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Kuala Lumpur, Malaysia

UCSI University is a multi-campus private university based in Malaysia, with a campus also in Bangladesh. UCSI University is a member of the UCSI Education Group which comprises UCSI International School Springhill, UCSI International School Subang, Sri UCSI School, UCSI Child Development Centre, UCSI Publishing House and UCSI Extension. Wikipedia.

Okechukwu N.P.,UCSI University
Asian Journal of Pharmaceutical and Clinical Research

Coscinium fenestratum is from the family Menispermaceae, is a woody plant found in Southeast Asia. Our previous pharmacological investigation reported that the dichloromethane (DCM) stem extracts of this plant possessed antiulcer, anti-diabetic, anti-hypertensive, and anti-histamine and free radical scavenging properties. This study aims to partially purify the crude DCM stem extracts and to investigate the anti-diabetic activity of its individual fractions A-E on streptozotocin (STZ)-induced diabetic rats. Free radical scavenging properties and phytochemical screening of the bioactive fraction E were also determined. Crude DCM extracts were partially purified using column chromatography techniques. Five fractions (A, B, C, D, and E) were obtained from crude DCM extracts and administered orally at a dose of 100 mg/kg on STZ-induced diabetic rats for 15 days. The blood glucose levels and the bodyweights of the diabetic rats were determined on day 1, 5, 10 and 15 of treatment. TPC was measured using 2.5ml of 10% FCR and 2ml of Na2 CO3 (2%w/v) was added to 0.5ml of each sample (3 replicates) of fraction E solution (1mg/ml) and determination of scavenging activity of DPPH free radical. One ml of 0.135 mM DPPH prepare in methanol was mixed with 1.0ml of fraction E ranging from 0.2-0.8 mg/ml. The data was compared statistically using one-way analysis of variance (ANOVA). Fraction E significantly (p < 0.05) reduced blood glucose levels and increased the bodyweight of the experimental STZ-induced diabetic rats to 8.2 ± 0.7mmol/L and 422.52 ± 11.1 g compare to negative control 25.0 ± 1.8 mmol/L and 143.47 ± 13.5 g respectively. The phytochemical screening of fraction E revealed the presence of flavonoids. The total phenolic compounds present in fraction E was 256.67mg GAE/g dry weight and the radical scavenging activity of the fraction E was 21.71%. This fraction E possesses anti-diabetic and free radical scavenging properties. This effect might be as a result of the presence of flavonoids which has been widely reported to have anti-diabetic effects. Source

Fatokun O.,UCSI University
International Journal of Clinical Pharmacy

Background: In Malaysia, antibacterial agents are among the most utilized drugs. There has been an increase in their use in recent years, contributing to an increase of antimicrobial resistance (AMR). Objectives: This study explores the pattern of antibiotic use and practices in a Malaysian community and identifies the variables associated with a likelihood of non-compliance with a course of antibiotic treatment. Setting: The study was conducted in Cheras, a community located to the south-east of Kuala Lumpur, the capital city of Malaysia. Method: A cross-sectional survey was conducted with 250 individuals, using an interviewer-administered questionnaire in Cheras, Kuala Lumpur, Malaysia. Main outcome measures: Frequency of antibiotic use, sources of antibiotics, use of antibiotics without prescription, discontinuation of antibiotic treatment, antibiotic resistance awareness, handling of unused antibiotics, and association between respondents characteristics and compliance with a course of antibiotic treatment. Results: Approximately 36 % of the participants (n = 91) had taken antibiotics in the year of the study. The majority (66.8 %) obtained antibiotics from clinics. Almost 80 % of the participants had never obtained antibiotics without a doctor's prescription. Nearly 55 % discontinued the course of antibiotics once symptoms disappeared. The most common method of disposing leftover antibiotics was throwing them into the household rubbish bin (78.8 %). Only 6.4 % of participants returned leftover antibiotics to the pharmacist or doctor. Univariate analysis revealed that male gender (p = 0.04), lack of knowledge of antibiotic functions (p < 0.0001), and lack of awareness of antibiotic resistance (p < 0.0001) were all significantly associated with a greater likelihood of non-compliance with a full course of prescribed antibiotic treatment. Conclusion: Most individuals in the Malaysian community obtained antibiotics through prescription. Non-completion of a course of antibiotic treatment and improper disposal of unused antibiotics need to be addressed to prevent AMR. Male gender, lack of knowledge and awareness of antibiotics and resistance were significantly associated with a greater likelihood of non-compliance with a full course of prescribed antibiotic treatment. Therefore, patient education and counselling about antibiotics and antibacterial resistance is very important to enhance compliance to antibiotic therapy. © 2014 Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie. Source

Das D.K.,UCSI University
International Journal of Collaborative Research on Internal Medicine and Public Health

Introduction: Non-Hodgkin's lymphoma of the breast is a rare malignancy. Lymphoma breast could mimic the clinical presentation of inflammatory breast carcinoma. Confirmatory diagnosis is usually performed by fine needle aspiration cytology(FNAC). Prognoses mainly depend on histological grade and stage of the disease. Chemo-radiation is the most actable treatment. Objective: Rare occurrence and important differential diagnosis with carcinoma breast justify reporting our case. Method: Report of a rare case. Results: We report a case of bilateral secondary Non-Hodgkin's Lymphoma (NHL) of the breast in a 39 years old Malay female. She presented to us with the chief complaints of left breast lump and pain with general weakness for last two months. On examination she was cachexic, had bilateral breast lumps with inflammation of the left breast skin and multiple axillaries lymph nodes on both sides. True cut biopsy of the both breast lumps showed NHL, type B. Ultrasound of abdomen was suggestive of lymphomas of the kidneys with enlarged para aortic lymph nodes. X-ray chest reveled multiple right sided ribs fracture. Laboratory investigations showed anemia and markedly raised lactic dehydrogenase (LDH). During hospital stay she detoriated very fast and developed fever and respiratory failure. She was planned for palliative management due to her advanced disease. Relative took discharge on request from hospital on 8 th day of her admission & she died at home on the same day of discharge from the hospital. Conclusions: Although Non-Hodgkin's lymphoma of the breast is a rare malignancy but it is an important differential diagnosis of the carcinoma of the breast. Source

Lee C.K.,UCSI University
JAMA dermatology (Chicago, Ill.)

To determine the prevalence of fingerprint verification failure and to define and quantify the fingerprint changes associated with fingerprint verification failure. Case-control study. Referral public dermatology center. The study included 100 consecutive patients with clinical hand dermatitis involving the palmar distal phalanx of either thumb and 100 age-, sex-, and ethnicity-matched controls. Patients with an altered thumb print due to other causes and palmar hyperhidrosis were excluded. Fingerprint verification(pass/fail) and hand eczema severity index score. Twenty-seven percent of patients failed fingerprint verification compared with 2% of controls. Fingerprint verification failure was associated with a higher hand eczema severity index score (P.001). The main fingerprint abnormalities were fingerprint dystrophy (42.0%) and abnormal white lines (79.5%). The number of abnormal white lines was significantly higher among the patients with hand dermatitis compared with controls(P=.001). Among the patients with hand dermatitis, theodds of failing fingerprint verification with fingerprint dystrophy was 4.01. The presence of broad lines and long lines was associated with a greater odds of fingerprint verification failure (odds ratio [OR], 8.04; 95% CI, 3.56-18.17 and OR, 2.37; 95% CI, 1.31-4.27, respectively),while the presence of thin lines was protective of verification failure (OR, 0.45; 95% CI, 0.23-0.89). Fingerprint verification failure is a significant problem among patients with more severe hand dermatitis. It is mainly due to fingerprint dystrophy and abnormal white lines. Malaysian National Medical Research Register Identifier: NMRR-11-30-8226 Source

Ishak S.I.Z.S.,University Putra Malaysia | Shohaimi S.,University Putra Malaysia | Kandiah M.,UCSI University
Nutrition Research and Practice

The food choices in childhood have high a probability of being carried through into their adulthood life, which then contributes to the risk of many non-communicable diseases. Therefore, there is a need to gather some information about children's views on foods which may influence their food choices for planning a related dietary intervention or programme. This paper aimed to explore the views of children on foods and the types of foods which are usually consumed by children under four food groups (snacks, fast foods, cereals and cereal products; and milk and dairy products) by using focus group discussions. A total of 33 school children aged 7-9 years old from Selangor and Kuala Lumpur participated in the focus groups. Focus groups were audio-taped, transcribed and analyzed according to the listed themes. The outcomes show that the children usually consumed snacks such as white bread with spread or as a sandwich, local cakes, fruits such as papaya, mango and watermelon, biscuits or cookies, tea, chocolate drink and instant noodles. Their choices of fast foods included pizza, burgers, French fries and fried chicken. For cereal products, they usually consumed rice, bread and ready-to-eat cereals. Finally, their choices of dairy products included milk, cheese and yogurt. The reasons for the food liking were taste, nutritional value and the characteristics of food. The outcome of this study may provide additional information on the food choices among Malaysian children, especially in urban areas with regard to the food groups which have shown to have a relationship with the risk of childhood obesity. © 2013 The Korean Nutrition Society and the Korean Society of Community Nutrition. Source

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