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Mi Z.,Tumor Radiation Therapy Center | Zang Z.,Tumor Radiation Therapy Center | Zhang X.,Tumor Radiation Therapy Center
Cancer Research and Clinic | Year: 2015

Objective: To evaluate the efficacy and untoward effects of brucea javanica oil emulsion combined with radiotherapy in the treatment of patients with esophageal cancer. Methods:50 initial treatment patients with esophageal squamous cell carcinoma were randomly assigned to observation group (25 cases) and control group (25 cases). All patients were treated with three dimensional conformal intensity modulated radiation therapy (3D-IMRT) and the radiation dose was 64 Gy/32 times (95 % PIT). The patients in observation group received the treatment of brucea javanica oil emulsion during radiotherapy. The differences between the two groups were compared in respect of the efficacy, the adverse reactions and the quality of life (QOL). Results: The effective rate in observation group was 92 % (23/25) and it was 68 % (17/25) in control group, there was significant difference between the two groups (χ2 = 4.500, P = 0.034). The incidence of radiation esophagitis at the level of RTOG2 and above in observation group was 20 % (5/25) and it was 60 % (15/25) in the control group, there was significant difference between the two groups (χ2 = 8.333, P = 0.004). The improvement rate of QOL in observation group was 68 % (17/25) and it was 40 % (10/25) in control group, there was significant difference between the two groups (χ2 = 3.945, P = 0.047). Conclusion: Brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer can improve the therapeutic effect and QOL, it can also reduce radiation reactions. Source


Mi Z.,Tumor Radiation Therapy Center | Zang Z.,Tumor Radiation Therapy Center | Zhang X.,Tumor Radiation Therapy Center | Zhang S.,Tumor Radiation Therapy Center | Fan L.,Tumor Radiation Therapy Center
Cancer Research and Clinic | Year: 2015

Objective: To explore the related factors of tumor regression speed during radiotherapy for esophageal cancer and analyze the relationship between recent clinical curative effect and tumor regression speed. Methods: 68 previously untreated esophageal cancer patients were treated with three dimensional conformal intensity modulated radiation therapy (3D-IMRT). The radiation dose was 64 Gy/32 times (95 % PTV). All the patients were divided into 3 groups according to the size of primary lesions during the entire course of radiotherapy. Fast regression was defined as a complete response before dose 32 Gy, slow regression with dose in the range of 64 Gy and other cases as residual disease. The correlations of tumor regression speed with age, gender, classification, length of lesion and the lesion location were analyzed. And the relationship between recent clinical curative effect and tumor regression speed was discussed. Results: The age, gender, classification and the lesion location were not associated with tumor regression (P > 0.05). There was a negative correlation between tumor regression speed and the length of lesion [88.9 % (16/18), 69.2 % (18/26) and 12.5 % (3/24) in fast, slow and residual group, respectively, χ2 = 27.923, P < 0.05]. There was a positive correlation between recent clinical curative effect and tumor regression speed (r = 0.415, P < 0.05). Conclusion: The length of primary lesion is an independent risk factor for recent clinical curative effect and tumor regression speed of esophageal cancer patients treated with 3D-IMRT. Source

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