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Lu H.P.,National Cheng Kung University | Lu H.P.,Tzu Hui Institute of Technology | Syka J.,Academy of Sciences of the Czech Republic | Chiu T.W.,National Chiao Tung University | Poon P.W.F.,National Cheng Kung University
Hearing Research | Year: 2014

Tone at moderate levels presented to young rats at a stage (postnatal week-4) presumably that has passed the cortical critical period still can enlarge neurons in the auditory cortex. It remains unclear whether this delayed plastic change occurs only in the cortex, or reflects a change taking place in the auditory brainstem. Here we compared sound-exposure effects on neuronal size in the auditory cortex and the midbrain. Starting from postnatal day 22, young rats were exposed to a low-frequency tone (4kHz at 65dB SPL) for a period of 3 (postnatal day 22-25) or 7 (postnatal day 22-29) days before sacrifice. Neurons were analyzed morphometrically from 7μm-thick histological sections. A marked increase in neuronal size (32%) was found at the cortex in the high-frequency region distant from the exposing tone. The increase in the midbrain was even larger (67%) and was found in both the low and high frequency regions. While cell enlargements were clear at day 29, only in the high frequency region of the cortex a slight enlargement was found at day 22, suggesting that the cortical and subcortical changes are synchronized, if not slightly preceded by the cortex. In contrast, no changes in neuronal size were found in the cochlear nucleus or the visual midbrain. Such differential effects of sound-exposure at the auditory centers across cortical and subcortical levels cannot be explained by a simple activity-driven change occurring earlier in the brainstem, and might involve function of other structures as for example the descending auditory system. © 2014 Elsevier B.V.


Chen K.,Kaohsiung Medical University | Lin P.,Tzu Hui Institute of Technology
Aslib Proceedings: New Information Perspectives | Year: 2011

Purpose: The aim of this paper is to determine the essential features of information literacy; what role it should play in university library user education; and how programs can be best implemented. Design/methodology/approach: The researchers systemically surveyed and reviewed publications related to information literacy and library user education. Findings: It was found that a well-designed information literacy program benefits the library and its staff, faculty, and students; librarians should play a leading role in the design and operation of programs, but collaboration with faculty, IT professionals and students is essential; programs should be embedded in the curriculum, be largely cooperative, and be problem-based; evaluation and assessment are essential components; emphasis should be placed on first-year students; and, ideally, the librarians will turn into educators and the library will become a learning center combining learning, research and technology. Research limitations/implications: This paper reflects the opinions of the researchers and the authors of the reviewed literature who have insights into the issues related to information literacy and library user education. These opinions present useful guidelines for both librarian and teacher practitioners. Originality/value: This paper provides a point of view on the relationship between information literacy and library user education in the six themes described above. © Emerald Group Publishing Limited.


Chang Y.-J.,Chang Gung University | Liang J.-N.,Chang Gung University | Hsu M.-J.,Kaohsiung Medical University | Lien H.-Y.,Chang Gung University | And 3 more authors.
Archives of Physical Medicine and Rehabilitation | Year: 2013

Objective: To investigate the possibility of restoring the adapted spinal circuit after spinal cord injury (SCI) by means of long-term continuous passive motion (CPM) of the ankle joint. Design: Randomized controlled trial with repeated measures. Setting: Research laboratory in a general hospital. Participants: Individuals with motor complete SCI (N=14) were recruited from a community. Intervention: CPM of the ankle joint for 1 hour a day, 5 days a week for 4 weeks. Main Outcome Measures: Modified Ashworth Scale (MAS) scores for evaluation of spasticity and postactivation depression (PAD) were documented prior to and after intervention. Results: MAS scores improved after 4 weeks of CPM intervention, indicating a reduction in spasticity of the ankle joint. PAD was restored after 4 weeks of training. Conclusions: Passive motion of the ankle joint alone was sufficient in reversing the adapted spinal circuit, and therefore indicates that spasticity after SCI could possibly be managed by CPM intervention. The results of this study support the use of the passive mode of robot-assisted therapy for humans with complete SCI who cannot exercise actively.


Chen Y.-M.,National Cheng Kung University | Kuo C.-E.,Tzu Hui Institute of Technology | Chen G.-R.,National Cheng Kung University | Kao Y.-T.,National Cheng Kung University | And 3 more authors.
Developmental and Comparative Immunology | Year: 2014

We cloned and sequenced 2C I-IFN, a two-cysteine containing type I interferon (I-IFN) gene, in orange-spotted grouper (Epinephelus coioides). The cDNA has 769 base pairs, the protein has 172 amino acids, and the predicted signal peptide has 18 amino acids with two cysteines. This gene is similar to I-FNs from sea bass and other teleosts. 2C I-IFN has 5 exons and 4 introns, also similar to other teleost I-IFNs. Immunohistochemical (IHC) analysis indicated that expression is predominantly membrane-localized in healthy grouper, but has a zonal distribution in nodavirus-infected grouper. Grouper infected with nodavirus had elevated levels of 2C I-IFN at 72. h and Mx at days 6-7. Recombinant 2C I-IFN activated grouper Mx, leading to upregulated antiviral activity. The grouper Mx promoter was highly induced after treatment with recombinant 2C I-IFN. The present results suggest that expression of grouper 2C I-IFN may participate in the immunologic barrier function against nodavirus. © 2014 Elsevier Ltd.


Shih W.-L.,National Pingtung University of Science and Technology | Yu F.-L.,Tzu Hui Institute of Technology | Chang C.-D.,National Pingtung University of Science and Technology | Liao M.-H.,National Pingtung University of Science and Technology | And 2 more authors.
Molecular Carcinogenesis | Year: 2013

Our previous studies demonstrated that autocrine motility factor/phosphoglucose isomerase (AMF/PGI) possesses tumorigenic activities through the modulation of intracellular signaling. We then investigated the effects of ursolic acid (UA), oleanolic acid (OA), tangeretin, and nobiletin against AMF/PGI-mediated oncogenesis in cultured stable Huh7 and Hep3B cells expressing wild-type or mutated AMF/PGI and in a mouse model in this study. The working concentrations of the tested compounds were lower than their IC10, which was determined by Brdu incorporation and colony formation assay. Only UA efficiently suppressed the AMF/PGI-induced Huh7 cell migration and MMP-3 secretion. Additionally, UA inhibited the AMF/PGI-mediated protection against TGF-β-induced apoptosis in Hep3B cells, whereas OA, tangeretin, and nobiletin had no effect. In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI. In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation. AMF/PGI enhances tumor growth, angiogenesis, and pulmonary metastasis in mice, which is correlated with its enzymatic activity, and critically, UA intraperitoneal injection reduces the tumorigenesis in vivo, enhances apoptosis in tumor tissues and also prolongs mouse survival. Combination of sub-optimal dose of UA and cisplatin, a synergistic tumor cell-killing effects was found. Thus, UA modulates intracellular signaling and might serve as a functional natural compound for preventing or alleviating hepatocellular carcinoma. © 2012 Wiley Periodicals, Inc.


Ko T.,Tzu Hui Institute of Technology
Asian Journal of Chemistry | Year: 2015

A deactivation kinetic model was used to predict the breakthrough curve for the adsorption of H2S from syngas with Zn-contaminated soil. The H2S adsorption experiments were carried out in a fixed-bed reactor at high temperature. Results indicated that the deactivation kinetic model can be well fitted the breakthrough curve within the experimental ranges. The breakthrough curves were accurately predicted and provided useful information for the time to reload the solid materials in the reaction. The activation energy of the reaction of Zncontaminated soil and H2S was experimentally calculated about 126.4 and 42.2 kJ/mol, respectively for deactivation kinetic model I (m =0, n = 1) and model II (m = 1, n = 1). Both of two types of deactivation kinetic models can fit the experimental results. The order of H2S adsorption in the deactivation model was probably ranged from zero to one.


Ku C.-T.,Tzu Hui Institute of Technology | Hung K.-C.,National Kaohsiung First University of Science and Technology | Wu T.-C.,National Kaohsiung First University of Science and Technology | Wu T.-C.,Tungnan University | Wang H.-S.,National Kaohsiung First University of Science and Technology
IEEE Transactions on Biomedical Engineering | Year: 2010

Maintaining reconstructed signals at a desired level of quality is crucial for lossy ECG data compression. Wavelet-based approaches using a recursive decomposition process are unsuitable for real-time ECG signal recoding and commonly obtain a nonlinear compression performance with distortion sensitive to quantization error. The sensitive response is caused without compromising the influences of word-length-growth (WLG) effect and unfavorable for the reconstruction quality control of ECG data compression. In this paper, the 1-D reversible round-off nonrecursive discrete periodic wavelet transform is applied to overcome the WLG magnification effect in terms of the mechanisms of error propagation resistance and significant normalization of octave coefficients. The two mechanisms enable the design of a multivariable quantization scheme that can obtain a compression performance with the approximate characteristics of linear distortion. The quantization scheme can be controlled with a single control variable. Based on the linear compression performance, a linear quantization scale prediction model is presented for guaranteeing reconstruction quality. Following the use of the MIT-BIH arrhythmia database, the experimental results show that the proposed system, with lower computational complexity, can obtain much better reconstruction quality control than other wavelet-based methods. © 2010 IEEE.


Ko T.-H.,Tzu Hui Institute of Technology
Scientific World Journal | Year: 2014

The objective of this study was to investigate the physical, chemical, and mineralogical composition of lateritic soils in order to use these soils as potential commercial products for industrial application in the future. Five lateritic soils derived from various parent materials in Taiwan, including andesite, diluvium, shale stone, basalt, and Pleistocene deposit, were collected from the B t 1 level of soil samples. Based on the analyses, the Tungwei soil is an alfisol, whereas other lateritic soils are ultisol. Higher pH value of Tungwei is attributed to the large amounts of Ca2+ and Mg 2+. Loupi and Pingchen soils would be the older lateritic soils because of the lower active iron ratio. For the iron minerals, the magnetic iron oxides such as major amounts of magnetite and maghemite were found for Tamshui and Tungwei lateritic soils, respectively. Lepidocrocite was only found in Soka soil and intermediate amounts of goethite were detected for Loupi and Pingchen soils. After Mg-saturated and K-saturated processes, major amounts of mixed layer were observed in Loupi and Soka soils, whereas the montmorillonite was only detected in Tungwei soil. The investigation results revealed that the parent materials would play an important role during soil weathering process and physical, chemical, and mineralogy compositions strongly affect the formation of lateritic soils. © 2014 Tzu-Hsing Ko.


Kang Y.-F.,Fooyin University | Liu C.-M.,Tzu Hui Institute of Technology | Kao C.-L.,Fooyin University | Kao C.-L.,Tzu Hui Institute of Technology | Chen C.-Y.,Fooyin University
Molecules | Year: 2014

Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (-)-anonaine (1), (-)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells. © 2014 by the authors; licensee MDPI, Basel, Switzerland.


Female breast cancer has been ranked as the leading cause of cancer death in Taiwan. Women who undergo a mastectomy are at risk of suffering emotional disturbance because of deteriorating body image. A nursing intervention designed to restore body image perceptions and to reduce anxiety and emotional distress in this vulnerable group should be developed and administered. This study was developed to evaluate the effectiveness of informational and emotional consultation on body image, anxiety, and emotional distress in women with breast cancer who underwent modified radical mastectomy. A quasi-experimental design with convenience sampling was used. Two hospitals within the same hospital system in southern Taiwan provided the research setting. Sixty-three women diagnosed with breast cancer completed the interviews (experimental group = 32, control group = 31). The experimental group participants received a two-session informational and emotional consultation, whereas those in the control group received routine nursing care only. All participants completed a series of three face-to-face interviews, including one pretest (Time 1, before surgery), a first posttest (Time 2, the day of discharge), and a second (follow-up) test (Time 3, 2 months after surgery). The intervention had an immediate positive effect (i.e., on the day of hospital discharge) on anxiety and a delayed positive effect (i.e., 2 months after surgery) on body image, anxiety, and emotional distress. The experimental group participants indicated a high level of satisfaction with the intervention. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: Our findings suggest the ability of this nursing informational and emotional consultation intervention to reduce patient anxiety at both short- and long-term stages. However, improved perception of body image and emotional distress only over the longer term indicates that these dimensions take time to be internalized and improved. This nursing informational and emotional consultation intervention may provide a guide for hospitals and nurses in caring for women recovering from modified radical mastectomy surgery.

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