Uberaba, Brazil
Uberaba, Brazil

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In this work we present single-stage formulations for the integrated soft drink lot-sizing and scheduling problem with two-stage synchronization. It is a multi-product, multi-machine problem, with sequence-dependent setup times and costs. Without loss of generality, these single-stage reformulations address the problem correctly and, in general, reduce the size of the synchronized two-stage model of Ferreira, Morabito e Rangel (2009), regarding the number of variables and constraints. The preliminary computational experiments on real-world instances from a soft-drink company show the competitiveness of the single-stage models against other formulations and solution approaches reported in the literature.

De Oliveira K.F.,Federal University of Triângulo Mineiro | Da Cunha D.F.,UFTM | Weffort V.R.S.,UFTM
Jornal de Pediatria | Year: 2011

Objectives: To assess adequacy of vitamin C intake in HIV-infected children and adolescents; to evaluate serum levels of vitamin C and indicators of oxidative stress; to compare with the uninfected group; to correlate serum vitamin C with oxidative stress and associate them according to the reference values. Methods: Comparative cross-sectional study. Two groups of 27 children and adolescents each, aged between 3 to 19 years. Group 1 (G1) comprised individuals vertically infected with HIV seen at a regional outpatient clinic. Group 2 (G2) comprised invited individuals without history of HIV infection. The groups were matched for age, sex, and socioeconomic status. The following variables were analyzed: body mass index for age; micronutrient intake and consumption; and serum vitamin C, C-reactive protein (CRP), and albumin. Results: The mean age was 12 years old. Most subjects were female (17, 63%), and there was prevalence of the economic class C (27, 50%). The most prevalent nutritional status was normal weight in 20 individuals (74.1%) in G1 and 21 (77.8%) in G2. The intake of vitamin C was significantly higher in G1 (p = 0.006; t = 2.987) according to the 24-hour dietary recall method. There were significant differences in serum vitamin C concentration between the groups, with a lower level in G1 (p = 0.000; t = -7.309). In relation to oxidative stress, values of CRP in G1 were significantly higher (p = 0.007; t = 2.958). There was no association between deficiency of vitamin, CRP, and albumin. Conclusion: Our findings show that HIV-infected individuals have low levels of vitamin C; however, this deficiency is not related to eating habits, since the intake of this nutrient was higher in this group than in the control group. HIV-infected individuals have specific characteristics that increase their oxidative stress, which is evidenced by increased CRP. Copyright © 2011 by Sociedade Brasileira de Pediatria.

Silva B.T.,UFTM | Santiago L.B.,University of Sao Paulo | Lamonier J.A.,Federal University of Minas Gerais
Revista Paulista de Pediatria | Year: 2012

Objective: To identify publications regarding the role of the father or partner in the breastfeeding practice. Data source: An integrative review of the literature was performed searching for articles published between 1995 and 2010, using the key-words "father" and "breastfeeding" in following databases: LILACS, SciELO, BDENF e PubMed/MEDLINE. Data were organized in three categories: the supporting role of the father on breastfeeding; paternal perceptions about breastfeeding; and the impact of educational intervention on breastfeeding for parents. Data synthesis: 44 articles showed that social, professional and family support is vital to successful breastfeeding. The father was highlighted as crucial supporter due to his strong influence over women ́s decision to breastfeed and to maintain breastfeeding. However, the involvement of the father presents evasive patterns: competition with the mother vs. protection, exclusion vs. increase strength in the family relationships, support vs. prejudices. Health professionals were reported as reference sources of education, however they were shown as unprepared to assist the parents. Conclusions: Several studies on the theme of paternal support were found in the literature, which highlights its importance for successful breastfeeding. However, most of the research had a descriptive approach and there were few studies on educational interventions.

Donizetti-Oliveira C.,Federal University of São Paulo | Semedo P.,Federal University of São Paulo | Burgos-Silva M.,Federal University of São Paulo | Cenedeze M.A.,Federal University of São Paulo | And 5 more authors.
Cell Transplantation | Year: 2012

Adipose tissue-derived stem cells (ASCs) are an attractive source of stem cells with regenerative properties that are similar to those of bone marrow stem cells. Here, we analyze the role of ASCs in reducing the progression of kidney fibrosis. Progressive renal fibrosis was achieved by unilateral clamping of the renal pedicle in mice for 1 h; after that, the kidney was reperfused immediately. Four hours after the surgery, 2 × 105 ASCs were intraperitoneally administered, and mice were followed for 24 h posttreatment and then at some other time interval for the next 6 weeks. Also, animals were treated with 2 × 105 ASCs at 6 weeks after reperfusion and sacrificed 4 weeks later to study their effect when interstitial fibrosis is already present. At 24 h after reperfusion, ASCtreated animals showed reduced renal dysfunction and enhanced regenerative tubular processes. Renal mRNA expression of IL-6 and TNF was decreased in ASC-treated animals, whereas IL-4, IL-10, and HO-1 expression increased despite a lack of ASCs in the kidneys as determined by SRY analysis. As expected, untreated kidneys shrank at 6 weeks, whereas the kidneys of ASC-treated animals remained normal in size, showed less collagen deposition, and decreased staining for FSP-1, type I collagen, and Hypoxyprobe. The renal protection seen in ASC-treated animals was followed by reduced serum levels of TNF-α, KC, RANTES, and IL-1α. Surprisingly, treatment with ASCs at 6 weeks, when animals already showed installed fibrosis, demonstrated amelioration of functional parameters, with less tissue fibrosis observed and reduced mRNA expression of type I collagen and vimentin. ASC therapy can improve functional parameters and reduce progression of renal fibrosis at early and later times after injury, mostly due to early modulation of the inflammatory response and to less hypoxia, thereby reducing the epithelial-mesenchymal transition. © 2012 Cognizant Comm. Corp.

Barroso S.M.,Federal University of Triângulo Mineiro | de Andrade V.S.,UFTM | Midgett A.H.,Boise University | de Carvalho R.G.N.,Federal University of Triângulo Mineiro
Jornal Brasileiro de Psiquiatria | Year: 2016

Objective: This study investigated the validity evidence of Loneliness Scale UCLA to be used in the Brazilian population. Methods: It was followed the phases authorization of the author and the Ethics Committee, translation and back-translation, semantic adaptation and validation of the test. Data were analyzed by descriptive analysis, exploratory factor, alpha Chronbach, Kappa, sphericity test of Bartlett, Kaiser-Meyer-Olkin test and Pearson’s correlation. To semantic adaptation the scale was submitted to specialists and a focus group with 8 participants and to cross-cultural adaptation the scale was submitted to a pilot study with 126 participants. In the validation participated 818 people, between 20 and 87 years, who responded to two versions of UCLA, Patient Health Questionnaire, Social Support Scale and a questionnaire made by the authors. Results: The scale showed two factors, which explained 56% of variance and alpha of 0.94. Conclusions: Loneliness Scale UCLA-BR indicated evidence of discriminant and construct validity, as well as good reliability. It can be used for evaluation of loneliness in the Brazilian population. © 2016, Editora Cientifica Nacional Ltda. All rights reserved.

Tribess S.,Federal University of Triângulo Mineiro | Virtuoso Jr. J.S.,UFTM | de Oliveira R.J.,University of Brasilia
Revista da Associacao Medica Brasileira | Year: 2012

Objective: To analyze physical activity in different domains (work, transportation, housework and leisure) as a predictor of the absence of frailty. Methods: An epidemiological cross-sectional study with a random sample of 622 individuals aged ≥ 60 years was carried out in Uberaba, MG, Brazil. Receiver operating characteristic (ROC) curves were generated and compared with physical activity in different domains and the absence of frailty. Cutoffs points of physical activity (minutes/week) were established to predict the absence of frailty. A confidence interval of 95% was established in order to find the largest areas under the ROC curves for work, transportation, household and leisure. The total physical activity and its domains were assessed by the international physical activity questionnaire. The index of frailty (unintentional weight loss, functional limitation to chair rise, handgrip strength, physical activity and exhaustion) was based on the study by Fried; the participants were dichotomously classified as not frail and frail. Results: The prevalence of frailty was 19.7% (men) and 20% (women). Physical activity of moderate or vigorous intensity accumulated in different domains for 145 minutes/week for women and 140 minutes/week for men or 85 minutes/week for women and 112.5 minutes/week for men for activities in the leisure domain showed the best cutoff to predict the absence of frailty. Conclusion: The practice of physical activity, especially in leisure time or accumulated in different domains, contributes to the prevention of frailty in the elderly. © 2012 Elsevier Editora Ltda. All right reserved.

Tirone N.R.,Federal University of Triângulo Mineiro | Michelin M.A.,UFTM | Murta E.F.C.,Federal University of Triângulo Mineiro
Recent Patents on Anti-Cancer Drug Discovery | Year: 2010

A big challenge for research today is the manipulation of the immune system in order to destroy the neoplastic cells of tumors different origins by using cytokines and other immunostimulants. Interferon-alpha (IFN-α) has been used clinically and has been shown to inhibit the proliferation of various cell types in vivo and in vitro. This cytokine has been widely used in the treatment of infectious and chronic degenerative diseases and cancer. In this review, we describe different patents covering the use of cytokines and peptides as therapies for cervical intraepithelial neoplasias and cervical cancer, paying special attention to the use of IFN-α. © 2010 Bentham Science Publishers Ltd.

PubMed | Federal University of Triângulo Mineiro and UFTM
Type: Journal Article | Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia | Year: 2016

To compare the diagnostic accuracy of the classic Meisels cytologic criteria and the Schneider secondary criteria relative to the hybrid capture method for diagnosing HPV infection.This was a retrospective study performed at a public university hospital. A total of 41 patients with a cytologic diagnosis of HPV infection and 40 HPV-negative patients were selected for review of the cervical-vaginal smears seeking to classical and secondary criteria. A single pathologist reviewed the slides in search of the criteria. The classical and secondary cytologic criteria were compared with the hybrid capture for diagnosing HPV infection. Bartleti test was applied for the age analysis, and Fishers exact test was used to compare proportions. The tests were considered significant when the probability of rejecting the null hypothesis was less than 5% (p < 0.05).The Meisels criteria were less sensitive (34.0%) than the secondary Schneider criteria (57.5%) when compared with the hybrid capture (p < 0.0001), although the specificity of the former criteria was non-significantly higher (91.2% and 67.7%, respectively). In cases of moderate or intense inflammation, the sensitivity and specificity of the Schneider criteria were decreased, 33.3% and 50.0% respectively (p = 0.0115).Compared with hybrid capture for diagnosis of HPV infection, the sensitivity of the secondary Schneider criteria was higher than the classical Meisels criteria.Moderate or intense inflammation reduces the sensitivity and specificity of the secondary Schneider criteria for diagnosing HPV infection using the hybrid capture as the gold standard.

Purpose: To evaluate the prevalence of testicular microlithiasis among pediatric patients with inguinoscrotal affections. Methods: Between January 2005 and January 2010, we evaluated, prospectively 1504 children ranging from 1 to 15 years with inguinoscrotal affections with a high-frequency ultrasound system, which employs a 10-MHz transducer. Results: Testicular microlithiasis was identified in 20 testes of eleven children (0.71% of 1504 patients evaluated), through an ultrasound scan. Testicular microlithiasis was found in 5 children with cryptorchidism (3.93% of 127 patients), 4 children with retractile testes (14.8% of 27 patients), 1 child with a hypotrophic testis (100% of 1 patient), and 1 child with inguinal hernia (0.07% of 1349 patients). The children with testicular microlithiasis were submitted to annual physical examinations and ultrasound evaluations. Conclusions: Testicular microlithiasis was a rare condition and occurred in 0.7% of the subjects studied. The association with cryptorchidism, retractile and hypotrophic testis was significant.

Objective: To review the literature on the importance of antioxidant vitamins, analyzed in the context of dietary intake, its plasma levels, and its current use as a supplementation treatment in obese children and adolescents with nonalcoholic fatty liver disease. Data sources: The articles were identified in Lilacs, Ibecs, SciELO, PubMed/Medline, and Scopus databases. To conduct the survey, the "fatty liver" descriptor was associated to the following words: "children", "antioxidants" and "vitamins". The search was limited to articles written in Portuguese, Spanish and English, with publication date until December, 2012. Data synthesis: Six studies were selected. The survey revealed a low dietary intake and low antioxidant vitamins serum levels in this population. The changes in lifestyle, with adequate dietary intake of vitamins, and the increase in physical activity were associated with a significant improvement in liver histology and in laboratory tests. Vitamin supplementation also improved the disease progression markers, as the alanine aminotransferase serum levels and the histological characteristics of lobular inflammation and hepatocellular damage. However, these improvements were not statistically significant in all studies. Conclusions: There is insufficient evidence to recommend or to refute antioxidant supplementation in patients with simple steatosis or steatohepatitis. The changes in lifestyle seem to be, at the present time, the more advisable therapy.

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