Tver State Medical Academy

Tver, Russia

Tver State Medical Academy

Tver, Russia
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Khizhnyak S.D.,Tver State University | Komarov P.V.,Tver State University | Ovchinnikov M.M.,Tver State Medical Academy | Zherenkova L.V.,Tver State University | Pakhomov P.M.,Tver State University
Soft Matter | Year: 2017

We discuss the results of experimental studies of the processes of gelation in aqueous solutions of silver nitrate with l-cysteine and its derivatives. We focus on understanding what determines if these small molecules will self-assemble in water at their extremely low concentration to form a gel. A mechanism of gel formation in a cysteine-silver solution (CSS) is proposed. The analysis of the results indicates that filamentary aggregates of a gel network are formed via interaction of NH3 + and C(O)O- groups that belong to neighboring silver mercaptide (SM) aggregates. In turn, formation of sulphur-silver bonds between silver mercaptide molecules is responsible for self-assembling these molecules into SM aggregates which can be considered as supramonomers. Free polar groups located on the surfaces of the aggregates can form hydrogen bonds with water molecules, which explains the unique ability of CSS hydrogels to trap water at low concentrations of low-molecular-weight hydrogelators. © The Royal Society of Chemistry 2017.


Korichkina L.N.,Tver State Medical Academy | Yesipova A.V.,Clinical Childrens Hospital No 2 | Zhmakin I.A.,Tver State Medical Academy
Human Ecology (Russian Federation) | Year: 2017

The purpose of the study was to evaluate the morphological types of autorotation (AR) in the peripheric blood in children under the influence of outdoor air pollution. Material and methods. 613 students of I-II health groups under ordinary life conditions were surveyed. They were divided into 2 groups depending on the index of atmospheric air pollution on the schoolyards. In blood smears (stained with Romanovsky-Giemsa) AR number was counted and determined their morphological types and the morphology. The modification of red blood cells was evaluated. Results. It was stated that with increase of the air pollution index the intensity of autorosette-formation (ARO) in the blood increased. AR morphotype depends on the nature of rosette cells (leukocyte), to which at least three modified autologous erythrocytes are tightly fixed. Leukocytal AutoRotate formed by neutrophils, monocytes, eosinophils, basophils, and large, medium and small platelet aggregates were distinguished. Conclusions. Contaminated atmospheric air is a risk factor for the health of children and adolescents. AR morphotype depends on the nature of the rosette cells. The frequency of the ARC in the peripheral blood grows with increasing number of modified red blood cells. Further research is needed in this area.


Turovtsev V.V.,Tver State University | Orlov Y.D.,Tver State Medical Academy
Russian Journal of Physical Chemistry B | Year: 2014

Based on the "quantum theory of atoms in a molecule," the Hohenberg-Kohn theorem, and "holographic" theorem, the principles of constructing phenomenological additive models for calculating the thermodynamic properties are considered. © 2014 Pleiades Publishing, Ltd.


Turovtsev V.V.,Tver State Medical Academy | Orlov Yu.D.,Tver State University
Russian Journal of General Chemistry | Year: 2011

A study of internal rotation in the radicals n-CnH 2n+1C•H2, (2 n 7) was carried out for the case of rotation around the bonds not including the radical center. 21 potential functions of internal rotation V(φ) were calculated. The coefficients in V(φ) were shown to depend only on the immediate environment at the bond of rotation. Characteristics of internal rotation in n-alkyl radicals were compared with related parameters of the corresponding alkane molecules. The generalized function Vav(φ) with the coefficients defined only by the position of the bond of rotation in the hydrocarbon chain and possessing the transposition property were proposed. The functions Vav(φ) were recommended for the simulation of the structure and properties of large molecules containing hydrocarbon fragments. This work continues a systematic study on the characteristics of the internal rotation in the n-alkane molecules and the groups containing free valence in n-alkyl radicals. © 2011 Pleiades Publishing, Ltd.


Agadzhanyan N.A.,Peoples' Friendship University of Russia | Makarova I.I.,Tver State Medical Academy
Human Ecology | Year: 2014

A review of data on morpho-functional features of disease course in subjects of various ethnic and race belonging in presented in the article. These features are due to genetic, cultural, socio-economic and environmental factors. © Northern State Medical University, Arkhangelsk.


Ignatova J.P.,Tver State Medical Academy | Kromin A.A.,Tver State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2010

Threshold stimulation of the lateral hypothalamus in starving and preliminary fed (satiated) rabbits in the absence of feed induces searching behavior associated with burst-like impulse activity of proper masticatory muscle with a bimodal distribution of interpulse intervals, what represents an anticipatory type of reaction. The increase in the level of food motivation during threshold stimulation of the lateral hypothalamus in starving and satiated rabbits with the food offered led to successful food-procuring behavior, during which the frequency and amplitude of spike bursts in the proper masticatory muscle become comparable with those under conditions of natural foraging behavior stimulated by the need in nutrients. Motivational excitation and backward afferentation from food reward are addressed to the same neurons of the masticatory center in the medulla oblongata. © 2010 Springer Science+Business Media, Inc.


Belchenko D.I.,Tver State Medical Academy
Gematologiya i Transfusiologiya | Year: 2011

Nonlymphoid myelokaryocytes and leukocytes, as well as platelets carrying receptors to immunoglobulins and the complement fragments, form cell associations (bone marrow erythroclasic clusters and auto-rosettes) from erythrocytes, transporting immune complexes and particles, covered by the complement fragments. Contacts with erythrocytes are associated with stimulation of nonlymphoid cells and exocytic lysis of erythrocytes and xenogenic agents transported by them. Hence, elimination of immune complexes and xenogenic antigens transported by them is realized by not only fixed cells of the monocyte/macrophagal system, but also by the blood system nonlymphoid cells by means of the bone marrow erythroclasic clusters and auto-rosettes formed by them.


Aim. To study the clinical features of inflammatory and atrophic changes (IAIs) in the gastroduodenal zone (GDZ) in people with varying severity of chronic heart failure (CHF) associated with coronary artery disease (CAD) and to determine gastric secretion, local microcirculation, and the presence of Helicobacter pylori. Subjects and methods. Seventy-four patients with CHF and gastric duodenal (GD) IAIs who were divided into 2 groups according to its severity were examined. The specific features of impaired gastric secretory function and blood flow in the GD mucosa and its contamination with H. pylori were elucidated. Results. GD IAIs were ascertained to be mainly focal in the patients with Stages I-IIa CHF and focal or diffuse in those with Stages IIb-III. According the clinical findings, these changes were generally shown in the concurrence of transient and unstable (in earlystage circulatory insufficiency) and prolonged and persistent (during severe congestive events) phenomena. The development of IAIs in the GDZ was linked to its thrombohemorrhagic microcirculatory disorders, the severity of which increased as the symptoms of CHF progressed. In Stages I-IIa circulatory insufficiency, this was accompanied by the normal activity of acid-peptic factor, by the decreased production gastromucoproteins, and, in 58.3% of cases, by H. pylori. The patients with Stages IIb-III showed the suppressed production of all constituents of gastric secretion and H. pylori in 63.2% of cases. Conclusion. The clinical manifestations and mechanisms of GD IAIs in CHF associated with CAD have a number of substantial differences in relation to its severity, which should be kept in mind when elaborating therapeutic and diagnostic measures.


Zyrina G.V.,Tver State Medical Academy
Advances in Gerontology | Year: 2013

The goal of our study was to compare mental disorders among elderly patients with chronic leukemia (CL) and dyscirculatory encephalopathy (DE). One hundred patients with CL were studied. The control group contained 85 patients with stage-I and -II DE. The Spielberger-Khanin anxiety scale and Zung depression scale were used. In patients with CL without clinical features of DE, mental disorders occurred mostly in the form of anxiety, while the combination of DE and CL led to depression. Patients with DE were characterized by anxiety and depression due to chronic cerebral ischemia. © 2013 Pleiades Publishing, Ltd.


Aim. To elucidate the state and importance of the calcium-regulating system, calcium and phosphorus balances, their impact on ulcer activity, regional microcirculation, and hemostasis during recurrent peptic ulcer disease (PUD). Subjects and methods. Sixty patients with recurrent PUD were examined. They underwent determinations of blood parathyrin and calcitonin and blood and urinary calcium and phosphorus levels and studies of regional microcirculation in the gastroduodenal mucosa and systemic hemostatic parameters in addition to clinical and endoscopic examinations. Results. Recurrent PUD is accompanied by a significant blood parathyrin rise and some calcitonin increase and by calciumphosphorus imbalance. Impaired calcium-regulating system functions attend significant microcirculatory disorders in the gastroduodenal mucosa and hemostatic changes characteristic of consumptive coagulopathy. Conclusion. A clear relationship between calcium-regulating hormone impairments, calcium and phosphorus metabolism with ulcer activity and microcirculatory and hemostatic changes may suggest the found shifts in ulcerogenesis and the pathogenetic substantiation of correction of these disorders may be of importance for the treatment of a disease recurrence.

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