Correa S.C.,UEPA |
Lobato R.C.,UEPA |
Acta Cirurgica Brasileira | Year: 2013
PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
Brito M.V.H.,Health Integrated |
Carvalho R.D.K.V.,UEPA |
Matos L.T.D.M.B.,UEPA |
Rodolfo C.L.,UEPA |
And 2 more authors.
Acta Cirurgica Brasileira | Year: 2010
Purpose: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. Methods: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2×106 concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. Results: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. Conclusion: The copaiba balsam stimulated the tumor growth.
PubMed | Pará State University and UEPA
Type: Journal Article | Journal: Acta cirurgica brasileira | Year: 2015
To evaluate the effect of fasting on gastric emptying in mice.Twenty-eight mice were distributed into three study groups: a normal group (N=4): normal standard animals; a total fasting group (N=12): subjected to food and water deprivation and a partial fasting group (N=12): subjected to food deprivation only. The fasting groups were subdivided into three subgroups of four animals each, according to the date of euthanasia: 24, 48 and 72 hours. Was analyzed: the gastric volume, degree of the gastric wall distention and the presence of food debris in gastrointestinal tract.The mean gastric volume was 1601 mm3 in the normal group, 847 mm3 in total fasting group and 997 mm3 in partial fasting group. There was difference between the fasting groups in any analyzed period (p<0.05). Regarding the presence of food debris in the gastrointestinal tract and the degree of distension of the stomach, there was no difference between the groups that underwent total or partial fasting (p>0.05).Total fasting or only-solids deprivation does not induce gastric emptying in mice.
Yasojima E.Y.,University of Sao Paulo |
Teixeira R.K.C.,UEPA |
Houat A.P.,UEPA |
Costa F.L.S.,UEPA |
And 3 more authors.
Acta Cirurgica Brasileira | Year: 2013
PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/ polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION: Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
Runoff in Oxisol under different agroecosystems in the northeast part of Pará State [Escoamento superficial em Latossolo Amarelo distrófico típico sob diferentes agroecossistemas no nordeste paraense]
da Costa C.F.G.,Embrapa Amazonia Oriental |
Figueiredo R.O.,Embrapa Meio Ambiente |
Oliveira F.A.,UFRA |
Revista Brasileira de Engenharia Agricola e Ambiental | Year: 2013
In the watershed of the Timboteua and Buiuna streams in the State of Pará, the effect of land use change and soil management on the runoff rates was evaluated. Eighteen experimental plots (1 m2) were established, three in each one of the six evaluated agroecosystems as follows: i) 20 years Secondary vegetation ("Capoeira") (CP), ii) Agroforestry system / slash-and-burn (SQ), iii) Agroforestry system / chop-and-mulch (ST), iv) Cassava crop / chop-and-mulch (RT), v) Cassava crop / slash-and-burn (RQ), vi) Cattle pasture / slash-and-burn (PQ). Nearby these plots two rain gauges and three rainwater collectors for monitoring of precipitation were also installed. Along 2010 rainy season 234 samples were collected on 26 different dates. A strong correlation was found between precipitation and runoff, being the highest value of 54.53% of total volume of superficial flow for Cattle pasture degraded and lowest of 1.11% for Agroforestry system that was under recovery for 7 years after burning. The runoff decreased in agroecosystems with lower percentage of organic material in relation to systems with higher percentage.
PubMed | Centro Universitario do Estado do Para, University Estadual do Para and UEPA
Type: Evaluation Studies | Journal: Acta cirurgica brasileira | Year: 2015
To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.
PubMed | Federal University of Rio de Janeiro, Federal University of São Paulo, Hospital Universitario Joao Of Barros Barreto, Pará State University and UEPA
Type: Journal Article | Journal: Acta cirurgica brasileira | Year: 2016
To determine the effectiveness of low-intensity therapeutic ultrasound (LITUS) on wound healing in rats with third-degree burns.Twenty rats were divided into the Control Group that comprised four rats without third-degree burns that did not undergo LITUS, the Burned Group (BG), comprising eight rats with third-degree burns that did not undergo LITUS, and the Burned with Treatment Group (BTG), comprising eight rats with third-degree burns that were administered LITUS. LITUS began 24 h after injury and involved daily applications for 8 min at 0.1 W/cm2 for 14 days.The BTG lost less weight than the BG (Q=2.75; p<0.05). No visible differences were apparent among the groups lesions on day 4. By the end of treatment, wound healing was more evident in the BTG. No statistically significant differences were found between the BG and the BTG in relation to the parameters measured using the histological changes in burn wound healing scoring system.The LITUS protocol applied to the animals with third-degree burns accelerated the formation of fibrin-leukocyte crusts and significantly reduced weight loss. However, burn wound healing was not accelerated.
PubMed | Federal University of Pará, Pará State University and UEPA
Type: Evaluation Studies | Journal: Acta cirurgica brasileira | Year: 2015
To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue.A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects.The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60).The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated with meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model.
Pereira T.J.G.,UEPA |
Serra C.M.V.,UEPA |
Melo A.C.S.,UEPA |
Branco N.C.N.M.,Pontifical Catholic University of Rio de Janeiro
Producao | Year: 2014
Despite the great advance brought by the National Interconnected System (NIS), which is able to provide clean hydroelectric power to almost all Brazilian customers, there are still cities supplied by power generated from fossil fuel, which are subsidized by taxes, they are called Isolated Electric Power Systems (IEPS). Pará State, that has 34 cities with IEPS, also has potential to crop raw material (palm and sugar cane) to produce biodiesel for power generation. Our study analyzes the supply and distribution network of biodiesel under some scenarios of waterways availability, considering that they are also source of power to the NIS by the construction of hydroelectric dams. We develop specific demand and facility location models and apply them to the scenarios. Our results point to the efficiency of the generated models, the importance of three cities for the network, and to the little impact of some waterways in the total transportation costs.
Teixeira R.K.C.,Pará State University |
Yamaki V.N.,Pará State University |
Botelho N.M.,Pará State University |
Brazilian Journal of Physical Therapy | Year: 2014
Background: Quotations in Brazilian journals are mainly obtained from national articles (articles from Brazilian journals); thus, it is essential to determine how frequently these articles reference Brazilian journals. Objective: This study sought to verify how frequently national papers are cited in the references of three Brazilian physical therapy journals. Method: All references for articles published in Fisioterapia em Movimento, Fisioterapia e Pesquisa and Revista Brasileira de Fisioterapia between 2010 and 2012 were evaluated. In particular, the numbers of national articles and international articles (articles from international journals) cited in these references were determined. Results: A total of 13,009 references cited by 456 articles were analyzed, and 2,924 (22.47%) of the cited works were national articles. There were no significant differences among the three examined years. A total of 36 (7.89%) articles did not cite national articles, whereas 65 (13.25%) articles cited more national articles than international articles. Conclusion: On average, 22.47% of the works cited by the evaluated articles were national articles. No significant differences were detected among the three analyzed years.