-SEM. Additionally, in vitro drug dissolution study and ex vivo drug diffusion study were performed. All the characterization studies together revealed that the ideal properties of HCTZ nanoparticles. From the study, we can conclude that the solvent evaporation method under ultra-sonication is a promising method to produce small, uniform and stable HCTZ nanoparticles. © 2014 Bentham Science Publishers
Kausley S.B.,UICT |
Fuel | Year: 2010
This work presents a detailed theoretical study of solid fuel combustion in a domestic stove (make Harsha, RRL, Bhubaneswar, India). In this work different steady state as well as unsteady state combustion models have been formulated, which include the description of all the chemical and physical processes taking place during the solid fuel combustion inside the stove. Steady state models involve the calculation of effective maximum flame temperature, suction of combustion air created by hot flue gases inside the stove and the propagation of ignition front inside the stove. Unsteady state mathematical model involves all the processes occurring simultaneously or sequentially during the solid fuel combustion such as moisture evaporation, devolatilization, pyrolysis and homogeneous and heterogeneous combustion reactions. This unsteady state model gives the temperature profiles at different locations inside the stove and fuel mass loss (combustion) rate, which can be further used to calculate the power delivery by the stove during combustion. The model shows good agreement with the experimental results. These models can be used to find the effect of stove geometry and fuel properties on the stove performance parameters such as effective maximum flame temperature, suction created inside the stove, propagation of ignition front inside the stove, and fuel burn rate, which play an important role in the design of such stoves for maximum thermal efficiencies. © 2009 Elsevier Ltd. All rights reserved.
PubMed | UICT
Type: Journal Article | Journal: Indian journal of biochemistry & biophysics | Year: 2012
Immobilized enzyme catalyzed biotransformations involving macromolecular substrates and/or products are greatly retarded due to slow diffusion of large substrate molecules in and out of the typical enzyme supports. Slow diffusion of macromolecules into the matrix pores can be speeded up by use of macroporous supports as enzyme carriers. Depolymerization reactions of polysaccharides like starch, pectin, and dextran to their respective low molecular weight products are some of the reactions that can benefit from use of such superporous matrices. In the present work, an indigenously prepared rigid cross-linked cellulose matrix (called CELBEADS) has been used as support for immobilizing alpha amylase (1,4-alpha-D-glucan glucanohydrolase, EC 188.8.131.52.) and pectinase (endo-PG: poly(1,4-alpha-galactouronide) glycanohydrolase, EC 184.108.40.206). The immobilized enzymes were used for starch and pectin hydrolysis respectively, in batch, packed bed and expanded bed modes. The macroporosity of CELBEADS was found to permit through-flow and easy diffusion of substrates pectin and starch to enzyme sites in the porous supports and gave reaction rates comparable to the rates obtained using soluble enzymes.