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Canpolat U.,Turkiye Yuksek Ihtisas Training and Research Hospital | Ozer N.,Hacettepe University
Anadolu Kardiyoloji Dergisi | Year: 2014

Cardiovascular diseases are the foremost cause of morbidity and mortality for both genders worldwide. Appropriate diagnostic tests with increased accuracy and safety provide the decisive relationship between diagnosis and treatment of coronary artery disease (CAD). However, it has been known that women at risk for occurrence of CAD are less often conducted for the proper diagnostic tests compared to men. Many noninvasive diagnostic modalities (exercise/stress electrocardiogram, echocardiography, nuclear imaging, magnetic resonance imaging and coronary computerized tomography) are available for this purpose in the women. In this review, we present the current data on the role of both conventional and modern noninvasive diagnostic tests in the assessment of women with CAD suspicion. © 2014 by Turkish Society of Cardiology. Source

Cicek G.,Ankara Numune Education and Research Hospital | Acikgoz S.K.,Turkiye Yuksek Ihtisas Training and Research Hospital | Bozbay M.,Marmara University | Altay S.,Edirne State Hospital | And 3 more authors.
Angiology | Year: 2015

We assessed the effect of combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting in-hospital and long-term mortality in patients (n = 2518) undergoing primary percutaneous coronary intervention (pPCI). Cutoff values for NLR and PLR were calculated with receiver-operating characteristic (ROC) curves. If both PLR and NLR were above the threshold, patients were classified as "high risk." If either PLR or NLR was above the threshold individually, patients were classified as "intermediate risk." High-risk (n = 693) and intermediate-risk (n = 545) groups had higher in-hospital and long-term mortality (7.2 4% vs 0.7%, P <.001; 14.1, 9.5% vs 4.5%, P <.001, respectively). Classifying patients into intermediate-risk group (hazards ratio [HR]: 1.492, 95% confidence interval [CI]: 1.022-2.178, P =.038) and high-risk group (HR: 1.845, 95% CI: 1.313-2.594, P <.001) was an independent predictor of in-hospital and long-term mortality. The combination of PLR and NLR can be useful for the prediction of in-hospital and long-term mortality in patients undergoing pPCI. © The Author(s) 2014. Source

Leblebisatan G.,Gaziantep Children Hospital | Bay A.,University of Gaziantep | Karakus S.C.,Gaziantep Children Hospital | Kekilli M.,Turkiye Yuksek Ihtisas Training and Research Hospital | Haznedaroglu I.C.,Hacettepe University
Blood Coagulation and Fibrinolysis | Year: 2012

Ankaferd blood stopper (ABS) is a hemostatic agent used topically for controlling bleedings of skin or mucosal surfaces in Turkey. It is currently topically used in bleedings of body injuries, traumas, and minor or major surgical interventions. Here we have evaluated 12 pediatric patients with hemorrhagic diathesis on whom Ankaferd was used for oral bleedings. Topical Ankaferd was administered for hemorrhages of oral cavity during 15 bleeding attacks. ABS administrations successfully stopped the bleedings, except for one patient with oral hemorrhage who did not respond to ABS application. Ankaferd is effective for oral bleedings of children with bleeding diathesis especially when other measures have failed. © 2012 Wolters Kluwer Health. Source

Haznedaroglu I.C.,Hacettepe University | Beyazit Y.,Hacettepe University | Beyazit Y.,Turkiye Yuksek Ihtisas Training and Research Hospital
Clinical Science | Year: 2013

The locally active ligand peptides, mediators, receptors and signalling pathways of the haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin-angiotensin system) affect the essential steps of definitive blood cell production. Haematopoiesis, erythropoiesis, myelopoiesis, formation of monocytic and lymphocytic lineages, thrombopoiesis and other stromal cellular elements are regulated by the local BM RAS. The local BM RAS is present and active even in primitive embryonic haematopoiesis. ACE (angiotensin-converting enzyme) is expressed on the surface of the first endothelial and haematopoietic cells, forming the marrow cavity in the embryo. ACE marks early haematopoietic precursor cells and long-term blood-forming CD34+ BM cells. The local autocrine tissue BM RAS may also be active in neoplastic haematopoiesis. Critical RAS mediators such as renin, ACE, AngII (angiotensin II) and angiotensinogen have been identified in leukaemic blast cells. The local tissue RAS influences tumour growth and metastases in an autocrine and paracrine fashion via the modulation of numerous carcinogenic events, such as angiogenesis, apoptosis, cellular proliferation, immune responses, cell signalling and extracellular matrix formation. The aim of the present review is to outline the known functions of the local BM RAS within the context of primitive, definitive and neoplastic haematopoiesis. Targeting the actions of local RAS molecules could represent a valuable therapeutic option for the management of neoplastic disorders. © The Authors Journal compilation. Source

Canpolat U.,Turkiye Yuksek Ihtisas Training and Research Hospital | Kabakci G.,Hacettepe University | Aytemir K.,Hacettepe University | Dural M.,Hacettepe University | And 6 more authors.
Journal of Cardiovascular Electrophysiology | Year: 2013

frQRS and Outcomes in ARVC/D Background Fragmented QRS (frQRS) complex, with various morphology, has been recently described as a diagnostic criterion of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, there are little data regarding the prognostic role of frQRS in these patients. Therefore, we aimed to investigate the association of frQRS with arrhythmic events in patients with ARVC/D. Methods Seventy-eight patients (51 men, 65.4%; mean age: 31.25 ± 11.5 years) with the diagnosis of ARVC/D according to 2010 modified Task Force Criteria were analyzed retrospectively. Baseline ECG evaluation revealed frQRS complex in 46 patients (59%). Eleven patients with complete/incomplete right bundle branch block were excluded from the study. The phenomenon of frQRS was defined as deflections at the beginning of the QRS complex, on top of the R-wave, or in the nadir of the S-wave similar to the definition in CAD in either one right precordial lead or in more than one lead including all standard ECG leads. Results During 38 ± 14 months follow-up period, 3 patients (3.8%) died suddenly, 36 patients (46.1%) experienced arrhythmic events (32 ventricular tachycardias [VTs] and 4 ventricular fibrillation [VF], 30 in the ICD group). The frQRS was significantly associated with arrhythmic events (P < 0.001). Also, the number of ECG leads with frQRS complex was higher in patients with arrhythmic events (5.08 ± 2.5 vs 1.14 ± 1.7, P < 0.001, respectively). Conclusion The frQRS complex on standard 12-lead ECG predicts fatal and nonfatal arrhythmic events in patients with ARVC/D. Therefore, large scale and prospective studies are needed to confirm those findings. © 2013 Wiley Periodicals, Inc. Source

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