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Yang C.-T.,Tunghai University | Chen C.-H.,Tungs Taichung MetroHarbor Hospital | Yang M.-F.,Tunghai University
Future Generation Computer Systems | Year: 2010

There are two challenges of using the PACS (Picture Archiving and Communications System). First, PACS are limited to certain bandwidths and locations. Second, the high cost of maintaining Web PACS and the difficult management of Web PACS servers. Besides, the quality of transporting images and the bandwidth of accessing large files from different locations are difficult to guarantee. For instance, radiologists make use of PACS information system for achieving high-speed accessing medical images. Physicians, on the other hand, utilize web browsers to indirectly access the PACS information system via non-high-speed network. The insufficient bandwidth may cause bottleneck under a host of querying and accessing. As hospitals exchange large files such as medical images with each other via WANs, the bandwidth cannot support the huge amount of file transportation. In this paper, we propose a PACS based on data grids, and utilize MIFAS (Medical Image File Accessing System) to perform querying and retrieving medical images from the co-allocation data grid. MIFAS is also suitable for data grid environments with a server node and several client nodes. MIFAS can take advantage of the co-allocation modules to reduce the medical image transfer time. Also, we provide experiments to show the performance of MIFAS. Furthermore, in order to enhance the security, stability and reliability in the PACS, we also provide the user-friendly management interface. © 2010 Elsevier B.V. All rights reserved. Source


Lin J.-W.,National Chung Hsing University | Chen C.-M.,Tungs Taichung MetroHarbor Hospital | Chang C.-C.,National Chung Hsing University
Vector-Borne and Zoonotic Diseases | Year: 2011

Bartonella henselae, the etiologic agent of cat-scratch disease, rarely causes back pain and is considered to be transmitted through animal scratches and bites. Here we report a cat-scratch disease case possibly with an unusual route of transmission. The patient was a 32-year-old man, and he was working as a veterinarian in a private veterinary clinic. He sought for clinical help because of unknown fever and persistent back pain for at least a month after an accidental needle puncture. Through serological testing and molecular identifications, this clinical case was confirmed to be caused by B. henselae. © Copyright 2011, Mary Ann Liebert, Inc. 2011. Source


Chou T.-C.,National Defense Medical Center | Shih C.-Y.,A-Life Medical | Chen Y.-T.,Tungs Taichung MetroHarbor Hospital
Journal of Agricultural and Food Chemistry | Year: 2011

Peroxisome proliferator-activated receptors (PPARs) isoforms (α, β/δ, and γ are present in human platelets, and activation of PPARs inhibits platelet aggregation. α-Lipoic acid (ALA), occurring naturally in human food, has been reported to exhibit an antiplatelet activity. However, the mechanisms underlying ALA-mediated inhibition of platelet aggregation remain unknown. The aim of this study was to investigate whether the antiplatelet activity of ALA is mediated by PPARs. ALA itself significantly induced PPARα/γ activation in platelets and increased intracellular amounts of PPARα/γ by blocking PPARα/γ secretion from arachidonic acid (AA)-activated platelets. Moreover, ALA significantly inhibited AA-induced platelet aggregation, Ca2+ mobilization, and cyclooxygenase-1 (COX-1) activity, but increased cyclic AMP production in rabbit washed platelets. Importantly, ALA also enhanced interaction of PPARα/γ with protein kinase Cα (PKCα) and COX-1 accompanied by an inhibition of PKCα activity in resting and AA-activated platelets. However, the above effects of ALA on platelets were markedly reversed by simultaneous addition of selective PPARα antagonist (GW6471) or PPARγ antagonist (GW9662). Taken together, the present study provides a novel mechanism by which ALA inhibition of platelet aggregation is mediated by PPARα/γ-dependent processes, which involve interaction with PKCα and COX-1, increase of cyclic AMP formation, and inhibition of intracellular Ca2+ mobilization. © 2011 American Chemical Society. Source


Lin L.-F.,Tungs Taichung MetroHarbor Hospital
Diagnostic and Therapeutic Endoscopy | Year: 2014

Background. Transpancreatic precut sphincterotomy (TPS) is an option for difficult common bile duct (CBD) access, and the reports are few, with immediate success rate varying from 60 to 96%. The description of relation between the size of TPS and the immediate success rate of CBD cannulation was not found in the literature. The Aim of the Study. To evaluate the relation of large TPS to immediate success rate of CBD cannulation. Methods. A retrospective analysis was performed in prospectively collected data of 20 patients. TPS was performed with traction papillotome in the main pancreatic duct (MPD) directing towards 11 o'clock. Needle knife (NK) was used to enlarge TPS in five patients, and the other 15 cases had large TPS from the beginning of sphincterotomy. Prophylactic pancreatic stent was inserted in 18 cases, with diclofenac given in 12 cases. Results. The immediate success rate of CBD cannulation was 90% and with an eventual success rate of 100%. The failure in one immediate CBD cannulation with large TPS was due to atypical location of CBD orifice, and the other failed immediate CBD cannulation was due to inadequate size of TPS. Complications included 3 cases of post-TPS bleeding and 3 cases of mild pancreatitis. Conclusion. TPS is an effective procedure in patients with difficult biliary access and can have high immediate success rate with large TPS. © 2014 Lien-Fu Lin. Source


Ma C.-L.,Tungs Taichung MetroHarbor Hospital | Chang W.-P.,Taipei Medical University | Lin C.-C.,Taipei Medical University
Supportive Care in Cancer | Year: 2014

Purpose: This study aimed to explore the relationships among pain, sleep disturbance, and circadian rhythms in advanced cancer patients. Methods: This cross-sectional study was conducted in 68 cancer patients from the oncology inpatient unit of a teaching hospital. Their demographic and medical characteristics, questionnaire surveys, including Brief Pain Inventory-Chinese version and Pittsburgh Sleep Quality Index Taiwanese version, and sleep logs and actigraphic recordings in consecutive 3 days and nights were collected and analyzed. Results: The mean (SD) scores for autocorrelation coefficient at 24 h (r24) and dichotomy index (I Source

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