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Montevideo, Uruguay

Rodriguez E.,Laboratory of Immunomodulation and Vaccine Development | Noya V.,Laboratory of Immunomodulation and Vaccine Development | Cervi L.,National University of Cordoba | Chiribao M.L.,UdelaR | And 5 more authors.
PLoS Neglected Tropical Diseases | Year: 2015

Helminths express various carbohydrate-containing glycoconjugates on their surface, and they release glycan-rich excretion/secretion products that can be very important in their life cycles, infection and pathology. Recent evidence suggests that parasite glycoconjugates could play a role in the evasion of the immune response, leading to a modified Th2-polarized immune response that favors parasite survival in the host. Nevertheless, there is limited information about the nature or function of glycans produced by the trematode Fasciola hepatica, the causative agent of fasciolosis. In this paper, we investigate whether glycosylated molecules from F. hepatica participate in the modulation of host immunity. We also focus on dendritic cells, since they are an important target of immune-modulation by helminths, affecting their activity or function. Our results indicate that glycans from F. hepatica promote the production of IL-4 and IL-10, suppressing IFNγ production. During infection, this parasite is able to induce a semi-mature phenotype of DCs expressing low levels of MHCII and secrete IL-10. Furthermore, we show that parasite glycoconjugates mediate the modulation of LPS-induced maturation of DCs since their oxidation restores the capacity of LPS-treated DCs to secrete high levels of the pro-inflammatory cytokines IL-6 and IL-12/23p40 and low levels of the anti-inflammatory cytokine IL-10. Inhibition assays using carbohydrates suggest that the immune-modulation is mediated, at least in part, by the recognition of a mannose specific-CLR that signals by recruiting the phosphatase Php2. The results presented here contribute to the understanding of the role of parasite glycosylated molecules in the modulation of the host immunity and might be useful in the design of vaccines against fasciolosis. © 2015 Rodríguez et al.


Mederos Catalano D.,University of Lisbon | Bazan Hernandez N.,UdelaR
Cuadernos de Medicina Forense | Year: 2011

Two cases are discussed, whose rarity, low number of publications in the literature, and the possibility of misdiagnosis in forensic practice, mean that their disclosure is relevant in interpreting the autopsy findings. The typical entrance gunshot wounds in the skull has internal beveling. However, John Coe noted that in some cases had external beveling. A bullet striking the skull at a tangential angle may produce a particular lesion called "keyhole lesion", in which one end will have the sharp edges typical of a wound of entrance, whereas the other end will have external beveling of a wound of exit.


Casanova S.,University of the Republic of Uruguay | Verdes J.M.,UdelaR | Okada K.,Volunteer of Japan International Cooperation Agency JICA
Ciencia Rural | Year: 2014

The presence of Cryptosporidium spp. was detected in broiler chickens of 32-40 days of age, colonizing the bursa of Fabricius. The histologic study with haematoxylin and eosin staining was done on specimens of trachea, complete intestinal tract and bursa. Samples of intestinal content were also studied using Kinyoun staining technique. All birds with signs of illness were positive to the presence of parasite, showing a hypertrophic bursa of Fabricius, filled with caseous content. The bursal epithelial cells were full of different developmental stages of Cryptosporidium spp. This note describing the presence of Cryptosporidium spp. in industrial flocks of broiler chickens, is the first report of this parasite in Uruguay. © 2014, Universidade Federal de Santa Maria. All rights reserved.


Aristoy G.,University of the Republic of Uruguay | Isaurralde S.,University of the Republic of Uruguay | Font E.,University of the Republic of Uruguay | Giusto A.,UdelaR
2015 IEEE PES Innovative Smart Grid Technologies Latin America, ISGT LATAM 2015 | Year: 2015

This article studies an algorithm for state estimation in electric power networks, adding information from phasor measurement units (PMU) to the classical SCADA data. This work describes the implementation in MatLab of one of the algorithms found in the literature and the migration of the code to C++ in order to test its time performance. The algorithm was tested on the 39 bus IEEE case study. A good tracking of the waveforms was achieved even in cases of three phase short-circuits or drastic load changes. Execution times obtained in C++ in regular desk computers where short enough to predict a suitable real time performance. © 2015 IEEE.


Bazerque J.A.,UTE | Monzon P.,University of the Republic of Uruguay | Pena P.,University of the Republic of Uruguay | Giusto A.,UdelaR
2015 IEEE PES Innovative Smart Grid Technologies Latin America, ISGT LATAM 2015 | Year: 2015

This paper advances a new method to predict trajectories of rotor angles and bus voltages in dynamic power systems, with data collected by phasor measurement units. The predictor incorporates real time data adaptively, leveraging the algebraic differential equations describing the system, while being able to accommodate model inaccuracies. Numerical tests on a one machine infinite bus system are carried out to illustrate the predictor properties. Then, further results are presented on a classical networked testbed of nine buses and three generators. © 2015 IEEE.

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