Tumour Biology Group

North Guwāhāti, India

Tumour Biology Group

North Guwāhāti, India
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Wang K.,Tumour Biology Group | Wang K.,Jilin University | Bacon M.L.,Tumour Biology Group | Tessier J.J.,Tumour Biology Group | And 5 more authors.
Journal of Cell Death | Year: 2012

Recent evidence suggests that protein encoded by the RNA Binding Motif 10 (RBM10) gene has the ability to modulate apoptosis. The objective of this study was to test this hypothesis by manipulating RBM10 expression levels and examining the down-stream consequences. The results showed that transient overexpression of RBM10 correlated with significantly elevated levels of tumour necrosis factor alpha (TNF-α) mRNA and soluble TNF-α (sTNF-α) protein, and increased apoptosis (phosphatidyl serine exposure on the outer cell membrane and nuclear condensation). Stable RNA interference-mediated RBM10 knockdown clones were less susceptible to TNF-α-mediated apoptosis, and had decreased sTNF-α protein levels. Elevated levels of TNF-α associated with RBM10 overexpression resulted from increased TNF-α transcription, not TNF-α mRNA stabilization. These results suggest that RBM10has the ability to modulate apoptosis, and that it does so via a mechanism involving alterations to TNFR super family-mediated signaling. These data provide the first direct evidence that human RBM10 can function as an apoptosis modulator and cytokine expression regulator. © the author(s), publisher and licensee Libertas Academica Ltd.


Karthikeyan C.,Rajiv Gandhi Technical University | Solomon V.R.,Tumour Biology Group | Solomon V.R.,Laurentian University | Lee H.,Tumour Biology Group | And 2 more authors.
Biomedicine and Preventive Nutrition | Year: 2013

Isatins are endogenous molecules present in human and mammals which exhibits diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures in numerous natural products belonging to the flavonoid family, show potent anticancer properties. A novel series of 3-(2-oxo-2-phenylethylidene)indolin-2-ones incorporating pharmacophoric elements of isatins and chalcones were designed and synthesized. The compounds were evaluated for anticancer activity against three breast cancer cell lines. Most of the compounds showed promising anticancer activity (<20μM) against the studied cell lines. Compound 2c, bearing a 5-chloro substituent in the benzo ring of the isatin moiety and 3,4-dimethoxy substitutions in the phenyl ring, was found to be the most active in the series with GI50 values of 8.54, 4.76 and 3.59 against MDA-MB231, MDA-MB468 and MCF7 cells, respectively. Overall, the findings of the study highlight 3-(2-oxo-2-phenylethylidene)indolin-2-one as a potential new lead in the search of drugs for the treatment of breast cancer. © 2013 Elsevier Masson SAS.


Karthikeyan C.,Rajiv Gandhi Technical University | Solomon V.R.,Tumour Biology Group | Solomon V.R.,Laurentian University | Lee H.,Tumour Biology Group | And 2 more authors.
Arabian Journal of Chemistry | Year: 2013

A series of novel substituted 2-(phenyl)-3H-benzo[d]imidazole-5-carboxylic acids (1a-1j) and its methyl esters (2a-2f) were synthesized and examined for their antiproliferative effects against three breast cancer cell lines (MDA-MB231, MDA-MB468 and MCF7) in vitro. Most of the compounds exhibited comparable or greater antiproliferative effects than the reference compound cisplatin. Compound 2e bearing 5-fluoro-2-hydroxyphenyl substituent was found to be the most active derivative of the series with GI50 values of 6.23, 4.09 and 0.18 μM against MDA-MB468, MDA-MB231 and MCF7 breast cancer cell lines, respectively. Our findings described here exemplify the usefulness of the title compounds as a lead for the development of more effective cancer therapeutics for the treatment of breast cancer. © 2013.

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