Venkatachalapathy T.S.,Government of Puducherry
Indian Journal of Surgery | Year: 2014
Following reports of heparin use in burn treatment, an ethics-committee-approved prospective randomized study with controls compared results obtained using traditional usual burn treatment without heparin with results in similar patients similarly treated with heparin added topically. The subjects were 100 consecutive burn patients (age <15 years) with second-degree superficial and deep burns of 5–45 % total body surface area size. Two largely similar cohort groups—a control group (C) and a heparin group (H) with 50 subjects per group—were randomly treated. The 50 control group patients received traditional routine treatment, including topical antimicrobial cream, debridement, and, when needed, skin grafts in the early postburn period. The 50 heparin group patients, without topical cream, were additionally treated, starting on day 1 postburn, with 200 IU/ml sodium aqueous heparin solution USP (heparin) dripped on the burn surfaces and inserted into the blisters two to four times a day for 1–2 days, and then only on burn surfaces for a total of 5–7 days, before skin grafting, when needed. Thereafter, control and heparin group treatment was similar. It was found that the heparin patients complained of less pain and received less pain medicine than the control patients. The heparin group needed fewer dressings and oral antibiotics than the control group. The 50 heparin group patients had 4 skin graftings (8 %), while the 50 control group patients had 10 (20 %). Five control group patients died (mortality 10 %). No heparin group patients died. The number of days in hospital for the heparin group versus control group was significantly less (overall P < 0.0001): 58 % of heparin group patients were discharged within 10 days versus 6 % of control group patients; 82 % of heparin group patients were out in 20 days versus 14 % of control group patients; 98 % of the heparin group versus 44 % of the control group were out in 30 days; and while 100 % of heparin group patients were discharged by day 40, 56 % of the control group required up to another 10 days. Burns in heparin group patients healed on average in 15 days (maximum period 37 days) versus an average of 25 days (maximum >48 days) in control group patients (P < 0.0006). Procedures and costs in the heparin group were much reduced compared with the control group. Differences between the heparin and control groups are presented for the sake of comparison. It was concluded that heparin applied topically for 5–7 days improved burn treatment: it reduced pain, pain medicine, dressings, and use of antibiotics; it significantly reduced IV fluids (P < 0.04), days in hospital (P < 0.0001), and healing time (P < 0.0006); and it reduced skin grafts, mortality, and costs. © 2012, Association of Surgeons of India.
Thirunavukarasu S.,Government of Puducherry
Journal of Clinical Imaging Science | Year: 2011
Bilateral temporal and frontal lobe involvement is a common characteristic of herpes simplex encephalitis (HSE). Clinical sequelae of herpes simplex encephalitis may manifest sometimes as Kluver Bucy syndrome (KBS). In herpes simplex encephalitis, apart from frontal lobe, extra temporal involvement is rare and uncommon. We report a case of HSE manifesting clinically as KBS with a rare radiological finding of temporal and extratemporal involvement of pons.
Prabhu M.,Health Science University |
Radha R.,Government of Puducherry
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012
A series of some novel aryl imidazole derivatives were prepared by the condensation of compounds containing primary aromatic amine and aryl aldehydes to give respective Schiff's bases, which was further reacted with ammonium acetate and isatin in the presence of glacial acetic acid. The synthesized compounds were characterized by using IR and screened for their invitro antibacterial and invitro antihelmintic activity. All the synthesized compounds showed moderate to good antibacterial activity against the tested bacteria Bacillus subtilis (Gram positive organism) and Klebsiella pneumonia (Gram negative organism) and moderate to good anthelmintic activity against Indian earthworm Pheretima posthuma.
Pramod K.V.,Cochin University of Science and Technology |
Manju C.,Government of Puducherry
Journal of Computer Science | Year: 2010
Problem statement: Cryptosystem using linear codes was developed in 1978 by Mc-Eliece. Later in 1985 Niederreiter and others developed a modified version of cryptosystem using concepts of linear codes. But these systems were not used frequently because of its larger key size. In this study we were designing a cryptosystem using the concepts of algebraic geometric codes with smaller key size. Error detection and correction can be done efficiently by simple decoding methods using the cryptosystem developed. Approach: Algebraic geometric codes are codes, generated using curves. The cryptosystem use basic concepts of elliptic curves cryptography and generator matrix. Decrypted information takes the form of a repetition code. Due to this complexity of decoding procedure is reduced. Error detection and correction can be carried out efficiently by solving a simple system of linear equations, there by imposing the concepts of security along with error detection and correction. Results: Implementation of the algorithm is done on MATLAB and comparative analysis is also done on various parameters of the system. Attacks are common to all cryptosystems. But by securely choosing curve, field and representation of elements in field, we can overcome the attacks and a stable system can be generated. Conclusion: The algorithm defined here protects the information from an intruder and also from the error in communication channel by efficient error correction methods. © 2010 Science Publications.
Little Flower J.R.,The Government of India |
Balamurugan E.,Government of Puducherry
British Journal of Medical Practitioners | Year: 2013
Aim: Organ donation rate in India is very poor. The factors contributing to donating and not donating an organ is not well known. Hence, the present study was conducted to identify the perceived barrier and facilitator of organ donation among general public of Puducherry, India. Method: A cross sectional explorative study was undertaken with a sample of 400 eligible subjects from the general public of puducherry. Each participant underwent a face to face interview with the help of a structured questionnaire; data collected was analyzed using appropriate descriptive and inferential statics in SPSS. Result: Of the 400 subjects interviewed, the most common perceived barriers identified were opposition from family (82.8%) and fear (72.4%). The most common perceived facilitators were thought that organ donation would save someone's life (95.9%) and sense of improved humanity (95%). While associating the public intention to donate organ with select variables only educational status was found to be positively associated (p =0.001). Conclusion: From the available scientific evidence it is conducted that the knowledge of organ donation remain still poor and the identified barriers and facilitators should be taken in the account while motivating the general public to donate organ in future.