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Market growth can be attributed to factors such as rising incidence of neurological disorders, growing disease awareness, introduction of novel antiepileptic drugs (AEDs), strong government support and initiatives. Moreover, increasing R&D investment and launch of extended-release formulations are further expected to fuel the market growth. However, high cost of patented drugs, concerns over decreasing healthcare costs as part of government austerity measures, particularly in Europe and low accessibility to antiepileptic drugs in low and middle income countries, are likely to restrict the market growth. Vimpat is the undisputed leading drug of Global Epilepsy Drugs Market. It has a market share of nearly 22% in 2016 and is expected that Vimpat will gain its momentum till the forecasting period. Keppra was the second highest market share taker with more than 19% share in 2016 but the prospect of this drug will change due to the patent expiration in 2018 and its share decline to XX% by 2021. It is expected that Lamictal will be second leading drug with nearly XX% share by 2021. Onfi will hold the third highest share of the Epilepsy Drugs market, being followed by Depakine by the year end of 2021. To get a sample of the report visit: https://www.bharatbook.com/drugs-market-research-reports-836912/epilepsy-drugs-global.html The research report titled "Epilepsy Drugs Market: Global Demand, Growth Potential & Opportunity Outlook 2021" examines the market, competitive landscape and trends of the Global Epilepsy Drug Market. This report analyzes market data and provides a better understanding of Epilepsy Drugs sales value and demand in the Global Market. Market outlook in value terms for the forecasted period for Epilepsy Drugs Market has been detailed in the report. Key trends in terms of collaborations, partnerships and licensing agreements are analysed with details. The report also explores detailed description of growth drivers and inhibitors of the Global Epilpesy Drugs Market. The report concludes with the profiles of major players in the Epilepsy Drugs Market such as UCB, EISAI, Pfizer, Sanofi and Lundbeck. The major market players are evaluated on various parameters such as company overview and latest development and trends in the Epilepsy Drugs Market • Key Drivers and Inhibitors of the Epilepsy Drugs Market Key Epilepsy Drugs Covered in the Report are as follows: Key Companies Covered in the Report are as follows: Bharat Book Bureau established in 1989 is the leading market research information aggregator that provides market research reports, industry analysis, company profiles, business reports, Country Reports, newsletters and online databases. Bharat Book Bureau provides over a million reports from more than 400 publishers around the globe.


Receive press releases from iHealthcareAnalyst, Inc.: By Email Monoclonal Antibody Therapeutics Market by Sources, Therapies, Applications, End Users and Forecast to 2021, Upcoming Research by iHealthcareAnalyst, Inc. Monoclonal Antibody Therapeutics Market by Source Type (Chimeric and Humanized, Human, Murine, Others), Therapy Type (Antibody-Directed Enzyme Prodrug Therapy, Antibody-Drug Conjugates, Radioimmunotherapy), Application (Autoimmune Diseases, Cancer, Hematological Diseases, Infection, Ophthalmological Diseases, Others), and End User (Hospitals, Private Clinics, Research Institutes) and Forecast 2017-2021 Maryland Heights, MO, May 12, 2017 --( Visit Monoclonal Antibody Therapeutics Market by Source Type (Chimeric and Humanized, Human, Murine, Others), Therapy Type (Antibody-Directed Enzyme Prodrug Therapy, Antibody-Drug Conjugates, Radioimmunotherapy), Application (Autoimmune Diseases, Cancer, Hematological Diseases, Infection, Ophthalmological Diseases, Others), and End User (Hospitals, Private Clinics, Research Institutes) and Forecast 2017-2021 at https://www.ihealthcareanalyst.com/report/monoclonal-antibody-therapeutics-market/ The global monoclonal antibody therapeutics market segmentation is based on source type (chimeric and humanized, human, murine, others), therapy type (antibody-directed enzyme prodrug therapy, antibody-drug conjugates, radioimmunotherapy), application (autoimmune diseases, cancer, hematological diseases, infection, ophthalmological diseases, others), and end user (hospitals, private clinics, research institutes). The global monoclonal antibody therapeutics market report provides market size (Revenue USD Million 2014 to 2021), market share, trends and forecasts growth trends (CAGR%, 2017 to 2021). The global monoclonal antibody therapeutics market research report is further segmented by geography into North America (U.S., Canada), Latin America (Brazil, Mexico, Rest of LA), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), and Rest of the World. The global monoclonal antibody therapeutics market report also provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis and also tracks the major competitors operating in the market by company overview, financial snapshot, key products, technologies and services offered, market share analysis and recent trends in the global market. Major players operating in the global monoclonal antibody therapeutics market and included in this report are AbbVie, Inc., Alexion Pharmaceuticals, Amgen, Inc., Bayer Healthcare Pharmaceuticals, Biogen. Inc., Bristol-Myers Squibb Company, Eli Lilly and Co., F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc., Johnson and Johnson, Merck and Co., Inc., Novartis Pharmaceuticals, Pfizer, Inc., Regeneron Pharmaceuticals, Sanofi, Spectrum Pharmaceuticals, Takeda Pharmaceutical Co., and UCB. 1. Source Type 1.1. Chimeric and Humanized 1.2. Human 1.3. Murine 1.4. Others 2. Therapy Type 2.1. Antibody-directed enzyme prodrug therapy 2.2. Antibody-drug conjugates 2.3. Radioimmunotherapy 3. Application 3.1. Autoimmune Diseases 3.2. Cancer 3.3. Hematological Diseases 3.4. Infection 3.5. Ophthalmological Diseases 3.6. Others 4. End User 4.1. Hospitals 4.2. Private Clinics 4.3. Research Institutes 5. Company Profiles 5.1. AbbVie, Inc. 5.2. Alexion Pharmaceuticals 5.3. Amgen, Inc. 5.4. Bayer Healthcare Pharmaceuticals 5.5. Biogen. Inc. 5.6. Bristol-Myers Squibb Company 5.7. Eli Lilly and Co. 5.8. F. Hoffmann-La Roche Ltd. 5.9. GlaxoSmithKline plc. 5.10. Johnson and Johnson 5.11. Merck and Co., Inc. 5.12. Novartis Pharmaceuticals 5.13. Pfizer, Inc. 5.14. Regeneron Pharmaceuticals 5.15. Sanofi 5.16. Spectrum Pharmaceuticals 5.17. Takeda Pharmaceutical Co. 5.18. UCB To request Table of Contents and Sample Pages of this report visit: https://www.ihealthcareanalyst.com/report/monoclonal-antibody-therapeutics-market/  About Us iHealthcareAnalyst, Inc. is a global healthcare market research and consulting company providing market analysis, and competitive intelligence services to global clients. The company publishes syndicate, custom and consulting grade healthcare reports covering animal healthcare, biotechnology, clinical diagnostics, healthcare informatics, healthcare services, medical devices, medical equipment, and pharmaceuticals. In addition to multi-client studies, we offer creative consulting services and conduct proprietary single-client assignments targeted at client’s specific business objectives, information needs, time frame and budget. Please contact us to receive a proposal for a proprietary single-client study. Contact Us iHealthcareAnalyst, Inc. 2109, Mckelvey Hill Drive, Maryland Heights, MO 63043 United States Email: sales@ihealthcareanalyst.com Website: https://www.ihealthcareanalyst.com Maryland Heights, MO, May 12, 2017 --( PR.com )-- Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to certain cells or proteins. This may then stimulate the patient's immune system to attack those cells. It is possible to create a mAb specific to almost any extracellular/ cell surface target. Research and development is underway to create antibodies for diseases (such as rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Ebola and different types of cancers). Chimeric antibodies are composed of murine variable regions fused onto human constant regions. Humanized antibodies are produced by grafting murine hypervariable regions on amino acid domains into human antibodies. Human monoclonal antibodies are produced using transgenic mice or phage display libraries by transferring human immunoglobulin genes into the murine genome and vaccinating the transgenic mouse against the desired antigen, leading to the production of appropriate monoclonal antibodies. Murine antibodies have short half-life in vivo, limited penetration into tumor sites and inadequately recruit host effector functions.Visit Monoclonal Antibody Therapeutics Market by Source Type (Chimeric and Humanized, Human, Murine, Others), Therapy Type (Antibody-Directed Enzyme Prodrug Therapy, Antibody-Drug Conjugates, Radioimmunotherapy), Application (Autoimmune Diseases, Cancer, Hematological Diseases, Infection, Ophthalmological Diseases, Others), and End User (Hospitals, Private Clinics, Research Institutes) and Forecast 2017-2021 at https://www.ihealthcareanalyst.com/report/monoclonal-antibody-therapeutics-market/The global monoclonal antibody therapeutics market segmentation is based on source type (chimeric and humanized, human, murine, others), therapy type (antibody-directed enzyme prodrug therapy, antibody-drug conjugates, radioimmunotherapy), application (autoimmune diseases, cancer, hematological diseases, infection, ophthalmological diseases, others), and end user (hospitals, private clinics, research institutes).The global monoclonal antibody therapeutics market report provides market size (Revenue USD Million 2014 to 2021), market share, trends and forecasts growth trends (CAGR%, 2017 to 2021). The global monoclonal antibody therapeutics market research report is further segmented by geography into North America (U.S., Canada), Latin America (Brazil, Mexico, Rest of LA), Europe (U.K., Germany, France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), and Rest of the World. The global monoclonal antibody therapeutics market report also provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis and also tracks the major competitors operating in the market by company overview, financial snapshot, key products, technologies and services offered, market share analysis and recent trends in the global market.Major players operating in the global monoclonal antibody therapeutics market and included in this report are AbbVie, Inc., Alexion Pharmaceuticals, Amgen, Inc., Bayer Healthcare Pharmaceuticals, Biogen. Inc., Bristol-Myers Squibb Company, Eli Lilly and Co., F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc., Johnson and Johnson, Merck and Co., Inc., Novartis Pharmaceuticals, Pfizer, Inc., Regeneron Pharmaceuticals, Sanofi, Spectrum Pharmaceuticals, Takeda Pharmaceutical Co., and UCB.1. Source Type1.1. Chimeric and Humanized1.2. Human1.3. Murine1.4. Others2. Therapy Type2.1. Antibody-directed enzyme prodrug therapy2.2. Antibody-drug conjugates2.3. Radioimmunotherapy3. Application3.1. Autoimmune Diseases3.2. Cancer3.3. Hematological Diseases3.4. Infection3.5. Ophthalmological Diseases3.6. Others4. End User4.1. Hospitals4.2. Private Clinics4.3. Research Institutes5. Company Profiles5.1. AbbVie, Inc.5.2. Alexion Pharmaceuticals5.3. Amgen, Inc.5.4. Bayer Healthcare Pharmaceuticals5.5. Biogen. Inc.5.6. Bristol-Myers Squibb Company5.7. Eli Lilly and Co.5.8. F. Hoffmann-La Roche Ltd.5.9. GlaxoSmithKline plc.5.10. Johnson and Johnson5.11. Merck and Co., Inc.5.12. Novartis Pharmaceuticals5.13. Pfizer, Inc.5.14. Regeneron Pharmaceuticals5.15. Sanofi5.16. Spectrum Pharmaceuticals5.17. Takeda Pharmaceutical Co.5.18. UCBTo request Table of Contents and Sample Pages of this report visit:https://www.ihealthcareanalyst.com/report/monoclonal-antibody-therapeutics-market/About UsiHealthcareAnalyst, Inc. is a global healthcare market research and consulting company providing market analysis, and competitive intelligence services to global clients. The company publishes syndicate, custom and consulting grade healthcare reports covering animal healthcare, biotechnology, clinical diagnostics, healthcare informatics, healthcare services, medical devices, medical equipment, and pharmaceuticals.In addition to multi-client studies, we offer creative consulting services and conduct proprietary single-client assignments targeted at client’s specific business objectives, information needs, time frame and budget. Please contact us to receive a proposal for a proprietary single-client study.Contact UsiHealthcareAnalyst, Inc.2109, Mckelvey Hill Drive,Maryland Heights, MO 63043United StatesEmail: sales@ihealthcareanalyst.comWebsite: https://www.ihealthcareanalyst.com Click here to view the list of recent Press Releases from iHealthcareAnalyst, Inc.


Market growth can be attributed to factors such as rising incidence of neurological disorders, growing disease awareness, introduction of novel antiepileptic drugs (AEDs), strong government support and initiatives. Moreover, increasing R&D investment and launch of extended-release formulations are further expected to fuel the market growth. However, high cost of patented drugs, concerns over decreasing healthcare costs as part of government austerity measures, particularly in Europe and low accessibility to antiepileptic drugs in low and middle income countries, are likely to restrict the market growth. Vimpat is the undisputed leading drug of Global Epilepsy Drugs Market. It has a market share of nearly 22% in 2016 and is expected that Vimpat will gain its momentum till the forecasting period. Keppra was the second highest market share taker with more than 19% share in 2016 but the prospect of this drug will change due to the patent expiration in 2018 and its share decline to XX% by 2021. It is expected that Lamictal will be second leading drug with nearly XX% share by 2021. Onfi will hold the third highest share of the Epilepsy Drugs market, being followed by Depakine by the year end of 2021. To get a sample of the report visit: https://www.bharatbook.com/drugs-market-research-reports-836912/epilepsy-drugs-global.html The research report titled "Epilepsy Drugs Market: Global Demand, Growth Potential & Opportunity Outlook 2021" examines the market, competitive landscape and trends of the Global Epilepsy Drug Market. This report analyzes market data and provides a better understanding of Epilepsy Drugs sales value and demand in the Global Market. Market outlook in value terms for the forecasted period for Epilepsy Drugs Market has been detailed in the report. Key trends in terms of collaborations, partnerships and licensing agreements are analysed with details. The report also explores detailed description of growth drivers and inhibitors of the Global Epilpesy Drugs Market. The report concludes with the profiles of major players in the Epilepsy Drugs Market such as UCB, EISAI, Pfizer, Sanofi and Lundbeck. The major market players are evaluated on various parameters such as company overview and latest development and trends in the Epilepsy Drugs Market • Key Drivers and Inhibitors of the Epilepsy Drugs Market Key Epilepsy Drugs Covered in the Report are as follows: Key Companies Covered in the Report are as follows: Bharat Book Bureau established in 1989 is the leading market research information aggregator that provides market research reports, industry analysis, company profiles, business reports, Country Reports, newsletters and online databases. Bharat Book Bureau provides over a million reports from more than 400 publishers around the globe.


-Submissions for CIMZIA® (certolizumab pegol) and glycopyrronium tosylate remain on schedule for later this year MENLO PARK, Calif., May 08, 2017 (GLOBE NEWSWIRE) -- Dermira, Inc. (NASDAQ:DERM), a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions, today reported financial results for the quarter ended March 31, 2017 and provided an update on its clinical development programs. “We are off to a great start in 2017, including the successful completion of our third Phase 3 clinical trial for CIMZIA, a pre-NDA meeting with the FDA for glycopyrronium tosylate and the closing of a successful follow-on offering,” said Tom Wiggans, chairman and chief executive officer of Dermira. “As we prepare for the remainder of the year, we anticipate UCB submitting marketing applications for CIMZIA for the treatment of chronic plaque psoriasis in the United States, Europe and Canada in the third quarter and we expect to submit a new drug application for glycopyrronium tosylate for the treatment of axillary hyperhidrosis in the second half of this year. We also continue to work on expanding our product portfolio and have made progress on building our commercial operations, which we plan to provide an update on later in the year.” About Dermira Dermira is a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions. Dermira is committed to understanding the needs of both patients and physicians and using its insight to identify and develop leading-edge medical dermatology programs. Dermira’s product pipeline includes three late-stage product candidates that could have a profound impact on the lives of patients: glycopyrronium tosylate (formerly DRM04), which has completed a Phase 3 program for the treatment of primary axillary hyperhidrosis (excessive underarm sweating); CIMZIA® (certolizumab pegol), in Phase 3 development in collaboration with UCB Pharma S.A. for the treatment of moderate-to-severe chronic plaque psoriasis; and olumacostat glasaretil (formerly DRM01), in Phase 3 development for the treatment of acne vulgaris. Dermira is headquartered in Menlo Park, Calif. For more information, please visit www.dermira.com. In addition to filings with the Securities and Exchange Commission (SEC), press releases, public conference calls and webcasts, Dermira uses its website (www.dermira.com) and LinkedIn page (https://www.linkedin.com/company/dermira-inc-) as channels of distribution of information about its company, product candidates, planned financial and other announcements, attendance at upcoming investor and industry conferences and other matters. Such information may be deemed material information and Dermira may use these channels to comply with its disclosure obligations under Regulation FD. Therefore, investors should monitor Dermira’s website and LinkedIn page in addition to following its SEC filings, press releases, public conference calls and webcasts. Forward-Looking Statements The information in this press release contains forward-looking statements and information within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. This press release contains forward-looking statements that involve substantial risks and uncertainties, including statements with respect to: the completion of, and timing expectations for the receipt and announcement of topline results from, Dermira’s CLAREOS-1 and CLAREOS-2 trials; the timing and submission of marketing applications in the United States, Europe and Canada for CIMZIA; the timing and submission of an NDA to the FDA for glycopyrronium tosylate; and estimates of 2017 collaboration and license revenue, operating expenses, stock-based compensation expense and 2017 year-end cash, cash equivalents and short- and long-term investments. These statements deal with future events and involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Factors that could cause actual results to differ materially include risks and uncertainties such as those relating to the design, implementation and outcome of Dermira’s clinical trials; Dermira’s dependence on third-party clinical research organizations, manufacturers and suppliers; the outcomes of future meetings with regulatory agencies; Dermira’s ability to attract and retain key employees; Dermira’s ability to obtain necessary additional capital; and Dermira’s ability to continue to stay in compliance with applicable laws and regulations. You should refer to the section entitled “Risk Factors” set forth in Dermira’s Annual Report on Form 10-K, Dermira’s Quarterly Reports on Form 10-Q and other filings Dermira makes with the SEC from time to time for a discussion of important factors that may cause actual results to differ materially from those expressed or implied by Dermira’s forward-looking statements. Furthermore, such forward-looking statements speak only as of the date of this press release. Dermira undertakes no obligation to publicly update any forward-looking statements or reasons why actual results might differ, whether as a result of new information, future events or otherwise, except as required by law.


News Article | May 10, 2017
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- NOVO A/S neuer strategischer Investor (>10%); Neues Mitglied zur Wahl in den Aufsichtsrat auf der nächsten Hauptversammlung benannt (Michael Shalmi, Novo A/S; nach Ende der Berichtsperiode) Der Konzernumsatz stieg im ersten Quartal 2017 um 34% gegenüber der Vergleichsperiode des Vorjahrs auf 50,2 Mio. EUR an (2016: 37,5 Mio. EUR). Dem Anstieg zugrunde lagen in erster Linie ein Wachstum der Basisumsätze, der Cyprotex-Beitrag (6,0 Mio. EUR) sowie Meilensteinzahlungen. Evotecs Basisumsatz im ersten Quartal 2017 belief sich auf 44,0 Mio. EUR, was einer Steigerung gegenüber der Vergleichsperiode des Vorjahrs von 30% entspricht (2016: 33,9 Mio. EUR). Die Umsätze aus Meilensteinen, Abschlagszahlungen und Lizenzen sind mit 6,2 Mio. EUR gegenüber der Vergleichsperiode des Vorjahrs (3,6 Mio. EUR) höher ausgefallen und beinhalten im Wesentlichen Meilensteine aus den Allianzen mit Bayer und Sanofi. Die Bruttomarge belief sich in den ersten drei Monaten 2017 auf 37,4% an (2016: 33,3%). Dieser erhebliche Anstieg gegenüber 2016 spiegelt insbesondere ein Wachstum der Basisumsätze, hohe Meilensteinerreichungen, eine verbesserte Kapazitätsauslastung sowie positive Währungseffekte wider. Der Bestand an liquiden Mitteln, der Kassenbestand und Guthaben bei Kreditinstituten (77,6 Mio. EUR) sowie Wertpapiere (107,4 Mio. EUR) umfasst, betrug am 31. März 2017 185,0 Mio. EUR (31. Dezember 2016: 126,3 Mio. EUR). Dieser starke Anstieg resultiert im Wesentlichen aus der Kapitalerhöhung mit Novo A/S, die im Februar 2017 bekannt gegeben wurde. Im ersten Quartal 2017 wurde eine sehr gute operative Performance im EVT Execute-Segment verzeichnet. Cyprotex konnte einen starken Jahresauftakt verzeichnen und die Integration in den Evotec-Konzern verläuft planmäßig. Anfang 2017 wurde der UK-Standort von Cyprotex von Macclesfield in den Alderley Park umgezogen. Dies ermöglicht die zukünftige Erweiterung und Konsolidierung der UK-Aktivitäten von Cyprotex in einer erstklassigen wissenschaftlichen Einrichtung. Entlang ihrer EVT Innovate-Strategie beteiligt sich Evotec weiterhin an Equity-Finanzierungen mit dem Ziel, Projekte bis zu den nächsten Wertsteigerungspunkten voranzubringen. In diesem Sinne hat Evotec ihre Beziehung mit Forge Therapeutics durch die Beteiligung an Forges jüngster Finanzierungsrunde (Series A) erweitert. Am 09. Februar 2017 gab Evotec bekannt, dass Novo A/S im Rahmen der Privatplatzierung der Kapitalerhöhung 90,3 Mio. EUR investiert und dafür Evotec-Aktien zeichnete. Infolge des Erwerbs weiterer Aktien über den öffentlichen Markt hält Novo A/S mittlerweile mehr als 10% der Evotec-Aktien. AG Evotec ist ein Wirkstoffforschungs- und -entwicklungsunternehmen, das in Forschungsallianzen und Entwicklungspartnerschaften mit führenden Pharma- und Biotechnologieunternehmen, akademischen Einrichtungen, Patientenorganisationen und Risikokapitalgesellschaften innovative Ansätze zur Entwicklung neuer pharmazeutischer Produkte zügig vorantreibt. Wir sind weltweit tätig und bieten unseren Kunden qualitativ hochwertige, unabhängige und integrierte Lösungen im Bereich der Wirkstoffforschung an. Dabei decken wir alle Aktivitäten vom Target bis zur klinischen Entwicklung ab, um dem Bedarf der Branche an Innovation und Effizienz in der Wirkstoffforschung begegnen zu können (EVT Execute). Durch das Zusammenführen von erstklassigen Wissenschaftlern, modernsten Technologien sowie umfangreicher Erfahrung und Expertise in wichtigen Indikationsgebieten wie zum Beispiel Neurowissenschaften, Diabetes und Diabetesfolgeerkrankungen, Schmerz und Entzündungskrankheiten, Onkologie und Infektionskrankheiten ist Evotec heute einzigartig positioniert. Auf dieser Grundlage hat Evotec ihre Pipeline bestehend aus mehr als 70 verpartnerten Programmen in klinischen, präklinischen und Forschungsphasen aufgebaut (EVT Innovate). Evotec arbeitet in langjährigen Forschungsallianzen mit Partnern wie Bayer, CHDI, Sanofi oder UCB zusammen. Darüber hinaus verfügt das Unternehmen über Entwicklungspartnerschaften u. a. mit Sanofi im Bereich Diabetes, mit Pfizer auf dem Gebiet Organfibrose und mit Celgene im Bereich neurodegenerative Erkrankungen. Weitere Informationen finden Sie auf unserer Homepage www.evotec.com und folgen Sie uns auf Twitter @EvotecAG.


ONCODESIGN (Paris:ALONC) (FR0011766229 - ALONC), société biotechnologique au service de l’industrie pharmaceutique pour la découverte de nouvelles molécules thérapeutiques contre les cancers et autres maladies graves sans traitement efficace connu, annonce être entrée en phase de négociation exclusive pour l’acquisition des activités de services en Métabolisme, Pharmaco-cinétique, Bioanalyse et Médecine Translationnelle de Bertin Pharma. Ces activités dans les domaines de l’immunologie et de l’infectiologie, viendraient compléter idéalement l’offre actuelle de services du groupe Oncodesign. Créée il y a plus de 20 ans par le Dr. Philippe Genne, PDG et actionnaire principal, Oncodesign est une entreprise biotechnologique qui maximise les chances de succès de l’industrie pharmaceutique pour découvrir de nouvelles molécules thérapeutiques contre les cancers et autres maladies graves sans traitement efficace connu. Fort d’une expérience unique acquise auprès de plus de 600 clients, dont les plus grandes entreprises pharmaceutiques du monde, et s’appuyant sur une plateforme technologique complète, alliant chimie médicinale, pharmacologie et imagerie médicale de pointe, Oncodesign est en mesure de prédire et d’identifier, très en amont, pour chaque molécule son utilité thérapeutique et son potentiel à devenir un médicament efficace. Appliquée aux inhibiteurs de kinases, des molécules qui représentent un marché estimé à plus de 46 milliards de dollars en 2016 et près de 25% des investissements en R&D de l’industrie pharmaceutique, la technologie d’Oncodesign a déjà permis de cibler plusieurs molécules d’intérêts à fort potentiel thérapeutique, en oncologie et hors-oncologie, et de signer des partenariats avec des groupes pharmaceutiques tels que Bristol-Myers Squibb et UCB. Basée à Dijon, au cœur du pôle universitaire et hospitalier et au sein du cluster de Paris-Saclay, Oncodesign compte 165 collaborateurs et dispose de filiales au Canada et aux États-Unis.


-Submissions for CIMZIA® (certolizumab pegol) and glycopyrronium tosylate remain on schedule for later this year MENLO PARK, Calif., May 08, 2017 (GLOBE NEWSWIRE) -- Dermira, Inc. (NASDAQ:DERM), a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions, today reported financial results for the quarter ended March 31, 2017 and provided an update on its clinical development programs. “We are off to a great start in 2017, including the successful completion of our third Phase 3 clinical trial for CIMZIA, a pre-NDA meeting with the FDA for glycopyrronium tosylate and the closing of a successful follow-on offering,” said Tom Wiggans, chairman and chief executive officer of Dermira. “As we prepare for the remainder of the year, we anticipate UCB submitting marketing applications for CIMZIA for the treatment of chronic plaque psoriasis in the United States, Europe and Canada in the third quarter and we expect to submit a new drug application for glycopyrronium tosylate for the treatment of axillary hyperhidrosis in the second half of this year. We also continue to work on expanding our product portfolio and have made progress on building our commercial operations, which we plan to provide an update on later in the year.” About Dermira Dermira is a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions. Dermira is committed to understanding the needs of both patients and physicians and using its insight to identify and develop leading-edge medical dermatology programs. Dermira’s product pipeline includes three late-stage product candidates that could have a profound impact on the lives of patients: glycopyrronium tosylate (formerly DRM04), which has completed a Phase 3 program for the treatment of primary axillary hyperhidrosis (excessive underarm sweating); CIMZIA® (certolizumab pegol), in Phase 3 development in collaboration with UCB Pharma S.A. for the treatment of moderate-to-severe chronic plaque psoriasis; and olumacostat glasaretil (formerly DRM01), in Phase 3 development for the treatment of acne vulgaris. Dermira is headquartered in Menlo Park, Calif. For more information, please visit www.dermira.com. In addition to filings with the Securities and Exchange Commission (SEC), press releases, public conference calls and webcasts, Dermira uses its website (www.dermira.com) and LinkedIn page (https://www.linkedin.com/company/dermira-inc-) as channels of distribution of information about its company, product candidates, planned financial and other announcements, attendance at upcoming investor and industry conferences and other matters. Such information may be deemed material information and Dermira may use these channels to comply with its disclosure obligations under Regulation FD. Therefore, investors should monitor Dermira’s website and LinkedIn page in addition to following its SEC filings, press releases, public conference calls and webcasts. Forward-Looking Statements The information in this press release contains forward-looking statements and information within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. This press release contains forward-looking statements that involve substantial risks and uncertainties, including statements with respect to: the completion of, and timing expectations for the receipt and announcement of topline results from, Dermira’s CLAREOS-1 and CLAREOS-2 trials; the timing and submission of marketing applications in the United States, Europe and Canada for CIMZIA; the timing and submission of an NDA to the FDA for glycopyrronium tosylate; and estimates of 2017 collaboration and license revenue, operating expenses, stock-based compensation expense and 2017 year-end cash, cash equivalents and short- and long-term investments. These statements deal with future events and involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Factors that could cause actual results to differ materially include risks and uncertainties such as those relating to the design, implementation and outcome of Dermira’s clinical trials; Dermira’s dependence on third-party clinical research organizations, manufacturers and suppliers; the outcomes of future meetings with regulatory agencies; Dermira’s ability to attract and retain key employees; Dermira’s ability to obtain necessary additional capital; and Dermira’s ability to continue to stay in compliance with applicable laws and regulations. You should refer to the section entitled “Risk Factors” set forth in Dermira’s Annual Report on Form 10-K, Dermira’s Quarterly Reports on Form 10-Q and other filings Dermira makes with the SEC from time to time for a discussion of important factors that may cause actual results to differ materially from those expressed or implied by Dermira’s forward-looking statements. Furthermore, such forward-looking statements speak only as of the date of this press release. Dermira undertakes no obligation to publicly update any forward-looking statements or reasons why actual results might differ, whether as a result of new information, future events or otherwise, except as required by law.


-Submissions for CIMZIA® (certolizumab pegol) and glycopyrronium tosylate remain on schedule for later this year MENLO PARK, Calif., May 08, 2017 (GLOBE NEWSWIRE) -- Dermira, Inc. (NASDAQ:DERM), a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions, today reported financial results for the quarter ended March 31, 2017 and provided an update on its clinical development programs. “We are off to a great start in 2017, including the successful completion of our third Phase 3 clinical trial for CIMZIA, a pre-NDA meeting with the FDA for glycopyrronium tosylate and the closing of a successful follow-on offering,” said Tom Wiggans, chairman and chief executive officer of Dermira. “As we prepare for the remainder of the year, we anticipate UCB submitting marketing applications for CIMZIA for the treatment of chronic plaque psoriasis in the United States, Europe and Canada in the third quarter and we expect to submit a new drug application for glycopyrronium tosylate for the treatment of axillary hyperhidrosis in the second half of this year. We also continue to work on expanding our product portfolio and have made progress on building our commercial operations, which we plan to provide an update on later in the year.” About Dermira Dermira is a biopharmaceutical company dedicated to bringing biotech ingenuity to medical dermatology by delivering differentiated, new therapies to the millions of patients living with chronic skin conditions. Dermira is committed to understanding the needs of both patients and physicians and using its insight to identify and develop leading-edge medical dermatology programs. Dermira’s product pipeline includes three late-stage product candidates that could have a profound impact on the lives of patients: glycopyrronium tosylate (formerly DRM04), which has completed a Phase 3 program for the treatment of primary axillary hyperhidrosis (excessive underarm sweating); CIMZIA® (certolizumab pegol), in Phase 3 development in collaboration with UCB Pharma S.A. for the treatment of moderate-to-severe chronic plaque psoriasis; and olumacostat glasaretil (formerly DRM01), in Phase 3 development for the treatment of acne vulgaris. Dermira is headquartered in Menlo Park, Calif. For more information, please visit www.dermira.com. In addition to filings with the Securities and Exchange Commission (SEC), press releases, public conference calls and webcasts, Dermira uses its website (www.dermira.com) and LinkedIn page (https://www.linkedin.com/company/dermira-inc-) as channels of distribution of information about its company, product candidates, planned financial and other announcements, attendance at upcoming investor and industry conferences and other matters. Such information may be deemed material information and Dermira may use these channels to comply with its disclosure obligations under Regulation FD. Therefore, investors should monitor Dermira’s website and LinkedIn page in addition to following its SEC filings, press releases, public conference calls and webcasts. Forward-Looking Statements The information in this press release contains forward-looking statements and information within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. This press release contains forward-looking statements that involve substantial risks and uncertainties, including statements with respect to: the completion of, and timing expectations for the receipt and announcement of topline results from, Dermira’s CLAREOS-1 and CLAREOS-2 trials; the timing and submission of marketing applications in the United States, Europe and Canada for CIMZIA; the timing and submission of an NDA to the FDA for glycopyrronium tosylate; and estimates of 2017 collaboration and license revenue, operating expenses, stock-based compensation expense and 2017 year-end cash, cash equivalents and short- and long-term investments. These statements deal with future events and involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Factors that could cause actual results to differ materially include risks and uncertainties such as those relating to the design, implementation and outcome of Dermira’s clinical trials; Dermira’s dependence on third-party clinical research organizations, manufacturers and suppliers; the outcomes of future meetings with regulatory agencies; Dermira’s ability to attract and retain key employees; Dermira’s ability to obtain necessary additional capital; and Dermira’s ability to continue to stay in compliance with applicable laws and regulations. You should refer to the section entitled “Risk Factors” set forth in Dermira’s Annual Report on Form 10-K, Dermira’s Quarterly Reports on Form 10-Q and other filings Dermira makes with the SEC from time to time for a discussion of important factors that may cause actual results to differ materially from those expressed or implied by Dermira’s forward-looking statements. Furthermore, such forward-looking statements speak only as of the date of this press release. Dermira undertakes no obligation to publicly update any forward-looking statements or reasons why actual results might differ, whether as a result of new information, future events or otherwise, except as required by law.


ONCODESIGN (Paris:ALONC) (FR0011766229 - ALONC), a biotechnology company serving the pharmaceutical industry in the discovery of new therapeutic molecules to fight cancer and other serious illnesses with no known effective treatment, has announced the opening of a period of exclusive negotiations to acquire Bertin Pharma's service businesses in Metabolism, Pharmacokinetics, Bio-analysis and Translational Medicine. These activities in the fields of immunology and infectiology will be an ideal fit with Oncodesign group's current service offering. The business portfolio under discussion has some 48 employees, with 2016 revenue of €5.3 million. It complements Oncodesign in many technological and regulatory areas and would contribute to the acceleration of Oncodesign group's 2017-2020 strategic plan for its service business. This project, which has been the subject of an information and consultation process with employee representative bodies, could be completed in the summer of 2017. At present it is not certain that any agreement will be reached nor that the transaction will be completed. No further comment will be made until an agreement is finalized. Founded over 20 years ago by Dr Philippe Genne, the Company’s CEO and Chairman, Oncodesign is a biotechnology company that maximises the pharmaceutical industry’s chances of success in discovering new therapeutic molecules to fight cancer and other serious illnesses with no known effective treatment. With its unique experience acquired by working with more than 600 clients, including the world’s largest pharmaceutical companies, along with its comprehensive technological platform combining state-of-the-art medicinal chemistry, advanced animal modelling and medical imaging, Oncodesign is able to predict and identify, at a very early stage, each molecule's therapeutic usefulness and potential to become an effective drug. Applied to kinase inhibitors, which represent a market estimated at over $46 billion in 2016 and accounting for almost 25% of the pharmaceutical industry’s R&D expenditure, Oncodesign’s technology has already enabled the targeting of several promising molecules with substantial therapeutic potential, in oncology and elsewhere, along with partnerships with pharmaceutical groups such as Bristol-Myers Squibb and UCB. Oncodesign is based in Dijon, France, in the heart of the town’s university and hospital hub, and within the Paris-Saclay cluster, Oncodesign has 165 employees and subsidiaries in Canada and the USA.


Taylor R.D.,UCB | Maccoss M.,Bohicket Pharma Consulting LLC | Lawson A.D.G.,UCB
Journal of Medicinal Chemistry | Year: 2014

We have analyzed the rings, ring systems, and frameworks in drugs listed in the FDA Orange Book to understand the frequency, timelines, molecular property space, and the application of these rings in different therapeutic areas and target classes. This analysis shows that there are only 351 ring systems and 1197 frameworks in drugs that came onto the market before 2013. Furthermore, on average six new ring systems enter drug space each year and approximately 28% of new drugs contain a new ring system. Moreover, it is very unusual for a drug to contain more than one new ring system and the majority of the most frequently used ring systems (83%) were first used in drugs developed prior to 1983. These observations give insight into the chemical novelty of drugs and potentially efficient ways to assess compound libraries and develop compounds from hit identification to lead optimization and beyond. © 2014 American Chemical Society.

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