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Gayed I.W.,Interventional Imaging | Wahba H.,U.S. National Cancer Institute | Wan D.,Interventional Imaging | Joseph U.,University of Texas M. D. Anderson Cancer Center | Murthy R.,TX
Journal of Cancer Science and Therapy

Objective: To evaluate the outcomes of patients receiving Y- 90 SIR-Spheres in patients with multiple liver metastases from different tumors. Methods: 29 consecutive patients with multiple liver metastases from colorectal (13), Islet cell tumors (9), carcinoid tumors (4) or non-small cell lung cancer (3) who were treated with Y-90 SIR-Spheres between March, 2003 and February, 2006 were included. Only patients who had follow-up radiological exams at our institution were included. Data regarding Y-90 SIR-Spheres dose, lobe of liver treated, and chemotherapy (CTx) administered were collected. Patients' outcomes were evaluated based on radiological evidence of change in size and number of liver metastases. Results: The study population included 8 females and 21 males at a mean age of 60y. The mean Y-90 SIR-Spheres dose administered was 39.8 mCi. Both lobes of the liver, the right lobe only or the left lobe only were treated in 26, 2, 1 patients, respectively. Sixteen patients received Y-90 SIR-Spheres after CTx failure, 5 patients as adjuvant therapy after completion of CTx, 7 patients as concurrent therapy and one patient refused repeat CTx. The mean interval between the last CTx and Y-90 SIR-Spheres was 108 days. Four patients (14%) demonstrated radiological improvement and 9 (31%) were stable for a mean interval of 2.8 mo. after Y-90 SIR-Spheres infusion. Sixteen patients (55%) demonstrated continued progress of liver metastases. Conclusion: Y-90 SIR-Spheres therapy is useful in reducing or stabilizing multiple liver metastases from a variety of tumors. © 2010 Gayed IW, et al. Source

Carranza R.G.,TX | Ospina J.,EAFIT University
WIT Transactions on Engineering Sciences

Many studies are conducted for pyramidal spine fins relating to temperature profiles and fin efficiencies. However, it is found that a deeper look into the boundary conditions is required. The conditions at the base are simple enough, but the conditions at the tip are more complicated. Despite what condition is applied to the tip, the value at the tip actually has a specific value that is a function of the square root of the Biot number. This result is proven using basic principles from calculus, like the Limit and L’Hospital’s rule. © 2014 WIT Press. Source

Stern R.J.,TX | Johnson P.,1242 Tenth Street NW
Earth-Science Reviews

The Arabian Plate originated ~25. Ma ago by rifting of NE Africa to form the Gulf of Aden and Red Sea. It is one of the smaller and younger of the Earth's lithospheric plates. The upper part of its crust consists of crystalline Precambrian basement, Phanerozoic sedimentary cover as much as 10. km thick, and Cenozoic flood basalt (harrat). The distribution of these rocks and variations in elevation across the Plate cause a pronounced geologic and topographic asymmetry, with extensive basement exposures (the Arabian Shield) and elevations of as much as 3000. m in the west, and a Phanerozoic succession (Arabian Platform) that thickens, and a surface that descends to sea level, eastward between the Shield and the northeastern margin of the Plate. This tilt in the Plate is partly the result of marginal uplift during rifting in the south and west, and loading during collision with, and subduction beneath, the Eurasian Plate in the northeast. But a variety of evidence suggests that the asymmetry also reflects a fundamental crustal and mantle heterogeneity in the Plate that dates from Neoproterozoic time when the crust formed.The bulk of the Plate's upper crystalline crust is Neoproterozoic in age (1000-540. Ma) reflecting, in the west, a 300-million year process of continental crustal growth between ~850 and 550. Ma represented by amalgamated juvenile magmatic arcs, post-amalgamation sedimentary and volcanic basins, and granitoid intrusions that make up as much as 50% of the Shield's surface. Locally, Archean and Paleoproterozoic rocks are structurally intercalated with the juvenile Neoproterozoic rocks in the southern and eastern parts of the Shield. The geologic dataset for the age, composition, and origin of the upper crust of the Plate in the east is smaller than the database for the Shield, and conclusions made about the crust in the east are correspondingly less definitive. In the absence of exposures, furthermore, nothing is known by direct observation about the composition of the crust north of the Shield. Nonetheless, available data indicate a geologic history for eastern Arabian crust different to that in the west. The Neoproterozic crust (~815-785. Ma) is somewhat older than in the bulk of the Arabian Shield, and igneous and metamorphic activity was largely finished by 750. Ma. Thereafter, the eastern part of the Plate became the site of virtually continuous sedimentation from 725. Ma on and into the Phanerozoic. This implies that a relatively strong lithosphere was in place beneath eastern Arabia by 700. Ma in contrast to a lithospheric instability that persisted to ~550. Ma in the west. Lithospheric differentiation is further indicated by the Phanerozoic depositional history with steady subsidence and accumulation of a sedimentary succession 5-14. km thick in the east and a consistent high-stand and thin to no Phanerozoic accumulation over the Shield. Geophysical data likewise indicate east-west lithospheric differentiation. Overall, the crustal thickness of the Plate (depth to the Moho) is ~40. km, but there is a tendency for the crust to thicken eastward by as much as 10% from 35-40. km beneath the Shield to 40-45. km beneath eastern Arabia. The crust also becomes structurally more complex with as many as 5 seismically recognized layers in the east compared to 3 layers in the west. A coincident increase in velocity is noted in the upper-crust layers. Complementary changes are evidenced in some models of the Arabian Plate continental upper mantle, indicating eastward thickening of the lithospheric mantle from ~80. km beneath the Shield to ~120. km beneath the Platform, which corresponds to an overall lithospheric thickening (crust and upper mantle) from ~120. km to ~160. km eastward. The locus of these changes coincides with a prominent magnetic anomaly (Central Arabian Magnetic Anomaly, CAMA) in the extreme eastern part of the Arabian Shield that extends north across the north-central part of the Arabian Plate. The CAMA also coincides with a major structural boundary separating a region of northerly and northwesterly basement trends in the west from a region of northerly and northeasterly trends in the northeastern part of the Plate, and with the transition from high-stand buoyant Shield to subsided Platform. Its coincidence with geophysically indicated changes in the lower crust and mantle structure suggests that a fundamental lithospheric boundary is present in the central part of the Arabian Plate. The ages and isotopic characteristics of xenoliths brought to the surface in Cenozoic basalt eruptions indicate that the lower crust and upper mantle are largely juvenile Neoproterozoic additions, meaning that the lower crust and upper mantle formed about the same time as the upper crust. This implies that the lithospheric boundary in the central part of the Arabian Plate dates from Neoproterozoic time. We conclude that lithospheric differentiation across the Arabian Plate is long lived and has controlled much of the Phanerozoic sedimentary history of the Plate. © 2010 Elsevier B.V. Source

Hanophy compares Supplemental Security Income and Social Security Disability Income as well as Ticket to Work to the public Vocational Rehabilitation (VR) program and methods of the Council of State Administrators of Vocational Rehabilitation (CSAVR). His evaluation suggests better outcomes for the beneficiaries, tax payers, local and federal budgets using the VR and CSAVR programs. © 2012-IOS Press and the authors. All rights reserved. Source

Modena B.D.,Scripps Research Institute | Kurian S.M.,Scripps Research Institute | Gaber L.W.,TX | Waalen J.,Scripps Research Institute | And 14 more authors.
American Journal of Transplantation

Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1-year biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when histological evidence of inflammation is present. Identifying the mechanistic etiology of IFTA is important to understanding why long-term graft survival has not changed as expected despite improved immunosuppression and dramatically reduced rates of clinical acute rejection (AR) (Services UDoHaH. http://www.ustransplant.org/annual_reports/current/509a_ki.htm). Gene expression profiles of 234 graft biopsy samples were obtained with matching clinical and outcome data. Eighty-one IFTA biopsies were divided into subphenotypes by degree of histological inflammation: IFTA with AR, IFTA with inflammation, and IFTA without inflammation. Samples with AR (n = 54) and normally functioning transplants (TX; n = 99) were used in comparisons. A novel analysis using gene coexpression networks revealed that all IFTA phenotypes were strongly enriched for dysregulated gene pathways and these were shared with the biopsy profiles of AR, including IFTA samples without histological evidence of inflammation. Thus, by molecular profiling we demonstrate that most IFTA samples have ongoing immune-mediated injury or chronic rejection that is more sensitively detected by gene expression profiling. These molecular biopsy profiles correlated with future graft loss in IFTA samples without inflammation. © 2016 The American Society of Transplantation and the American Society of Transplant Surgeons. Source

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