UGC de Pediatria

Sada, Spain

UGC de Pediatria

Sada, Spain

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Gonzalez-Tome M.I.,Hospital 12 Of Octubre | Rivera M.,UGC de Pediatria | Camano I.,Hospital 12 Of Octubre | Norman F.,Hospital Ramon y Cajal | And 9 more authors.
Enfermedades Infecciosas y Microbiologia Clinica | Year: 2013

Congenital transmission of Chagas disease now occurs in areas where the disease is non-endemic, and alsofrom one generation to another. According to epidemiological data from Latin America, the prevalence of the disease in pregnant women is 0.7%-54%, and the prevalence of vertical transmission is around 5%-6%.Congenital T. cruzi infection is an acute infection in newborns that should be treated with anti-parasitictherapy. The treatment of pregnant women could also have an impact on the control of the disease. Thisarticle has been prepared following the recommendations suggested by a group of experts in Infectious Diseases, Microbiology, Gynaecology and Paediatrics. © 2012 Elsevier España, S.L.


Belizon C.T.,UGC de Pediatria | Paez E.O.,UGC Maracena | Claros A.F.M.,UGC de Pediatria | Sanchez I.R.,UGC de Pediatria | And 3 more authors.
Anales de Pediatria | Year: 2016

Introduction The aim of the study was to assess the use of faecal calprotectin (FCP) in infants with signs and symptoms of non-IgE-mediated cow's milk protein allergy (CMA) for both diagnosis and prediction of clinical response at the time of withdrawal of milk proteins. Patients and methods A one year prospective study was conducted on 82 infants between 1 and 12 months of age in the Eastern area of Málaga-Axarquía, of whom 40 of them had been diagnosed with non-IgE-mediated CMA (with suggestive symptoms and positive response to milk withdrawal), 12 not diagnosed with CMA, and 30 of them were the control group. FCP was measured at three different times: time of diagnosis, and one and three months later. ANOVA for repeated measures, nominal logistic regression and ROC curves were prepared using the SPSS.20 package and Medcalc. Results Differences between diagnostic and control groups were assessed: there was a statistically significant relationship (p<.0001) between high FCP levels and infants suffering CMA, as well as the levels at time of diagnosis, 1 and 3 months (p <.001). A ROC curve was constructed between FCP levels and diagnosis of CMA, with 138 ug/g, with the best cut-off being with an area under the curve of 0.89. However, it is only 0.68 to predict a clinical response. Conclusions FCP levels lower than 138 ug/g could be useful to rule out non-IgE-mediated CMA diagnosis. Calprotectin is not a good test to predict clinical response to milk withdrawal. © 2015 Asociación Española de Pediatría.


PubMed | UGC Maracena and UGC de Pediatria
Type: Journal Article | Journal: Anales de pediatria (Barcelona, Spain : 2003) | Year: 2016

The aim of the study was to assess the use of faecal calprotectin (FCP) in infants with signs and symptoms of non-IgE-mediated cows milk protein allergy (CMA) for both diagnosis and prediction of clinical response at the time of withdrawal of milk proteins.A one year prospective study was conducted on 82 infants between 1 and 12 months of age in the Eastern area of Mlaga-Axarqua, of whom 40 of them had been diagnosed with non-IgE-mediated CMA (with suggestive symptoms and positive response to milk withdrawal), 12 not diagnosed with CMA, and 30 of them were the control group. FCP was measured at three different times: time of diagnosis, and one and three months later. ANOVA for repeated measures, nominal logistic regression and ROC curves were prepared using the SPSS.20 package and Medcalc.Differences between diagnostic and control groups were assessed: there was a statistically significant relationship (p<.0001) between high FCP levels and infants suffering CMA, as well as the levels at time of diagnosis, 1 and 3 months (p <.001). A ROC curve was constructed between FCP levels and diagnosis of CMA, with 138 ug/g, with the best cut-off being with an area under the curve of 0.89. However, it is only 0.68 to predict a clinical response.FCP levels lower than 138ug/g could be useful to rule out non-IgE-mediated CMA diagnosis. Calprotectin is not a good test to predict clinical response to milk withdrawal.

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