UCB New Medicines

Braine, Belgium

UCB New Medicines

Braine, Belgium

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Denonne F.,UCB New Medicines | Atienzar F.,UCB New Medicines | Celanire S.,UCB New Medicines | Christophe B.,UCB New Medicines | And 12 more authors.
ChemMedChem | Year: 2010

(Chemical Equation Presented) Drug design: Oxazoles and thiazoles were designed and synthesised based on previously reported ligands of the 3rd histamine receptor (H3R). The aminopropoxy-phenyl-oxazole chemotype was identified as a promising H3R inverse agonist with superior drug-like properties, good efficacy in vivo and good safety margin. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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