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Turovtsev V.V.,Tver State University | Orlov Y.D.,Tver State Medical Academy
Russian Journal of Physical Chemistry B | Year: 2014

Based on the "quantum theory of atoms in a molecule," the Hohenberg-Kohn theorem, and "holographic" theorem, the principles of constructing phenomenological additive models for calculating the thermodynamic properties are considered. © 2014 Pleiades Publishing, Ltd.


Turovtsev V.V.,Tver State Medical Academy | Orlov Yu.D.,Tver State University
Russian Journal of General Chemistry | Year: 2011

A study of internal rotation in the radicals n-CnH 2n+1C•H2, (2 n 7) was carried out for the case of rotation around the bonds not including the radical center. 21 potential functions of internal rotation V(φ) were calculated. The coefficients in V(φ) were shown to depend only on the immediate environment at the bond of rotation. Characteristics of internal rotation in n-alkyl radicals were compared with related parameters of the corresponding alkane molecules. The generalized function Vav(φ) with the coefficients defined only by the position of the bond of rotation in the hydrocarbon chain and possessing the transposition property were proposed. The functions Vav(φ) were recommended for the simulation of the structure and properties of large molecules containing hydrocarbon fragments. This work continues a systematic study on the characteristics of the internal rotation in the n-alkane molecules and the groups containing free valence in n-alkyl radicals. © 2011 Pleiades Publishing, Ltd.


Agadzhanyan N.A.,Peoples' Friendship University of Russia | Makarova I.I.,Tver State Medical Academy
Human Ecology | Year: 2014

A review of data on morpho-functional features of disease course in subjects of various ethnic and race belonging in presented in the article. These features are due to genetic, cultural, socio-economic and environmental factors. © Northern State Medical University, Arkhangelsk.


Spira C.,Universitatsklinikum des Saarlandes | Grigoryan A.,Universitatsklinikum des Saarlandes | Grigoryan A.,Tver State Medical Academy | Szentmary N.,Universitatsklinikum des Saarlandes | And 3 more authors.
Ophthalmologe | Year: 2015

Purpose: Are the classifications achieved by the Belin-Ambrósio (BA) enhanced ectasia module, the keratoconus indices of the Pentacam HR and the ectasia screening index (ESI) using CASIA anterior segment optical coherence tomography (OCT) comparable to the topographical keratoconus classification (TKC) of the Pentacam HR? Can the indices be used interchangeably to assist in the diagnosis of keratoconus? Methods: This retrospective study examined 228 datasets (eyes) of patients with a mean age of 36.6 ± 13.6 years which were grouped into a non-keratoconus group (group I, n = 59) and a keratoconus group (group II, n = 169) according to the clinical assessment. From the data sets of these eyes the sensitivity and specificity of various ectasia and keratoconus indices (KI) were calculated with the help of receiver operating characteristics (ROC). Groups were compared using the Mann-Whitney and χ2-tests. Results: Groups I and II had a mean KI of 1.04 and 1.26 and a mean ESI of 3.0 and 66.6, respectively. The χ2-test showed no significant coincidence of the distance of the thinnest point from the apex with TKC (χ2 > 2, p > 0.35). All other BA parameters as well as the ESI showed a significant coincidence with the keratoconus diagnosis and the classification of TKC (p < 0.001). The ESI and KI along with some BA parameters (Df, Db, Dp and D) showed a good separation between groups I and II with an area under the ROC curves of > 0.93. Conclusion: The enhanced indices and classifiers, such as the BA module or the ESI were comparable with the purely anterior corneal surface based TKC. © 2015, Springer-Verlag Berlin Heidelberg.


Ignatova J.P.,Tver State Medical Academy | Kromin A.A.,Tver State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2010

Threshold stimulation of the lateral hypothalamus in starving and preliminary fed (satiated) rabbits in the absence of feed induces searching behavior associated with burst-like impulse activity of proper masticatory muscle with a bimodal distribution of interpulse intervals, what represents an anticipatory type of reaction. The increase in the level of food motivation during threshold stimulation of the lateral hypothalamus in starving and satiated rabbits with the food offered led to successful food-procuring behavior, during which the frequency and amplitude of spike bursts in the proper masticatory muscle become comparable with those under conditions of natural foraging behavior stimulated by the need in nutrients. Motivational excitation and backward afferentation from food reward are addressed to the same neurons of the masticatory center in the medulla oblongata. © 2010 Springer Science+Business Media, Inc.


Belchenko D.I.,Tver State Medical Academy
Gematologiya i Transfusiologiya | Year: 2011

Nonlymphoid myelokaryocytes and leukocytes, as well as platelets carrying receptors to immunoglobulins and the complement fragments, form cell associations (bone marrow erythroclasic clusters and auto-rosettes) from erythrocytes, transporting immune complexes and particles, covered by the complement fragments. Contacts with erythrocytes are associated with stimulation of nonlymphoid cells and exocytic lysis of erythrocytes and xenogenic agents transported by them. Hence, elimination of immune complexes and xenogenic antigens transported by them is realized by not only fixed cells of the monocyte/macrophagal system, but also by the blood system nonlymphoid cells by means of the bone marrow erythroclasic clusters and auto-rosettes formed by them.


Aim. To study the clinical features of inflammatory and atrophic changes (IAIs) in the gastroduodenal zone (GDZ) in people with varying severity of chronic heart failure (CHF) associated with coronary artery disease (CAD) and to determine gastric secretion, local microcirculation, and the presence of Helicobacter pylori. Subjects and methods. Seventy-four patients with CHF and gastric duodenal (GD) IAIs who were divided into 2 groups according to its severity were examined. The specific features of impaired gastric secretory function and blood flow in the GD mucosa and its contamination with H. pylori were elucidated. Results. GD IAIs were ascertained to be mainly focal in the patients with Stages I-IIa CHF and focal or diffuse in those with Stages IIb-III. According the clinical findings, these changes were generally shown in the concurrence of transient and unstable (in earlystage circulatory insufficiency) and prolonged and persistent (during severe congestive events) phenomena. The development of IAIs in the GDZ was linked to its thrombohemorrhagic microcirculatory disorders, the severity of which increased as the symptoms of CHF progressed. In Stages I-IIa circulatory insufficiency, this was accompanied by the normal activity of acid-peptic factor, by the decreased production gastromucoproteins, and, in 58.3% of cases, by H. pylori. The patients with Stages IIb-III showed the suppressed production of all constituents of gastric secretion and H. pylori in 63.2% of cases. Conclusion. The clinical manifestations and mechanisms of GD IAIs in CHF associated with CAD have a number of substantial differences in relation to its severity, which should be kept in mind when elaborating therapeutic and diagnostic measures.


Zyrina G.V.,Tver State Medical Academy
Advances in Gerontology | Year: 2013

The goal of our study was to compare mental disorders among elderly patients with chronic leukemia (CL) and dyscirculatory encephalopathy (DE). One hundred patients with CL were studied. The control group contained 85 patients with stage-I and -II DE. The Spielberger-Khanin anxiety scale and Zung depression scale were used. In patients with CL without clinical features of DE, mental disorders occurred mostly in the form of anxiety, while the combination of DE and CL led to depression. Patients with DE were characterized by anxiety and depression due to chronic cerebral ischemia. © 2013 Pleiades Publishing, Ltd.


Aim. To elucidate the state and importance of the calcium-regulating system, calcium and phosphorus balances, their impact on ulcer activity, regional microcirculation, and hemostasis during recurrent peptic ulcer disease (PUD). Subjects and methods. Sixty patients with recurrent PUD were examined. They underwent determinations of blood parathyrin and calcitonin and blood and urinary calcium and phosphorus levels and studies of regional microcirculation in the gastroduodenal mucosa and systemic hemostatic parameters in addition to clinical and endoscopic examinations. Results. Recurrent PUD is accompanied by a significant blood parathyrin rise and some calcitonin increase and by calciumphosphorus imbalance. Impaired calcium-regulating system functions attend significant microcirculatory disorders in the gastroduodenal mucosa and hemostatic changes characteristic of consumptive coagulopathy. Conclusion. A clear relationship between calcium-regulating hormone impairments, calcium and phosphorus metabolism with ulcer activity and microcirculatory and hemostatic changes may suggest the found shifts in ulcerogenesis and the pathogenetic substantiation of correction of these disorders may be of importance for the treatment of a disease recurrence.


PubMed | Tver State Medical Academy
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Reflection of the state of hunger in impulse activity of nose wing muscles and upper esophageal sphincter muscles was studied in chronic experiments on rabbits subjected to 24-h food deprivation in the absence of locomotion and during search behavior. In the absence of apparent behavioral activity, including sniffing, alai nasi muscles of hungry rabbits constantly generated bursts of action potentials synchronous with breathing, while upper esophageal sphincter muscles exhibited regular aperiodic low-amplitude impulse activity of tonic type. Latent form of food motivation was reflected in the structure of temporal organization of impulse activity of alai nasi muscles in the form of bimodal distribution of interpulse intervals and in temporal structure of impulse activity of upper esophageal sphincter muscles in the form of monomodal distribution. The latent form of food motivation was manifested in the structure of temporal organization of periods of the action potentials burst-like rhythm, generated by alai nasi muscles, in the form of monomodal distribution, characterized by a high degree of dispersion of respiratory cycle periods. In the absence of physical activity hungry animals sporadically exhibited sniffing activity, manifested in the change from the burst-like impulse activity of alai nasi muscles to the single-burst activity type with bimodal distribution of interpulse intervals and monomodal distribution of the burst-like action potentials rhythm periods, the maximum of which was shifted towards lower values, which was the cause of increased respiratory rate. At the same time, the monomodal temporal structure of impulse activity of the upper esophageal sphincter muscles was not changed. With increasing food motivation in the process of search behavior temporal structure of periods of the burst-like action potentials rhythm, generated by alai nasi muscles, became similar to that observed during sniffing, not accompanied by animals locomotion, which is typical for the increased respiratory rhythm frequency. Increased hunger motivation was reflected in the temporal structure of impulse activity of upper esophageal sphincter muscles in the form of a shift to lower values of the maximum of monomodal distribution of interpulse intervals on the histogram, resulting in higher impulse activity frequency. The simultaneous increase in the frequency of action potentials bursts generation by alai nasi muscles and regular impulse activity of upper esophageal sphincter muscles is a reliable criterion for enhanced food motivation during search behavior in rabbits.

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