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Uberaba, Brazil

Tribess S.,Federal University of Triangulo Mineiro | Virtuoso Jr. J.S.,UFTM | de Oliveira R.J.,University of Brasilia
Revista da Associacao Medica Brasileira | Year: 2012

Objective: To analyze physical activity in different domains (work, transportation, housework and leisure) as a predictor of the absence of frailty. Methods: An epidemiological cross-sectional study with a random sample of 622 individuals aged ≥ 60 years was carried out in Uberaba, MG, Brazil. Receiver operating characteristic (ROC) curves were generated and compared with physical activity in different domains and the absence of frailty. Cutoffs points of physical activity (minutes/week) were established to predict the absence of frailty. A confidence interval of 95% was established in order to find the largest areas under the ROC curves for work, transportation, household and leisure. The total physical activity and its domains were assessed by the international physical activity questionnaire. The index of frailty (unintentional weight loss, functional limitation to chair rise, handgrip strength, physical activity and exhaustion) was based on the study by Fried; the participants were dichotomously classified as not frail and frail. Results: The prevalence of frailty was 19.7% (men) and 20% (women). Physical activity of moderate or vigorous intensity accumulated in different domains for 145 minutes/week for women and 140 minutes/week for men or 85 minutes/week for women and 112.5 minutes/week for men for activities in the leisure domain showed the best cutoff to predict the absence of frailty. Conclusion: The practice of physical activity, especially in leisure time or accumulated in different domains, contributes to the prevention of frailty in the elderly. © 2012 Elsevier Editora Ltda. All right reserved. Source

Santos A.S.,Federal University of Triangulo Mineiro | Ikegami E.M.,UFTM | da Silveira R.E.,Coordination of Disease Control of Health SecretariatSao Paulo State
Bioscience Journal | Year: 2016

The aim of this study was to verify the functional capacity between genders as well as the practice of physical exercises in accordance with procedures among elderly people from municipalities in the South Triangle, Minas Gerais, Brazil. Data relating to the practice of physical exercise and functional capacity were obtained by means of a structured questionnaire and the Katz scale, respectively. It was found that most of the elderly was independent to carry out the activities of daily life, even if they were not adept at exercising. Women showed a higher dependency level compared to men. As regards the modalities of exercise and those who practice them, men prefer to walk and swim, while women prefer aerobics and weight training. These results allow concluding that elderly respondents do not practice the modalities under study (walking, aqua aerobics, weight training and swimming), although they are independent to daily life activities. Regular and supervised exercise programs are recommended for elderly of all age groups, with a view to promoting a better quality of life and preventing functional incapacity. © 2016, Universidade Federal de Uberlandia. All rights reserved. Source

Tirone N.R.,Federal University of Triangulo Mineiro | Michelin M.A.,UFTM | Murta E.F.C.,Federal University of Triangulo Mineiro
Recent Patents on Anti-Cancer Drug Discovery | Year: 2010

A big challenge for research today is the manipulation of the immune system in order to destroy the neoplastic cells of tumors different origins by using cytokines and other immunostimulants. Interferon-alpha (IFN-α) has been used clinically and has been shown to inhibit the proliferation of various cell types in vivo and in vitro. This cytokine has been widely used in the treatment of infectious and chronic degenerative diseases and cancer. In this review, we describe different patents covering the use of cytokines and peptides as therapies for cervical intraepithelial neoplasias and cervical cancer, paying special attention to the use of IFN-α. © 2010 Bentham Science Publishers Ltd. Source

Silva B.T.,UFTM | Santiago L.B.,University of Sao Paulo | Lamonier J.A.,Federal University of Minas Gerais
Revista Paulista de Pediatria | Year: 2012

Objective: To identify publications regarding the role of the father or partner in the breastfeeding practice. Data source: An integrative review of the literature was performed searching for articles published between 1995 and 2010, using the key-words "father" and "breastfeeding" in following databases: LILACS, SciELO, BDENF e PubMed/MEDLINE. Data were organized in three categories: the supporting role of the father on breastfeeding; paternal perceptions about breastfeeding; and the impact of educational intervention on breastfeeding for parents. Data synthesis: 44 articles showed that social, professional and family support is vital to successful breastfeeding. The father was highlighted as crucial supporter due to his strong influence over women ́s decision to breastfeed and to maintain breastfeeding. However, the involvement of the father presents evasive patterns: competition with the mother vs. protection, exclusion vs. increase strength in the family relationships, support vs. prejudices. Health professionals were reported as reference sources of education, however they were shown as unprepared to assist the parents. Conclusions: Several studies on the theme of paternal support were found in the literature, which highlights its importance for successful breastfeeding. However, most of the research had a descriptive approach and there were few studies on educational interventions. Source

Donizetti-Oliveira C.,Federal University of Sao Paulo | Semedo P.,Federal University of Sao Paulo | Burgos-Silva M.,Federal University of Sao Paulo | Cenedeze M.A.,Federal University of Sao Paulo | And 5 more authors.
Cell Transplantation | Year: 2012

Adipose tissue-derived stem cells (ASCs) are an attractive source of stem cells with regenerative properties that are similar to those of bone marrow stem cells. Here, we analyze the role of ASCs in reducing the progression of kidney fibrosis. Progressive renal fibrosis was achieved by unilateral clamping of the renal pedicle in mice for 1 h; after that, the kidney was reperfused immediately. Four hours after the surgery, 2 × 105 ASCs were intraperitoneally administered, and mice were followed for 24 h posttreatment and then at some other time interval for the next 6 weeks. Also, animals were treated with 2 × 105 ASCs at 6 weeks after reperfusion and sacrificed 4 weeks later to study their effect when interstitial fibrosis is already present. At 24 h after reperfusion, ASCtreated animals showed reduced renal dysfunction and enhanced regenerative tubular processes. Renal mRNA expression of IL-6 and TNF was decreased in ASC-treated animals, whereas IL-4, IL-10, and HO-1 expression increased despite a lack of ASCs in the kidneys as determined by SRY analysis. As expected, untreated kidneys shrank at 6 weeks, whereas the kidneys of ASC-treated animals remained normal in size, showed less collagen deposition, and decreased staining for FSP-1, type I collagen, and Hypoxyprobe. The renal protection seen in ASC-treated animals was followed by reduced serum levels of TNF-α, KC, RANTES, and IL-1α. Surprisingly, treatment with ASCs at 6 weeks, when animals already showed installed fibrosis, demonstrated amelioration of functional parameters, with less tissue fibrosis observed and reduced mRNA expression of type I collagen and vimentin. ASC therapy can improve functional parameters and reduce progression of renal fibrosis at early and later times after injury, mostly due to early modulation of the inflammatory response and to less hypoxia, thereby reducing the epithelial-mesenchymal transition. © 2012 Cognizant Comm. Corp. Source

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