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O'Gorman A.,UCD Conway Institute | O'Gorman A.,Food For Health Ireland | Wallace M.,UCD Conway Institute | Wallace M.,Food For Health Ireland | And 6 more authors.

The use of metabolomic based techniques to aid oocyte and embryo selection has gained attention in recent years. Previous work from our laboratory has demonstrated that the H NMR-based metabolic profile of follicular fluid correlates with oocyte developmental potential. Patients undergoing IVF at the Merrion Fertility Clinic had follicular fluid collected at the time of oocyte retrieval. The fatty acid composition of follicular fluid from follicles where oocytes fertilised and developed into multi-cell embryos (n=15) and from oocytes that fertilised normally but failed to cleave (n=9) (cleaved vs non-cleaved) was compared. Statistical analysis was performed on the data using univariate and multivariate techniques. Analysis of the fatty acid composition revealed that there were nine fatty acids significantly different between follicular fluid from the cleaved and the non-cleaved sample groups. Of particular interest were the higher concentration of total saturated (P=0.03) and the lower concentration of total polyunsaturated fatty acids in the non-cleaved sample group (P=0.001). Random forest classification models were used to predict successful cleavage in follicular fluid samples producing models with errors rates of <10%. Receiver operating characteristic analysis demonstrated that the model had good predictability with an area under the curve of 0.96. The panel of fatty acid biomarkers identified in this study indicates that the fatty acid composition of follicular fluid may be more predictive in comparison to other previously identified biomarkers. Following validation in a larger cohort, these biomarkers may have the potential to be used in fertility clinics to aid the selection of oocytes in the future. © 2013 Society for Reproduction and Fertility. Source

Cronin F.M.,University College Dublin | Segurado R.,University College Dublin | McAuliffe F.M.,UCD Obstetrics and Gynaecology | McAuliffe F.M.,University College Dublin | And 3 more authors.
European Child and Adolescent Psychiatry

Understanding the developmental course of all health issues associated with preterm birth is important from an individual, clinical and public health point-of-view. Both the number of preterm births and proportion of survivors have increased steadily in recent years. The UK Millennium Cohort Study (n = 18,818) was used to examine the association of gestational age with maternal ratings of general health and behavior problems at ages 5 and 11 years using binary and multinomial logistic regression analyses. The association between mothers’ ratings of general health and behavior problems was relatively weak at each time point. Children rated as being in poor general health remained constant over time (4.0 % at age 5, 3.8 % at age 11), but children rated as having behavioral problems increased by almost 100 % (5.6 % at 5; 10.5 % at 11). A gradient of increasing risk with decreasing gestational age was observed for a composite health measure (general health problems and/or behavior problems) at age 5, amplified at age 11 and was strongest for those with chronic problems (poor health at both age 5 and age 11). This association was found to be compounded by child sex, maternal characteristics at birth (education, employment, marital status) and duration of breast feeding. Integrated support to at-risk families initiated during, or soon after pregnancy, may prevent chronic problems and might potentially reduce long term health costs for both the individual and health services. © 2016 Springer-Verlag Berlin Heidelberg Source

Smith N.A.,University College Dublin | McAuliffe F.M.,UCD Obstetrics and Gynaecology | McAuliffe F.M.,University College Dublin | Quinn K.,University College Dublin | And 2 more authors.
Animal Reproduction Science

Maternal undernutrition during pregnancy has negative effects on fetal development and offspring health. However, the effect of maternal undernutrition about the time of conception on neonatal outcome is not clear. We investigated the impact of ewe undernutrition during the periconceptional period on offspring body weight and cortisol and insulin concentrations at birth and the insulin response to a glucose challenge and the cortisol response to a corticotrophin releasing hormone (CRH) challenge at 10 weeks of age. Ewes (76 ± 1. kg) were fed 70% (restricted) or 110% (control) maintenance requirements from 28 days prior until 7 days after mating and characteristics of their lambs were assessed. Restricted ewes lost 2.6 ± 0.3. kg (n= 35) over the treatment period compared to control ewes which gained 1.7 ± 0.3. kg (n= 31) (P< 0.01). Male lambs born to ewes that were nutritionally restricted had significantly lower plasma glucose concentrations at birth and a higher insulin response to the glucose challenge at 10 weeks; female offspring were not affected. Lamb weight and cortisol response to CRH at 10 weeks was unaffected by treatment. We conclude that a short period of maternal undernutrition about the time of conception did not affect the adrenal function of offspring but that there was a significant negative effect on the glucose-insulin system of male but not female offspring. © 2010 Elsevier B.V. Source

Mone F.,UCD Obstetrics and Gynaecology | McAuliffe F.M.,UCD Obstetrics and Gynaecology
Irish Medical Journal

Obstetric practice is evolving; the future will see a shift in the focus of care to the pre-conceptual period and early trimester with a move towards interventions which optimize maternal and neonatal outcome. 1 Low dose Aspirin (LDA) is one such intervention. The safety and efficacy of this medicinal product has already been proven 2,3 and subsequently it is now used common in practice for at-risk pregnancies for prevention of pre-eclampsia, fetal growth restriction and complications of anti-phospholipid syndrome. 4,5 © 2014 Irish Medical Association. All rights reserved. Source

Lindsay K.L.,UCD Obstetrics and Gynaecology | Gibney E.R.,UCD Obstetrics and Gynaecology | Mcauliffe F.M.,UCD Obstetrics and Gynaecology
Journal of Human Nutrition and Dietetics

Pregnant women in countries of Sub-Saharan Africa (SSA) are at risk of poor nutritional status and adverse outcomes as a result of poverty, food insecurity, sub-optimal healthcare facilities, frequent infections and frequent pregnancies. Studies from Nigeria, for example, have revealed a high prevalence of both under- and over-nutrition, as well as nutrient deficiencies, including iron, folate, vitamin D and vitamin A. Subsequently, obstetric complications, including hypertension, anaemia, neural tube defects, night-blindness, low birth weight and maternal and perinatal mortality, are common. Migration patterns from SSA to the Western world are on the rise in recent years, with Nigerians now representing the most prevalent immigrant African population in many developed countries. However, the effect of immigration, if any, on the nutritional status and pregnancy outcomes of these women in their host countries has not yet been studied. Consequently, it is unknown to what extent the nutritional deficiencies and pregnancy complications occurring in Nigeria, and other countries of SSA, present in these women post-emigration. This may result in missed opportunities for appropriate antenatal care of a potential high-risk group in pregnancy. The present review discusses the literature regarding nutrition in pregnancy among SSA women, using Nigeria as an example, the common nutrition-related complications that arise and the subsequent obstetric outcomes. The concept of dietary acculturation among immigrant groups is also discussed and deficiencies in the literature regarding studies on the diets of pregnant immigrant women are highlighted. © 2012 The Authors. Journal of Human Nutrition and Dietetics © 2012 The British Dietetic Association Ltd. Source

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