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Canbay S.,Oncology Training and Research Hospital | Turhan N.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Bozkurt M.,Ankara University | Arda K.,Oncology Training and Research Hospital | Caglar S.,Ankara University
Turkish Neurosurgery | Year: 2013

Aim:The purpose of the present study is to analyze the expression of matrix metalloproteinase-3 (MMP-3), magnetic resonance imaging (MRI) grading and histopathological alterations of the intervertebral disc (IVD) for correlations with each other and with the age, gender and low back pain duration of the patients who had undergone operations for lumbar disc herniation (LDH). Material and Methods: Forty-two patients were admitted to our clinic with signs of LDH and underwent surgery for LDH at 48 IVD levels. In all cases, specimens for histological and immunohistochemical analyses were removed from the IVD space. Lumbar IVD degeneration on MRI of the 48 IVDs from which surgical specimens had been obtained was classified into five grades using the Pfirrmann classification. Results: In the degenerated IVD, the expression of MMP-3, MRI grading and histopathological alterations of the IVD displayed significant correlation. Increased age is closely related with aforementioned alterations. There was no correlation between MMP-3 expression and age, gender and duration of the pain. Conclusion: For evaluating and treating IVD degeneration, MRI is a good and non-invasive diagnostic tool to determine the severity of degeneration. MMP-3 may be a therapeutic target of the degenerated IVD. Source


Kurt M.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Onal I.K.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Akdogan M.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Kekilli M.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | And 4 more authors.
Canadian Journal of Gastroenterology | Year: 2010

OBJECTIVE: To assess the hemostatic efficacy of the Ankaferd Blood Stopper (ABS, Ankaferd Health Products Ltd, Turkey) hemostatic agent for controlling gastrointestinal bleeding associated with various benign lesions refractory to conventional antihemorrhagic measures. METHODS: The records of all patients who underwent upper and lower endoscopy procedures at the Turkiye Yuksek Ihtisas Teaching and Research Hospital (Ankara, Turkey) between April 2008 and June 2009 were reviewed. Patients in whom ABS was used as a primary or adjuvant hemostatic agent were included in the study. Rates of bleeding control and postprocedural complications were documented. RESULTS: Hemostasis with no immediate complications was achieved in all patients within seconds of endoscopic application of ABS. CONCLUSIONS: ABS may have a role as a primary treatment or as an adjuvant to conventional modalities used to control gastrointestinal bleeding. Prospective controlled studies are needed to help establish its efficacy and, perhaps, offer a comparison with conventional hemostatic interventions. ©2010 Pulsus Group Inc. All rights reserved. Source


Beyazit Y.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Purnak T.,Ankara Numune Education and Research Hospital | Guven G.S.,Hacettepe University | Haznedaroglu I.C.,Turkiye Yuksek Ihtisas Teaching and Research Hospital
Cardiology Research and Practice | Year: 2011

Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis. Copyright © 2011 Yavuz Beyazit et al. Source


Okten S.,General Surgery Clinic | Kurt M.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Onal I.K.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Haznedaroglu I.C.,Hacettepe University
Singapore Medical Journal | Year: 2011

Variceal bleeding is one of the most important and life-threatening complications of portal hypertension. Although less common than oesophageal varices that have a lower frequency of bleeding, gastric varices tend to result in more severe and mortal bleeding. The Ankaferd Blood Stopper (ABS) has been used with varying success in recent years for the management of bleeding from skin lesions and after dental surgery, and in other clinical conditions in which conventional haemostatic measures have proved to be deficient. In serious bleeding gastric fundal varices, ABS can also act as a bridge in the absence or unavailability of definitive therapies. Source


Korkut E.,Ankara University | Bektas M.,Ankara University | Oztas E.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | Kurt M.,Turkiye Yuksek Ihtisas Teaching and Research Hospital | And 2 more authors.
European Journal of Internal Medicine | Year: 2010

Background and aims: Celiac disease shares several symptoms which constitute some of the ROME criteria used for the diagnosis of irritable bowel syndrome (IBS), and as such many patients with underlying Celiac disease may be mistakenly diagnosed as having IBS. The aim of the present study was to determine the prevalence of Celiac disease in patients with IBS fulfilling ROME III criteria. Materials and methods: Patients who fulfilled ROME III criteria for irritable bowel syndrome were screened for Celiac disease using the Biocard TM Celiac Disease Stick test, and patients who tested positive had their serum samples analyzed for antigliadin IgA and IgG, and anti-tissue transglutaminase IgA antibodies. Patients with detectable antibody levels underwent endoscopic duodenal biopsy to confirm a diagnosis of Celiac disease. Results: Two of 100 patients who were diagnosed as having irritable bowel syndrome as per the Roma III criteria were found to have elevated levels of serum antigliadin IgA and IgG, and anti-tissue transglutaminase IgA antibodies, with histological evidence of Celiac disease on examination of duodenal biopsy. Both patients were started on a gluten-free diet, showing significant improvement in their symptoms on follow-up. Conclusions: Celiac disease is a common finding among patients labeled as IBS. Celiac disease must be considered in differential diagnosis of IBS especially in the therapy refractory group. © 2010 European Federation of Internal Medicine. Source

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