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Nanchang, China

Xiao D.,Hunan Agricultural University | Wang Y.,Twins Group Co. | Liu G.,CAS Institute of Subtropical Agriculture | He J.,Hunan Agricultural University | And 8 more authors.
PLoS ONE | Year: 2014

The aim of this study was to investigate whether supplementation with chitosan (COS) could reduce diarrhea and to explore how COS alleviates intestinal inflammation in weaned pigs. Thirty pigs (DurocxLandracexYorkshire, initial BW of 5.65±0.27) weaned at age 21 d were challenged with enterotoxigenic Escherichia coli during a preliminary trial period, and then divided into three treatment groups. Pigs in individual pens were fed a corn-soybean meal diet, that contained either 0 (control), 50 mg/kg chlortetracycline, or 300 mg/kg COS for 21 days. The post-weaning diarrhea frequency, calprotectin levels and TLR4 protein expression were decreased (P<0.05) in both the COS and chlortetracycline groups compared with control. Simultaneously, supplemental COS and chlortetracycline had no effect on the mRNA expression of TNF-α in the jejunal mucosa, or on the concentrations of IL-1β, IL-6 and TNF-α in serum. However, COS supplementation improved (P<0.05) the mRNA expression of IL-1β and IL-6 in the jejunal mucosa. The results indicate that supplementation with COS at 300 mg/kg was effective for alleviating intestinal inflammation and enhancing the cell-mediated immune response. As feed additives, chitosan and chlortetracycline may influence different mechanisms for alleviating inflammation in piglets. © 2014 Xiao et al. Source

Duan J.,Chinese Academy of Sciences | Yin J.,Chinese Academy of Sciences | Wu M.,Chinese Academy of Sciences | Liao P.,Chinese Academy of Sciences | And 16 more authors.
PLoS ONE | Year: 2014

The purpose of this study was to investigate the hypothesis that dietary supplementation with glutamic acid has beneficial effects on growth performance, antioxidant system, intestinal morphology, serum amino acid profile and the gene expression of intestinal amino acid transporters in growing swine fed mold-contaminated feed. Fifteen pigs (LandracexLarge White) with a mean body weight (BW) of 55 kg were randomly divided into control group (basal feed), mycotoxin group (contaminated feed) and glutamate group (2% glutamate+contaminated feed). Compared with control group, mold-contaminated feed decreased average daily gain (ADG) and increased feed conversion rate (FCR). Meanwhile, fed mold-contaminated feed impaired anti-oxidative system and intestinal morphology, as well as modified the serum amino acid profile in growing pigs. However, supplementation with glutamate exhibited potential positive effects on growth performance of pigs fed mold-contaminated feed, ameliorated the imbalance antioxidant system and abnormalities of intestinal structure caused by mycotoxins. In addition, dietary glutamate supplementation to some extent restored changed serum amino acid profile caused by mold-contaminated feed. In conclusion, glutamic acid may be act as a nutritional regulating factor to ameliorate the adverse effects induced by mycotoxins. Source

Zhang J.,Chinese Academy of Sciences | Yin Y.,Chinese Academy of Sciences | Yin Y.,Wuhan Polytechnic University | He Q.,Chinese Academy of Sciences | And 7 more authors.
Journal of Food, Agriculture and Environment | Year: 2012

Glutamate is extensively metabolized in small intestine epithelial cells during its transcellular transfer from the lumen to bloodstream and after its uptake from the bloodstream. In order to study the effect of monosodium glutamate (MSG) supplementation given either by the parenteral route or by the enteral route on the circulating amino acid concentrations in growing-finishing pigs, animals received MSG at a dose equal to 0.25 g/kg body weight by intraperitoneal injection or by injection into the stomach. Up to 255 min, arterial and portal venous blood was collected and amino acid concentrations were measured. The results show that the glutamate concentrations in venous and arterial plasma increase rapidly after injection of MSG in stomach. However, glutamate concentration in both venous and arterial plasma was much higher after peritoneal than stomach injection. Aspartate and alanine concentrations in both venous and arterial plasma were higher after stomach than peritoneal injection. The results obtained are compatible with the view that i) a large part of glutamate in MSG is metabolized by the intestine in pigs; ii) at the dose used, MSG is, however, not entirely metabolized by the intestine and iii) glutamate metabolism in pig intestine leads to aspartate and alanine production. Source

Wang Y.,Twins Group Co. | Feng Z.,CAS Institute of Subtropical Agriculture | Feng Z.,Hunan Engineering and Research Center Animal and Poultry Science | Zhang Y.,CAS Institute of Subtropical Agriculture | And 2 more authors.
Journal of Animal and Veterinary Advances | Year: 2014

Amino acids are important nutrients that function as both tissue building blocks and metabolic regulators. How amino acid balance is vital for the development and metabolism. Amino acid sensors, serials of particular functional molecules, possess the function of sensing amino acids has been reported in recent years. Here, both intracellular and extracellular amino acid sensors were expounded including their composition, amino acid sensing mechanism and their applications. © Medwell Journals, 2014. Source

Wang Y.,Twins Group Co. | Zhang Y.,Observation and Experiment Station of Animal Nutrition | Zhang Y.,CAS Institute of Subtropical Agriculture | Feng Z.,Observation and Experiment Station of Animal Nutrition | And 5 more authors.
Journal of Food, Agriculture and Environment | Year: 2012

Accurate determination of the dietary proteins and amino acid requirements of swine is essential to improve growth and reduce production costs and nitrogen excretion in the environment. The paper reviewed the measurement of N and amino acid availability, including the conception of the standardized ileal digestibility (SID) of amino acids and ileal protein, and the measuring techniques of quantify endogenous nitrogen flow at the distal ileum of the pig. In addition, the impact of some factors, such as dietary fibre, exogenous enzymes, environment and carbohydrate supply, on ileal digestibility and utilization of N and amino acids, is discussed. Source

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