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Tübingen, Germany

Hussain M.,Tuebingen University
RSC Advances | Year: 2015

One of the challenges faced by today's clinics is unavailability of practical, precise and accurate determination of the most commonly used anti-coagulant 'heparin' in human blood/plasma in surgery. This is the first report of the application of a heparin imprinted thin film on a Quartz Crystal Microbalance with Dissipation (QCM-D) platform. Based on a novel, straight-forward and robust imprinting approach, a lowest volume consumption of 2 μL of real sample (of human plasma) has been demonstrated. This is a leap for launching spot testing for heparin sensing in laboratory practice. This approach could shorten the coagulation times to 48% and 45% for clinically important sensing range of heparin doses of 0.75 and 0.50 IU mL-1 respectively and could improve precision 3-fold (n = 20 samples) compared to that of today's 'gold standard'. Activated partial thromboplastin time (aPTT) on the plastic antibodies based QCM-D platform for plasma with doses of heparin 0.75 IU mL-1 and 0.50 IU mL-1 yielded 6.5% and 5% lower %RSD respectively as compared to that of the 'gold standard'. The present studies could provide a launch pad to laboratory methods for ultra-refining of point of care (POC) settings in the perspectives of coagulation time shortening, precision of the method and sample volume consumption. This journal is © The Royal Society of Chemistry 2015. Source

How should we shape the practice of pastoral care, especially in the context of bioethical counseling? Martin Luther grounded it in a mutual dialogue of brethren. Friedrich Schleiermacher transformed this Protestant understanding according to the modern ideals of freedom and responsibility for oneself. In response to the other basic question of pastoral care: What is the human soul?, Sigmund Freud overcame the Platonic model undergirding Schleiermacher's account. Whoever seeks to care for his own soul and the soul of the other should learn from Freud. One of the most fruitful consequences of such study lies in the formation of a mature religiosity. Another such consequence concerns the pastor's aspiring to an attitude of self-control in counseling. Building one's own competence on the experience and the knowledge of Freud can help one counteract the temptation to transfer one's own (unconscious) wishes onto the conversation partner and conversely to ward off transference from the other onto oneself. On the level of ideals and ultimate principles, however, Christian pastors, unlike Freud, will not see fate and the anonymous forces of Eros and Thanatos, as the ultimate last horizons of human self-understanding. Instead, the good news of sinful man's justification by God transcends even the limits of human existence imposed by fate. © The Author 2010. Published by Oxford University Press, on behalf of The Journal of Christian Bioethics, Inc. All rights reserved. Source

Schlegel M.,Tuebingen University
Nuovo Cimento della Societa Italiana di Fisica C | Year: 2012

It is argued that transverse-momentum-dependent (TMD) gluonic parton distributions can be relevant for physics probed in proton collisions at high energies. The production of two real photons in proton collisions is discussed within the framework of TMD factorization at small transverse pair momenta where information on gluon TMDs can be extracted. Spin-dependent gluon TMDs can be studied in polarized proton collisions at RHIC. On the other hand, the effect of the distribution of linearly polarized gluons on unpolarized proton collisions at the LHC may be utilized to determine the parity of the Higgs boson. © Societa Italiana di Fisica. Source

Schlegel M.,Tuebingen University
Progress in Particle and Nuclear Physics | Year: 2012

The role of transverse momentum dependent (TMD) gluonic parton distributions is discussed for proton collisions at high energies. In particular the production of two real photons in proton collisions in the kinematical regime of small transverse pair momenta may be used to obtain information on gluon TMDs. While spin-dependent gluon TMDs can be studied in polarized proton collisions at RHIC the effect of linearly polarized gluons on unpolarized proton collisions at the LHC may be utilized to determine the parity of the Higgs boson. © 2012 Elsevier B.V. All rights reserved. Source

Abdanipour A.,Islamic Azad University at Ardabil | Abdanipour A.,Tarbiat Modares University | Schluesener H.J.,Tuebingen University | Tiraihi T.,Tarbiat Modares University
Iranian Biomedical Journal | Year: 2012

Background: The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory and repair processes. Methods: In this study, rats were randomly assigned to five experimental groups (laminectomy, untreated, and three VPA-treated groups). For SCI, severe contusion was used. In treated groups, VPA was administered intraperitoneally at doses of 100, 200 and 400 mg/kg daily three hours after injury for 7 days. To compare locomotor improvement among experimental groups, behavioral assessments were performed by the Basso, Beattie and Bresnahan (BBB) rating scale. The expression of neurotrophins was evaluated by RT-PCR and real-time PCR. Results: VPA administration increased regional brain-derived neurotrophic factor and glial cell-derived neurotrophic factor mRNA levels. Local inflammation and the expression of the lysosomal marker ED1 by activated macrophages/microglial cells were reduced by VPA and immunoreactivity of acetylated histone and microtubule-associated protein were increased. Conclusion: The results showed a reduction in the development of secondary damage in rat spinal cord trauma with an improvement in the open field test (BBB scale) with rapid recovery. Source

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