Turgut Ozal University

Turgut, Turkey

Turgut Ozal University

Turgut, Turkey
SEARCH FILTERS
Time filter
Source Type

Gencler O.S.,Turgut Ozal University | Gencler B.,Koru Hospital | Altunel C.T.,Veni Vidi Hospital | Arslan N.,Turgut Ozal University
Saudi Pharmaceutical Journal | Year: 2015

Levetiracetam (LEV) is an established second generation anti-epileptic drug and LEV associated severe cutaneous reactions are rare. Here we report the case of psoriasiform drug eruption in a patient with newly diagnosed epilepsy who had been treated with levetiracetam. To our knowledge this is the first report of a patient with a psoriasiform eruption that appeared after the administration of LEV. © 2015 The Authors.


Gokce E.C.,Turgut Ozal University | Kahveci R.,Canakkale State Hospital | Gokce A.,Diskapi Yildirim Beyazit Education and Research Hospital | Cemil B.,Turgut Ozal University | And 7 more authors.
Journal of neurosurgery. Spine | Year: 2016

OBJECTIVE Ischemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord. METHODS Thirty-two rats were randomly allocated into 4 groups. Group 1 underwent only laparotomy. For Group 2, aortic clip occlusion was introduced to produce I/R injury. Group 3 was given 30 mg/kg of methylprednisolone intraperitoneally immediately after the I/R injury. Group 4 was given 10 mg/kg of TQ intraperitoneally for 7 days before induction of spinal cord I/R injury, and administration was continued until the animal was euthanized. Locomotor function (Basso, Beattie, and Bresnahan scale and inclined plane test) was assessed at 24 hours postischemia. Spinal cord tissue samples were harvested to analyze tissue concentrations of malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1, superoxide dismutase, glutathione-peroxidase, catalase, and caspase-3. In addition, histological and ultrastructural evaluations were performed. RESULTS Thymoquinone treatment improved neurological outcome, which was supported by decreased levels of oxidative products (malondialdehyde and nitric oxide) and proinflammatory cytokines (tumor necrosis factor-α and interleukin-1), increased activities of antioxidant enzymes (superoxide dismutase, glutathione-peroxidase, and catalase), as well as reduction of motor neuron apoptosis. Light microscopy and electron microscopy results also showed preservation of tissue structure in the treatment group. CONCLUSIONS As shown by functional, biochemical, histological, and ultrastructural analysis, TQ exhibits an important protective effect against I/R injury of the spinal cord.


Gunes A.,Meteksan Savunma Sanayii A.S. | Bereketli A.,Meteksan Savunma Sanayii A.S. | Guldogan M.B.,Turgut Ozal University
2014 22nd Signal Processing and Communications Applications Conference, SIU 2014 - Proceedings | Year: 2014

Underwater acoustic vector sensors (AVS) are devices which can measure scalar pressure and three dimensional acceleration or particle velocity with only one sensor. Bearing estimation for the target can be accomplished by these four measured scalar values. Algorithms based on closed-form expressions or beamforming can be carried out for direction finding by using the axial projections of the gradient vector of the pressure from the target. In this work, the performances of direction of arrival estimation algorithms for underwater acoustic vector sensors are analyzed in detail under the effects of various error sources such as imperfect projections and ambient noise. © 2014 IEEE.


Sharifi A.,Auburn University | Kalin L.,Auburn University | Hantush M.M.,National Risk Management Research Laboratory | Isik S.,Turgut Ozal University | Jordan T.E.,Smithsonian Environmental Research Center
Ecological Modelling | Year: 2013

Described in this article is development and validation of a process based model for carbon cycling in flooded wetlands, called WetQual-C. The model considers various biogeochemical interactions affecting C cycling, greenhouse gas emissions, organic carbon export and retention. WetQual-C couples carbon cycling with other interrelated geochemical cycles in wetlands, i.e. nitrogen and oxygen; and fully reflects the dynamics of the thin oxidized zone at the soil-water interface. Using field collected data from a small wetland receiving runoff from an agricultural watershed on the eastern shore of Chesapeake Bay, we assessed model performance and carried out a thorough sensitivity and uncertainty analysis to evaluate the credibility of the model. Overall, model performed well in capturing TOC export fluctuations and dynamics from the study wetland. Model results revealed that over a period of 2 years, the wetland removed or retained equivalent to 47. ±. 12% of the OC carbon intake, mostly via OC decomposition and DOC diffusion to sediment. The study wetland appeared as a carbon sink rather than source and proved its purpose as a relatively effective and low cost mean for improving water quality. © 2013 Elsevier B.V.


PubMed | Turgut Ozal University, Canakkale State Hospital, Bülent Ecevit University, Hacettepe University and 4 more.
Type: Journal Article | Journal: Journal of neurosurgery. Spine | Year: 2016

OBJECTIVE Ischemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord. METHODS Thirty-two rats were randomly allocated into 4 groups. Group 1 underwent only laparotomy. For Group 2, aortic clip occlusion was introduced to produce I/R injury. Group 3 was given 30 mg/kg of methylprednisolone intraperitoneally immediately after the I/R injury. Group 4 was given 10 mg/kg of TQ intraperitoneally for 7 days before induction of spinal cord I/R injury, and administration was continued until the animal was euthanized. Locomotor function (Basso, Beattie, and Bresnahan scale and inclined plane test) was assessed at 24 hours postischemia. Spinal cord tissue samples were harvested to analyze tissue concentrations of malondialdehyde, nitric oxide, tumor necrosis factor-, interleukin-1, superoxide dismutase, glutathione-peroxidase, catalase, and caspase-3. In addition, histological and ultrastructural evaluations were performed. RESULTS Thymoquinone treatment improved neurological outcome, which was supported by decreased levels of oxidative products (malondialdehyde and nitric oxide) and proinflammatory cytokines (tumor necrosis factor- and interleukin-1), increased activities of antioxidant enzymes (superoxide dismutase, glutathione-peroxidase, and catalase), as well as reduction of motor neuron apoptosis. Light microscopy and electron microscopy results also showed preservation of tissue structure in the treatment group. CONCLUSIONS As shown by functional, biochemical, histological, and ultrastructural analysis, TQ exhibits an important protective effect against I/R injury of the spinal cord.


Bilgic I.C.,Turgut Ozal University | Gelecek S.,Ankara Numune Teaching and Research Hospital | Ozmen M.M.,Hacettepe University | Kasapoglu B.,Ankara University
Blood Coagulation and Fibrinolysis | Year: 2015

Mesenteric ischemia is a life-threatening vascular emergency with high mortality rates. Mean platelet volume (MPV) has been shown to be closely related to platelet activation. We investigated whether MPV was associated with outcome of acute mesenteric ischemia (AMI). Sixty-one patients who were operated for AMI were retrospectively evaluated. Patients were divided into two groups: survivors and nonsurvivors, according to the outcome, and the two groups were compared in terms of MPV levels and other prognostic factors. Urea, creatinine, alkaline phosphatase, amylase, gamma-glutamyl transferase and MPV levels were significantly higher in nonsurvivors, when compared to that of survivors. In addition, hypertension, atherosclerotic heart diseases and rhythm disorders were statistically significant risk factors for mortality. AMI is an uncommon but highly lethal surgical emergency. Our results indicate that an elevated MPV is associated with a worse outcome in patients with AMI. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Ozcan R.,Turgut Ozal University | Altingovde I.S.,Middle East Technical University | Cambazoglu B.B.,Yahoo! | Ulusoy O.R.,Bilkent University
ACM Transactions on the Web | Year: 2013

Web search engines are known to cache the results of previously issued queries. The stored results typically contain the document summaries and some data that is used to construct the final search result page returned to the user. An alternative strategy is to store in the cache only the result document IDs, which take much less space, allowing results of more queries to be cached. These two strategies lead to an interesting trade-off between the hit rate and the average query response latency. In this work, in order to exploit this trade-off, we propose a hybrid result caching strategy where a dynamic result cache is split into two sections: an HTML cache and a docID cache. Moreover, using a realistic cost model, we evaluate the performance of different result prefetching strategies for the proposed hybrid cache and the baseline HTML-only cache. Finally, we propose a machine learning approach to predict singleton queries, which occur only once in the query stream. We show that when the proposed hybrid result caching strategy is coupled with the singleton query predictor, the hit rate is further improved. © 2013 ACM.


Eren A.,Turgut Ozal University | Bilgin H.,Turgut Ozal University | Kara S.,Turgut Ozal University
Asia Pacific journal of clinical nutrition | Year: 2015

Abstract available from the publisher.For infants with high arched palate, feeding is one of the most immediate challenges faced by parents and caretakers. General suggestions for feeding in infants with cleft palate may be adapted to infants with high arched palate. These include oral feeding facilitation techniques and special feeding tools. Here we present a newborn with a high arched palate and serious feeding problems who was fed easily by a large size and a large hole nipple, ordinarily used for infants older than 6 months, instead of specialized feeding equipment.


Bilgin H.,Turgut Ozal University | Eren A.,Turgut Ozal University | Kara S.,Turgut Ozal University
Asia Pacific journal of clinical nutrition | Year: 2015

Abstract available from the publisher.BACKGROUND: The possible pathophysiology of the relationship between gastro-esophageal reflux disease and apnea of prematurity has been widely investigated. Various physiological protective reflex responses provide a plausible biological link between gastro-esophageal reflux and apnea of prematurity. It is uncertain whether or not there is a causal relationship between the two diseases. PATIENT'S FINDINGS: Twins were admitted to the neonatal intensive care unit due to feeding problems. Physical examination was normal except for reticulated, blueviolet skin changes. Short apneic attacks occurred on the first day in twin 1 and on the second day in twin 2, and these were initially treated by stimulation and increased ambient O2 concentration. Then, we conducted methylxanthine and continuous positive airway pressure treatment. Laboratory and radiological analysis were normal. As gastro-esophageal reflux disease was thought to be the causes of the treatment-refractory apnea, therapy with gaviscon and domperidon was begun for both cases. Apneic attacks did not recur after gaviscon and domperidon therapy.CONCLUSION: Pharmacological therapy for gastro-esophageal reflux disease has not definitively been shown to be effective in improving symptoms and hence, should be reserved especially for infants with treatment refractory apnea episodes suspected as being gastro-esophageal reflux in premature infants.


PubMed | Turgut Ozal University and Zekai Tahir Burak Womens Health Education and Research Hospital
Type: Journal Article | Journal: Journal of physical therapy science | Year: 2016

[Purpose] The aim of this study was to translate the Pregnancy Physical Activity Questionnaire into Turkish and test its reliability and validity among Turkish pregnant women. [Subjects and Methods] The subjects were 204 healthy, single pregnant women between the ages 18 and 40 who volunteered to participate in this study. Reliability was evaluated by measuring the one-week test-retest reliability with the intraclass correlation coefficient and Pearsons correlation analysis. Concurrent validity was examined by comparing the Pregnancy Physical Activity Questionnaire with the long form of the International Physical Activity Questionnaire and step counts with pedometer. [Results] The mean age of the participants was 28.234.94years, and the mean for BMI was 26.094.40. For test-retest reliability, r values were respectively 0.961, 0.934, 0.957 and 0.981 for self-reported sedentary, light, moderate, and vigorous activity, respectively. Intraclass correlation coefficient scores ranged from 0.924 to 0.993. For validity, the Pearsons correlation coefficients between the Pregnancy Physical Activity Questionnaire and long form of the International Physical Activity Questionnaire ranged from moderate (r = 0.329) to high (r = 0.672). The correlation value between the total score of the Pregnancy Physical Activity Questionnaire and the step counts was 0.70. [Conclusion] The Turkish version of the Pregnancy Physical Activity Questionnaire is a valid and reliable tool for measurement of the physical activity level of pregnant women.

Loading Turgut Ozal University collaborators
Loading Turgut Ozal University collaborators