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Saglar E.,Hacettepe University | Unlu S.,Turkish Atomic Energy Authority | Babalioglu I.,Ankara University | Gokce S.C.,Ankara University | Mergen H.,Hacettepe University
Journal of Biochemical and Molecular Toxicology

Acute radiation leads to several toxic clinical states and triggers some molecular pathways. To shed light on molecular mechanisms triggered by ionizing radiation (IR), we examined the expression profiles of endoplasmic reticulum (ER) stress and autophagy-related genes in individuals who were exposed to IR. Blood samples were collected from 50 cancer patients before radiotherapy and on the 5th, 15th, and 25th days of the treatment. Peripheral blood samples from 10 healthy volunteers were also obtained for ex vivo irradiation, divided into five and irradiated at a rate of 373 kGy/h to 0, 0.1, 0.5, 1, and 3Gy γ-rays using a constant gamma source. GRP78, ATG5, LC3, ATF4, XBP1, and GADD153 genes were analyzed by quantitative real-time polymerase chain reaction (QRT-PCR) using beta 2 microglobulin (B2M) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as references. In both groups, expressions of the selected genes have increased. It can be concluded that IR induces ER stress and related authophagy pathway in the peripheral lymphocyte cells proportionally by dose. © 2014 Wiley Periodicals, Inc. Source

Deger C.,Marmara University | Ozdemir M.,Turkish Atomic Energy Authority | Yildiz F.,Kocaeli University
Journal of Magnetism and Magnetic Materials

Behavior of spin waves was investigated in patterned Mu-metal thin film both theoretically and experimentally. The Mu-metal(111) thinfilms with 7 nm thickness were grown by thermal evaporation technique in high vacuum condition. X-ray diffraction measurements showed that the film has a highly FCC crystalline structure. Saturation magnetization and coercive field values of sample obtained from vibrating sample magnetometer are around 500 emu/cm3 and 10 Oe respectively at room temperature. The patterns were square shaped and size of squares were changed between 40-80 μm. Theoretical model and computer program were developed for analyzing the FMR spectra. There is no magnetic anisotropy for in-plane and out-of-plane geometry by both theoretical and experimental investigations. Magnetostatic modes were observed for out-of-plane geometry and these modes were highly compatible with outputs of simulation model. © 2016 Elsevier B.V. Source

Akay A.N.,TOBB University of Economics and Technology | Karadeniz H.,Turkish Atomic Energy Authority | Sultansoy S.,TOBB University of Economics and Technology | Sultansoy S.,Azerbaijan Academy of Sciences
International Journal of Modern Physics A

There are three possible types of particle colliders schemes: familiar (well-known) ringring colliders, less familiar but sufficiently advanced linear colliders, and less familiar and less advanced linacring-type colliders. The aim of this paper is twofold: to present a possibly complete list of papers on linacring-type collider proposals and to emphasize the role of linacring-type machines for future HEP research. © 2010 World Scientific Publishing Company. Source

Kocmen M.A.,Turkish Atomic Energy Authority | Tegmen A.,Ankara University | Tureci D.,75. Yil Anadolu Lisesi | Gulecyuz M.C.,Ankara University | Tureci R.G.,Kirikkale University

The half-space albedo problem and the constant source problem have been solved for a combination of the linearly anisotropic scattering and İnönü's scattering functions. The linear transport equation for extremely anisotropic scattering kernel can be converted into an equivalent equation with a linearly anisotropic scattering kernel and the modified F N method can be used for albedo calculations. © Carl Hanser Verlag, München. Source

Bulut S.,Ankara Nuclear Research And Training Center | Celenk I.,Ankara Nuclear Research And Training Center | Artan S.,Turkish Atomic Energy Authority

The application of numerical codes is well established in the regulatory practice for nuclear power plants. Therefore, requirements for computer-aided analyses can be found in different places of the nuclear technical rules and standards. These requirements also apply for CFD analyses which reached more and more the spot light of research activities and component design, because computing capacities increased significantly in the past years. Hence, the actual status of CFD as a possible design and analysis tool in the supervising process of nuclear power plants will be discussed in this paper. The focus is set on the prerequisites which have to be fulfilled by codes and in particular by the user who wants to use CFD methods. The prerequisites will be derived directly from the existing German technical rules and standards. Finally, two examples for typical CFD applications for nuclear safety analyses are given. © Carl Hanser Verlag München. Source

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