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Torremolinos, Spain

Padilla-Perez M.,UGC Cardiologia | Salas-Bravo D.,UGC Cardiologia | Vazquez-Ruiz de Castroviejo E.,UGC Cardiologia | Lozano-Cabezas C.,UGC Cardiologia | And 3 more authors.
Cardiocore | Year: 2016

Introduction/Objectives: There are discrepancies in the data on the presence of systolic dysfunction, measured using the left ventricular ejection fraction (LVEF) in patients with anorexia nervosa. The aim of this study is to measure left ventricular systolic function using Tissue Doppler and Speckle-tracking and see if there is any correlation with nutritional parameters. Methods: A transthoracic echocardiogram was performed on 16 anorexic patients with a Body Mass Index (BMI) < 18.5. The LVEF was measured using Simpson's method, and the mitral annulus systolic velocity (SV) and Longitudinal Strain (LS) by Tissue-Doppler. Several nutritional parameters were also determined in plasma. A descriptive analysis and bivariate correlations (Spearman correlation coefficient) were performed. Results: The mean BMI of the sample was 17.38 ± 0.12 kg/m2, and mean weight 44.68 ± 9.46 kg. The systolic function parameters were, LVEF 59.06 ± 5.64%, LV SV 0.0787 ± 0.015 m/s, and LS -20.72 ± 2.47%. A strong and statistically significant correlation was found between the LS and a low plasma magnesium (-0.819, P < .01), with a weaker one between LS and Vitamin B12 (-0.614, P = .044). Conclusions: Our data appears to go against a possible systolic dysfunction in patients with malnourishment due to anorexia nervosa. The strong inverse association between the LS and plasma levels of magnesium and Vitamin B12 is highlighted. © 2016 SAC.

Entrala-Bernal C.,LORGEN GP | Montes-Castillo C.,UGC Endocrinologia y Nutricion | Alvarez-Cubero M.J.,University of Granada | Gutierrez-Alcantara C.,UGC Endocrinologia y Nutricion | And 4 more authors.
Hormones | Year: 2014

Kallmann Syndrome (KS) is a genetic disease of embryonic development which is characterized by the association of hypogonadotropic hypogonadism (HH) due to a deficit of the gonadotropin-releasing hormone (GnRH) and a hypo/anosmia (including a hypoplasia of the nasal sulcus and agenesis of the olfactory bulbs). Even though it is a genotypically and phenotypically heterogeneous clinical disease, there are some key genes related to KS (KAL1, FGFR1 (KAL2), GNRHR, KISSR1 (GPR54), GNRH1, NELF and PROK2). The aim of this study was to present a case report of a genetic diagnosis of KS linked to the presence of mutations in the FGFR1 (fibroblast growth factor receptor 1, also known as KAL2) gene. This diagnosis was made in a 44-year old female affected by a hypogonadism for which she had received intermittent treatment until she was 30 years old based on the patient's own decision. The molecular analysis of FGFR1 identified the mutation c. 246_247delAG (p.T82Xfs110) in heterozygosis on exon 3 of the KAL2 gene. This is the first report of this mutation related to idiopathic hypogonadotrophic hypogonadism (IHH).

Olmedo Carrillo P.,Distrito Sanitario Jaen | Garcia Fuentes E.,Hospital Regional Universitario | Garcia Fuentes E.,CIBER ISCIII | Gutierrez Alcantara C.,UGC Endocrinologia y Nutricion | And 4 more authors.
Endocrinologia y Nutricion | Year: 2015

Conclusiones: Background and objective: Iodine deficiency affecting both pregnant women and schoolchildren has been reported in Jaén. Iodine deficiency is one of the leading causes of thyroid dysfunction and goiter, and adequate iodine prophylaxis with iodized salt, milk, and dairy products, or iodine supplementation have been shown to significantly improve iodine status in pregnancy. The purpose of this study was to assess iodine nutritional status in the general population of a iodine-deficient area with no previous institutional campaigns of iodine prophylaxis. Material and methods: A descriptive, cross-sectional study. Urinary iodine levels were measured in subjects from the Jaén healthcare district. The data were stratified by sex and age groups, and a survey was conducted on iodized salt consumption. Results: Median and mean urinary iodine levels were 110.59 mcg/L and 130.11 mcg/L respectively. Urinary iodine levels were significantly higher in schoolchildren as compared to other age groups (161.52 μg/L vs 109.33 μg/L in subjects older than 65 years). Forty-three percent of the population had urinary iodine levels less than 100 μg/L, and 68% of women of childbearing age had levels less than 150 μg/L. Conclusions: Iodine nutritional status appears to be adequate, but the proportion of the population with urinary iodine levels less than 100 μg/L is still very high, and iodized salt consumption is much less common than recommended by the WHO. © 2015 SEEN.

Garcia-Almeida J.M.,UGC Endocrinologia y Nutricion | Fdez G.M.C.,UGC Endocrinologia y Nutricion | Aleman J.G.,UGC Endocrinologia y Nutricion
Nutricion Hospitalaria | Year: 2013

In this chapter we review the role and potential benefits of non-caloric sweeteners, as part of the diet. After appearing and interest in the beneficial effects attributed to them, face different situations and conditions (obesity, diabetes...), more and more numerous studies, show their ineffective use. In conclusion, further research and results are needed to provide convincing evidence of their long-term effectiveness and the absence of negative effects from their use. The interest of the chapter lies in examining the distinctive aspects of sweeteners compared with sugar, measured as the standard of comparison. We will focus then on the other substances that are commonly used to sweeten foods instead of sugar.

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