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Bulbul O.,Istanbul University | Duvenci A.,Istanbul University | Zorlu T.,Istanbul University | Gurkan C.,Turkish Cypriot DNA Laboratory | And 4 more authors.
Forensic Science International: Genetics Supplement Series | Year: 2015

There are numerous ancestry informative markers (e.g., SNPs, InDels) used for distinguishing ancestral origins among continental regions of the world. This work presents the 46-plex ancestry informative InDels set data for three East European populations (Turkish, Turkish Cypriot and Azerbaijani). © 2015 Elsevier Ireland Ltd. Source

Canturk K.M.,Council of Forensic Medicine | Emre R.,Council of Forensic Medicine | Gurkan C.,Turkish Cypriot DNA Laboratory | Komur I.,Council of Forensic Medicine | And 2 more authors.
Medicine, Science and the Law | Year: 2016

Here, we report an incest paternity case involving three biological brothers as alleged fathers (AFs), their biological sister and her child that was investigated using the Investigator ESSplex Plus, AmpFLSTR Identifiler Plus/Investigator IDplex Plus and PowerPlex 16 kits. Initial duo paternity investigations using 15-loci autosomal short tandem repeat (STR) analyses failed to exclude any of the AFs. Despite the fact that one of the brothers, AF1, had a mismatch with the child at a single locus (D2S1338), the possibility of a single-step mutation could not be ruled out. When the number of autosomal STR loci analysed was increased to 22 without the inclusion of the mother, AF2 and AF3 still could not be excluded, since both of them again had no mismatches with the child. A breakthrough was possible only upon inclusion of the mother so that trio paternity investigations were carried out. This time AF1 and AF2 could be excluded at two loci (D2S1338 and D1S1656) and six loci (vWa, D1S1656, D12S391, FGA, PENTA E and PENTA D), respectively, and AF3 was then the only brother who could not be excluded from paternity. Subsequent statistical analyses suggested that AF3 could be the biological father of the child with a combined paternity index >100 billion and a probability of paternity >99.99999999%. These findings consolidate the fact that complex paternity cases such as those involving incest could benefit more from the inclusion of the mother than simply increasing the number of STR loci analysed. © 2015, © The Author(s) 2015. Source

Terali K.,Queen Mary, University of London | Terali K.,Turkish Cypriot DNA Laboratory | Beavil R.L.,Kings College London | Pickersgill R.W.,Queen Mary, University of London | van der Giezen M.,University of Exeter
Biochemical and Biophysical Research Communications | Year: 2013

Small inorganic assemblies of alternating ferrous/ferric iron and sulphide ions, so-called iron-sulphur (Fe-S) clusters, are possibly nature's most ancient prosthetic groups. One of the early actors in Fe-S cluster biosynthesis is a protein complex composed of a cysteine desulphurase, Nfs1, and its functional binding partner, Isd11. Although the essential function of Nfs1·Isd11 in the liberation of elemental sulphur from free cysteine is well established, little is known about its structure. Here, we provide evidence that shows Isd11 has a profound effect on the oligomeric state of Nfs1. © 2013 Elsevier Inc. Source

Pakstis A.J.,Yale University | Haigh E.,Yale University | Cherni L.,Tunis el Manar University | Cherni L.,University of Monastir | And 19 more authors.
Forensic Science International: Genetics | Year: 2015

Ancestry inference for a person using a panel of SNPs depends on the variation of frequencies of those SNPs around the world and the amount of reference data available for calculation/comparison. The Kidd Lab panel of 55 AISNPs has been incorporated in commercial kits by both Life Technologies and Illumina for massively parallel sequencing. Therefore, a larger set of reference populations will be useful for researchers using those kits. We have added reference population allele frequencies for 52 population samples to the 73 previously entered so that there are now allele frequencies publicly available in ALFRED and FROG-kb for a total of 125 population samples. 2015 The Authors. Published by Elsevier Ireland Ltd. Source

Gurkan C.,Turkish Cypriot DNA Laboratory | Demirdov D.K.,Turkish Cypriot DNA Laboratory | Yamaci R.F.,Sair Pembe Marmara Street No 10A | Yamaci R.F.,University of Regensburg | Sevay H.,Near East University
Forensic Science International: Genetics | Year: 2015

Fifteen autosomal short tandem repeat (STR) markers [D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA] were analyzed in 501 unrelated, randomly selected Turkish Cypriot individuals from the island of Cyprus. While no locus duplications or null alleles were detected in these samples, eight allelic variants were observed in total, 75% of which were intermediate allelic variants that were absent in the system allelic ladder. Allelic frequencies and statistical parameters of forensic interest were calculated at each locus. For the 15 STR loci tested, combined matching probability (pM) was 2.15717 × 10-18 and combined power of exclusion (PE) was 0.9999995213. No deviations from the Hardy-Weinberg equilibrium were observed, except for the vWA locus, which became insignificant after the Bonferroni correction for multiple testing. Locus-by-locus comparisons of the Turkish Cypriot allelic frequencies with those published for the neighboring and/or historically related populations with similar loci coverage (Turkish, Greek, Greek Cypriot, Italian and Lebanese) revealed some statistically significant differences at one to five loci. In general, an increase in the number of such significant differences between the Turkish Cypriot data and those for other populations correlated closely with an increase in the geographic distance and/or a decrease in the amount of historical contact. The Turkish Cypriot autosomal STR population study will find immediate use in the Committee on Missing Persons in Cyprus Project on the "Exhumation, Identification and Return of Remains of Missing Persons" and it will also be available for criminal, parentage and other missing person investigations. © 2014 Elsevier Ireland Ltd. Source

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