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Gultekin S.S.,Diskapi Yildirim Beyazit Training and Research Hospital | Odabas O.,Turkey Yuksek Ihtisas Training and Research Hospital | Ginis Z.,Diskapi Yildirim Beyazit Training and Research Hospital | Gokce A.,Diskapi Yildirim Beyazit Training and Research Hospital | And 3 more authors.
Annals of Nuclear Medicine | Year: 2013

Objective: This study aimed to compare the effect on renal functions of ischemia-reperfusion (I-R) injury models by renal scintigraphy and to investigate possible correlations among scintigraphic, biochemical and pathological findings. Methods: An experimental I-R injury was performed on the left kidneys of 40 Wistar rats: pedincular continuous clamping in Group 1 (n = 10), pedincular cyclic clamping in Group 2 (n = 10), arterial continuous clamping in Group 3 (n = 10) and arterial cyclic clamping in Group 4 (n = 10). A functional and morphological assessment was made by 99mTc-MAG3 scintigraphy, biochemical tests and histopathological examination in the late period of I-R injury. Data were analyzed statistically. Results: Statistically significant differences were found in the peak counting (C max), normalized residual activity (NORA), renal retention (RR), split renal function (SRF) and the time to the C max (T max) parameters between the right and left kidneys in each group (p < 0.001). In multiple group comparisons for the left kidney statistically significant differences were determined for C max (F = 4.75, df = 3, p < 0.05), NORA (F = 4.362, df = 3, p < 0.05), RR (F = 10.49, df = 3, p < 0.001) and SRF (F = 4.17, df = 3, p < 0.05) but not T max (F = 1.13, df = 3, p > 0.05). The total scores of Groups 1, 2, 3, and 4 were, respectively, found to be 18, 30, 20 and 24 by grading of renogram curves and 22, 28, 23 and 25 by pathological scoring system. There was a significant correlation among the two score data (r = 0.867, p < 0.001). Conclusions: 99mTc-MAG3 scintigraphy was a reliable method to evaluate renal dysfunction in the late period of I-R injury. Cyclic clamping, especially pedincular type was compatible with higher tubular dysfunction and structural damage. © 2013 The Japanese Society of Nuclear Medicine. Source


Yuksel M.,Turkey Yuksek Ihtisas Training and Research Hospital | Kaplan M.,Turkey Yuksek Ihtisas Training and Research Hospital | Ates I.,Ankara Numune Training and Research Hospital | Kilic Z.M.Y.,Turkey Yuksek Ihtisas Training and Research Hospital | And 4 more authors.
Medicine (United States) | Year: 2016

Our aim in this study was to determine soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in celiac disease, and their association with the gluten diet and autoantibodies. Eighty patients with celiac diagnosis and 80 healthy control individuals with similar age, gender and body mass index to the patient group were included in the study. Serum sTWEAK and IL-17A levels were measured by the serum enzyme-linked immunosorbent assay kit. The median IL-17A (117.5 pg/mL vs. 56.7 pg/mL; P = 0.001) level in celiac patients was higher than in the control group, while the median sTWEAK (543 pg/mL vs. 643 pg/mL; P = 0.016) level in patients was determined to be lower. In the patient group, patients who complied with the gluten diet had a lower level of median IL-17A (98.1 pg/mL vs. 197.5 pg/mL; P = 0.034) and a higher level of sTWEAK (606 pg/mL vs. 522.8 pg/mL; P = 0.031) than those who did not adhere. Furthermore, the IL-17A level was higher and the sTWEAK level was lower in celiac patients with positive antibody than those with negative antibody. A positive correlation was determined among anti-gliadin antibody IgA, anti-gliadin antibody IgG, anti-tissue transglutaminase IgG levels and the IL-17A level, and a negative correlation was determined with the sTWEAK level. In celiac disease, the sTWEAK and IL-17A levels differ between patients who cannot adapt to the gluten diet and who are autoantibody positive, and patients who adapt to the diet and are autoantibody negative. We believe that sTWEAK and IL-17A are associated with the inflammation in celiac pathogenesis. © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source


Kaplan M.,Turkey Yuksek Ihtisas Training and Research Hospital | Yuksel M.,Turkey Yuksek Ihtisas Training and Research Hospital | Ates I.,Ankara Numune Training and Research Hospital | Yalin Kilic Z.M.,Turkey Yuksek Ihtisas Training and Research Hospital | And 3 more authors.
Inflammatory Bowel Diseases | Year: 2015

We aimed to identify the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 17A (IL-17A) in inflammatory bowel disease (IBD) and to examine their relationship with disease activity. Methods: A total of 92 patients with IBD, in which 54 patients were diagnosed with ulcerative colitis and 38 patients with Crohn's disease (CD), and 104 healthy controls were included in the study. The Rachmilewitz endoscopic activity index was calculated in ulcerative colitis, and the CD activity index was calculated in CD. Results: sTWEAK (P < 0.001) and IL-17A (P= 0.006) levels were higher in the IBD group than in the control group. Both in the IBD group and ulcerative colitis and CD subgroups, in active patients, sTWEAK and IL-17A levels were found to be higher than in inactive and control groups. In the IBD group, a positive correlation was determined between sTWEAK and IL-17A, and C-reactive protein, endoscopic activity index, and CD activity index. In multivariable regression analysis, C-reactive protein and sTWEAK levels were determined to be an independent risk factor for both endoscopic activity index and CD activity index. In receiver operating curve analysis, the sTWEAK level was determined to predict IBD with high sensitivity and specificity with a value of >588.34 pg/mL and activity with a value of >669.28 pg/mL. Conclusion: Based on these results, we ascertain that sTWEAK has a role in etiopathogenesis of IBD. In addition, we believe that sTWEAK could be used as a marker for both disease activity criteria and treatment monitoring. © 2015 Crohn's and Colitis Foundation of America, Inc. Source


Cetin E.H.O.,Turkey Yuksek Ihtisas Training and Research Hospital | Cetin M.S.,Turkey Yuksek Ihtisas Training and Research Hospital | Canpolat U.,Hacettepe University | Aydin S.,Turkey Yuksek Ihtisas Training and Research Hospital | And 4 more authors.
Biomarkers in Medicine | Year: 2016

Background: We assessed the predictive value of estimated whole blood viscosity (WBV) in-hospital and long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI). Materials & methods: One thousand eight hundred and thirty-five STEMI patients were followed up for median 34.6 months. WBV was calculated consistent with the de Simone's formula. Results: In-hospital and long-term major adverse cardiovascular events (MACE) demonstrated an incremental trend in ascending order of WBV tertiles at low and high shear rate. Kaplan-Meier analysis showed a higher occurrence of long-term MACE in third WBV tertiles compared with other tertiles. Conclusion: WBV seems to be a feasible prognostic indicator of short- and long-term cardiovascular adverse events in patients with STEMI. As an easily available parameter, WBV may be utilized in identifying high-risk patients for subsequent MACE. © 2016 Future Medicine Ltd. Source


Gazel E.,Turkey Yuksek Ihtisas Training and Research Hospital | Tastemur S.,Turkey Yuksek Ihtisas Training and Research Hospital | Acikgoz O.,Turkey Yuksek Ihtisas Training and Research Hospital | Yigman M.,Turkey Yuksek Ihtisas Training and Research Hospital | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Background: The aim of this study was to research the importance of the neutrophil to lymphocyte ratio (NLR) in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far. Materials and Methods: The data of 175 patients who were diagnosed with localised prostate cancer and underwent retropubic radical prostatectomy was retrospectively examined. Patient pre-operative hemogram parameters of neutrophil count, lymphocyte count and NLR were assessed. The patients whose PSAs were too low to measure after radical prostatectomy in their follow-ups, and then had PSAs of 0,2 ng/mL were considered as patients with PSA recurrence. Patients with recurrence made up Group A and patients without recurrence made up Group B. Results: In terms of the power of NLR value in distinguishing recurrence, the area under OCC was statistically significant (p<0.001) .The value of 2.494 for NLR was found to be a cut-off value which can be used in order to distinguish recurrence according to Youden index. According to this, patients with a higher NLR value than 2.494 had higher rates of PSA recurrence with 89.7% sensitivity and 92.6% specificity. Conclusions: There are certain parameters used in order to predict recurrence with today's literature data.We think that because NLR is easy to use in clinics and inexpensive, and also has high sensitivity and specificity values, it has the potential to be one of the parameters used in order to predict biochemical recurrence in future. Source

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