Munich, Germany
Munich, Germany

The Technische Universität München is a research university with campuses in Munich, Garching and Freising-Weihenstephan. It is a member of TU9, an incorporated society of the largest and most notable German institutes of technology. Wikipedia.

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TU Munich | Date: 2016-11-28

A method is provided for demodulation of an analog receive signal carrying information, wherein a number of more than two analog signals is formed from the receive signal in separate channels such that the receive signal is multiplied in each case by a period function, the phase thereof respectively differing in the channels, and wherein the multiple signals are each low-pass filtered.

Duell M.,TU Munich
Communications in Mathematical Physics | Year: 2017

We develop Haag–Ruelle scattering theory for Wigner particles in local relativistic Quantum Field Theory without assuming mass gaps or any other restrictions on the spectrum of the mass operator near the particle masses. Our approach is based on the Reeh–Schlieder property of the vacuum state. It is shown that a strengthened variant of this property, concerning the relative approximation error for single-particle states, implies the existence of scattering states. © 2017, Springer-Verlag Berlin Heidelberg.

Kinder H.,TU Munich
IEEE Transactions on Applied Superconductivity | Year: 2017

A successful method for the fabrication of coated conductors is winding the tape helically around a drum and rotating it in vacuum between a deposition zone and an oxidation zone. This is a batch process, however, so that the conductor length is limited by the size of the drum. Scaling up then means ever larger vacuum systems. This problem can be overcome by using a continuous process with co-rotating reels where the tape is shifted along the drum surface. This shift can be easily accomplished by inducing a stick-slip motion. As a byproduct, the uniformity is increased because the conductor is subjected to the same conditions over its entire length. Here, an experimental model is described that has reached tape speeds of 2 m/min, enough for production. The corresponding theory indicates that the parameters can be optimized even further. © 2002-2011 IEEE.

This paper investigates the manipulation of reputation in the context of innovation and knowledge exchange communities. Reputation is crucial for overcoming the free-riding problem and enables community members to be rewarded because their contributions to the common good can be measured. However, the concept of reputation can include the notion of manipulation, which we define as the attempt to change one's reputation without contributing to the community. To investigate the topic of reputation manipulation, we build on the concept of reputation-based reward systems and extend it by distinguishing between implicit reputation, which is uncodified, and explicit reputation, which is codified and centrally counted. We argue that the possibilities for manipulation differ between these two distinctions. We investigate reputation manipulation empirically in the context of science, which is built on an explicit reputation-based reward system, and we use the received citations as an indicator for reputation. We distinguish two forms of manipulation—unjustified self-citing and unjustified reciprocal citing—and find evidence of both within a bibliometric dataset. This paper contributes to the design of knowledge exchange communities by highlighting the opportunities and challenges arising from explicit reputation-based reward systems, specifically the opportunities for manipulation. It also contributes to the work on misconduct in science. © 2017 Elsevier B.V.

Lowke D.,TU Munich | Gehlen C.,TU Munich
Cement and Concrete Research | Year: 2017

This paper considers the zeta potential of Portland cement and mineral additions in cementitious suspensions with high solid fractions and ionic strengths typical for fresh concrete. The zeta potentials of additions were measured for suspensions to which different salts were added. Furthermore, suspensions made with synthetic and real aqueous phases extracted from cement pastes were investigated. It is shown that the concentrations of divalent calcium and sulphate ions determine the zeta potential. Owing to the adsorption of these ions, the zeta potentials of the additions tend towards similar low absolute values. Furthermore, the effect of aqueous phase composition on the zeta potential of cementitious suspensions was quantified. It was found that the composition of the aqueous phase is of greater importance than the type of the addition. The zeta potential of highly concentrated cementitious suspensions is determined by the molar Ca/SO4 concentration ratio and increases with this ratio. © 2017 Elsevier Ltd

Winter S.,TU Munich
WCTE 2016 - World Conference on Timber Engineering | Year: 2016

Wood is good! - A statement - used by the New Zealand wood promotion - which should face on a World Conference of Timber Engineering no opposition. But - is it true without any restrictions? Aren't there a lot of prejudices of customers and pure rejections from other building industries and often from building authorities? Is the material sustainable available? Are enough skilled workers and fabrication facilities and is enough knowledge available? These and other questions are raised in the presentation and options for possible consequences, further research, development of woodworking industry or education and knowledge spread are given.

Objective:Examination of major duodenal papilla (MDP) by standard forward-viewing esophagogastroduodenoscopy (S-EGD) is limited. Cap assisted esophagogastroduodenoscopy (CA-EGD) utilizes a cap fitted to the tip of the endoscope that can depress the mucosal folds and thus might improve visualization of MDP. The aim of this study was to compare CA-EGD to S-EGD for complete examination of the MDP.Methods:Prospective, randomized, blinded, controlled crossover study. Subjects scheduled for elective EGD were randomized to undergo S-EGD (group A) or CA-EGD (group B) before undergoing a second examination by the alternate method. Images of the MDP were evaluated by three blinded multicenter-experts. Our primary outcome measure was complete examination of the papilla. Secondary outcome measures were duration and overall diagnostic yield.Results:A total of 101 patients were randomized and completed the study. Complete examination of MDP was achieved in 98 patients using CA-EGD compared to 24 patients using S-EGD (97 vs. 24%, P<0.001). Median duration from intubation of the esophagus until localization of the MDP was shorter with CA-EGD (46. vs. 96 s., P<0.001). In group A, 11 extra lesions and 12 additional incidental findings were detected by secondary CA-EGD, whereas neither were detected by secondary S-EGD in group B (22 vs. 0% and 24 vs. 0%, P<0.001 and P<0.001).Conclusion:CA-EGD enabled complete examination of MDP in almost all cases compared to a low success rate of S-EGD. CA-EGD detected a significant amount of lesions and incidental findings when added to S-EGD. CA-EGD is a safe and effective method for examination of MDP.Am J Gastroenterol advance online publication, 14 March 2017; doi:10.1038/ajg.2017.47. © 2017 American College of Gastroenterology

Naber A.,TU Munich
Computers and Operations Research | Year: 2017

This paper addresses the resource-constrained project scheduling problem with flexible resource profiles (FRCPSP) in continuous time. In contrast to the discrete-time system, each task may start, end, or change its resource allocation at any point in time. The additional decisions for the continuous times of these events greatly amplify the problem complexity. We propose a mixed-integer linear programming model together with problem-specific inequalities and heuristic time limits, both of which are applied in the branch-and-cut procedure. In addition, the fractional period-width preprocessing and heuristic as well as the event estimation method are proposed to estimate the time and event parameters. Through the computational results, we investigate the pros and cons of the continuous-time model against the discrete-time counterpart both in terms of solution quality and runtimes, as well as the effectiveness of the preprocessing and different solution procedures. © 2017 Elsevier Ltd

Gong X.Y.,TU Munich | Schaufele R.,TU Munich | Schnyder H.,TU Munich
Journal of Experimental Botany | Year: 2017

Bundle-sheath leakiness (φ) is a key parameter of the CO2-concentrating mechanism of C4 photosynthesis and is related to leaf-level intrinsic water use efficiency (WUEi). This work studied short-term dynamic responses of φ to alterations of atmospheric CO2 concentration in Cleistogenes squarrosa, a perennial grass, grown at high (1.6 kPa) or low (0.6 kPa) vapour pressure deficit (VPD) combined with high or low N supply in controlled environment experiments. φ was determined by concurrent measurements of photosynthetic gas exchange and on-line carbon isotope discrimination, using a new protocol. Growth at high VPD led to an increase of φ by 0.13 and a concurrent increase of WUEi by 14%, with similar effects at both N levels. φ responded dynamically to intercellular CO2 concentration (Ci), increasing with Ci. Across treatments, φ was negatively correlated to the ratio of CO2 saturated assimilation rate to carboxylation efficiency (a proxy of the relative activities of Rubisco and phosphoenolpyruvate carboxylase) indicating that the long-term environmental effect on φ was related to the balance between C3 and C4 cycles. Our study revealed considerable dynamic and long-term variation in φ of C. squarrosa, suggesting that φ should be determined when carbon isotope discrimination is used to assess WUEi. Also, the data indicate a trade-off between WUEi and energetic efficiency in C. squarrosa. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Amjad R.A.,TU Munich
2016 15th International Symposium on Problems of Redundancy in Information and Control Systems, REDUNDANCY 2016 | Year: 2016

Resolution Coding deals with the problem of approximate random number generation when the input is uniform Discrete Memoryless Source (DMS) and the measure of approximation is un-normalized divergence. The minimum number of input symbols required per output symbol equal entropy of the target DMS. In this paper we present two practical resolution encoders inspired by the exact random number generation algorithm by Knuth and Yao. We show the asymptotic optimality of these encoders and provide a numerical comparsion with the fixed-to-variable length resolution encoder in [1]. © 2016 IEEE.

Wilde F.,TU Munich
ACM International Conference Proceeding Series | Year: 2017

SRAM-based physical unclonable functions (SRAM PUFS) derive a device dependent secret from the start-up pattern of their memory cells and have shown very promising results in previous publications. This work presents a dataset measured on 144 Infineon XMC4500 microcontrollers containing 160 KiB of SRAM sampled 101 times each in 2015 and 2016. Analyses are done using state-of-the-art metrics by Maiti et al., Hori et al., and by custom inspections. In extensive comparison to previous work, this work is found to score best in average Reliability and Bit-Alias, match with previous top results in average Uniformity and still mid-range in Uniqueness. This confirms previous results that general purpose SRAM on microcontrollers is adequate for most PUFapplications. To support further research into SRAM PUFS and their post-processing, the full dataset originating from this work will be made publicly available on the internet. © 2017 Copyright held by the owner/author(s).

Holzl J.,TU Munich
CPP 2017 - Proceedings of the 6th ACM SIGPLAN Conference on Certified Programs and Proofs, co-located with POPL 2017 | Year: 2017

Markov processes with discrete time and arbitrary state spaces are important models in probability theory. They model the infinite steps of non-terminating programs with (not just discrete) probabilistic choice and form the basis for further probabilistic models. Their transition behavior is described by Markov kernels, i.e. measurable functions from a state to a distribution of states. Markov kernels can be composed in a monadic way from distributions (normal, exponential, Bernoulli, etc.), other Markov kernels, and even other Markov processes. In this paper we construct discrete-time Markov processes with arbitrary state spaces, given the transition probabilities as a Markov kernel. We show that the Markov processes form again Markov kernels. This allows us to prove a bisimulation argument between two Markov processes and derive the strong Markov property.We use the existing probability theory in Isabelle/HOL and extend its capability to work with Markov kernels. As application we construct continuous-time Markov chains (CTMCs). These are constructed as jump & hold processes, which are discrete-time Markov processes where the state space is a product of continuous holding times and discrete states. We prove the Markov property of CTMCs using the bisimulation argument for discrete-time Markov processes, and that the transition probability is the solution of a differential equation. © 2017 ACM.

There exist a significant number of models, which describe the dynamics of pneumatic transmission lines. The models are based on different assumptions and, thereby, vary in the physical phenomena they incorporate. These assumptions made are not always stated clearly and the models are rarely validated with measurement data. The aim of this article is to present multiple distributed parameter models that, starting from a physical system description, successively decrease in complexity and finally result in a rather simple system representation. Data, both from simulation studies as well as from a pneumatic test bench, serve as a quantitative validation of these assumptions. Based on a detailed discussion of the different models, this article aims at facilitating the choice of an appropriate model for a given task where the effect of long pneumatic transmission lines cannot be neglected and a trade-off between accuracy and complexity is required. © 2017 Informa UK Limited, trading as Taylor & Francis Group

Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with 'classical' two-component reactions, fulfilling the rules of Green Chemistry. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-cost materials, drugs and compound libraries. © 2017 by the author.

Schlipf J.,TU Munich | Muller-Buschbaum P.,TU Munich
Advanced Energy Materials | Year: 2017

Grazing-incidence X-ray scattering (GIXS) methods have proven to be a valuable asset for investigating the morphology of thin films at different length scales. Consequently, GIXS has been applied to the fast-progressing field of organometal halide perovskites. This exciting class of materials has propelled research in the areas of cheap and sustainable photovoltaics, light emitting devices, and optoelectronics in general. Especially, perovskite solar cells (PSC) have seen a remarkable rise in power conversion efficiencies, crossing the 20% mark after only five years of research. This research news outlines GIXS studies focusing on the most challenging research topics in the perovskite field today: Current-voltage hysteresis, device reproducibility, and long-term stability of PSC are inherently linked to perovskite film morphology. On the other hand, film formation depends on the choice of precursors and processing parameters; understanding their interdependence opens possibilities to tailor film morphologies. Owing to their tunability and moisture resistance, 2D perovskites have recently attracted attention. Examples of GIXS studies with different measurement and data analysis techniques are presented, highlighting especially in-situ investigations on the many kinetic processes involved. Thus, an overview on the toolbox of GIXS techniques is linked to the specific needs of research into organometal halide perovskite optoelectronics. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Praetorius F.,TU Munich | Dietz H.,TU Munich
Science | Year: 2017

We describe an approach to bottom-up fabrication that allows integration of the functional diversity of proteins into designed three-dimensional structural frameworks. A set of custom staple proteins based on transcription activator-like effector proteins folds a doublestranded DNA template into a user-defined shape. Each staple protein is designed to recognize and closely link two distinct double-helical DNA sequences at separate positions on the template.We present design rules for constructing megadalton-scale DNA-protein hybrid shapes; introduce various structural motifs, such as custom curvature, corners, and vertices; and describe principles for creating multilayer DNA-protein objects with enhanced rigidity.We demonstrate self-assembly of our hybrid nanostructures in one-pot mixtures that include the genetic information for the designed proteins, the template DNA, RNA polymerase, ribosomes, and cofactors for transcription and translation.

Rossetti L.,TU Munich
Nature Materials | Year: 2017

The exceptional mechanical properties of the load-bearing connection of tendon to bone rely on an intricate interplay of its biomolecular composition, microstructure and micromechanics. Here we identify that the Achilles tendon–bone insertion is characterized by an interface region of ∼500 μm with a distinct fibre organization and biomolecular composition. Within this region, we identify a heterogeneous mechanical response by micromechanical testing coupled with multiscale confocal microscopy. This leads to localized strains that can be larger than the remotely applied strain. The subset of fibres that sustain the majority of loading in the interface area changes with the angle of force application. Proteomic analysis detects enrichment of 22 proteins in the interfacial region that are predominantly involved in cartilage and skeletal development as well as proteoglycan metabolism. The presented mechanisms mark a guideline for further biomimetic strategies to rationally design hard–soft interfaces. © 2017 Nature Publishing Group

Hentrich M.,TU Munich | Pfister D.,University of Cologne
Oncology Research and Treatment | Year: 2017

Non-AIDS-defining malignancies (NADM) are a leading cause of morbidity and mortality for HIV-infected subjects. The risk of testicular germ cell cancer (GCC) and renal cell cancer is slightly increased in the setting of HIV, whereas there is a slightly decreased risk of prostate cancer and bladder cancer. As in industrialized countries the majority of people living with HIV are men, and people aged 55 and older now account for more than a quarter of persons living with HIV, both testis and prostate cancer are assumed to occur with increased frequency in HIV-infected subjects. Overall, treatments should be the same as in HIV-negative patients with urogenital malignancies. Since the introduction of combination antiretroviral therapy (cART) the outcome appears to have improved due to a decrease in HIV-related deaths. HIV-infected men who are treated with standard therapies for GCC now have a similar cancer-free survival compared with their HIV-negative counterparts. Screening and treatment for prostate cancer should follow recommendations established for HIV-negative men. During radio-or chemotherapy patients should receive concurrent cART but the drug-drug interaction potential must be taken into account. © 2017 S. Karger GmbH, Freiburg.

Zolg D.P.,TU Munich
Nature Methods | Year: 2017

We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography–tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Steinhorst S.,TU Munich
2016 International Symposium on Integrated Circuits, ISIC 2016 | Year: 2016

Lithium-Ion (Li-Ion) battery packs are continuously gaining in importance in many energy storage applications such as electric vehicles and smart energy grids. Such battery packs require advanced Battery Management Systems (BMSs), which are contributions from the embedded systems and integrated circuits domain. The BMS monitors and controls the battery cells in a pack and ensures the functionality, efficiency, safety and reliability of the pack. Conventional BMS designs employ a centralized controller architecture for the whole battery pack. Recently, Smart Battery Cells have been proposed which enable a complete decentralization of the BMS. In Smart Battery Cells, each cell is equipped with a Cell Management Unit (CMU) which individually manages the cell it is attached to. By communication with other Smart Battery Cells, the pack-level functionality of the BMS is provided in a distributed fashion. While this architecture provides many benefits such as scalability, minimal integration effort and increased functional safety, existing design and verification methodologies can neither be applied on hardware nor on software level. Consequently, this contribution will discuss how such methodologies for Smart Battery Cells could be developed and points out which further research contributions are needed. For this purpose, we address modeling and simulation of cyberphysical aspects on all abstraction levels and illustrate how verification approaches can be introduced to this new field of application. © 2016 IEEE.

Bilandzic A.,TU Munich
Journal of Physics: Conference Series | Year: 2017

Multiparticle azimuthal correlations are nowadays utilized regularly by all major collaborations worldwide which are analyzing heavy-ion data. Most notably, correlation techniques are used to explore the collective properties of the new state of matter, the Quark-Gluon Plasma, by performing measurements of anisotropic flow phenomenon in heavy-ion collisions. In these proceedings we highlight the theory of multiparticle azimuthal correlations and summarize briefly the most important recent physical results obtained with them. Some unresolved problems and next future steps in their development are discussed as well. © Published under licence by IOP Publishing Ltd.

Krinner F.,TU Munich
EPJ Web of Conferences | Year: 2017

The goal of the Compass experiment at CERN is to study the structure and spectroscopy of hadrons. The two-stage spectrometer has large acceptance and covers a wide kinematic range for charged as well as neutral particles allowing to access a wide range of reactions. Light mesons are studied with negative (mostly π-) and positive (p, π+) hadron beams with a momentum of 190 GeV/c. The light-meson spectrum is measured in different final states produced in diffractive dissociation reactions with squared four-momentum transfer t to the target between 0.1 and 1.0 (GeV/c)2. The flagship channel is the π-π+π- final state, for which Compass has recorded the currently world's largest data sample. These data not only allow us to measure the properties of known resonances with high precision, but also to search for new states. Among these is a new axial-vector signal, the a1(1420), with unusual properties. The findings are confirmed by the analysis of the π-π0π0 final state. © The Authors, published by EDP Sciences, 2017.

Hugenschmidt C.,TU Munich
Journal of Physics: Conference Series | Year: 2017

Bright slow positron beams enable not only experiments with drastically reduced measurement time and improved signal-to-noise ratio but also the realization of novel experimental techniques. In solid state physics and materials science positron beams are usually applied for the depth dependent analysis of vacancy-like defects and their chemical surrounding using positron lifetime and (coincident) Doppler broadening spectroscopy. For surface studies, annihilation induced Auger-electron spectroscopy allows the analysis of the elemental composition in the topmost atomic layer, and the atomic positions at the surface can be determined by positron diffraction with outstanding accuracy. In fundamental research low-energy positron beams are used for the production of e.g. cold positronium or positronium negative ions. All the aforementioned experiments benefit from the high intensity of present positron beam facilities. In this paper, we scrutinize the technical constraints limiting the achievable positron intensity and the available kinetic energy at the sample position. Current efforts and future developments towards the generation of high intensity spin-polarized slow positron beams paving the way for new positron experiments are discussed. © Published under licence by IOP Publishing Ltd.

Weber J.H.,TU Munich
EPJ Web of Conferences | Year: 2017

We discuss calculations of the Polyakov loop and of Polyakov loop correlators using lattice gauge theory. We simulate QCD with 2+1 flavors and almost physical quark masses using the highly improved staggered quark action (HISQ).We demonstrate that the entropy derived from the Polyakov loop is a good probe of color screening. In particular, it allows for scheme independent and quantitative conclusions about the deconfinement aspects of the crossover and for a rigorous study of the onset of weak-coupling behavior at high temperatures. We examine the correlators for small and large separations and identify vacuum-like and screening regimes in the thermal medium. We demonstrate that gauge-independent screening properties can be obtained even from gauge-fixed singlet correlators and that we can pin down the asymptotic regime. © The Authors, published by EDP Sciences, 2017.

Castella J.T.,TU Munich
EPJ Web of Conferences | Year: 2017

We report on the results of [1] for the calculations of quarkonium hybrids. We have developed and Effective Field Theory (EFT) for quarkonium hybrids that systematically incorporates an expansion with respect to the adiabatic limit. We matched the potentials in our EFT to the static energies computed on the lattice. We discuss our results and compare them with direct lattice calculations and possible experimental candidates. © The Authors, published by EDP Sciences, 2017.

Shtabovenko V.,TU Munich
EPJ Web of Conferences | Year: 2017

We report on the calculation [1] of the relativistic O(αs 0 ν2) corrections to the quarkonium production process e+e- → χcJ + γ in non-relativistic QCD (NRQCD). In our work we incorporate effects from operators that contribute through the sub-leading Fock state |QQ g), that were not taken into account by previous studies. We determine the corresponding matching coeffcients that should be included into theoretical predictions for the electromagnetic production cross-section of χcJ. This process could be, in principle, measured by the Belle II experiment. © The Authors, published by EDP Sciences, 2017.

Rasthofer U.,ETH Zurich | Gravemeier V.,TU Munich
Archives of Computational Methods in Engineering | Year: 2017

The variational multiscale method is reviewed as a framework for developing computational methods for large-eddy simulation of turbulent flow. In contrast to other articles reviewing this topic, which focused on large-eddy simulation of turbulent incompressible flow, this study covers further aspects of numerically simulating turbulent flow as well as applications beyond incompressible single-phase flow. The various concepts for subgrid-scale modeling within the variational multiscale method for large-eddy simulation proposed by researchers in this field to date are illustrated. These conceptions comprise (i) implicit large-eddy simulation, represented by residual-based and stabilized methods, (ii) functional subgrid-scale modeling via small-scale subgrid-viscosity models and (iii) structural subgrid-scale modeling via the introduction of multifractal subgrid scales. An overview on exemplary numerical test cases to which the reviewed methods have been applied in the past years is provided, including explicit computational results obtained from turbulent channel flow. Wall-layer modeling, passive and active scalar transport as well as developments for large-eddy simulation of turbulent two-phase flow and combustion are discussed to complete this exposition. © 2017 CIMNE, Barcelona, Spain

Englert M.,University of War Wick | Racke H.,TU Munich
Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms | Year: 2017

In the reordering buffer problem a sequence of items located in a metric space arrive online, and have to be processed by a single server moving within the metric space. At any point in time, the first k still unprocessed items from the sequence are available for processing and the server has to select one of these items and process it by visiting its location. The goal is to process all items while minimizing the total distance the server moves. Englert, Racke, Westermann (STOC'07) gave a deterministic O(D log k)-competitive online algorithm for weighted tree metrics with hop-diameter D. We improve the analysis of this algorithm and significantly improve the dependency on D. Specifically, we show that the algorithm is in fact O(logD+log k)-competitive. Our analysis is quite robust. Even when an optimal algorithm, to which we compare the online algorithm, is allowed to choose between the first h > k unprocessed items, the online algorithm is still O(h(logD+log h)=k)- competitive. For h = (1 + ϵ) , with constant > 0, this is optimal. Our results also imply better competitive ratio for general metric spaces, improving the randomized O(log n . log2 k) result for n-point metric spaces from STOC'07 to O(log n log k). Copyright © by SIAM.

Wenner F.,TU Munich
Land Use Policy | Year: 2016

Where real estate taxation differentiates between land uses, size of built structures, developed and undeveloped land, it has an influence on the decisions of landowners what and how to build. Still, real estate taxation is often only used to generate a stable source of revenue for the public administration, rather than as an active control mechanism in land policy and planning, despite its relationship with urban development.As a form of real estate taxation, a tax on land values only is recurrently discussed in literature to have beneficial effects for urban development. Planners who propose a land value tax (LVT) often argue that it leads to higher building density and a more frequent re-use of brownfields. LVT could curb undesired 'urban sprawl' and lead to a more efficient land use, compliant to zoning and urban planning designations.In most countries however, the real estate tax is determined by the value or size of buildings, and not by the value of land. Only a small number of countries has introduced a land-based only real estate tax system. Estonia is the only country in the European Union that in 1993 has done so, but there has been no case study of the effects of it on urban structure so far. This is surprising given its relatively rigorous implementation.In this paper, I will give an overview of the debate on land value tax and urban planning, before I briefly analyse the dynamics of land policy that ensued from the introduction of the land value tax on urban development in the Estonian capital Tallinn since its introduction in 1993. I compare my findings with neighbouring Riga in Latvia, which has retained a building-based taxation system. I conclude that, while statistical results indeed seem to suggest an increased capital-land-ratio and slightly increasing population density in Tallinn as opposed to Riga, both regions show considerable suburbanisation and sprawl, challenging the effectiveness of the LVT implementation in Tallinn. The result also points to the importance of other influences on urban development, and the difficulties in separating the effects of LVT from them. © 2016 Elsevier Ltd.

BACKGROUND:: Therapeutic drug monitoring (TDM) of immunosuppressants is essential to optimize patient care after organ transplantation. In blood, most immunosuppressive drugs are bound to plasma proteins or located inside blood cells. However, it is generally assumed that only protein-unbound (free) drug concentrations are pharmacologically active and could therefore better reflect the clinical outcome. Study data are still limited due to lacking rapid analytical methods. Therefore, a simple multiplex method for direct measurement of free cyclosporine A (CsA) and mycophenolic acid (MPA) has been developed. METHODS:: The sample preparation included ultracentrifugation, followed by liquid-liquid extraction. Stable isotope labeled analogues of CsA and MPA were used as internal standards. The LC-MS/MS analysis was performed on a triple quadrupole mass spectrometer in the multiple reaction monitoring mode. The validated assay was used in a study of 40 blood samples from kidney transplant patients. RESULTS:: The lower limits of quantification were 0.1 ng/mL (CsA) and 0.5 ng/mL (MPA). Assay linearity was confirmed in the concentrations range of 0.1-10.0 ng/mL (CsA) and 0.5-100 ng/mL (MPA). For both analytes, inaccuracy was ≤ 9.8% and imprecision was ≤ 7.8%. The extraction efficiency ranged between 91 and 96%. In the patient samples the average free CsA and MPA fractions were 5.8% (2.1 – 16.8%) and 1.2% (0.5 – 2.4%) respectively. CONCLUSIONS:: A reliable and highly sensitive LC-MS/MS method as a new suitable tool for measuring protein-unbound CsA and MPA has been developed, validated and applied in kidney transplant patient samples. Now, larger studies can be conducted to investigate the benefit of free drug monitoring in transplant recipients. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

La Rosa G.,TU Munich | Zacharias M.,TU Munich
Nucleic Acids Research | Year: 2016

Oxidation of guanine (Gua) to form 7,8-dihydro-8- oxoguanine (8oxoG) is a frequent mutagenic DNA lesion. DNA repair glycosylases such as the bacterial MutM can effciently recognize and eliminate the 8oxoG damage by base excision. The base excision requires a 8oxoG looping out (flipping) from an intrahelical base paired to an extrahelical state where the damaged base is in the enzyme active site. It is still unclear how the damage is identified and flipped from an energetically stable stacked and paired state without any external energy source. Free energy simulations have been employed to study the flipping process for globally deformed DNA conformational states. DNA deformations were generated by systematically untwisting the DNA to mimic its conformation in repair enzyme encounter complex. The simulations indicate that global DNA untwisting deformation toward the enzyme bound form alone (without protein) significantly reduces the penalty for damage flipping to about half of the penalty observed in regular DNA. The finding offers a mechanistic explanation how binding free energy that is transformed to binding induced DNA deformation facilitates flipping and helps to rapidly detect a damaged base. It is likely of general relevance since repair enzyme binding frequently results in significant deformation of the target DNA. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Rozhon W.,TU Munich
Plasmid | Year: 2017

pHW126 belongs to a small group of rolling circle plasmids. So far, the region mediating autonomous replication has been identified and it was shown that the rep gene is required for replication. However, the regulation of rep expression remained elusive. Here evidence is presented that expression of the replication gene rep is auto-regulated. Sequence analysis revealed a conserved stretch in the rep promoter consisting of three imperfect direct repeats (DR2.1, DR2.2 and DR2.3). Assays for promoter activity showed that these direct repeats act as an enhancer of transcriptional activity. Interestingly, the activating effect was reduced in the presence of Rep protein. Electrophoretic mobility shift assays demonstrated that the Rep protein can directly bind to direct repeats DR2.1 and DR2.3 while DR2.2 is not bound but places DR2.1 and DR2.3 in an appropriate distance. These results show that the synthesis of Rep protein is auto-regulated. In the absence of Rep protein the promoter is, due to the presence of the direct repeats acting as a transcriptional enhancer, highly active. Binding of Rep to the direct repeats reduces the transcription rate significantly. Since this regulation mechanism is independent of a specialised regulator protein it is presumably a very economic strategy. © 2017 Elsevier Inc.

Wenzel M.,University of Cardiff | Casini A.,TU Munich
Coordination Chemistry Reviews | Year: 2017

Metal-based compounds form a promising class of therapeutic agents, whose mechanisms of action still need to be elucidated, and that are in general prone to undergo extensive speciation in physiological environment. Thus, determination of the fate of the metal compounds in complex biological systems, contributing to their overall pharmacological and toxicological profiles, is important to develop more rationalised and targeted metal-based drugs. To these aims, a number of spectroscopic and biophysical methods, as well as analytical techniques, are nowadays extensively applied to study the reactivity of metal complexes with different biomolecules (e.g. nucleic acids, proteins, buffer components). Among the various techniques, molecular mass spectrometry (MS) has emerged in the last decade as a major tool to characterise the interactions of metallodrugs at a molecular level.In this review, we present an overview of the information available on the reactivity of various families of therapeutic metallodrugs (mainly anticancer compounds based on Pt, Ru, Au and As) with biomolecules studied by different MS techniques, including high-resolution ESI-, MALDI- and ion mobility-MS among others. Representative examples on the potential of the MS approach to study non-covalent interactions are also discussed. The review is organized to present results obtained on samples with different degrees of complexity, from the interactions of metal compounds with small model nucleophiles (amino acids and nucleobases), model peptides/oligonucleotides, target proteins/nucleic acids, to the analysis of serum, cell extracts and tissue samples. The latter requiring combination of proteomic methods with advanced MS techniques. Correlations between molecular reactivity of metallodrugs and biological activity are hard to establish, but differences in the reactivity of metallodrugs to biomolecules and their different adducts, as revealed by MS methods, may indicate differences in their modes of action. Overall, the knowledge offered by MS methods on metallodrugs speciation is invaluable to establish new rules and define new trends in the periodic table aimed at rationalizing the behavior of metal compounds in complex living systems. © 2017 Elsevier B.V.

News Article | May 4, 2017

Just like peering through a window, holograms project a seemingly three-dimensional image. While optical holograms require elaborate laser technology, generating holograms with the microwave radiation of a Wi-Fi transmitter requires merely one fixed and one movable antenna, as Dr. Friedenmann Reinhard and Philipp Holl report in the current issue of the renowned scientific journal Physical Review Letters. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," says Friedemann Reinhard, director of the Emmy Noether Research Group for Quantum Sensors at the Walter Schottky Institute of the TU Munich. The researchers envision fields of deployment especially in the domain of industry 4.0 - automated industrial facilities, in which localizing parts and devices is often difficult. Processes that allow the localization of microwave radiation, even through walls, or in which changes in a signal pattern signify the presence of a person already exist. The novelty is that an entire space can be imaged via holographic processing of Wi-Fi or cell phone signals. "Of course, this raises privacy questions. After all, to a certain degree even encrypted signals transmit an image of their surroundings to the outside world," says the project leader, Friedemann Reinhard. "However, it is rather unlikely that this process will be used for the view into foreign bedrooms in the near future. For that, you would need to go around the building with a large antenna, which would hardly go unnoticed. There are simpler ways available." Hitherto, generating images from microwave radiation required special-purpose transmitters with large bandwidths. Using holographic data processing, the very small bandwidths of typical household Wi-Fi transmitters operating in the 2.4 and 5 gigahertz bands were sufficient for the researchers. Even Bluetooth and cell phone signals can be used. The wavelengths of these devices correspond to a spatial resolution of a few centimeters. "Instead of a using a movable antenna, which measures the image point by point, one can use a larger number of antennas to obtain a video-like image frequency," says Philipp Holl, who executed the experiments. "Future Wi-Fi frequencies, like the proposed 60 gigahertz IEEE 802.11 standard will allow resolutions down to the millimeter range." Looking to the future Well-known optical methods for image processing can also be deployed in Wi-Fi holography: One example is the dark-field methodology used in microscopy, which improves the recognition of weakly diffracting structures. A further process is white-light holography in which the researchers use the remaining small bandwidth of the Wi-Fi transmitter to eliminated noise from scattered radiation. The concept of treating microwave holograms like optical images allows the microwave image to be combined with camera images. The additional information extracted from the microwave images can be embedded into the camera image of a smart phone, for example to trace a radio tag attached to a lost item. But the scientists are just at the beginning of the technological development. For example, research on the transparency of specific materials is lacking. This knowledge would facilitate the development of paint or wall paper translucent to microwaves for privacy protection, while transparent materials could be deployed in factory halls to allow parts to be tracked. The researchers hope that further advancement of the technology may aid in the recovery of victims buried under an avalanche or a collapsed building. While conventional methods only allow point localization of victims, holographic signal processing could provide a spatial representation of destroyed structures, allowing first responders to navigate around heavy objects and use cavities in the rubble to systematically elucidate the easiest approach to quickly reach victims. More information: Philipp M. Holl and Friedemann Reinhard: Holography of Wi-fi Radiation. Physical Review Letters, 05.04.2017. DOI: 10.1103/PhysRevLett.118.183901

News Article | May 4, 2017

Scientists at the Technical University of Munich (TUM) have developed a holographic imaging process that depicts the radiation of a Wi-Fi transmitter to generate three-dimensional images of the surrounding environment. Industrial facility operators could use this to track objects as they move through the production hall. Just like peering through a window, holograms project a seemingly three-dimensional image. While optical holograms require elaborate laser technology, generating holograms with the microwave radiation of a Wi-Fi transmitter requires merely one fixed and one movable antenna, as Dr. Friedenmann Reinhard and Philipp Holl report in the current issue of the renowned scientific journal Physical Review Letters. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," says Friedemann Reinhard, director of the Emmy Noether Research Group for Quantum Sensors at the Walter Schottky Institute of the TU Munich. The researchers envision fields of deployment especially in the domain of industry 4.0 - automated industrial facilities, in which localizing parts and devices is often difficult. Processes that allow the localization of microwave radiation, even through walls, or in which changes in a signal pattern signify the presence of a person already exist. The novelty is that an entire space can be imaged via holographic processing of Wi-Fi or cell phone signals. "Of course, this raises privacy questions. After all, to a certain degree even encrypted signals transmit an image of their surroundings to the outside world," says the project leader, Friedemann Reinhard. "However, it is rather unlikely that this process will be used for the view into foreign bedrooms in the near future. For that, you would need to go around the building with a large antenna, which would hardly go unnoticed. There are simpler ways available." Hitherto, generating images from microwave radiation required special-purpose transmitters with large bandwidths. Using holographic data processing, the very small bandwidths of typical household Wi-Fi transmitters operating in the 2.4 and 5 gigahertz bands were sufficient for the researchers. Even Bluetooth and cell phone signals can be used. The wavelengths of these devices correspond to a spatial resolution of a few centimeters. "Instead of a using a movable antenna, which measures the image point by point, one can use a larger number of antennas to obtain a video-like image frequency," says Philipp Holl, who executed the experiments. "Future Wi-Fi frequencies, like the proposed 60 gigahertz IEEE 802.11 standard will allow resolutions down to the millimeter range." Looking to the future Well-known optical methods for image processing can also be deployed in Wi-Fi holography: One example is the dark-field methodology used in microscopy, which improves the recognition of weakly diffracting structures. A further process is white-light holography in which the researchers use the remaining small bandwidth of the Wi-Fi transmitter to eliminated noise from scattered radiation. The concept of treating microwave holograms like optical images allows the microwave image to be combined with camera images. The additional information extracted from the microwave images can be embedded into the camera image of a smart phone, for example to trace a radio tag attached to a lost item. But the scientists are just at the beginning of the technological development. For example, research on the transparency of specific materials is lacking. This knowledge would facilitate the development of paint or wall paper translucent to microwaves for privacy protection, while transparent materials could be deployed in factory halls to allow parts to be tracked. The researchers hope that further advancement of the technology may aid in the recovery of victims buried under an avalanche or a collapsed building. While conventional methods only allow point localization of victims, holographic signal processing could provide a spatial representation of destroyed structures, allowing first responders to navigate around heavy objects and use cavities in the rubble to systematically elucidate the easiest approach to quickly reach victims.

News Article | May 4, 2017

Scientists at the Technical University of Munich (TUM) have developed a holographic imaging process that depicts the radiation of a Wi-Fi transmitter to generate three-dimensional images of the surrounding environment. Industrial facility operators could use this to track objects as they move through the production hall. Just like peering through a window, holograms project a seemingly three-dimensional image. While optical holograms require elaborate laser technology, generating holograms with the microwave radiation of a Wi-Fi transmitter requires merely one fixed and one movable antenna, as Dr. Friedenmann Reinhard and Philipp Holl report in the current issue of the renowned scientific journal Physical Review Letters. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," says Friedemann Reinhard, director of the Emmy Noether Research Group for Quantum Sensors at the Walter Schottky Institute of the TU Munich. The researchers envision fields of deployment especially in the domain of industry 4.0 - automated industrial facilities, in which localizing parts and devices is often difficult. Processes that allow the localization of microwave radiation, even through walls, or in which changes in a signal pattern signify the presence of a person already exist. The novelty is that an entire space can be imaged via holographic processing of Wi-Fi or cell phone signals. "Of course, this raises privacy questions. After all, to a certain degree even encrypted signals transmit an image of their surroundings to the outside world," says the project leader, Friedemann Reinhard. "However, it is rather unlikely that this process will be used for the view into foreign bedrooms in the near future. For that, you would need to go around the building with a large antenna, which would hardly go unnoticed. There are simpler ways available." Hitherto, generating images from microwave radiation required special-purpose transmitters with large bandwidths. Using holographic data processing, the very small bandwidths of typical household Wi-Fi transmitters operating in the 2.4 and 5 gigahertz bands were sufficient for the researchers. Even Bluetooth and cell phone signals can be used. The wavelengths of these devices correspond to a spatial resolution of a few centimeters. "Instead of a using a movable antenna, which measures the image point by point, one can use a larger number of antennas to obtain a video-like image frequency," says Philipp Holl, who executed the experiments. "Future Wi-Fi frequencies, like the proposed 60 gigahertz IEEE 802.11 standard will allow resolutions down to the millimeter range." Looking to the future Well-known optical methods for image processing can also be deployed in Wi-Fi holography: One example is the dark-field methodology used in microscopy, which improves the recognition of weakly diffracting structures. A further process is white-light holography in which the researchers use the remaining small bandwidth of the Wi-Fi transmitter to eliminated noise from scattered radiation. The concept of treating microwave holograms like optical images allows the microwave image to be combined with camera images. The additional information extracted from the microwave images can be embedded into the camera image of a smart phone, for example to trace a radio tag attached to a lost item. But the scientists are just at the beginning of the technological development. For example, research on the transparency of specific materials is lacking. This knowledge would facilitate the development of paint or wall paper translucent to microwaves for privacy protection, while transparent materials could be deployed in factory halls to allow parts to be tracked. The researchers hope that further advancement of the technology may aid in the recovery of victims buried under an avalanche or a collapsed building. While conventional methods only allow point localization of victims, holographic signal processing could provide a spatial representation of destroyed structures, allowing first responders to navigate around heavy objects and use cavities in the rubble to systematically elucidate the easiest approach to quickly reach victims.

News Article | May 4, 2017

Scientists at the Technical University of Munich (TUM) have developed a holographic imaging process that depicts the radiation of a Wi-Fi transmitter to generate three-dimensional images of the surrounding environment. Industrial facility operators could use this to track objects as they move through the production hall. Just like peering through a window, holograms project a seemingly three-dimensional image. While optical holograms require elaborate laser technology, generating holograms with the microwave radiation of a Wi-Fi transmitter requires merely one fixed and one movable antenna, as Dr. Friedenmann Reinhard and Philipp Holl report in the current issue of the renowned scientific journal Physical Review Letters. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," says Friedemann Reinhard, director of the Emmy Noether Research Group for Quantum Sensors at the Walter Schottky Institute of the TU Munich. The researchers envision fields of deployment especially in the domain of industry 4.0 - automated industrial facilities, in which localizing parts and devices is often difficult. Processes that allow the localization of microwave radiation, even through walls, or in which changes in a signal pattern signify the presence of a person already exist. The novelty is that an entire space can be imaged via holographic processing of Wi-Fi or cell phone signals. "Of course, this raises privacy questions. After all, to a certain degree even encrypted signals transmit an image of their surroundings to the outside world," says the project leader, Friedemann Reinhard. "However, it is rather unlikely that this process will be used for the view into foreign bedrooms in the near future. For that, you would need to go around the building with a large antenna, which would hardly go unnoticed. There are simpler ways available." Hitherto, generating images from microwave radiation required special-purpose transmitters with large bandwidths. Using holographic data processing, the very small bandwidths of typical household Wi-Fi transmitters operating in the 2.4 and 5 gigahertz bands were sufficient for the researchers. Even Bluetooth and cell phone signals can be used. The wavelengths of these devices correspond to a spatial resolution of a few centimeters. "Instead of a using a movable antenna, which measures the image point by point, one can use a larger number of antennas to obtain a video-like image frequency," says Philipp Holl, who executed the experiments. "Future Wi-Fi frequencies, like the proposed 60 gigahertz IEEE 802.11 standard will allow resolutions down to the millimeter range." Looking to the future Well-known optical methods for image processing can also be deployed in Wi-Fi holography: One example is the dark-field methodology used in microscopy, which improves the recognition of weakly diffracting structures. A further process is white-light holography in which the researchers use the remaining small bandwidth of the Wi-Fi transmitter to eliminated noise from scattered radiation. The concept of treating microwave holograms like optical images allows the microwave image to be combined with camera images. The additional information extracted from the microwave images can be embedded into the camera image of a smart phone, for example to trace a radio tag attached to a lost item. But the scientists are just at the beginning of the technological development. For example, research on the transparency of specific materials is lacking. This knowledge would facilitate the development of paint or wall paper translucent to microwaves for privacy protection, while transparent materials could be deployed in factory halls to allow parts to be tracked. The researchers hope that further advancement of the technology may aid in the recovery of victims buried under an avalanche or a collapsed building. While conventional methods only allow point localization of victims, holographic signal processing could provide a spatial representation of destroyed structures, allowing first responders to navigate around heavy objects and use cavities in the rubble to systematically elucidate the easiest approach to quickly reach victims. The research was funded by the Emmy Noether Program of the German Research Foundation (DFB) and the TUM Junior Fellow Fund.

News Article | May 7, 2017

A cross made of aluminum foil between the viewer and the Wi-FI router can easily be reconstructed from the Wi-Fi hologram as can be seen in the inserted picture (Credit: Friedemann Reinhard/Philipp Holl / TUM) We think of Wi-Fi as primarily bathing our homes and offices in a comfy, invisible blanket of data and internet access, but just as a blanket can take on the shapes of the bodies it covers, the microwave radiation sent out from a hotspot can be used to generate a three-dimensional image of the surrounding environment and the things and people in it. Researchers at the Technical University of Munich have come up with a process that creates a holographic image of a space from the microwave radiation of a Wi-Fi signal bouncing off people and objects. The scientists say their method could be used in automated industrial settings, to track objects moving through a facility, for example. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," says Friedemann Reinhard, director of the Emmy Noether Research Group for Quantum Sensors at TU Munich. We've seen similar approaches use Wi-Fi to see through walls, even distinguishing human figures on the other side and performing head counts of people in an open area. But the TU Munich scientists say they've gone a step further: using Wi-Fi and even cellular signals to image an entire space with holographic processing. Reinhard concedes that this new ability to use Wi-Fi to essentially spy on entire rooms and buildings does raise questions of privacy. "After all, to a certain degree even encrypted signals transmit an image of their surroundings to the outside world," he says. "However, it is rather unlikely that this process will be used (to look) into foreign bedrooms in the near future. For that, you would need to go around the building with a large antenna, which would hardly go unnoticed." The holographic imaging system requires simply one fixed and one movable antenna, but researcher Philipp Holl says a larger number of antennas could replace the movable antenna for higher-resolution images closer to that of video. "Future Wi-Fi frequencies, like the proposed 60 gigahertz IEEE 802.11 standard will allow resolutions down to the millimeter range," Holl adds. Potential future applications for this "Wi-Fi vision" include embedding microwave image data into camera images, allowing for easy tracking of lost items. Imagine taking a photo of a room and being able to see in the image that a lost object is hidden under a piece of furniture, for example. The researchers also hope that the technology could advance to be useful in rescue operations to help reach victims buried by an avalanche or a collapsed building. They also hope to learn about materials that are more translucent or transparent to microwaves to provide better privacy protection or allow for better tracking of equipment in factory floors. The research was published in the most recent issue of Physical Review Letters.

News Article | May 4, 2017

Soon Wi-Fi could do more than connect you to the internet. Scientists at the Technical University of Munich have developed a holographic imaging process that uses the radiation of a Wi-Fi transmitter to generate three-dimensional images of the surrounding environment, down to centimeter-scale precision, according to a paper (PDF) in the Physical Review Letters announced Thursday by the university. In other words, they can effectively make holograms out of thin air. Generating holograms with the microwave radiation of a Wi-Fi transmitter requires merely one fixed and one movable antenna, which is much simpler than optical holograms that require elaborate laser technology, according to Friedemann Reinhard, co-author of the paper and director of the Emmy Noether Research Group for Quantum Sensors at the Walter Schottky Institute of the TU Munich. "Using this technology, we can generate a three-dimensional image of the space around the Wi-Fi transmitter, as if our eyes could see microwave radiation," Reinhard said in a statement. Since Wi-Fi signals penetrate walls, this means going forward it can be used to locate and recover victims buried under an avalanche or a collapsed building. The development of this technology is still in an early state. but for those concerned about privacy, Reinhard said the movable antenna required to scan an entire room or a building would be very large and couldn't be installed clandestinely.

Schmidbaur H.,TU Munich | Schmidbaur H.,King Abdulaziz University | Raubenheimer H.G.,Stellenbosch University | Dobrzanska L.,Catholic University of Leuven
Chemical Society Reviews | Year: 2014

In the first part of this review, the characteristics of Au-H bonds in gold hydrides are reviewed including the data of recently prepared stable organometallic complexes with gold(i) and gold(iii) centers. In the second part, the reports are summarized where authors have tried to provide evidence for hydrogen bonds to gold of the type Au⋯H-X. Such interactions have been proposed for gold atoms in the Au(-i), Au(0), Au(i), and Au(iii) oxidation states as hydrogen bonding acceptors and H-X units with X = O, N, C as donors, based on both experimental and quantum chemistry studies. To complement these findings, the literature was screened for examples with similar molecular geometries, for which such bonding has not yet been considered. In the discussion of the results, the recently issued IUPAC definitions of hydrogen bonding and the currently accepted description of agostic interactions have been used as guidelines to rank the Au⋯H-X interactions in this broad range of weak chemical bonding. From the available data it appears that all the intra- and intermolecular Au⋯H-X contacts are associated with very low binding energies and non-specific directionality. To date, the energetics have not been estimated, because there are no thermochemical and very limited IR/Raman and temperature-dependent NMR data that can be used as reliable references. Where conspicuous structural or spectroscopic effects have been observed, explanations other than hydrogen bonding Au⋯H-X can also be advanced in most cases. Although numerous examples of short Au⋯H-X contacts exist in the literature, it seems, at this stage, that these probably make only very minor contributions to the energy of a given system and have only a marginal influence on molecular conformations which so far have most often attracted researchers to this topic. Further, more dedicated investigations will be necessary before well founded conclusions can be drawn. © 2014 The Royal Society of Chemistry.

Schmidt A.,TU Munich | Casini A.,University of Groningen | Kuhn F.E.,TU Munich
Coordination Chemistry Reviews | Year: 2014

Metal-mediated self-assemblies of the general formula MxLy (M=metal ion, L=ligand) have emerged as a promising research area of supramolecular chemistry because of their applicability in various fields such as molecular recognition, catalysis and drug delivery. The focus of this review is on discrete coordination cages of the type M2L4 using square-planar, square-pyramidal or octahedral coordinated metal ions (e.g. Pd, Pt, Co, Cu, Ni or Zn) and bis(monodentate) N-ligands. The synthesis and characterization of these metallocages is discussed, and special attention is given to the molecular structures with well-defined internal cavities and the molecular recognition properties. The self-assembled M2L4 cages are capable to encapsulate anionic, neutral or cationic guest molecules within their cavity. Therefore, some of these M2L4 host-guest systems are certainly promising for application in medical diagnostic, drug delivery, catalytic reactions, environmental analytics, material science and chemosensing. © 2014 Elsevier B.V.

Huckelhoven R.,TU Munich | Panstruga R.,RWTH Aachen | Panstruga R.,Max Planck Institute for Plant Breeding Research
Current Opinion in Plant Biology | Year: 2011

Powdery mildew fungi represent a paradigm for obligate biotrophic parasites, which only propagate in long-lasting intimate interactions with living host cells. These highly specialized phytopathogens induce re-organization of host cell architecture and physiology for their own demands. This probably includes the corruption of basal host cellular functions for successful fungal pathogenesis. Recent studies revealed secretory processes by both interaction partners as key incidents of the combat at the plant-fungus interface. The analysis of cellular events during plant-powdery mildew interactions may not only lead to a better understanding of plant pathological features, but may also foster novel discoveries in the area of plant cell biology. © 2011 Elsevier Ltd.

Taruttis A.,University of Groningen | Ntziachristos V.,Helmholtz Center Munich | Ntziachristos V.,TU Munich
Nature Photonics | Year: 2015

Optoacoustic imaging, or photoacoustic imaging, is insensitive to photon scattering within biological tissue and, unlike conventional optical imaging methods, makes high-resolution optical visualization deep within tissue possible. Recent advances in laser technology, detection strategies and inversion techniques have led to significant improvements in the capabilities of optoacoustic systems. A key empowering feature is the development of video-rate multispectral imaging in two and three dimensions, which offers fast, spectral differentiation of distinct photoabsorbing moieties. We review recent advances and capabilities in the technology and its corresponding emerging biological and clinical applications. © 2015 Macmillan Publishers Limited. All rights reserved.

Tang Y.-Y.,Texas Tech University | Tang Y.-Y.,University of Oregon | Holzel B.K.,TU Munich | Holzel B.K.,Massachusetts General Hospital | Posner M.I.,University of Oregon
Nature Reviews Neuroscience | Year: 2015

Research over the past two decades broadly supports the claim that mindfulness meditation - practiced widely for the reduction of stress and promotion of health - exerts beneficial effects on physical and mental health, and cognitive performance. Recent neuroimaging studies have begun to uncover the brain areas and networks that mediate these positive effects. However, the underlying neural mechanisms remain unclear, and it is apparent that more methodologically rigorous studies are required if we are to gain a full understanding of the neuronal and molecular bases of the changes in the brain that accompany mindfulness meditation. © 2015 Macmillan Publishers Limited. All rights reserved.

Eichler A.,Catalan Institute of Nanoscience and Nanotechnology | Moser J.,Catalan Institute of Nanoscience and Nanotechnology | Chaste J.,Catalan Institute of Nanoscience and Nanotechnology | Zdrojek M.,Catalan Institute of Nanoscience and Nanotechnology | And 2 more authors.
Nature Nanotechnology | Year: 2011

The theory of damping is discussed in Newton's Principia1 and has been tested in objects as diverse as the Foucault pendulum, the mirrors in gravitational-wave detectors and submicrometre mechanical resonators. In general, the damping observed in these systems can be described by a linear damping force. Advances in nanofabrication mean that it is now possible to explore damping in systems with one or more atomic-scale dimensions. Here we study the damping of mechanical resonators based on carbon nanotubes 2-11 and graphene sheets12-15. The damping is found to strongly depend on the amplitude of motion, and can be described by a nonlinear rather than a linear damping force. We exploit the nonlinear nature of damping in these systems to improve the figures of merit for both nanotube and graphene resonators. For instance, we achieve a quality factor of 100,000 for a graphene resonator.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 2.69M | Year: 2012

Organic semiconductor solar cells are a promising route to scalable, economically viable, energy conversion technologies due to the potential for development of low-cost, flexible, large-area cells and modules. In order to achieve the goal of obtaining efficient bulk heterojunction solar cells (BHJ-SCs), graphene electrodes have been recently proposed as a promising candidate. Research is however at the very beginning, so that if graphene will manage to accomplish this task still has to be proved. In particular, many questions remains open like the degree of interaction of graphene with the polymeric layer, which could degrade the outstanding graphene electron conductivity, as well as the graphene/polymer electron affinity, which plays an important role in the overalls solar cell efficiency. Furthermore, up to now no analysis on light management improvements induced by structuring graphene as photonic crystal for light trapping in BHJ-SC has been reported. The GO-NEXTS project, will focus its attention on new kind of electrodes based on doped, textured (ie 3D) graphene electrodes, in order to increase the overall efficiency and performance of bulk heterojunction solar cells. To our knowledge, this represents the first proposal to enhance light trapping in a solar cell by structuring one or more graphene contact electrode(s) to act as photonic crystal(s). The project will leverage the combination of two different fabrication processes, and in particular the doping of the graphene, to obtain semi-transparent electrodes as well as the texturing of the electrodes. This approach, which has never been proposed before, represents a high-risk, high-impact approach. If successful, it should lead to improvements in solar cell efficiency by up to 14%. Furthermore, all the technologies proposed are suitable for large area realization paving the way for a scalable, economic fabrication technologies on low-cost flexible substrates.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-2 | Award Amount: 6.99M | Year: 2013

The key concept behind this proposal is the development of a very high resolution and high efficiency brain dedicated Positron Emission Tomograph (PET) imager that can visualize neurotransmitter pathways and their disruptions in the quest to better diagnose and consequently to better treat schizophrenia. In addition, the plan is for this compact PET imager to be integrated with a Magnetic Resonance Imager Radio Frequency (MRI RF) system to be able to operate as a brain insert in a hybrid imaging setup with practically any MRI scanner. From the technical point of view, we propose to optimize the PET technology for imaging of the human brain with the accuracy typically achieved for small animal brain imaging. To achieve this, we will incorporate the solid state based MRI-compatible PET modules that will be designed to achieve below systemic 1mm spatial resolution in a tomographic reconstruction of the human brain. We aim to achieve the level of PET-MRI compatibility allowing for simultaneous PET and MRI imaging. By combining PET measurements of neurotransmission with fMRI (functional MRI) measurements of Blood Oxygen Level Detection (BOLD) signal changes we will advance to a position where it is possible to learn more about the neurochemical determination of neural activity reflected in BOLD signal changes. The novelty is that both the PET and RF coil systems are integrated into a portable and compact design dedicated to brain examination. This will allow current MR equipment to be easily upgraded into PET/MR systems. To achieve its diagnostic goal, MINDView will be paired with the set of dedicated specific PET imaging agents and endogenous compounds that will be labeled with short-lived positron isotopes. The goal is that dopaminergic, glutamatergic and other pathways will be able to be studied with the new high performance imaging tool. Innovative paradigms such as activation and perturbation and their impact on brain function will be in focus.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.23M | Year: 2012

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is to gain insight into the mechanisms of action of GvL and GvHD in order to improve current therapies and develop and test novel ones via clinical trials and/or animal model experiments. The research is therefore necessarily multidisciplinary including clinical medicine, immunology, genomics, proteomics, molecular biology and pathology. In order to implement cellular therapies across Europe the current EU Directive 2001/83/EC applies. These regulations stipulate that the cellular therapies which are advanced therapeutic medical products (ATMP) must be produced under current Good Manufacturing Practice (cGMP). Not only is there a lack of understanding of GvL vs. GvHD effects but there is also a lack of training in cGMP for both clinical and non-clinical scientists. We aim to re-address these basic current needs, as well as those of industry, which include lack of access to clinical tissue for validation of bio-markers prior to commercialisation.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.87M | Year: 2015

The aim of this Innovative Training Network is to train a new generation of creative, entrepreneurial and innovative early-stage researchers (ESRs) in the research area of measurement and estimation of signals using knowledge or data about the underlying structure. With its combination of ideas from machine learning and sensing, we refer to this research topic as Machine Sensing. We will train all ESRs in research skills needed to obtain an internationally-recognized PhD; to experience applying their research a non-Academic sector; and to gain transferrable skills such as entrepreneurship and communication skills. We will further encourage an open reproducible research approach to research, through open publication of research papers, data and software, and foster an entrepreneurial and innovation-oriented attitude through exposure to SME and spin-out Partners in the network. In the research we undertake, we will go beyond the current, and hugely popular, sparse representation and compressed sensing approaches, to develop new signal models and sensing paradigms. These will include those based on new structures, nonlinear models, and physical models, while at the same time finding computationally efficient methods to perform this processing. We will develop new robust and efficient Machine Sensing theory and algorithms, together methods for a wide range of signals, including: advanced brain imaging; inverse imaging problems; audio and music signals; and non-traditional signals such as signals on graphs. We will apply these methods to real-world problems, through work with non-Academic partners, and disseminate the results of this research to a wide range of academic and non-academic audiences, including through publications, data, software and public engagement events.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST-2007-5.1-01;SST-2007-5.1-02 | Award Amount: 4.90M | Year: 2008

Ergonomic evaluation of a product requires building up a physical mock-up or a prototype, having a group of experts or a representative sample of users to test it and to give their discomfort feeling. This is an expensive and time-consuming process. Digital Mock-Ups together with Digital Human Models, are more and more used in the early phase of product design for reducing the product development time and cost. In order to help the designer to evaluate the future product, the digital human should ideally behave like human beings, not only in terms of anthropometry but also in terms of motion, discomfort perception and work related tissue injury. So the main objective of the project is to develop more advanced digital humans for ergonomic design of products (DHErgo), which are capable of: 1) Evaluating the discomfort based on advanced musculoskeletal models of the human body, 2) Simulating a population behaviour especially including age effects, 3) Simulating the interaction of the human body with the task-related environment, 4) Proposing design variants even for applications subjected to restricted resources and 5) Demonstration of productive usage. To achieve this objective, the project will mainly develop a generic biomechanical human model for modelling motion induced discomfort. As motion is generated by the contraction of muscles, only kinematic parameters can not explain perceived discomfort. Dynamic and muscular parameters must also be investigated. The development of such a generic dynamic human musculoskeletal model will rely on existing data and computerized human models. A European consortium composed of complementary expertises is the only way to collect data and to validate models for industrial applications. Automotive industry is one of most active end-users of digital human simulation tool, because of high pressure for reducing time-to-market and cost. The final results of the project will be demonstrated through case studies related to car design.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2007.1.1 | Award Amount: 9.17M | Year: 2008

NEWCOM\\ is the acronym of a proposed Network of Excellence in Wireless COMmunications, submitted to Call 1 of the VII Framework Programme under the Objective ICT-2007.1.1: The Network of the Future, mainly in its target direction Ubiquitous network infrastructure and architectures. The current proposal draws inspiration, shape/form, and substantive direction from its successful predecessor, the NoE NEWCOM, which was approved and funded by the EC for 36 months starting March 1st, 2004 and ending February 28, 2007. At the same time, NEWCOM\\ aspires to inject new vision, expanded roles, ever-higher degrees of research integration, and a definitive roadmap to financial security for the long-term life of this undertaking in the European research and higher-learning space. The core concept of NEWCOM\\ is that of an NoE of medium size, greatly reduced from the initial NEWCOM Consortium, formed by keeping the most committed and performing partners, exploiting the successful integration tools that NEWCOM designed and activated, and which is created for the purpose of scientifically addressing medium/long term, complex, interdisciplinary, fundamental research problems in the field of wireless networks, focused towards identifying, posing in the right modelling perspective, and at least partially characterizing the information-communication theoretical limits. Its main objectives are: Identify a selective set of scenarios, Define suitable performance measures that take into account the wireless channel nature, Perform a detailed analysis of the main theoretical results available, Evaluate information-theoretical bounds on the achievable performance, Design and analyze transmitting/receiving algorithms and protocols in order to approach those limits, Analyze implementation aspects of the above algorithms in flexible, energy-aware user terminals, Output the major findings into an integrated simulation library, Enhance the already good cooperation level among research

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2011.3.1.9-1 | Award Amount: 6.39M | Year: 2012

INBIOSOIL is a timely project that proposes novel eco-efficient environmentally friendly technologies substantially contributing to the reduced input of conventional chemical pesticides for the control of subterranean crop pests of global economic importance. This would be accomplished through the generation of new formulations of biological control agents (BCAs) based on entomopathogenic fungi and nematodes within integrated pest management strategies. The strategies exploit synergies between BCAs which result in higher pest mortality. The proposed strategies: (1) contribute to reduced pesticide inputs in sustainable agricultural-horticultural systems, (2) offer potential savings for growers, (3) promote biodiversity and (4) offer solutions for both organic and conventional growers, thus ensuring the competitiveness of European growers. INBIOSOIL also includes risk assessment studies which should accelerate registration of new BCA products. The goals will be accomplished through 5 complementary work packages carried out by 15 European partners. The experienced, multidisciplinary team includes researchers from academia and SMEs. The project meets the challenges of globalization, climate change, and new plant protection policies leading to the production of high-quality and safer crops; it is in accordance with the scope of the Eco-Innovation call FP7-ENV-2011-3.1.9.-1. INBIOSOIL contributes to implementation of EC regulation 1107/2009 and Directive 2009/128/EC which make it obligatory for EU Member States to implement principles of IPM with priority being given to non-chemical methods of integrated pest management. INBIOSOIL addresses direct and indirect impacts, as well as primary and secondary effects, and clearly demonstrates a substantial improvement of the sustainability performance of BCAs along the entire life cycle of the proposed solutions and considers rebound effects with respect to currently available state-of-the-art technologies or solutions.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.8.4 | Award Amount: 7.17M | Year: 2009

We will develop Complexity Science based modelling, prediction and simulation methods for large scale socio-technical systems. We focus on the specific example of Ambient Intelligence (AmI) based smart environments. A key component of such environments is the ability to monitor user actions and to adjust its configuration and functionality accordingly. Thus, the system reacts to human behaviour while at the same influencing it. This creates a feedback loop and leads to a tight entanglement between the human and the technical system. At the same time there is dynamic, heterogeneous human-human, human-technology, and technology-technology communication leading to ad-hoc coupling between components and different feedback loops. The project will study global properties and emergent phenomena that arise in AmI based socio-technical systems from such local feedback loops and their coupling on two concrete scenarios: transportation and emergency/disaster.\nSOCIONICAL takes a parallel, multi facetted research approach. Thus, we will investigate analytical methods, complex networks based representations, and agent based models. The advances in modelling and prediction will be verified by large scale, distributed simulation driven by real life data. We will develop a methodology by which a small number of instrumented users can be realistically integrated in a large scale simulation as additional agents, experiencing the system and driving it. A separate WP is devoted to the integration of different approaches into a coherent framework. Another ensures generalization.\nTo take into account all technological, psychological and social dimensions and realistic diversity of behaviours we have assembled a multi disciplinary consortium with separate WPs for technology analysis and the modelling of human technology interactions.\nSOCIONICAL has a WP devoted to the development and dissemination of guidelines and recommendation for businesses and policy makers.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-2-4-01;KBBE-2007-2-4-02 | Award Amount: 8.89M | Year: 2008

Flavouring, Additive and Food Contact Material Exposure Task: FACET FACET will deliver to the European Community a sustainable surveillance system, to estimate target food chemical intake. The project will consist of three main groupings of its 20 partners. The Chemicals group will prioritise the flavourings, additives and food contact materials for investigation and the food categories applicable to them. The Food group will take those food categories and will establish food ingredient occurrence data through the primary collection of food packaging material and the recording of all food ingredients in purchased foods. It will also create tired food consumption databases linked to the target food categories. In addition, where intake data is limited, models of regional diets will be developed. A group on chemical concentration will provide data on the concentration of target chemicals in target food groups. Databases on food intake, food chemical occurrence and food chemical concentration will be linked in algorithms which will be converted into computer code for the estimation of probabilistic exposure to target food chemical intake.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2009-1-2-04 | Award Amount: 7.82M | Year: 2010

SOLIBAM will develop specific and novel breeding approaches integrated with management practices to improve the performance, quality, sustainability and stability of crops adapted to organic and low-input systems, in their diversity in Europe and taking into account small-scale farms in Africa. SOLIBAM will: 1. Identify traits specific for adaptation to low-input/organic conditions over a wide range of agro-climatic conditions in Europe 2. Develop efficient phenotyping, genotyping and molecular tools to monitor heritable variation during selection. Molecular analysis of functional polymorphisms will increase accuracy in breeding methodologies and improve monitoring of genetic diversity and adaptation along generations. It will also increase the understanding of adaptive phenomena 3. Develop the use of within-crop diversity to stabilise yield and quality in the face of current and increasing variation in organic and low-input agriculture 4. Design, develop and test innovative arable and vegetable cropping systems based on integration of a high level of diversification in crop management with the use of genetically diverse populations or varieties 5. Compare the effectiveness of different breeding strategies under conventional, low input and certified organic farming to set up optimal strategies for the production of varieties suitable for organic and low input farming taking into account the traits which are avoided in conventional breeding 6. Develop methodologies for farmers participatory research that exploit SOLIBAMs advances in low-input and organic farming 7. Quantify the effects and interactions of breeding and management innovations on crop nutritional, organoleptic and end-use quality 8. Evaluate socio-economic and environmental impacts of SOLIBAM breeding and management innovations in order to identify farm business, consumer preference, food supply and legislation related issues that are likely to influence their adoption

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FoF-08-2015 | Award Amount: 4.15M | Year: 2015

The rise of the system complexity, the rapid changing of consumers demand require the European industry to produce more customized products with a better use of resources. The main objective of IMPROVE is to create a virtual Factory of the Future, which provides services for user support, especially on optimization and monitoring. By monitoring anomalous behaviour will be detected before it leads to a breakdown. Thereby, anomalous behaviour is detected automatically by comparing sensor observation with an automatically generated model, learned out of observations. Learned models will be complemented with expert knowledge because models cannot learn completely. This will ensure and establish a cheap and accurate model creation instead of manual modelling. Optimization will be performed and results will be verified through simulations. Therefore, the operator has a broad decision basis as well as a suggestion of a DSS (Decision Support System), which will improve the manufacturing system. Operator interaction will be done by a new developed HMI (Human Machine Interface) providing the huge amount of data in a reliable manner. To reach this aim, every step of the research process is covered by a minimum of two experienced consortium partners, who conclude the results of the project using four demonstrators. The basis for IMPROVE are industrial use-cases, which are transferable to various industrial sectors. Main challenges are reducing ramp-up phases, optimizing production plants to increase the cost-efficiency, reducing time to production with condition monitoring techniques and optimise supply chains including holistic data. Consequently, the resource consumption, especially the energy consumption in manufacturing activities, can be reduced. The optimized plants and supply chains enhance the productivity of the manufacturing during different phases of production. Furthermore, the industrial competitiveness and sustainability in EU will be strengthened.

Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 4.93M | Year: 2014

The global Robotics and Autonomous Systems (RAS) market was $25.5bn in 2001 and is growing. The market potential for future robotics and autonomous systems is of huge value to the UK. The need for expansion in this important sector is well recognised, as evidenced by the Chancellor of the Exchequers announcement of £35m investment in the sector in 2012, the highlighting of this sector in the 2012 BIS Foresight report Technology and Innovation Futures and the identification of robotics and autonomous systems by the Minister for Universities and Science in 2013 as one of the 8 great technologies that will drive future growth. This expansion will be fuelled by a step change in RAS capability, the key to which is their increased adaptability. For example, a home care robot must adapt safely to its owners unpredictable behaviour; micro air vehicles will be sent into damaged buildings without knowing the layout or obstructions; a high value manufacturing robot will need to manufacture small batches of different components. The key to achieving increased adaptability is that the innovators who develop them must, themselves, be very adaptable people. FARSCOPE, the Future Autonomous and Robotic Systems Centre for PhD Education, aims to meet the need for a new generation of innovators who will drive the robotics and autonomous systems sector in the coming decade and beyond. The Centre will train over 50 students in the essential RAS technical underpinning skills, the ability to integrate RAS knowledge and technologies to address real-world problems, and the understanding of wider implications and applications of RAS and the ability to innovate within, and beyond, this sector. FARSCOPE will be delivered by a partnership between the University of Bristol (UoB) and the University of the West of England (UWE). It will bring together the dedicated 3000 square metre Bristol Robotics Laboratory (BRL), one of the largest robotics laboratories in Europe, with a trainin and supervising team drawn from UoB and UWE offering a wide breadth of experience and depth of expertise in autonomous systems and related topics. The FARSCOPE centre will exploit the strengths of BRL, including medical and healthcare robotics, energy autonomous robotics, safe human-robot interactions, soft robotics, unconventional computing, experimental psychology, biomimicry, machine vision including vision-based navigation and medical imaging and an extensive aerial robotics portfolio including unmanned air vehicles and autonomous flight control. Throughout the four-year training programme industry and stakeholder partners will actively engage with the CDT, helping to deliver the programme and sharing both their domain expertise and their commercial experience with FARSCOPE students. This includes regular seminar series, industrial placements, group grand challenge project, enterprise training and the three-year individual research project. Engaged partners include BAE Systems, DSTL, Blue Bear Systems, SciSys, National Composites Centre, Rolls Royce, Toshiba, NHS SouthWest and OC Robotics. FARSCOPE also has commitment from a range of international partners from across Europe, the Americas and Asia who are offering student exchange placements and who will enhance the global perspective of the programme.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 1.94M | Year: 2010

As the range of phenomena that need to be simulated in engineering practice broadens, the limitations of conventional computational methods, such as finite elements (FE), finite volumes or finite difference methods, have become apparent. There are many problems of industrial and academic interest which cannot be easily treated with these classical methods. To overcome the limitations of classical methods, several advanced discretization techniques (mesh-free methods, extended/generalized FE or Dicontinuous Galerkin methods) have recently become very popular in the research community. However, despite their high potential and the important effort devoted to them in the last decade, advanced techniques require still very much attention to reach the popularity of conventional techniques for industrial applications. In fact, engineers are usually not trained in these techniques. The purpose of the ITN research project is to advance in the development and analysis of advanced techniques, with special attention to particular industrial applications of interests in the framework of computational mechanics. However, the introduction of new techniques in industry is only possible if industrial researchers have a deep knowledge and confidence on these techniques and are aware of their advantages. The ITN training program is addressed to researchers that, in the future, may be incorporated in industry. It is based on training-through-research with individual research projects, active participation in network activities and a wide offer of specific courses. In present, the network partners have a wide offer of training courses (joint Erasmus Mundus Master of Science in Computational Mechanics, etc). No experienced researchers or visiting professors are considered in this proposal. The dimension of the academic network teams and the scientific production of all of them clearly demonstrate that they are able to carry out the planned training program.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: WASTE-1-2014 | Award Amount: 9.95M | Year: 2015

The aims of BAMB (Buildings as Material Banks) are the prevention of construction and demolition waste, the reduction of virgin resource consumption and the development towards a circular economy through industrial symbiosis, addressing the challenges mentioned in the Work Programme on Climate action, environment, resource efficiency and raw materials. The focus of the project is on building construction and process industries (from architects to raw material suppliers). The BAMB-project implements the principles of the waste hierarchy: the prevention of waste, its reuse and recycling. Key is to improve the value of materials used in buildings for recovery. This is achieved by developing and integrating two complementary value adding frameworks, (1) materials passports and (2) reversible building design. These frameworks will be able to change conventional (cradle-to-grave) building design, so that buildings can be transformed to new functions (extending their life span) or disassembled to building components or material feedstock that can be upcycled in new constructions (using materials passports). This way, continuous loops of materials are created while large amounts of waste will be prevented. Activities from research to market introduction are planned. Fundamental knowledge gaps should be bridged in order to introduce both frameworks on the market. Advanced ICT tools and management models will enable market uptake and the organization of circular value chains in building and process industries. New business models for (circular) value chains will be developed and tested on selected materials. The inclusion of strategic partners along the value chains in an industrial board will maximize market replicability potential, while several (mostly privately funded) building pilots will demonstrate the potential of the new techniques. Awareness will be raised to facilitate the transition towards circularity by policy reform and changing consumer behavior.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.5 | Award Amount: 3.73M | Year: 2008

Wavelength-tunable lasers are key components for future reconfigurable optical networks and for cost-effective and compact telecommunication infrastructures. Moreover, a broadband and continuously tunable laser with high purity emission spectrum is a versatile tool for many sensing applications, e.g. for greenhouse gases (laser absorption spectroscopy) or deformations of buildings (fiber Bragg grating sensors).\nA novel concept for widely and continuously wavelength-tunable single-mode laser diodes in the 750-2100 nm wavelength range will be developed. The underlying VCSEL structure is completed by a micro-machined moveable Bragg-mirror with a sub-wavelength grating (SWG). The single-mode property of the VCSEL structure is thus ideally combined with the polarization stability of the SWG and the wide and continuous tunability of the electro-thermally or electro-statically actuated mirror. For the fabrication of the nano-scale SWGs an electron-beam writing process will be developed.\nThe curvature of the micro-mirror will be matched to the phase front of the fundamental mode to achieve its maximum support while suppressing undesired polarization modes by means of a SWG. This technology can select the single fundamental mode from relatively large apertures. The optical output power will be high and a very good sidemode suppression will be achieved during tuning. The project will develop both long wavelength InP-based VCSELs (1.3m to 2.1m) and short wavelength GaAs VCSELs (down to 800nm), and thus introduces widely tunable VCSELs in a broad range of the optical spectrum. Additionally, a technology for integrated tunable VCSELs with dielectric Bragg mirrors will be developed for efficient manufacturing of the laser modules.\nThe devices will be optimized in close cooperation between the university and industrial partners. Devices for gas detection, fiber Bragg grating sensing and optical communications will be investigated.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2011-IAPP | Award Amount: 1.38M | Year: 2012

The overall goal of LaScISO (Large Scale Industrial Structural Optimisation for Advanced Applications) is to enhance structural optimisation methods to be capable of optimisation with current industrial state-of-the-art simulation techniques, i.e. to optimize what can be simulated. This requires a tight cooperation between leading research institutions and industry within the fields of numerical optimisation, structural mechanics and software engineering. Current industrial structural optimisation software packages are capable of optimizing linear static and modal finite element (FE) modelled structures. The optimisation is mainly carried out by the CAE (computer aided engineering) simulation groups which are typically also in charge of carrying out more complex simulations involving multiphysics effects and different types of nonlinearities. The demand for optimisation tools which can handle the latter is obvious because many effects can only be investigated and controlled by using these analysis methods. To solve these optimisation problems in an efficient and flexible way, sensitivity based optimisation methods must be extended to cope with multiphysics and nonlinearities. This requires skill in development of new methods and software capabilities. With the consortium consisting of different specialists within the project area, it will be ensured that all skills needed to overcome the current limitation are available such that current state-of-the-art large scale simulations may be used directly in optimisation with good performance. The benefit of LaScISO is a faster and more cost-efficient simulation driven European product development. The optimisation methods will provide a competitive advantage over non-European developers to create low-weight, CO2-saving high quality products within a shorter development time.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: EeB-ENERGY.2010.8.1-2 | Award Amount: 7.84M | Year: 2011

The vision of E2ReBuild is to transform the retrofitting construction sector from the current craft and resource based construction towards an innovative, high-tech, energy efficient industrialised sector. E2ReBuild aims to - investigate, promote and demonstrate cost effective and advanced energy efficient retrofit strategies that create added value for existing apartment buildings and endorse end-users to stay and build a dynamic society - to establish and demonstrate sustainable renovation solutions that will greatly reduce the energy use - to create a holistic industrialised process that minimises technical and social disturbance for tenants and facilitates energy efficient operation and use of the buildings including encouraging energy efficient behaviour This will be achieved by transferring technical innovations and advances from research to application and wide use. It will also change current inefficient way of doing business to a win-win situation for all involved actors. By understanding and matching the needs of stakeholders a holistic, new design and decision tool will be introduced. E2ReBuild will create added values by optimizing space use, improving comfort and integration of advanced technologies. By introducing industrial manufacturing methods and standardise retrofit measures that allow a high replication potential (60 % of existing apartment buildings for the studied regions and period), the energy use (during construction and operation) and waste can be minimised, ad, the quality and indoor environment can be improved. E2ReBuild will demonstrate, monitor and evaluate proposed technologies, processes and measures in 7 full-scale residential building projects, with typologies representative for large geographical areas in Europe.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-5 | Award Amount: 7.21M | Year: 2013

GREEN SURGE will identify, develop and test ways of connecting green spaces, biodiversity, people and the green economy, in order to meet the major urban challenges related to land use conflicts, climate change adaptation, demographic changes, and human health and wellbeing. It will provide a sound evidence base for green infrastructure planning and implementation, exploring the innovation potential, and linking environmental, social and economic services with local communities. Working from the local to the city-regional level, the project aims to: 1) Develop urban green infrastructure as a planning concept for both integration and promotion of biodiversity and ecosystem services, and adapt it to local contexts; 2) apply an innovative biocultural diversity perspective to develop successful governance arrangements facilitating socio-ecological integration and local engagement in planning of urban green spaces; and 3) explore how valuation and real market integration of biodiversity and ecosystem services can facilitate choices in favour of the development of multifunctional green spaces in urban areas. Approaches and tools under these three interlinked objectives will be developed and implemented through an integrative, iterative and transdisciplinary process. GREEN SURGE will embrace a three-tiered approach of comparative European cases, synthesis of good practices, and establishment of five Urban Learning Labs strategically selected to represent different urban situations in Europe. GREEN SURGE will work within cooperative Learning Alliances, a specific type of multi-stakeholder involvement designed to enhance a process of shared learning and understanding in situations with a high degree of complexity and un-predictability. Two-loop learning applied combines a project-wide science-driven approach based on a common framework methodology with a bottom-up knowledge or experience-based approach at the local level.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2013.2.1-1 | Award Amount: 5.99M | Year: 2014

Typically, end users or consumers are perceived as adopters of sustainable products and services, developed by companies. Thus, a lot of attention is paid to the (non-) diffusion of sustainable products and services. From this perspective end users are seen as more or less passive recipients of sustainable products and services. We propose to investigate the active roles of end users in shaping sustainable lifestyles and the transition to a green economy in Europe. More specifically, we suggest exploring, explaining and enhancing the role of end users in (co-) innovating novel sustainable products, services, and systems (Sustainable Lifestyles 2.0). Generally, there are two options: First, end users are integrated in the process of sustainability innovations driven by companies (user integration). Second, end users innovative for themselves, and eventually form enterprises to capture value from their sustainability innovations (user innovation and entrepreneurship). We argue that end user integration, innovation and entrepreneurship offer great potentials for smart, sustainable and inclusive growth in the upcoming years, which is largely untapped and unexplored. While acknowledging the value of company-driven sustainability innovations, we want to investigate pathways towards a sustainable society, which is more user-centred and user-driven. We aim to gain a better and broadened understanding of the active roles of end users in sustainability innovation processes with a special emphasis on the four domains food, living, mobility, and energy. These domains are responsible for the highest life cycle environmental impacts related to the final consumption, and put together shape sustainable lifestyles in Europe.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.82M | Year: 2013

The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features of mitochondrial biology and represents an ideal platform for the training of young investigators who will develop a broad view of biomedical sciences working in such a multifaceted area of research. The project will create a network of 10 basic and translational laboratories (among which 2 SMEs) and 2 associated partners who will provide well established professional tools for training and dissemination. MEET will train 11 ESRs and 3 ERs supervised in their research by 15 mentors and by their collaborators. In addition, the 14 trainees will attend at least 1 advanced course in the genetic field, 1 complementary training course about public and private financial sources for R&D and Innovation projects and 1 or 2 selected technical workshops organized by the 10 partner laboratories. The cohesion of the research and teaching activities will be guaranteed by: monthly telematic meetings of, an international scientific Symposium specifically addressed to associations and foundations of patients and patients families in order to exchange the most up-to-date knowledge advances.By creating the critical mass of scientific excellence documented by the track records of the individual investigators, most of whom have worked together in the FP6 EUMITOCOMBAT project, MEET will combine the efforts of leading clinicians with those of more basic oriented groups and will have important implications for the comprehension and treatment of mitochondria-related pathologies

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.5 | Award Amount: 12.39M | Year: 2010

BEAMING is the process of instantaneously transporting people (visitors) from one physical place in the world to another (the destination) so that they can interact with the local people there. This is achieved through shifting their means for perception into the destination, and decomposing their actions, physiological and even emotional state into a stream of data that is transferred across the internet. Simultaneous streams of data from the destination site to the visitors perceptual apparatus, and from the actions and state of the visitor to the destination site, cohere together to form a unified virtual environment representing the physical space of the destination in real-time a destination that now includes the beamed people. BEAMING will endow this process with physicality.\nThe visitors actions at the destination site can have physical consequences, the actions of local people at the destination site can have physical consequences for the visitor. The visitor may be embodied at the destination site as a physical robot, and yet be seen by the locals virtually in human form. This project will bring todays networking, computer vision, computer graphics, virtual reality, haptics, robotics and user interface technology together in a way that has never been tried before thereby transcending what is possible today. The goal is to produce a new kind of virtual transportation, where the person can be physically embodied interacting with life-sized people who may be thousands of kilometres away. Moreover, this is underpinned by the practical utilisation of recent advances in cognitive neuroscience in understanding the process whereby the brain represents our own body. The project brings technology researchers together with neuroscientists in order to develop and understand this complex but far reaching technology. The profound ethical and legal issues raised by a (near) future world in which this will be possible are considered in a dedicated workpackage.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-15-2015 | Award Amount: 6.83M | Year: 2016

CLINICAL PROBLEM AND UNMET NEED There are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection. TETRA PROJECT Our SME-led project will address the limitations of standard clinical care and competitor products under development and will: - Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients - Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases - Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication - Prepare a dossier for MAA submission BENEFITS Our product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of 517 million per year. We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.4.2-3 | Award Amount: 3.85M | Year: 2013

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, diastolic heart failure). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medical treatment has been shown to be effective and the economic, social and personal burden of HFPEF is enormous; this disease constitutes one of the most pressing unmet clinical needs. A cardinal feature of HFPEF is exercise intolerance. The pathophysiology of exercise intolerance in HFPEF depends on multiple factors in heart, endothelium and skeletal muscles. From a pathophysiological point of view, exercise could by far outweigh any pharmacological intervention in this heterogeneous syndrome, since lifestyle dependent risk factor, physical inactivity, and physical deconditioning underlay and contribute to HFPEF. OptimEx will focus on the cardiovascular effects of exercise training as primary and secondary prevention of HFPEF. We will combine in vivo and in vitro studies in man and rats in serial experiments that will advance our understanding of fundamental cellular and molecular mechanisms underpinning dose-dependent exercise-induced changes in the heart, blood vessels and skeletal muscles. This research is aimed to tackle one of the major health problems the developed world faces with its ageing societies and increasing prevalence of the HFPEF and will support sustainable health systems in EU member states through improvements in the clinical management of a common and disabling disease. The project is therefore highly relevant to improve the health of European citizens and important to promote healthy ageing and preventing disease.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2008-1-2-01 | Award Amount: 3.92M | Year: 2009

Organic and low-input farming systems have been shown to benefit farmland biodiversity although a generic indicator system to assess these benefits at the European level is lacking. The BIOBIO project will therefore pursue the following objectives: 1. Conceptualization of criteria for a scientifically-based selection of biodiversity indicators for organic/low-input farming systems; 2. Assessment and validation of a set of candidate biodiversity indicators in representative case studies across Europe (and in ICPC countries); 3. Preparation of guidelines for the implementation of biodiversity indicators for organic/low-input farming systems for Europe and beyond. Existing indirect farm management indicators as well as direct indicators for genetic, species and habitat diversity will be assessed for their scientific soundness, practicality, geographic scope and usefulness for stakeholders. Candidate indicators will be tested in a standardised design in twelve case studies across Europe and later in three ICPC countries. Case study regions will include pannonian, alpine, boreal, Atlantic and Mediterranean grassland systems (both organic and/or low-input), rain fed organic farms under temperate and Mediterranean conditions, mixed organic farming, organic special crops and low-input tree/agroforestry systems. Plot, farm and regional scales (where applicable) will be addressed. The investigation will include new agricultural practices, e.g. soil conservation, crop rotation management, seed and crop mixtures and economic issues relating to the costs of indicator measurement and to benefits of biodiversity as perceived by different groups of the population. Stakeholders (farming communities, conservation NGOs, administrators) will be integrated at critical stages of the indicator selection process. A handbook with factsheets will be produced for validated indicators and a sampling design for biodiversity monitoring in organic and low-input farming systems across Europe.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.69M | Year: 2014

Neurogastroenterology is a new and emerging medical/scientific subspecialty that currently has no formal training opportunities in medicine and related disciplines. It includes basic science aspects (neurophysiology, neurobiology, neuropsychology, psychophysiology) and clinical aspects (gastroenterology, neurology, internal medicine, surgery, psychology, psychosomatic medicine) of the neural control of intestinal functions (motility, secretion, absorption, immunity, sensitivity) in health and disease. Functional disorders of the gastrointestinal tract are among the most frequent disorders in the general population, are associated with high psychiatric (depression, anxiety, chronic fatigue) and somatic comorbidities (back pain, headache), and account for substantial direct and indirect health care costs occurring throughout Europe. Functional disorders of the gastrointestinal tract are thought to be due to disorganized gut-brain interaction of either afferent or efferent or both pathways in control of intestinal functions. In addition, low-grade inflammation, nutritional challenges of the local immune system, and/or post-infectious neuroplastic changes of the enteric nervous system of the gut are believed to be common pathogenetic mechanisms. Genetic contributions have been established, and psychological modulators of its clinical expression have been shown to be effective; both contribute to the efficacy of therapeutic interventions. The standards of diagnosis of functional bowel disorders are still a matter of debate, and only a few effective treatment strategies are available. The NeuroGut network, consisting of experienced academic and industrial partners organized in the European Neurogastroenterology and Motility Society (ESNM), is therefore aimed at offering young researchers excellent training opportunities in neurogastroenterology and in complementary skills in order to generate a new generation of scientists dedicated to resolving open questions.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.30M | Year: 2011

TESIS, Towards an Embodied Science of InterSubjectivity, is an integrated ITN programme to investigate the foundations of human sociality. It brings together the complementary expertise of 13 European research institutes, clinical centres and private enterprises that span the biomedical sciences and the humanities. Thus, TESIS provides critical mass in the fields of philosophy, cognitive neuroscience, developmental psychology, psychiatry and societal outreach. It will advance our understanding of human intersubjectivity based on the following research and training objectives: (1) To investigate the neural underpinnings of affective exchange with others, of shared action spaces and joint object relations, endorsing a novel interactive embodied neuroscience; (2) To investigate the development of social skills in infants in the context of the awareness of others during interaction, yielding an interactive concept of embodied social cognition; (3) To investigate the intersubjective factors affecting psychopathologies, especially schizophrenia, autism and somatoform disorders and to draw implications for treatment; (4) To investigate in toddlers and young children the understanding of toys, objects and cultural artefacts and the links between materiality and sociality; (5) To investigate cultural interactive patterns and shared practices such as group learning, playing, teamwork, distributed cognition, creating applied knowledge for education, management, and organizational development. By integrating state of the art and novel approaches to studying interactive situations, TESIS will significantly extend the individualistic and static paradigm still dominant in social cognition research. The major breakthrough to be expected from TESIS is a comprehensive framework for embodied intersubjectivity applicable in the biomedical sciences, the humanities, and society in general, showing how we become human by embodied interaction with others from the beginning.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.4-2 | Award Amount: 7.76M | Year: 2011

The BIOHYBRID consortium was build up with the overall aim to develop, in a preclinical perspective, an innovative biohybrid artificial nerve device for the regenerative treatment of traumatic injuries of peripheral nerves. This consortium consists of three active and well integrated SMEs as well as seven academic partners that are recognised leaders in the scientific areas of interest for this project. Furthermore, another partner has substantiated expertises to meet the regulatory work for ATMP development. Traumatic injuries of peripheral nerves represent a major cause for morbidity and morbility in Europe and their social impact is considerably high. It has been estimated that the incidence of peripheral nerve injuries derived from trauma is about 300,000 cases per year. Moreover, nerve injuries are an important component of traumatic limb amputations, with an incidence of 2/100,000 persons per year described for hand amputations. Therefore, repair and regeneration of peripheral nerve injuries represent a major field where clinical application of innovative therapies in regenerative medicine should be sought. Peripheral nerve fibers are able to regenerate and lead to functional recovery provided that an appropriate milieu and guide is available. However, the clinical outcome of neural repair after extended substance loss after nerve injury is often unsatisfactory and therefore innovative strategies for improving the outcome after neural damage are in demand. The main objective of the BIOHYBRID project is the development of a regenerative therapy using an innovative biohybrid artificial nerve device with the goal of repairing damaged nerve trunks. The work program includes an integrated experimental approach bringing together the main aspects of regenerative medicine: a) reconstructive microsurgery, b) regenerative scaffolds and c) transplantation. This approach will allow the biological pre-fabrication of biohybrid nerve devices, their transplantation into nerve gaps in various animal models and the comprehensive evaluation of the regenerative outcome. The SME involvement, for the first time in this biomedical field, will not be limited to production and supply of materials and services but includes also active participation in the conduction of the experiments for in vivo preclinical assessment and follow-up. Based on the extensive basic and clinical experience within this consortium a biohybrid artificial nerve device will be developed together with standardised application and evaluation parameters. A key objective of this study will be to generate, for the first time, a protocol that can serve as a template for future clinical trials in the regenerative therapy of damaged peripheral nerves. The BIOHYBRID project with its consortium partners combines excellent expertise to successfully reach the objectives and stands therfore on the front line of regenerative medicine approaches.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SST-2007-1.1-05 | Award Amount: 27.48M | Year: 2008

The project HERCULES-B is the Phase II of the HERCULES programme, conceived in 2002 as a 7-year strategic R&D Plan, to develop the future generation of optimally efficient and clean marine diesel powerplants. The project is the outcome of a joint vision by the two major European engine manufacturer Groups, MAN Diesel and WARTSILA, which together hold 90% of the worlds marine engine market. The research objectives in HERCULES-B focus on the drastic reduction of CO2 emissions from maritime transport, considering the existing and foreseen composition of the world fleet and fuel infrastructure. The principal aim in HERCULES-B is to reduce fuel consumption of marine diesel engines by 10%, to improve efficiency of marine diesel propulsion systems to a level of more than 60%, and thus reduce CO2 emissions substantially. An additional concurrent aim is towards ultra low exhaust emissions (70% Reduction of NOx, 50% Reduction of Particulates) from marine engines by the year 2020. Today diesel propulsion systems power 99% of the world fleet. HERCULES-B targets the development of engines with extreme operational pressure and temperature parameters, considering the thermo-fluid-dynamic and structural design issues, including friction and wear as well as combustion, air charging, electronics and control, so as to achieve the efficiency / CO2 target. To achieve the emissions target, combustion and advanced aftertreatment methods will be concurrently developed. To improve the whole powertrain, the interaction of engine with the ship, as well as the use of combined cycles in overall system optimization, will be considered. The project HERCULES-B structure of work comprises 54 subprojects, grouped into 13 Tasks and 7 Workpackages, spanning the complete spectrum of marine diesel engine technology. The project HERCULES-B has a total budget of 27M, a duration of 40 months and a Consortium with 32 participants.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2010-3.1-1 | Award Amount: 3.99M | Year: 2011

Systems provide value through their ability to fulfill stakeholders needs. Inevitably, these needs evolve over time and diverge from an original systems capabilities. Thus, the system must be disposed of or periodically upgraded at substantial cost. The objective of the AMISA project is to develop a generic, quantitative methodology for architecting manufacturing lines, product systems and customer services for optimal adaptability to unforeseen changes in stakeholder needs, technology development, and government regulations. The methodology will be validated in six real-life pilot projects to provide concrete evidence that it is: 1) Generic and tailorable, 2) Scalable, 3) Usable and 4) Cost effective. AMISA will deliver a step-change in the performance of European industry, characterized by a higher reactivity to needs and more economically compatible products and services. Manufacturing systems or products/services designed for adaptability will save 20% either in cost or cycle time and increase their valuable lifespan by 25%. During manufacturing these systems will consume less energy and natural resources and produce less pollution and waste. Adaptable systems will also be more amenable to adjustments in regulatory frameworks (i.e. environmental, health, safety, etc.). The AMISA consortium is composed of four large manufacturers and two SMEs representing the Food, Machinery, Aerospace, Automotive, Communication and Optronics sectors. The consortium also includes four research centers with experience in fusing engineering and economic theories with practical applications in industry and government. Since AMISA deals with systemic issues, its expected impact is vastly wider than just the industries that are directly involved in the project. Accordingly, the project will operate within an international framework, including U.S. scientists and collaboration with relevant Intelligent Manufacturing System (IMS) projects.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.94M | Year: 2015

Cavitation, described as the formation of vapour/gas bubbles of a flowing liquid in a region where the pressure of the liquid falls below its vapour pressure, often leads to vibration and damage of mechanical components, for example, bearings, fuel injectors, valves, propellers and rudders, impellers, pumps and hydro turbines. Cavitation erosion when experienced, normally leads to significant additional repair and maintenance costs or component replacement. Even if erosion problems can be avoided by design or operation, most often the performance of the systems is sub-optimal because countermeasures by design are needed to prevent cavitation problems. Despite the long-lasting problems associated with cavitation, computational models that could simulate cavitation and identify locations of erosion are still not thoroughly developed. The proposed interdisciplinary training and research programme aims to provide new experimental data and an open-source simulation tool for hydrodynamic cavitation and induced erosion. Insight into the detailed bubble collapse mechanism leading to surface erosion will be realised through DNS simulations, which are now feasible by the significant progress in fluid flow computational methods and parallel simulations. Information from such models will be implemented as sub-grid scale models of URANS and LES approaches, typically employed for cavitation simulation at engineering scales. Model validation will be performed against new advanced X-ray, laser diagnostics and high speed imaging measurements to be performed as part of this project. Application of the developed models to cases of industrial interest includes fuel injectors, marine propellers, hydro-turbines, pumps and mechanical heart valves. From this understanding the development of methodologies for design of cavitation-free or remedial measures and operation of devices suffering from cavitation erosion can then be established for the benefit of the relevant communities.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-02-2015 | Award Amount: 3.50M | Year: 2015

TELWIND unites a strong complimentary team of renowned European companies and research institutions, which join forces to develop a revolutionary integrated floating offshore system. The concept, which has already undergone trial tank testing with overly positive results, shall enable a radical cost reduction both in terms of material usage and required means and operations. The system has been conceived in a holistic approach to the overall substructure, tower and turbine, generating ground breaking synergies between the integrated elements to specifically address the particular requirements of offshore wind, focusing in the capacity for low-cost industrialization in the inshore construction and offshore installation processes. The Telwind concept integrates a novel floating substructure and a pioneer self-erecting telescopic tower. The former provides all the performance advantages of a spar-buoy substructure while allowing for qualitatively lower material usage, the latter enables a full onshore preassembly of the overall system and a highly beneficial reduction of offshore works and auxiliary means. Together they overcome the limitations imposed by the available inshore infrastructure and offshore heavylift vessels, and thus generate a fully scalable system, perfectly fitted for the effective integration of the next generation of extremely large (10MW\) offshore wind turbines which are key to enhance the reduction of the Levelised Cost of Energy (LCOE). The system will also profit from the proven structural efficiency and economy of precast concrete, a material particularly well suited for low-cost industrialized production of repetitive units. Robust, reliable and virtually maintenance-free marine constructions result, reducing OPEX costs, greatly increasing durability and fatigue tolerance, and setting the ground for extended service life of the infrastructure, which could further magnify the systems capacity for drastic reduction of the LCOE.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.00M | Year: 2015

The height of conventional wind turbines is limited by the enormous stresses on the structure. The idea of the Airborne Wind Energy (AWE) is to replace the most efficient part of a conventional wind turbine, the tip of the turbine blade, with a fast flying high efficiency kite, and to replace the rest of the structure by a tether which anchors the kite to the ground. Power is generated either by periodically pulling a ground based generator via a winch, or by small wind turbines mounted on the kite that exploit its fast cross wind motion. While the concept is highly promising, major academic and industrial research is still needed to achieve the performance required for industrial deployment. This can best be done by innovative junior researchers in a closely cooperating consortium of academic and industrial partners. The ITN AWESCO combines six interdisciplinary academic and four industrial network partners with seven associated partners, all selected on the basis of excellence and complementarity. All partners work already intensively on AWE systems, several with prototypes, and they are committed to create synergies via the cooperation in AWESCO. The main task is to train fourteen Early Stage Researchers (ESRs) in training-by-research and to create a closely connected new generation of leading European scientists that are ready to push the frontiers of airborne wind energy. AWESCO is the first major cooperation effort of the most important European actors in the field and will help Europe to gain a leading role in a possibly huge emerging renewable energy market, and to meet its ambitious CO2 targets. In addition, the AWESCO early stage researchers will be trained in cutting-edge simulation, design, sensing, and control technologies that are needed in many branches of engineering.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 2.43M | Year: 2015

The main objective and basic concept of our proposal is to improve intra-operative and post-operative targeted surgical probes and new detection systems for surgical intervention of cancer. The work revolves around the mobility of clinicians, scientists and technologists between twelve consortium partners and across four different countries. The goal is the implementation of inter-disciplinary, inter-sector, cross-training of personnel. As a consequence, this will serve to accelerate the development of improved imaging technologies and hybrid fluorescence/radionuclide probes for the surgical intervention of cancer. The hypothesis is that if we can develop a hybrid probe for both targeted image-guided surgery and post-operative molecular radiotherapy, we would be implementing a revolutionary imaging and therapeutic approach for oncology surgeons to help their patients by improving better overall survival and quality of life for the patient. There are four key objectives within this project: 1) synthesis of a near infra-red fluorescence (NIRF)-dye conjugated to a peptide that is targeted towards a tumour associated antigen, 2) deliver a novel clinical optoacoustic handheld camera to detect the fluorescence probe in deep tissue, 3) validate the probe/target combination across the subcellular, cellular, endoscopic and macroscopic levels with state-of-art technologies, and 4) develop the probe further by targeting a radionuclide entity to the fluorescent construct for postoperative radiotherapy. Surgeons would have a more definitive reference for resection, if the tumour margin can be clearly defined. If this can be achieved, the impact would be (a) reduced recurrence rates in patients by lowering the risk of residual tumour tissue remaining after surgery and as a consequence improve survival, (b) minimised removal of healthy tissues, c) reduced patient morbidity and hospital stay and d) significant health cost benefits.

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.4-03 | Award Amount: 4.01M | Year: 2011

Coexistence is still a controversial topic within the EU. Member States, farmers, and participants within the food chain have expressed an interest on the implications of different coexistence polices on costs, feasibility of achieving segregated supply chains, as well as implications for labeling and traceability. While a number of issues have already been addressed in previous projects, information about feasible and cost-effective coexistence measures at farm and supply chain level is still missing. PRICE will investigate the cost of coexistence practices in a number of Member States including the innovative solutions chosen by farmers to reduce coexistence compliance costs. A software module based on models resulting from previous projects (Co-Extra, SIGMEA) will be further developed with the aim to combine the natural science-based knowledge of cross pollination including biological containment methods at farm and regional level with solutions based on farmers knowledge and experience with co-existence measures. The software module will be tested in the field, used to systematically analyze different strategies for achieving coexistence, and developed into a user-friendly decision-support tool for stakeholders (e.g. farmers, grain handlers). Implications for traceability and labeling at farm and regional level will also be assessed. The risk of adventitious presence of GM events in GMO-free commodities is also important within international supply chains of agricultural commodities. PRICE outlines several scenarios about the evolution of the global market of GMO-free commodities taking into account a number of important parameters (e.g. prices, compliance costs) supported by two detailed case studies. A wide range of stakeholders participate form the start of the project via an interactive stakeholder platform for securing the practical relevance of PRICE activities and the link with similar activities in the EU and worldwide.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.1-6 | Award Amount: 4.27M | Year: 2008

The MICROENVIMET project proposes innovative approaches for building a comprehensive understanding of the interplay between cancer cells and their microenvironment both at primary and secondary sites. The objectives are to identify molecular pathways involved in the regulation of metastatic dissemination to lung, liver, lymph node and bone. To achieve these objectives, the original experimental approach proposed is to modulate the production/activity of proteases or their inhibitors. Proteases are now recognized as key regulators of a complex network of interacting molecules that modulate the properties of cancer cells and their microenvironment. The project is intended to identify key molecular pathways underlying early steps of metastatic dissemination by interfering with the protease network and studying the impact of such experimentally manipulated microenvironment on metastasis formation. In addition to identifying key regulators of metastasis, we aim at developing blocking antibodies towards these new candidates, with efficacy for therapeutic intervention, by using the most advanced state-of-the-art technologies. The study of cancer stem cells will be integrated into current concepts that consider and attempt to explain the importance of the microenvironment during cancer progression. The 9 academic and 1 SME Participants will combine expertise in genomics, proteomics, bioinformatics, in vivo imaging, transgenic mice, mouse models of metastasis, genetic manipulation of transplantable tumour cells, computerized image analysis, virus-mediated gene transfer, phage display and production of neutralizing antibodies. This consortium will facilitate shared access to a new microRNA platform, innovative technologies, human tumour tissue banks, in vivo and in vitro models mimicking different steps of metastatic dissemination, as well as know how in tumour-host cell interplay, angiogenesis, lymphangiogenesis, cancer stem cell biology and generation of database.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2010.2.2-1 | Award Amount: 3.98M | Year: 2011

Functional organic molecules and metal and semiconductor nanocrystals represent attractive building blocks due to their composition-, size- and structure-dependent electronic properties, and the ability to design and manipulate these properties via low-cost and established chemical synthesis. Building from the pressing need of the European market to develop novel, scalable and cheaper technologies for sensing applications, the main objective of the HYSENS project is to exploit inexpensive organic functional molecules and inorganic nanocrystals as building blocks to synthesize novel high-knowledge materials for the development of sensors for Group I, II transition metal cations and anions (Cl-, NO3-). The hybrid material intelligence resulting from the engineered combination of individual units will allow the execution of logic functions able to reduce false sensing outputs towards the development of sensors with enhanced selectivity and sensitivity. Our goal is to elucidate the mechanisms governing the optical and electrical response of such engineered hybrid materials arising from the interaction between the organic functional molecule component and the inorganic nanocrystal core component. Establishment of component-function relationships will lead to disruptive new knowledge that will impact on optical and electrical sensors technologies.

Agency: European Commission | Branch: H2020 | Program: FCH2-RIA | Phase: FCH-01.1-2015 | Award Amount: 6.88M | Year: 2016

The objective is to develop and integrate the most advanced critical PEMFC stack components, many from recent FCH JU programmes, into an automotive stack showing BOL performance of 1.5 W/cm2 at 0.6V, <10% power degradation after 6,000 hours, with a technical and economic assessment showing a cost of less than 50/kW at a 50,000 annual production scale. This will be achieved by leading industrial and academic partners with expertise in the design and manufacture of PEMFC stacks, their components and materials. They will select and build on components which can achieve key target metrics, e.g. catalyst materials showing mass activities of 0.44 A/mg Pt. There will be focus on integration of the key components and optimisation of the interfaces regarding the electrochemistry, mass and heat transport, and mechanical interactions. Several iterations of an advanced stack design will be evaluated. Work is organised to optimise the flow of development, which begins with catalysts being advanced and down-selected, scaled then fed into the design and development of catalyst layers, integration with membranes and the demonstration of CCM performance. The CCMs feed into stack component development where they will be integrated with GDLs to form MEAs; and where bipolar plates will be designed and developed and supplied with the MEAs for iterative stack design, assembly and testing. All mandatory and optional objectives of the FCH 2 JU Work Plan are addressed. Performance and durability are evaluated from small single cell to stack level using standardised test protocols. Degradation is addressed by stability testing, structural visualisation and modelling. Interfaces and specification alignment is an important focus, being integrated with the evaluation of new architectures and synthesis methods and informing balance of plant component specifications. Dismantling and recycling for the recovery and re-use of all critical MEA components is included in the costing evaluation.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: MG-5.5a-2015 | Award Amount: 19.31M | Year: 2016

The cities of Madrid, Stockholm, Munich, Turku and Ruse have formed the CIVITAS ECCENTRIC consortium to tackle the challenges of mobility in suburban districts and clean, silent and CO2 free city logistics. In many cities, these two important areas have received less attention in urban mobility policies. Though European cities have made significant steps forward in making city centres attractive and liveable urban nodes, there is a remaining conflict between providing high quality public space and meeting the accessibility requirements for freight deliveries. The suburban areas have remained largely unaddressed with a much higher car usage as a consequence. Recent or expected urban growth processes are posing additional pressure to peri-central areas, which face the specific challenges of: Becoming sufficiently appealing to avoid an unnecessary traffic flow towards to the city centre; Providing sustainable and high quality mobility options to enable and encourage car independent lifestyles; and Planning the urban future according to carbon neutral mobility principles. ECCENTRIC will demonstrate and test the potential and replicability of integrated and inclusive urban planning approaches, innovative policies and emerging technologies to reach sustainable urban mobility objectives. The solutions will be implemented in 5 living laboratory areas in the outskirts that face high population growth and an increasing pressure on the existing transport networks. As highlighted in the SUMPs of the ECCENTRIC cities, this action on a wider geographical scale than the city centre is needed in order to meet the targets of the Transport White Paper in terms of air quality, energy use and CO2 emissions, road casualties and wide uptake of clean vehicles. To reach CO2 free city logistics by 2030, ECCENTRIC will test clean vehicles and fuels, formulate new regulations and services and develop consolidation solutions in close partnerships with the private sector.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.28M | Year: 2011

Today there is 5% error in estimation of biomass in fish farming. This represents 91M in loss for the European fish farming industry. Around 80 % of all sales of farmed fish are arranged pre-harvest. To make profit on the sale, farmers and processors are dependent on correct estimations of weight, size distribution and total biomass. Furthermore, fish feed constitutes 50% of the production costs in fish farming. Cost of excess feeding is therefore high. It is a fact that European fish farmers have been facing serious competition from low cost countries during over the recent years, especially the sea bass & bream sector in southern Europe. The FishScan project will develop a novel system for continuous remote monitoring of weight, growth and size distribution of fish for use within aquaculture enclosures. The aim is to achieve an accuracy of 99% in size measurements for fish > 1kg, and 97 % for fish at 100g. The FishScan system has a potential in aid a reduction from the current 5% to 3% error in biomass estimates. This represents increased profit of 40,445 p.a. per farm license and corresponds to economical benefits of 41M p.a. in increased profits for the European aquaculture industry. To achive this, the FishScan project will: Increase knowledge of fish behaviour in net cages to enable representative sampling; Transferring Time-of-Flight (ToF) technology and software to an aquaculture setting; Design robust camera module & optimise LED power & positioning; Design translation system for movement of camera module in fish cage; Develope software for use underwater on fish; Develop LED driver to increase frequency from 20MHZ up to 40MHz to increase depth resolution of ToF data; Design control system for camera module movement, light settings and camera and image processing software; Integrate and validate the FishScan system to obtain a working prototype. The SMEs in the FishScan project expects a NPV (10yrs, 7%) of 1.3M from the project.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-03 | Award Amount: 3.91M | Year: 2012

There is a need to improve sustainability in farming systems particularly through soil care and improvement, but not at the expense of productivity. One approach is to focus on a comprehensive advance in conservation tillage. This will be developed from improved ways of integrating subsidiary crops (SC) as living or dead mulches or cover crops with the main crops in rotations so as to simultaneously improve crop nutrition, health, and productivity. The SC will deliver multiple ecological services by increasing the duration of soil cover in the rotation overall while increasing species diversity, minimising the use of tillage and agrochemicals, enhancing biological N fixation and soil C content, and both reducing water demand in dry climates and improving soil workability in wetter climates. The research will draw on a wide range of previous and ongoing EU and related projects and will be based on 11 coordinated field experiments in different climatic regions together with three long-term experiments in Europe and Brazil. These experiments will all be assessed for economic and ecological impact including the often neglected issue of legume root health. Breeding companies and manufacturers of agricultural equipment from all regions of interest will be involved in finding adapted solutions for the different environments by extending the range of potentially useful plant species and by developing appropriate machinery to promote adoption in practical agriculture. The potential for useful chemical extraction from the existing and novel SCs will also be investigated. A central deliverable will be a database supported Cover Crop and Living Mulch Toolbox and Decision Support Tool which will encourage multilingual stakeholder exchange and dissemination during and beyond the lifetime of the project so as to capture farmer experience. The results of the project as a whole will be of use for and improve sustainability in low-input, organic, and conventional farming systems.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 7.66M | Year: 2010

Consumer bandwidth is showing no signs of slowing down and operators are now forced to explore access network migration strategies that will satisfy the anticipated bandwidth demands for the next decade. However, evolving todays access networks towards NG-OA architectures will require a multi-billion euro investment. Consequently, an important strategic aspect is the need for a thorough techno-economic analysis underpinning the development of NG-OA architectures that feature a minimised total cost of ownership (TCO). New approaches and methodologies to analyse TCO will therefore be required to provide the necessary business case data underlying the multiple commercial opportunities arising from such a regulated, yet competitive market environment. Network energy efficiency issues are also becoming an increasingly crucial aspect due to economic and environmental pressures. The evolution towards anopen access network environment in which multiple market players will have to cooperate at various levels will require reliable, zero-touch, automated management and open interfacing, clear service definitions and low operational complexity. The use of optical technologies as well as network consolidation (reduction of sites and active nodes) to reduce network costs will have to be consistent with the open access network model.Focused on European requirements, OASE (Optical Access Seamless Evolution) will addres these challenges to develop an optimised multi-terabit NG-OA architecture that will span at least 100km and serve Gbit/s services to a minimum of 1000 customers.In contrast to other approaches, OASE will be unique in developing the future NG-OA architecturefrom a multi-faceted perspective. This shall not only include the technology point of view, but alsoencompass the economic, regulatory, environmental and complex business models associated with such open access network architectures.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 394.80K | Year: 2014

The project aims at characterizing and comparing food webs associated with aphids developing on 6 distinct ecosystems in native vs. invaded areas (continents). By considering food webs associated with pest insects and comparing food web structure & functioning on an international scale, we will broaden our understanding of processes underpinning food web functioning and herbivore population regulation. We will also document structural and functional changes owing to migration or invasion processes. Comparison of food webs in native and invaded regions will also focus on factors structuring trophic networks associated with aphid pests in various ecosystems worldwide. The key actions will be to: (1) Develop molecular identification techniques to detect trophic links in field collected samples. Ease of implementation should be aimed at (2) Create food webs: quantify trophic links between aphids, their natural enemies and other key species. Standardized sampling protocols will be used in the various ecosystems at various locations worldwide (3) Use existing food web analysis methods and develop new ones to quantify changes in food webs on an international scale (4) Investigate determinants and mechanisms affecting the outcome of invasion (or introduction for classical biological control) of aphid-associated alien species The scope of potential results of the project is wide. Aphids being a worldwide pest, food web studies can provide crucial data for biological control applications, from classical to conservation approaches. The international scale of the study will enable investigating biogeographic hypotheses, which are a valuable contribution to ecological theory but are also applicable to biosecurity, e.g. safety of classical biological control programs for endemic biodiversity. Possible additional local scale comparisons and studies would provide information documenting theories on apparent competition, host range, specialization and their effects on trophic levels

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 2.67M | Year: 2009

Movement is vital to all living organisms, from the transport of single molecules in cells to the movement of entire organisms. Sarcomeres are the smallest cellular unit behind the operation of skeletal and heart muscles. Furthermore, dysfunctional sarcomeres are responsible for a long list of diseases that reduce the quality of life and burden the health care sector throughout the world. Understanding the function of sarcomere Z-disk the focus of MUZIC - requires knowledge ranging from cellular dynamics to structural details of individual molecules and complexes. Such knowledge of molecular and cellular mechanisms, in healthy and diseased muscle cells, should lead to novel treatments of muscle diseases. Generating such knowledge - at the interface between cellular and structural biology - requires research workers with a much broader training than is currently available. To provide this, a unique blend of cellular and structural biology laboratories with a focus on muscle research, united in the MUZIC network, will aim to: Bridge the gap between cellular and structural biology by training young researchers as Cellular Structural Biologists. A training program will be created that meshes these disciplines and provides young researchers with a unique set of skills in methods, management and communication. Mentoring will play a crucial role in the training process Critically advance knowledge of the molecular components and the cellular mechanisms involved in the function, dynamics and regulation of the muscle Z-disk. This will be achieved by studying the Z-disk at different levels of complexity, from atomic structure to physiological function, by combining molecular and cell biology approaches, together with investigation of the molecular structures Through training a new type of scientist with a unique set of skills, and through studies on muscles in both health and disease, this network shall have a profound impact on and future research in this area.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.17 | Award Amount: 9.41M | Year: 2010

EXPEER will bring together, major observational, experimental, analytical and modelling facilities in ecosystem science in Europe. By uniting these highly instrumented ecosystem research facilities under the same umbrella and with a common vision, EXPEER will form a key contribution to structuring and improving the European Research Area (ERA) within terrestrial ecosystem research. EXPEER builds on an ambitious plant for networking research groups and facilities. The joint research activities will provide a common framework and roadmap for improving the quality, interaction and individual as well as joint performance of these infrastructures in a durable and sustainable manner. EXPEER will provide a framework for increased use and exploitation of the unique facilities through a strong and coordinated programme for Transnational Access to the infrastructures. Extensive outreach and collaboration with related networks, infrastructures as well as potential funding bodies will ensure that EXPEER will contribute with its key experiences to the shaping and designing of future research networks and infrastructures, and that it has full support from all stakeholders in reaching its long-term objectives. The establishment of the EXPEER Integrated Infrastructure will enable integrated studies of the impacts of climate change, land use change and loss of biodiversity in terrestrial ecosystems through two major steps: 1. Bringing together the EXPEER Infrastructures to enable collaboration and integration of observational, experimental and modelling approaches in ecosystem research (in line with the concept developed in ANAEE); 2. Structuring existing network of ecosystem observational, monitoring and experimental sites across Europe (LTER-Europe). Through its integrated partnership, uniting both the experimental, observational, analytical and modelling research communities, EXPEER has the multidisciplinary expertise and critical mass to integrate and structure the European long-term ecosystem research facilities providing improved services and benefits to the whole research community as well as the society in general.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SEC-2009-7.0-02 | Award Amount: 726.71K | Year: 2010

The focus of the OSMOSIS project will be to support different organizations (mainly SMEs), in being involved in the overall European security market, by increasing their capabilities to understand and focus on security market trend and untapped potentials, link with relevant stakeholders, and facilitate their involvement in the technological supply chain, also by favoring joint research and development activities with RTD organizations and large industries. To achieve the project objectives, the proposers with their unique background deriving from the implementation of several analogous actions, will focus on the following activities: Identify opportunities in the Security technology supply chain. This will be achieved through the involvement of key stakeholders such as Large Organizations and RTD performers Identify organizations (mainly SMEs) not involved in such technological supply chain to stimulate and favor their capability to enter in such market Set up meta-clusters of SMEs defined around specific parameters/competences of specific interest of categories of stakeholders in the security domain. This will include the implementation of IT communication means (web portal and Database of pre-qualified SMEs) that will favor the connection of SMEs with the key stakeholders in the Security domain Set up communication and networking actions that will favor the entrance of organizations (mainly SMEs) in the security technological supply chain, including the setting up of workshops and webinars, the implementation of technology transfer tools available from the web site to allow the dialogue and the exchange of information related to the identified market opportunities towards the registered (in the db) organizations. Facilitate the setting up of RTD and Take Up actions in the security sector where SMEs and other identified organizations could join stakeholders and integrators of the security supply chain.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-05-2015 | Award Amount: 5.14M | Year: 2016

The main objective of GoodBerry is to provide the necessary knowledge and procedures to facilitate the development of highly productive and top quality berry fruits, even under multiple suboptimal growth conditions, at a competitive cost. The project is based on an integrative multi-actor approach, from cultivation techniques to molecular studies, aiming the development and validation of a range of tools to improve competitiveness of European berry production, and eventually the attraction and confidence of consumers. The selection of the model species can be considered as strategic since strawberry is the most important berry crop in Europe and the production of raspberry and blackcurrant are increasing strongly in recent years. The project will apply the most recent technical advances in: a) The identification of berry germplasm exhibiting advantageous balance of production vs nutritional quality throughout the EU, b) The search of innovative production systems to maintain high yield in a range of European-wide environments, c) The development of standardized and reliable analytical tools to evaluate berry production and fruit quality. As result, it is expected: a) the implementation of modern breeding strategies to accelerate the release of new berry cultivars; b) The adoption by EU-growers of high quality production systems to improve fruit quality. The proposal establishes as obligatory to disseminate and communicate the results to the scientific community, industry, the broad public and interested stakeholders user. The final impact will be to consolidate the emerging needs of high-quality berries, and to boost consumer and market confidence supported by an improved competitiveness of producers. It is a multidisciplinary, collaborative project based on complementary expertise and skills of internationally recognized berry research institutions, and highly involved key berry SMEs that will combine their effort to secure the robustness of the results.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 3.31M | Year: 2016

Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scientists and operators of radio-astronomical facilities, by widely advocating its science capabilities and its role as research infrastructure provider within the international radio astronomy community. These activities will focus on outreach and on reinforcing science cases for the next decade. New partnerships will be pursued, and in addition JIVE will expand its potential user base by offering geodetic and enhanced astrometric processing. Finally, the possibility of the International LOFAR Telescope using the same ERIC governance structure in the future will be investigated. With respect to global VLBI, the aim is to place JIV-ERIC in a leading role in the definition of scientific and technical standards in the SKA era. JIVE will take charge of a number of operational interfaces that will be essential for truly global VLBI, and establish close connections with the African VLBI Network and the SKA as the main strategic partners for the next decade.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SC1-HCO-02-2016 | Award Amount: 2.08M | Year: 2017

Molecular in vitro diagnostics and biomedical research have allowed great progress in personalised medicine but further progress is limited by insufficient guidelines for pre-analytical workflow steps (sample collection, preservation, storage, transport, processing etc.) as well as by insufficient quality assurance of diagnostic practice. This allows using compromised patients samples with post collection changes in cellular and extra-cellular biomolecules profiles thus often making diagnostic test results unreliable or even impossible. To tackle this, SPIDA4P aims to generate and implement a comprehensive portfolio of 22 pan-European pre-analytical CEN/Technical Specifications and ISO/International Standards, addressing the important pre-analytical workflows applied to personalized medicine. These will also applicable to biomarker discovery, development and validation as well as to biobanks. Corresponding External Quality Assurance (EQA) Schemes will be developed and implemented as well, aiming to survey the resulting quality of samples and diagnostic practice. SPIDIA4P will ensure stakeholder organisations involvements as well as training, education, and counselling as additional major foci of the project. The consortium will closely coordinate with large European public research consortia to obtain access to research and validation studies data serving as evidence for the new standards developments and achieved improvements of diagnosis, patient stratification and prognosis of disease outcome. At this crucial moment in the development of personalised medicine, SPIDIA4P proposes a coordination and support action that reunites 19 highly experienced partners in international standardisation for in vitro diagnostics, coming from private industry including SMEs, public institutions and from one official European Standards Organisation. This strong consortium is balanced and empowered to maximise the impacts of in vitro diagnostics on personalised medicine.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-01-2016 | Award Amount: 15.04M | Year: 2017

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations. MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of 37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions. To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response. MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-5-2016 | Award Amount: 1.50M | Year: 2016

The ISECG identifies one of the first exploration steps as in situ investigations of the moon or asteroids. Europe is developing payload concepts for drilling and sample analysis, a contribution to a 250kg rover as well as for sample return. To achieve these missions, ESA depends on international partnerships. Such missions will be seldom, expensive and the drill/sample site selected will be based on observations from orbit not calibrated with ground truth data. Many of the international science communitys objectives can be met at lower cost, or the chances of mission success improved and the quality of the science increased by making use of an innovative, low mass, mobile payload following the LEAG recommendations. This smart payload when used alone will accurately determine lunar volatile distribution over a wide area, including PSRs, as well as providing ground truth data to calibrate orbital observations. If two, or more, smart payloads are deployed, a greater area will be covered. If the smart payload is used as a scout for ESAs planned 250kg drilling rover or sample return mission, sampling locations of higher value will be identified. The main innovation is to develop an in situ sampling technology capable of depth-resolved extraction of volatiles, and then to package within this tool, the analyser itself, so as to maximise transfer efficiency and minimise sample handling and its attendant mass requirements and risk of sample alteration. By building on national, EC and ESA funded research and developments, this project will develop to TRL6 instruments that together form a smart modular mobile payload that could be flight ready in 2020. This instrument will be tested in a highly representative environment including thermal, vacuum and regolith simulant and the integrated payload demonstrated in a representative environment. A roadmap, complemented by an innovative PPP funding approach, for the implementation of the LUVMI flight model will also be developed.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: SCC-01-2015 | Award Amount: 29.12M | Year: 2016

SMARTER TOGETHERs overarching vision is to find the right balance between smart technologies and organizational/ governance dimensions in order to deliver smart and inclusive solutions and to improve citizens quality of life. SMARTER TOGETHER gather the European Lighthouse cities Lyon, Munich, Vienna, the Follower cities Santiago de Compostela, Sofia, Venice and Kyiv and Yokohama as observer cities bringing the perspective of East Europe and Asia. The cities are complemented by business partners from energy, mobility and ICT sectors, leading European research and academia organizations, european city network. From the various combinations of the different selected Light House areas, multiples opportunities to learn are offering. SMARTER TOGETHER delivers 5 clusters of co-created, smart and integrated solutions: (1) Living labs for citizen engagement, (2) District heating and RES for low energy districts, (3) Holistic refurbishment for low energy districts addressing public and private housing, (4) Smart Data management platform and smart services (5) E-mobility solutions for sustainable mobility. Expected results are: 1) >151,800 m2 of refurbished buildings, primarily housing estate with a 50-60 % average energy and CO2 reduction; 2) 14.6 MW of newly installed renewable capacity; 3) 10/15new e-mobility solutions for passengers and freight); 4) 1400 created jobs, 130 M investments, all deployed with support of integrated ICT solutions and in dialogue with the inhabitants. Large-scale replication will be prepared; 1) in the Lighthouse cities; 2) the Follower cities, which already selected their target area; 3) A Club of 15-20 cities, associate to intensify its roll-out, ensuring a broad geographical and climate coverage. Commercial exploitation is enhanced by the development of new business models for widespread use by the stakeholders. Contributions to open data are expected to create business opportunities as well as inputs to standardization work.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.1.1-1 | Award Amount: 14.69M | Year: 2013

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from different sources and to directly interrogate gene functions on a large scale in order to differentiate driver alterations, which directly contribute to tumor progression, from indolent passenger alterations. As a consequence, examples of successful translation of knowledge generated from omics approaches into novel clinical concepts and applications are scarce. Pancreatic cancer is a prime example of this dilemma. Representing the 4th to 5th most common cause of cancer related deaths, it is a disease with a major socioeconomic impact. Despite enormous advances in the identification of molecular changes associated with the disease, new treatment options have not emerged. Thus, 5-year survival rates remain unchanged at a dismal 6%, the lowest for all solid tumors. Using pancreatic cancer as a model disease, the goal of this integrative project is to develop novel cellular and animal models, as well as novel strategies to generate, analyze and integrate large scale metabolic and transcriptomic data from these models, in order to systematically characterize and validate novel targets for therapeutic intervention. In addition to the general tumor cell population, special consideration will be given to sub-populations of tumor-initiating cells, a.k.a. tumor stem cells. To this end, the consortium comprises i) SMEs with strong focus on technology development, ii) clinical and academic partners with extensive experience in pancreatic cancer molecular biology and management of pancreatic cancer patients, and iii) technology and data analysis experts from academic groups.

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.01M | Year: 2012

OLIMPIA is a training network initiative built on research and development of innovative organic optoelectronic devices interfaced and integrated with living systems. The living systems of choice are neural cells (glia and neuron) that will be interfaced and integrated in vitro and in vivo with different organic electronic and optoelectronic devices (such as OLED, OFET/OLET, OECT, OPD). The major objective of OLIMPIA is to establish an innovative training program aimed at enabling and supporting the development of a novel supradisciplinary field that combines the worlds of organic optoelectronics and of neuroscience. Novel tools based on organic optoelectronic devices will be engineered and developed to stimulate and to record neuron bioelectrical activity, such as neuron excitability and membrane polarization, as well as to modulate cell proliferation and neurite outgrowth. The OLIMPIA research will provide radically new understanding of neural cell-cell communication processes and will impact a wide variety of fields, from biomedical research to neuro-regenerative medicine. The OLIMPIA consortium is both interdisciplinary and intersectorial. It includes key European players with long standing and internationally recognized research tradition in the field of organic electronics and optoelectronics, organic synthesis as well as neural cell biology and neurophysiology and, as such, is uniquely qualified to implement this ambitious supradisciplinary training program. Moreover, the consortium combines 10 partners belonging to 6 European countries from academia, public research centers and industrial labs thereby offering an exciting and broad training landscape to the new generation of researchers.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.2 | Award Amount: 13.63M | Year: 2010

The webinos project will define and deliver an Open Source Platform and specific components for the Future Internet, which will enable web applications and services to be used and shared consistently and securely over a broad spectrum of converged and connected devices, including mobile, PC, home media (TV) and in-car units. Promoting a single service for every device vision, webinos will move the existing baseline from installed applications to services, running consistently across a wide range of connected devices, ensuring that the technologies for describing, negotiating, securing, utilizing device functionalities and adapting to context are fit for purpose. Innovations in contextual description will be broad covering but not limited to device capabilities, network access, user identity and preferences, location, behaviourally induced properties and finally the more complex issue of the users social network context.\nwebinos will directly address security and privacy issues as part of Quality of Service that users of web services expect. The addressed challenges comprise: how to provision and adapt security across a range of devices, services, networks as well as how individuals can gain control over the privacy aspects of their web presence regardless of the service that is being used. Context and privacy are intimately intertwined: rich context is valuable but without user controlled privacy it becomes a liability.\nwebinos will boost the industry migration towards web-based services. webinos can back this by providing inter-operable, standardised, open source technology utilizable across domains with direct commercially exploitable value. webinos will also act as an industry catalyst to encourage collaboration and discourage fragmentation in this space.\nThere are strong industry moves towards Internet friendly and Internet integrated offerings, and there exists a window of opportunity to place this Web OS technology on a robust open foundation that will remove economic barriers to engagement, embody policy on data privacy in concrete technology (protecting consumers and enterprise) and creating a centre of web centric expertise (benefiting technical competitiveness).

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 9.17M | Year: 2009

Groundwater resources are facing increasing pressure from consumptive uses (irrigation, water supply, industry) and contamination by diffuse loading (e.g. agriculture) and point sources (e.g. industry). This cause major threat and risks to our most valuable water resource and on ecosystems dependent on groundwater. New information is need on how to better protect groundwaters and groundwater dependent ecosystems (GDE) from intensive land-use and climate change. The impacts of land-use changes and climate changes are difficult to separate as they partly result in similar changes in the ecosystems affected. The effects are highly interwoven and complex. The EU groundwater directive (GWD) and the water framework directive (WFD) provide means to protect groundwater (GW) aquifers from pollution and deterioration. At present, the maximum limits for groundwater pollutant concentrations have been set for nitrate and various pesticides. Also, water of sufficient quality and quantity should be provided to ecosystems dependent on groundwater. The European aquifers differ by their geology, climate, and threats to aquifers. This must be considered when general guidelines for management of these systems are developed. The concept of the present proposal is to base the research on different relevant aquifer sites in various European countries to test scientific issues and find new results to important problems. Seven WP are foreseen: WP1 Case studies on impacts and threats to GWs and GDEs WP2 Groundwater dynamics, re-charge and water balance WP3 Leaching to groundwater aquifers from different land-uses WP4 Groundwater dependent ecosystems: groundwater-surface water interaction WP5 Modelling processes in groundwater systems WP6 Concepts, scenarios and risk assessment WP7 Co-ordination

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-1.3-1 | Award Amount: 15.59M | Year: 2008

ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to inter-species variation - non-ESC assays rely on primary cells or cells of malignant origin that are hard-to-standardise and limited in regard to quantity, homogeneity and genetic diversity - existing assay systems based on primary animal cell lines do not reliably represent the physiological situation ESNATS will develop a battery of toxicity tests using hESC lines subjected to different standardised culture protocols. Tests will cover embryoid bodies in different developmental stages and differentiated derivatives including gamete and neuronal lineages, complemented with test systems for hepatic metabolism. Predictive toxicogenomics and proteomics markers will be identified. The individual tests will be integrated into an all-in-one test system. To enable future industrial use ESNATS will prepare automating and scaling up of hESC culture. The predictivity, quality and reproducibility of ESNATS will be evaluated in a proof of concept study. ESNATS benefits are to increase safety due to better predictivity of human test systems, to reduce, refine and replace animal tests, to lower testing cost, and to support medium/high throughput testing. ESNATS objectives will be achieved in a 5 year multi-disciplinary collaboration of leading European researchers in alternative testing, toxicology, ESC research, genomics, modelling, and automation. The consortium will also include representatives from regulatory bodies, the pharmaceutical industry and ethical advisors to provide guidance to ensure rapid applicability of the developed tests systems.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.20. | Award Amount: 12.58M | Year: 2012

The Project promotes the access to five European Research Infrastructures, and it is structured into nine Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities. The Project will profit of the success of the previous HadronPhysics project in FP6 and the current HadronPhysics2 in FP7, and originates from the initiative of more than 2.500 European scientists working in the field of hadron physics. Hadron physics deals with the study of strongly interacting particles, the hadrons. Hadrons are composed of quarks and gluons. Their interaction is described by Quantum Chromo Dynamics, the theory of the strong force. Hadrons form more complex systems, in particular atomic. Under extreme conditions of pressure and temperature, hadrons may loose their identity and dissolve into a new state of matter similar to the primordial matter of the early Universe. The Networking Activities are related to the organization of experimental and theoretical collaborative work concerning both ongoing activities at present Research Infrastructures and planned experiments at future facilities. In hadron physics the close interaction between experimentalists and theoreticians is of paramount importance. The Joint Research Activities concentrate on technological innovations for present and future experiments. Applications in material science, medicine, information, technology, etc., represent natural fall-outs. The main objective of this Integrating Activity is to optimize the use and development of the Research Infrastructures existing in Europe working in the field of hadron physics. The Project aims as well at structuring, on European scale, the way Research Infrastructures operate, and at fostering their joint development in terms of capacity and performance. The approach used is the bottom up approach, to respond to the needs of the scientific community in all fields of science and technology.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 11.76M | Year: 2015

NFFA-EUROPE will implement the first open-access research infrastructure as a platform supporting comprehensive projects for multidisciplinary research at the nanoscale extending form synthesis to nanocharacterization to theory and numerical simulation. The integration and the extension of scope of existing specialized infrastructures within an excellence network of knowledge and know-how will enable a large number of researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. The full suite of key infrastructures for nanoscience will become, through the NFFA-EUROPE project, accessible to a broader community extended to research actors operating at different levels of the value chain, including SMEs and applied research, that are currently missing the benefits of these enabling technologies. NFFA-EUROPE sets out to offer an integrated, distributed infrastructure to perform comprehensive nanoscience and nanotechnology projects from synthesis and nanolithography (with nanofoundry installations) to advanced characterization and theoretical modellization/numerical simulation (with experimental installations including analytical large scale facilities and a distributed theoretical installation including high-performance computing). Coordinated access will be given to complementary facilities co-located in nine well distributed main sites in Europe, ensuring the optimal match between user proposal and technical offer. The research activity of the Consortium will realize innovative solutions on key bottlenecks of nanoscience research, therefore upgrading the facility quality and uniqueness.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-1.2-5 | Award Amount: 13.82M | Year: 2008

In vitro diagnostics have allowed a great deal of progress in medicine but are limited by two factors: (a) the lack of guidelines in collection, handling, stabilisation and storage of biosamples which limits the reproducibility of subsequent diagnoses, and (b) its scale is restrained to the cellular level. To address this first point, this IP, SPIDIA, built of clinicians, academics, tool and assay developers, aims to develop quality guidelines for molecular in vitro diagnostics and to standardize the pre-analytical workflow in related procedures. Regarding the second point, SPIDIA aims to develop modern pre-analytical tools for diagnostics improving the stabilisation, handling and study of free biomolecules within blood, plasma, serum, tissues and tumours. Recent discoveries have revealed that RNA, DNA or proteins, released from pathological sites, like tumour cells or Alzheimers disease (AD) brain lesions, into the blood or as a secondary blood based response to the disease can serve as biomarkers for early and reliable molecular diagnosis of such debilitating diseases. Further discoveries have shown that the cellular profiles of these molecules and structures in clinical samples can change during transport and storage thus making clinical assay results and pharmaceutical research unreliable or even impossible. It will therefore be a decisive prerequisite for future and current diagnostic assays to develop standards and new technologies, tools and devices that eliminate the human error in the pre-analytical steps of in vitro diagnostics. At this crucial moment in the development of molecular diagnostics, SPIDIA proposes an IP that reunites 7 private research companies (including 4 SMEs), 1 private research institute, 6 public research organisms, including universities, hospitals and biobanks, one management SME and an official European Standards Organisation. This strong consortium is balanced and empowered to maximise the impacts of in vitro diagnostics on human health.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.1 | Award Amount: 486.75K | Year: 2012

We seek to bring together all major European and Israeli research centres in Optimal Control of Quantum Information Processing. This project will coordinate ongoing research activities, best practice dissemination, personnel training and public engagement as well as interaction with public stakeholders and policymakers for 17 established research groups from 15 universities in 6 countries a total of about 60 scientists and 30 PhD students, spanning a variety of nationalities, races, cultures, social backgrounds, genders and career stages.The proposed Consortium will join the forces of multiple EU and Israeli research groups to explore a radical alternative to the currently established information processing technologies quantum information processing, where bits are carried by atoms or elementary particles and dramatic acceleration is believed to be possible for several types of computational tasks. Our specific research area within Quantum Information Processing is optimal control of quantum bits a set of technologies that enable extremely accurate manipulation of quantum bits with minimal expenditure of energy.Within this Coordination Action, we aim to create a vibrant, productive and efficient European research community, to deliver value to the society and to grow a new generation of young European physicists.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.1.1-1 | Award Amount: 3.07M | Year: 2013

The main general goal of DECORE is to achieve the fundamental knowledge needed for the development of a fuel cell (FC) electrode, which can operate efficiently (both in terms of activity and selectivity) as the anode of a direct ethanol (EOH) FC (DEFC) in the temperature range between 150-200 C (intermediate-T). Such a technology is still lacking in the market. The choice for EOH as an alternative energy source is well founded on the abundance of bioethanol, and on the relatively simpler storage and use with respect to other energy carriers. The intermediate-T is required for an efficient and selective total conversion of EOH to CO2, so exploiting the maximum number of electrons in the DEFC. DECORE will explore the use of fully innovative supports (based on titanium oxycarbide, TiOxCy) and nano-catalysts (based on group 6 metal carbides, MCx, M=Mo,W), which have never been tested in literature as anodes for DEFCs. The new support is expected to be more durable than standard carbon supports at the targeted temperature. The innovative nano-catalysts would be noble-metal free, so reducing Europes reliance on imported precious metals. To tailor the needed materials, the active role of the support and nano-catalyst will be studied at atomic level. Demonstrating an activity of such nano-catalyst/support assembly at intermediate-T would open a novel route where DEFCs with strongly reduced production costs would have an impact on a fast industrialisation. The power range for the envisioned application is of the order of hundreds of Watts, i.e. the so called distributed generation, having an impact for devices such as weather stations, medical devices, signal units, auxiliary power units, gas sensors and security cameras. By the end of the project, a bench-top single DEFC operating at intermediate-T will be built and tested.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY-2007-3.6-01 | Award Amount: 3.46M | Year: 2008

Pure vegetable oil use as engine fuel has the potential for the most comprehensive ecologic, economic and social benefits of all biofuels. The production involves few process steps and can be done economically with small production units. The production process has only small energy losses and provides potential for additional income generation on farms, thereby strengthening rural economic structures. The challenges to be met by pure vegetable oil are engine adaptation, fuel quality control, emissions control and limits to overall production potential. State-of-the-art concepts allow for achieving EURO3 emission levels for road vehicles in specifically adapted diesel engines for rape seed oil fitting to the German pre-norm DIN V 51605. However, advanced biofuels should allow that emissions keep within the limits of the forthcoming EURO6 norm for road vehicles and EU Stage 4 / US Final TIER4 for non-road vehicles. This proposal covers research and demonstration on 2nd generation vegetable oil fuels in advanced engines. It follows a double strategy: engines as well as the fuel are adapted such that both match and the combination allows for achieving high engine performance at minimum fuel consumption fitting with most severe emission limits. The objectives are (1) to widen the range of considered oils, (2) to research on and demonstrate additives for vegetable oils, (3) to research on and demonstrate improved engine oils, (4) to achieve EU stage 4 / US TIER4 emission levels in medium-scale demonstration fleets running in France, Austria, Germany and Poland, (5) to transfer the engine and fuel concepts to hybrid engines, allowing to achieve forthcoming EURO6 emission levels, (6) to prepare proposals for future fuel standards. The outcome of the project includes advanced engine and fuel concepts for vegetable oil and the preparation of a European standard for 2nd generation vegetable oil.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2010-1 | Award Amount: 32.25M | Year: 2011

One of the most important strategic sectors in which Europe is developing, integrating and delivering high-quality products is the transportation domain. Here, high-class safety-related products as e.g. airplanes, cars and trains have a huge market impact. More and more of the market value of these vehicles is gained by embedded systems inside these products, and the number and importance of these embedded systems is steadily growing. One of the most important enablers to assure the quality of embedded systems is the application of powerful validation and verification (V&V) technologies accompanying the embedded systems development process. Unfortunately, the V&V technologies already in industrial use are still too expensive while often not effective enough. MBAT will provide European industry with a new leading-edge V&V technology in form of a Reference Technology Platform (MBAT RTP) that will enable the production of high-quality and safe embedded systems at reduced cost in terms of time and money. This will be made possible by a new and very promising approach in which model-based testing technologies will be combined with static analysis techniques. Besides this combination, a further new approach is to use (and re-use) specially designed test & analysis models as basis for model-based V&V. This advanced model-based V&V technology will lead to a more effective and at the same time cost-reducing approach compared to traditional ones. In addition, MBAT RTP will be connected to other ARTEMIS RTPs to extend existing platforms. Developed by industrial key players (large companies and SMEs) in this domain and supported by leading research partners, the MBAT RTP will be of high value for the European industry, providing very effective means to assure utmost quality embedded systems at reduced costs. Version approved by the ARTEMIS JU on 07/12/2011

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2011.2.2.1-1 | Award Amount: 6.98M | Year: 2011

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to halt or reverse PKAN or any other NBIA. This is especially unfortunate as both the iron accumulation in NBIA and the biochemical defect in PKAN are predicted to be amenable to drug-based treatment. Thus, the current absence of clinical trials is not due to lack of therapeutic options but to rarity of the disease, lack of patient registries and fragmentation of therapeutic research worldwide. For example, the iron-chelating drug deferiprone has been administered to PKAN patients on an individual basis or in pilot trials, both precluding firm conclusions about its efficacy. With TIRCON, we will address this urgent and unmet need for NBIA/PKAN therapy with an ambitious and highly collaborative plan that leverages worldwide expertise. We propose a large investigator-driven randomized clinical trial of deferiprone in PKAN, bringing together leading centres and patient advocacy groups from Europe and the US to reach the required patient cohort size. In addition, together with a European SME, we propose to pursue preclinical development of pantethine and its derivatives which have shown promising efficacy in a Drosophila PKAN model. To facilitate future research, we will develop a harmonized patient registry and biomaterial bank to allow for natural history studies and biomarker development, two critical needs in NBIA research. TIRCON partners, apart from their unique clinical and basic science expertise in NBIA, have longstanding experience in investigator-driven and industry-driven randomized clinical trials. Importantly, they have been closely collaborating in recent years.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.93M | Year: 2015

Reduction of soot emissions from Diesel engines will be explored by utilising simultaneously (a) injection pressure between 2000-4500bar, (b) engine operation at supercritical conditions relative to the injected fuels critical point and (c) additives that improve atomisation and reduce pollutant formation. The detailed processes of nozzle flow cavitation/boiling, atomisation, phase-change and mixing, combustion and soot emissions under such conditions will be explored both experimentally and computationally. Experimental techniques include fuel property measurements, optical/laser diagnostics, high speed imaging, micro CT and high energy X-rays. Tests will be performed in CVC, optical engines, single-cylinder and production engine test beds. Identification of nozzles internal geometry and testing of clean and aged injectors with internal deposits build-up is central to the programme. Simulation tools to be developed include molecular-structure-based equation of state for the properties of surrogate, summer Diesel and low quality Diesel fuels enriched with additives at elevated pressures/temperatures, DNS for bubble dynamics, cavitation and fuel atomisation, and soot oxidation in LES/RANS models coupling the in-nozzle flow with the macroscopic fuel spray development, mixing and pollutant formation in engines. The validated simulation models will be used as design tools to industrial development of fuels, fuel injection systems and Diesel engines. The 15 EU-funded ESRs plus 1 ESR funded independently by industry, will be recruited/seconded by universities, research centres and multinational engine, fuel injection system, fuel and fuel additives manufacturers from the EU, US, China, Japan and S.Korea. The new tests and the developed simulation tools, currently missing from the literature, will allow for an environmental assessment of the tested technologies at real-world operating conditions, underpinning the forthcoming 2020 EU emission reduction directives.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NFRP-01-2014 | Award Amount: 6.64M | Year: 2015

The thermal-hydraulics Simulations and Experiments for the Safety Assessment of Metal cooled reactor (SESAME) project supports the development of European liquid metal cooled reactors (ASTRID, ALFRED, MYRRHA, SEALER). The project focusses on pre-normative, fundamental, safety-related, challenges for these reactors with the following objectives: Development and validation of advanced numerical approaches for the design and safety evaluation of advanced reactors; Achievement of a new or extended validation base by creation of new reference data; Establishment of best practice guidelines, Verification & Validation methodologies, and uncertainty quantification methods for liquid metal fast reactor thermal hydraulics. The SESAME project will improve the safety of liquid metal fast reactors by making available new safety related experimental results and improved numerical approaches. These will allow system designers to improve the safety relevant equipment leading to enhanced safety standards and culture. Due to the fundamental and generic nature of SESAME, developments will be of relevance also for the safety assessment of contemporary light water reactors. By extending the knowledge basis, SESAME will allow the EU member states to develop robust safety policies. At the same time, SESAME will maintain and further develop the European experimental facilities and numerical tools. The consortium of 25 partners provides American-European-wide scientific and technological excellence in liquid metal thermal hydraulics, as well as full alignment with ESNII and with NUGENIA where of interest. A close interaction with the European liquid metal cooled reactor design teams is foreseen involving them in the Senior Advisory Committee. They will actively advise on the content of the project and will be the prime end-users, ensuring their innovative reactor designs will reach highest safety standards using frontier scientific developments.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRASUPP-6-2014 | Award Amount: 1.70M | Year: 2015

This CREMLIN proposal is to foster scientific cooperation between the Russian Federation and the European Union in the development and scientific exploitation of large-scale research infrastructures. It has been triggered by the recent so-called megascience projects initiative launched by and in the Russian Federation which is now very actively seeking European integration. The proposed megascience facilities have an enormous potential for the international scientific communities and represent a unique opportunity for the EU to engage in a strong collaborative framework with the Russian Federation. The CREMLIN proposal is a first and path finding step to identify, build and enhance scientific cooperation and strong enduring networks between European research infrastructures and the corresponding megascience facilities to maximize scientific returns. The proposal follows the specific recommendations of an EC Expert Group by devising concrete coordination and support measures for each megascience facility and by developing common best practice and policies on internationalisation and opening. CREMLIN will thus effectively contribute to better connect Russian RIs to the European Research Area.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 2.86M | Year: 2015

AWESOME network aims to educate eleven young researchers in the wind power operation and maintenance (O&M) field by constructing a sustainable training network gathering the whole innovation value chain. The main EU actors in the field of wind O&M have worked together, under the umbrella of the European Wind Energy Academy (EAWE), in order to design a training program coping with the principal R&D challenges related to wind O&M while tackling the shortage of highly-skilled professionals on this area that has been foreseen by the European Commission, the wind energy industrial sector and the academia. The overall AWESOME research programme tackles the main research challenges in the wind O&M field identified by the European wind academic and industrial community: (1) to develop better O&M planning methodologies of wind farms for maximizing its revenue, (2) to optimise the maintenance of wind turbines by prognosis of component failures and (3) to develop new and better cost-effective strategies for Wind Energy O&M. These main goals have been divided into eleven specific objectives, which will be assigned to the fellows, for them to focus their R&D project, PhD Thesis and professional career. The established training plan answers the challenges identified by the SET Plan Education Roadmap. Personal Development Career Plans will be tuned up for every fellow, being their accomplishment controlled by a Personal Supervisory Team. The training plan includes intra-network activities, as well as network-wide initiatives. The secondments at partner organizations and between beneficiaries are a key attribute of the training programme. Each fellow will be exposed to three different research environments from both, academic and industrial spheres. All the network activities will be developed in accordance with the established in the Ethical Codes and Standards for research careers development, looking therefore for talent, excellence and opportunity equality.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: MG-4.1-2014 | Award Amount: 25.11M | Year: 2015

The project HERCULES-2 is targeting at a fuel-flexible large marine engine, optimally adaptive to its operating environment. The objectives of the HERCULES-2 project are associated to 4 areas of engine integrated R&D: Improving fuel flexibility for seamless switching between different fuel types, including non-conventional fuels. Formulating new materials to support high temperature component applications. Developing adaptive control methodologies to retain performance over the powerplant lifetime. Achieving near-zero emissions, via combined integrated aftertreatment of exhaust gases. The HERCULES-2 is the next phase of the R&D programme HERCULES on large engine technologies, which was initiated in 2004 as a joint vision by the two major European engine manufacturer groups MAN and WARTSILA. Three consecutive projects namely HERCULES - A, -B, -C spanned the years 2004-2014. These three projects produced exceptional results and received worldwide acclaim. The targets of HERCULES-2 build upon and surpass the targets of the previous HERCULES projects, going beyond the limits set by the regulatory authorities. By combining cutting-edge technologies, the Project overall aims at significant fuel consumption and emission reduction targets using integrated solutions, which can quickly mature into commercially available products. Focusing on the applications, the project includes several full-scale prototypes and shipboard demonstrators. The project HERCULES-2 comprises 4 R&D Work Package Groups (WPG): - WPG I: Fuel flexible engine - WPG II: New Materials (Applications in engines) - WPG III: Adaptive Powerplant for Lifetime Performance - WPG IV: Near-Zero Emissions Engine The consortium comprises 32 partners of which 30% are Industrial and 70% are Universities / Research Institutes. The Budget share is 63% Industry and 37% Universities. The HERCULES-2 proposal covers with authority and in full the Work Programme scope B1 of MG.4.1-2014.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-02-2016 | Award Amount: 1.96M | Year: 2017

The general objective of PRO-METROFOOD is to bring the emerging METROFOOD-RI ESFRI project to the level of maturity required for entering in the active project list, strengthening the Consortium and planning the future phases. The specific objectives have been set up in close relationship with the ESFRI SWG & IG Recommendation. 4 specific objectives have been identified: OBJ1 design strategies on the medium and long terms; OBJ2 provide the organizational framework of METROFOOD-RI; OBJ3 demonstrate the capability of METROFOOD-RI to supply scientific services and prepare the chart of services; OBJ4 establish plans to coherently integrate METROFOOD-RI into the European landscape, realising coordination with EU and National initiatives and positioning at a global level. The strategic Plan will be tailored to the Pan European Infrastructure current and envisaged capabilities, market opportunities and business needs. It will be developed by involving funding agencies, relevant authorities supporting METROFOOD-RI and other stakeholders. A management conceptual model will be developed and the framework will be designed under operational, strategic and institutional aspects. Management procedures suitable for the different phases will set up, so to cover short and long-term goals. A Quality Documentation System (QDS) will be developed and a data management plan (DMP) will be defined. In order to demonstrate the capability of PRO-METROFOOD to supply services and to test its inter-operability, pilot services will be performed. In strict accordance with the METROFOOD-RI strategies, plans to coherently integrate METROFOOD-RI into the European landscape will be developed. A Communication plan and education and training programmes will be developed for the different phases of METROFOOD-RI realization (earl, preparatory, implementation and operational phases). For each phase the main coordinator, the target group and the main training subject areas will be specified.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: EE-07-2015 | Award Amount: 1.55M | Year: 2016

40% of all energy consumption and 36% of CO2 emissions in the European Union arise in private and public buildings. Thus, major advancements have to be made in this sector to reach the EUs climate and energy targets. Energy-efficient buildings will also contribute to the vision of secure, affordable and climate-friendly energy for citizens and businesses as well as generating additional societal, environmental and economic benefits. To strengthen policies that promote retrofitting and modernizing existing buildings, the EU has adopted the Directive 2012/27/EU on Energy Efficiency (EED). It requires EU Member States and candidate countries to establish a long-term strategy for mobilizing investment in the renovation of the national building by 30 April 2014, and every 3 years thereafter. These action plans are an integral part of a countrys National Energy Efficiency Action Plans. As of May 2015, 27 EU Member States have adhered to the requirement of Article 4, EED, and submitted their national building renovation strategy, albeit most did not meet the April deadline and some submitted their strategies as late as March 2015. However, the requirements to prepare these renovation strategies appear to have overburdened most EU member states. According to an analysis conducted by the Buildings Performance Institute Europe, only five countries have at least adequately complied with the five core elements described in Article 4 of the EED. To date, no renovation strategy has been submitted that can count as a best practice and provide orientation for other countries. The project EmBuild (Empower public authorities to establish a long-term strategy for mobilizing investment in the energy efficient renovation of the building stock) is designed to empower public authorities at local, regional and national level, to formulate renovation strategies for the building sector that foster deep renovation and facilitate the acceleration of the renovation.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 4.60M | Year: 2016

Medium- to large-scale bioenergy utilisation for electricity and combined industrial or district heating is predicted to increase by 160% in 2020 compared to 2010, while carbon emission quotas are becoming stricter. Finding new ways to efficiently utilise cheap and currently unused feedstocks are necessary in order to meet these challenges. Within the project Biofficiency we will investigate how to handle ash-related problems in order to increase steam temperatures up to 600C in biomass-based CHP plants, including pulverised fuel and fluidised bed systems. The major aspects are fly ash formation, the use of additives, and pre-treatment technologies for difficult fuels. This leads to highly reduced emissions, in particular CO2 and fine particulates, as well as a secure and sustainable energy production. Biofficiency gathers a unique consortium of excellent academic facilities and industrial partners, providing an exceptional platform for the development of new, highly-efficient CHP plants in order to significantly expand their potential in the fast-growing field of renewable energies. By sharing our collective experience, we will strengthen European bio-energy technologies and help solving global climate and energy challenges. The project approach addresses current bottlenecks in solid biomass combustion, namely enhanced deposit formation, corrosion and ash utilisation by a variety of new, promising technologies. Our goal is to deepen the understanding of fly ash formation, to improve current biomass pre-treatment technologies, as well as to contribute to the field of biomass ash utilisation. Through our strong collaboration with industry and academic partners, we want to pave the way for highly-efficient, low-emitting biomass CHP plants, capable of firing low-grade fuels. This benefits industry, communal partners and public authorities by providing sustainable heat and electricity at significantly decreased emissions.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-17-2015 | Award Amount: 9.63M | Year: 2016

The share of renewable energy is growing rapidly driven by the objective to reduce greenhouse gas emissions. The amount of electric power which can be supplied to the grid depends on the time of the day and weather conditions. A conventional fleet of thermal power plants is required to compensate for these fluctuations before large scale energy storage technologies will be mature and economically viable. All power market projections expect this to be the case for the next 50 years at least. For a strong expansion of renewables, this fleet has to operate flexibly at competitive cost. Current power plants cannot fill this role immediately without impeding their efficiency and engine lifetime through increased wear and damage induced by the higher number of (shorter) operating/loading cycles. New technologies need to be introduced to balance demand peaks with renewable output fluctuations at minimal fuel consumption and emissions without negative effects on cycling operation. The FLEXTURBINE partners have developed a medium to long term technology roadmap addressing future and existing power plants. The FLEXTURBINE project presented hereafter is the first step in such technology roadmap and consists of: (1) new solutions for extended operating ranges to predict and control flutter, (2) improved sealing and bearing designs to increase turbine lifetime and efficiency by reducing degradation/damages, and (3) an improved lifecycle management through better control and prediction of critical parts to improve competitive costs by more flexible service intervals and planned downtime, and by reducing unplanned outages. In all areas, individual technologies will be developed from TRL 3 to TRL 4-6. FLEXTURBINE brings together the main European turbine manufacturers, renowned research institutes and universities. It involves plant and transmission system operators to include user feedback and to prepare the take-up of the FLEXTURBINE technologies in power plants world-wide.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ISIB-04b-2015 | Award Amount: 4.00M | Year: 2016

European forests are expected to provide a broad range of ecosystem services (ES). This capacity is however threatened by the uncertainties of climate change, the complex dynamics of evolving global markets and the pressures for increased use of bioenergy. Such challenges cannot be effectively addressed with an uncritical regional or national commitment to traditional forest management models (FMMs), as these are unlikely to ensure the sustained long-term provisioning of desired ES, let alone their optimised delivery. ALTERFORs goal is thus to facilitate the implementation of FMMs better suited to meeting the challenges of the 21st century by: (1) Identifying and developing FMMs robust in their capacity to deliver ES and overcome projected socio-ecological risks and uncertainties; (2) Assessing the impact of different FMM combinations in terms of resultant ES baskets on the European and landscape level, and (3) Facilitating the implementation of desired FMMs and improving cross-national knowledge transfer regarding their benefits, costs, management, and utilization. The project will involve a consortium of 19 organisations from nine countries chosen due to their possession of the transdisciplinary expertise necessary to achieve these objectives, and for ensuring an encompassing representation of Europes socio-economic conditions and prevailing forest management paradigms. Based on carefully designed case studies, the consortium will make sure realistic models of forest owner behaviour are employed; guarantee the involvement of forest stakeholders throughout the project; anchor the desired FMMs to relevant forest actors; and help disseminate project findings to local, national and European stakeholders. The main long-term impact of ALTERFOR is the implementation of FMMs that secure the capacity of Europes forests to continue providing a balanced ES basket that societies will depend upon over the coming century.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-01-2016 | Award Amount: 8.59M | Year: 2016

The Bonseyes project aims to develop a platform consisting of a Data Marketplace, Deep Learning Toolbox, and Developer Reference Platforms for organizations wanting to adopt Artificial Intelligence in low power IoT devices (edge computing), embedded computing systems, or data center servers (cloud computing). It will bring about orders of magnitude improvements in efficiency, performance, reliability, security, and productivity in the design and programming of Systems of Artificial Intelligence that incorporate Smart Cyber Physical Systems while solving a chicken-egg problem for organizations who lack access to Data and Models. Its open software architecture will facilitate adoption of the whole concept on a wider scale. It aims to address one of the most significant trends in the Internet of Things which is the shifting balance between edge computing and cloud computing. The early days of the IoT have been characterized by the critical role of cloud platforms as application enablers. Intelligent systems have largely relied on the cloud level for their intelligence, and the actual devices of which they consist have been relatively unsophisticated. This old premise is currently being shaken up, as the computing capabilities on the edge level advance faster than those of the cloud level. This paradigm shiftfrom the connected device paradigm to the intelligent device paradigm opens up numerous opportunities. To evaluate the effectiveness, technical feasibility, and to quantify the real-world improvements in efficiency, security, performance, effort and cost of adding AI to products and services using the Bonseyes platform, four complementary demonstrators will be built: Automotive Intelligent Safety, Automotive Cognitive Computing, Consumer Emotional Virtual Agent, and Healthcare Patient Monitoring. Bonseyes platform capabilities are aimed at being aligned with the European FI-PPP activities and take advantage of its flagship project FIWARE.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-3.1-2016 | Award Amount: 5.58M | Year: 2016

SafeClouds is a research project supported by EASA and powered by a full spectrum of aviation stakeholders (Airlines, Airports, ANSPs, Eurocontrol, Research Entities, Safety Agencies) that develops cutting-edge technologies for aviation safety assurance in a cost-effective manner. SafeClouds proposes a data-driven approach to achieve a deeper understanding of the dynamics of the system, where risks are pro-actively identified and mitigated in a continuous effort to enhance the already excellent European aviation safety records. SafeClouds develops an innovative aviation safety data analysis approach. Currently each stakeholder owns different isolated datasets and data-sharing paradigms are rare. However, the combination of those datasets is critical in discovering unknown safety hazards and in understanding and defining a performance-based system safety concept. The new data-driven paradigm, capable of extracting safety intelligence in a fast, connected and inexpensive way requires the collaboration of aviation and IT entities sharing their raw datasets, tools, techniques and information. SafeClouds high level objectives are: - To define a user-requirement driven approach for data mining in aviation safety, covering several current safety challenges within airlines and runway operations. - To develop novel data structures and safety intelligence representation. Given the complexity of the datasets, SafeClouds aims to solve their current challenges in data handling and knowledge discovery. - To develop the proof of concept and validate in a laboratory the safety data analysis paradigms, at different levels: historical analysis, predictive analytics, automatic safety data monitoring and unknown hazards identification. - To assemble a group of entities that encompasses the entire data-cycle for a unified, achievable vision for the future of safety analytics in Europe, including: users, data providers, data infrastructure researchers, operators and data scientists.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2012.1.1-3. | Award Amount: 5.94M | Year: 2013

In order to achieve the greening of the European air transport with the deployment of low emission and low noise propulsion systems the reduction of core noise plays an important role. The ability to design low core noise aero-engines requires the development of reliable prediction tools. This development demands extensive research with dedicated experimental test cases and sophisticated numerical and analytical modelling work to broaden the physical understanding of core noise generation mechanisms. This objective is only reachable with an extensive cooperation on the European level. In this proposal Research on Core Noise Reduction (RECORD) the major aero-engine manufacturers of five different European countries collaborate to enable the design of low core noise aero-engines. In RECORD the fundamental understanding of core noise generation and how can it be reduced will be achieved by combining the research competence of all European experts in universities and research organizations working in this field of core noise. This concept of the RECORD project is completed by the technology development of small and medium size enterprises distributed in Europe. RECORD will promote the understanding of noise generating mechanism and its propagation taking the interaction of combustor and turbine into account. The importance of direct and indirect noise will be quantified. Through carefully designed experiments and extensive numerical calculations, the numerical methods and assumptions will be validated and extended. As a result, low-order models will provide a quick approach for the noise design of combustors and subsequent turbine stages while the more time-consuming and expensive LES calculation will provide a more detailed picture of the flow physics. Finally, RECORD will develop means and methods for core noise reduction.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-28-2015 | Award Amount: 4.60M | Year: 2016

Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-resolution optical mesoscopy and macroscopy and by (3) novel label-free anatomical, physiological and molecular contrast at the tissue and single-cell-level, based on spectrally-resolved optical absorption. MSOT, originally supported by an ERC Advanced Award (2008) (TUM: Prof. Ntziachristos), is already commercialized by iThera Medical for macroscopy with systems sold around the world for small animal imaging. In parallel, ERC MSOT funding developed a mesoscopic implementation, termed raster-scan optoacoustic mesoscopy (RSOM), which has demonstrated innovative imaging capacity at 1-5mm depths. Driven by leading dermatologists (TUM: Prof. Biedermann; SUR: Prof. Costanzo) and market leader SMEs in optoacoustic and ultrasound technology (iThera, Rayfos, Sonaxis), INNODERM will design and prototype a handheld, portable, scalable, label-free RSOM device for point-of care dermatology applications, based on recommendations developed under an ERC proof of concept grant (2013) on MSOT. INNODERM brings together key photonic & ultrasound technologies and will validate the technical and economic viability of RSOM in dermatology suites for fast diagnosis and skin disease monitoring. RSOM can go beyond the abilities of current optical or optoacoustic devices and offer a paradigm shift in dermatology imaging, substantiating successful business cases.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: HEALTH-2007-2.1.2-6 | Award Amount: 1.75M | Year: 2009

The aim of the PSIMEx proposal is to systematically make published molecular interaction data computationally accessible. We plan to further develop the existing standard for molecular interactions developed by the HUPO Proteomics Standards Initiative, and to promote its implementation in the entire chain from experiment planning via data formatting and analysis to data representation in journal publications and public databases. Key aspects will be the dissemination of and user training on minimum requirements for publication of molecular interaction data; the further development of the PSI-MI standard for representation of data fulfilling these minimal requirements; the specification of efficient data deposition tools and data flow from data producers to public repositories as part of the publication process; implementation of international data exchange among databases; training and exchange of curation staff in the participating databases; and the definition of analysis tools for the efficient use of data following the PSI-MI standards.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2011.1.6 | Award Amount: 5.99M | Year: 2011

The goal of EINS is coordinating and integrating European research aimed at achieving a deeper multidisciplinary understanding of the development of the Internet as a societal and technological artefact, whose evolution is increasingly interwined with that of human societies. Its main objective is to allow an open and productive dialogue between all the disciplines which study Internet systems under any technological or humanistic perspective, and which in turn are being transformed by the continuous advances in Internet functionalities and applications. EINS will bring together research institutions focusing on network engineering, computation, complexity, security, trust, mathematics, physics, sociology, game theory, economics, political sciences, humanities, law, energy, transport, artistic expression, and any other relevant social and life sciences.\nThis multidisciplinary bridging of the different disciplines may also be seen as the starting point for a new Internet Science, the theoretical and empirical foundation for an holistic understanding of the complex techno-social interactions related to the Internet. It is supposed to inform the future technological, social, political choices concerning Internet technologies, infrastructures and policies made by the various public and private stakeholders, for example as for the far-ended possible consequences of architectural choices on social, economic, environmental or political aspects, and ultimately on quality of life at large.\nThe individual contributing disciplines will themselves benefit from a more holistic understanding of the Internet principles and in particular of the network effect. The unprecedented connectivity offered by the Internet plays a role often underappreciated in most of them; whereas the Internet provides both an operational development platform and a concrete empirical and experimental model. These multi- and inter-disciplinary investigations will improve the design of elements of Future Internet, enhance the understanding of its evolving and emerging implications at societal level, and possibly identify universal principles for understanding the Internet-based world that will be fed back to the participating disciplines. EINS will:\nCoordinate the investigation, from a multi-disciplinary perspective, of specific topics at the intersection between humanistic and technological sciences, such as privacy & identity, reputation, virtual communities, security & resilience, network neutrality\nLay the foundations for an Internet Science, based i.a. on Network Science and Web Science, aiming at understanding the impact of the network effect on human societies & organisations, as for technological, economic, social & environmental aspects\nProvide concrete incentives for academic institutions and individual researchers to conduct studies across multiple disciplines, in the form of online journals, conferences, workshops, PhD courses, schools, contests, and open calls

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.4-3 | Award Amount: 8.73M | Year: 2011

The consortium aims to develop and produce an Anticalin, a member of a novel high-affinity scaffold derived from the lipocalin protein family. The Anticalin is specific for hepcidin which is a central regulator of iron homeostasis, and will be used to antagonize hepcidin for the treatment of anemia of chronic disease (ACD). Anticalins are genetically modified lipocalins that can target almost any desired molecule. Unlike Immunoglobulins, they can be produced at low cost in microbial expression systems, are expected to be non immunogenic and offer therapeutic advantages where antibody effector functions are not desired. ACD, the most frequent anemia in hospitalized patients, develops in subjects suffering from infections, inflammatory and auto-immune disease, cancer and chronic kidney disease. It is often successfully treated by administering Erythropoiesis-Stimulating Agents. However, a significant number of patients are hypo- or non-responsive to ESA. Anti-hepcidin therapies, alone or together with ESAs, may improve anemia and the patients erythropoietic response and enable the use of no or even much lower ESA doses, avoiding the potential detrimental effects of high doses of ESA. The Consortium has already generated proof-of-concept data in an animal model with early candidates. The project aims at identifying, validating, and developing a specific, high affinity drug candidate based on the lipocalin scaffold as promising alternatives to immunoglobulins and a therapeutic approach based on the neutralization of hepcidin. Animal models will be developed and utilized to characterize pharmacokinetic and pharmacodynamic relationships, optimize dosing, to determine safety, biomarker responses and potential synergy with ESAs. Furthermore, production processes will be optimized leading to a scalable GMP process which provides material for preclinical and clinical studies to establish the safety, tolerability, and PK/PD of an Anticalin hepcidin blocker (Phase Ia/b).

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SIS-2008- | Award Amount: 5.24M | Year: 2009

Helping teachers raise the quality of science teaching and its educational environment has the potential to increase student engagement, attainment, scientific literacy and science career choices. S-TEAM will achieve this by connecting existing science education research and teacher knowledge to teacher education. This task requires the power of coordinated action across a wide range of institutions and national contexts. The 26 partners and 15 nations engaged in S-TEAM have a unique opportunity to systematically integrate their knowledge of teaching, research and teacher education, and to adapt science education to the diverse needs of citizens and the economy in Europe, focusing on inquiry-based methods. These involve problem-solving, hands-on experimentation, authentic, student-led content and critical dialogue, but they require wider development of teacher skills and knowledge. Many teachers are already competent in these methods, and are thus the best source of learning for others. S-TEAM will achieve its aims by disseminating research on, and teachers' experiences of inquiry-based methods to existing and future science teachers. Its actions will involve listening to teachers, working with teacher educators and researchers, and providing support for better science education. This support will include workshops, training packages, video case-studies, teaching materials and publications. S-TEAM will involve not only teachers, but also teacher educators, researchers, students, parents and policymakers in dialogue, to ensure that this dissemination is effective. S-TEAM is sustainable since learning through teacher collaboration and education can be continually regenerated, but also necessary because science teacher education needs to be shared across Europe. By enabling teachers to deliver more efficient and efficacious learning, S-TEAM will improve the attitudes, motivation and learning of young people, including girls, in science education.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 7.17M | Year: 2016

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The facilities for upstream and downstream migration are evaluated, different bypass systems including their use as habitats and the influence of sediment on habitat. In addition existing tools and devices will be enhanced during the project and will be used in the experimental set-ups in the laboratories and at the test sites for e.g. detection of fish or prediction of behavior. This includes sensor fish, different solutions for migration as e.g. trash rack variations, different fish tracking systems, but also numerical models as habitat and population model or virtual fish swimming path model. Therefore a three-level-based workplan was created with preparatory desk work at the beginning to analyze shortcomings and potential in environment-friendly hydropower. Following the experimental tests will be conducted at the different test sites to demonstrate and evaluate the effects of the different options not covered by the desk-work. Thirdly, these results are fed into a risk based Decision Support System (DSS) which is developed for planning, commissioning and operating of HPPs. It is meant to enable operators to fulfill the requirements of cost-effective production and at the same time meet the environmental obligations and targets under European legislation and achieve a self-sustained fish population.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 4.93M | Year: 2016

Current practice in wind turbines operation is that every turbine has its own controller that optimizes its own performance in terms of energy capture and loading. This way of operating wind farms means that each wind turbine operates based only on the available information on its own measurements. This gets the wind farm to operate in a non-optimum way, since wind turbines are not operating as players of a major system. The major reasons for this non-optimum approach of wind farms operation are based on the lack of knowledge and tools which can model the dynamics of the flow inside the wind farm, how wind turbines modifies this flow, and how the wind turbines are affected by the perturbed flow. In addition, this lack of tools deals to also a lack of advanced control solutions, because there are not any available tool which can help on developing and testing virtually advanced control concepts for wind farms. CL-WINDCON will bring up with new innovative solutions based on wind farm open and closed loop advanced control algorithms which will enable to treat the entire wind farm as a unique integrated optimization problem. This will be possible thanks to the development of appropriate dynamic tools for wind farm simulation, at a reasonable computing effort. These tools for wind farm dynamic modelling of wind farm models will be fully open source at the end of the project, while control algorithms will be extensively validated simulations, in wind tunnel tests. Some open loop validations will be performed at wind farm level tests. Proposed control algorithms, useful for future but also for already existing wind farms. Then these will improve the LCOE, as well as the O&M costs will decrease, and improves in terms of reliability the wind turbine and wind farm. These performance improvements will be evaluated for both, wind turbine operation and wind farm operation.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: Fission-2009-2.3.1 | Award Amount: 10.59M | Year: 2010

For the long-term development of nuclear power, innovative nuclear systems such as Gen-IV reactors and transmutation systems need to be developed for meeting future energy challenges. Thermal-hydraulics is recognized as a key scientific subject in the development of innovative reactor systems. This project is devoted to important crosscutting thermal-hydraulic issues encountered in various innovative nuclear systems, such as advanced reactor core thermal-hydraulics, single phase mixed convection and turbulence, specific multiphase flow, and code coupling and qualification. The main objectives of the project are: Generation of a data base for the development and validation of new models and codes describing the selected crosscutting thermal-hydraulic phenomena. This data base contains both experimental data and data from direct numerical simulations (DNS). Development of new physical models and modeling approaches for more accurate description of the crosscutting thermal-hydraulic phenomena such as heat transfer and flow mixing, turbulent flow modeling for a wide range of Prandtl numbers, and modeling of flows under strong influence of buoyancy. Improvement of the numerical engineering tools and establishment of a numerical platform for the design analysis of the innovative nuclear systems. This platform contains numerical codes of various classes of spatial scales, i.e. system analysis, sub-channel analysis and CFD codes, their coupling and the guidelines for their applications. The project will achieve optimum usage of available European resources in experimental facilities, numerical tools and expertise. It will establish a new common platform of research results and research infrastructure. The main outcomes of the project will be a synergized infrastructure for thermal-hydraulic research of innovative nuclear systems in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 6.56M | Year: 2009

Climate change is one of the most critical global challenges of our time which also threatens cultural heritage. As a non-renewable important resource to the European identity, sustainable adaptation strategies are required for long term preservation. For this purpose and for the first time ever, the CLIMATE FOR CULTURE project will couple completely new high resolution (10x10km) climate change evolution scenarios with whole building simulation models to identify the risks for specific regions. The innovation lies in the elaboration of a more reliable damage assessment by connecting the future climate data with whole building simulation models and new damage assessment functions. In situ measurements at UNESCO sites throughout Europe will allow a much more precise and integrated assessment of the real damage impact of climate change on cultural heritage. Appropriate sustainable mitigation/adaptation strategies, also from previous projects, are further developed and applied on the basis of these findings simultaneously. All these results will be incorporated into an assessment of the economic impacts. In order to ensure an efficient use of resources, this project will build on the results of already concluded EU research projects (Noahs Ark). Techniques from FP5/6 projects will be reassessed for their applicability in future scenarios at different regions in Europe and Mediterranean to fully meet sustainability criteria. The proposed project will thus be able to estimate more systematically the damage potential of climate change on European cultural heritage. The team consists of 27 multidisciplinary partners from all over Europe and Egypt including the worlds leading institutes in climate modelling and whole building simulation. The final achievement of the project will be a macro-economic impact report on cultural heritage in the times of climate change akin to the STERN report which would be a truly European contribution to future IPCC Reports.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-3.4-1 | Award Amount: 10.23M | Year: 2010

CROPS will develop scientific know-how for a highly configurable, modular and clever carrier platform that includes modular parallel manipulators and intelligent tools (sensors, algorithms, sprayers, grippers) that can be easily installed onto the carrier and are capable of adapting to new tasks and conditions. Several technological demonstrators will be developed for high value crops like greenhouse vegetables, fruits in orchards, and grapes for premium wines. The CROPS robotic platform will be capable of site-specific spraying (targets spray only towards foliage and selective targets) and selective harvesting of fruit (detects the fruit, determines its ripeness, moves towards the fruit, grasps it and softly detaches it). Another objective of CROPS is to develop techniques for reliable detection and classification of obstacles and other objects to enable successful autonomous navigation and operation in plantations and forests. The agricultural and forestry applications share many research areas, primarily regarding sensing and learning capabilities.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: ENV.2010.2.1.5-1 | Award Amount: 4.40M | Year: 2010

The social and economic impact of natural disasters in emerging economies and developing countries is growing. Many African countries have fragile economies unable to absorb the shocks caused by natural disasters enhanced by the increasing vulnerability of rapidly expanding urban areas. Climate change is likely to rapidly exacerbate this situation. The overall objective of CLUVA is to develop methods and knowledge to be applied to African cities to manage climate risks, to reduce vulnerabilities and to improve coping capacity and resilience towards climate changes. CLUVA will explore these issues in selected African cities (Addis Ababa, Dar es Salaam, Douala, Ougadougou, St.Louis). The project aims at improving the capacity of scientific institutions, local councils and civil society to cope with climate change. CLUVA will assess the environmental, social and economic impacts and the risks of climate change induced hazards expected to affect urban areas (floods, sea-level rise, storm surges, droughts, heat waves, desertification, storms and fires) at various time frames. The project will develop innovative climate change risk adaptation strategies based on strong interdisciplinary components. CLUVA will be conducted by a balanced partnership of European and African partners. The 7 European partners will bring together some of EUs leading experts in climate, quantitative hazard and risk assessment, risk management, urban planners and social scientists. The 6 African partners from South Africa and from the Universities of the selected cities cover a similar range of expertises, making possible an effective integrated research effort. The project is structured in 6 WorkPackages dealing with climate change and impact models (WP1), multiple vulnerability (WP2), urban planning and governance as key issues to increase the resilience (WP3), capacity building and dissemination (WP4), coordination of the activities in the selected cities (WP5) and project management (WP6).

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.83M | Year: 2012

Aim of the project Photogenerated Hydrogen by Organic Catalytic Systems (PHOCS) is the realization of a new-concept,photoelectrochemical system for hydrogen production, based on the hybrid organic/inorganic and organic/liquid interfaces. PHOCS takes the move from the recent demonstration of reduction/oxidation reactions taking place, under visible light and at zero bias, at the interface of an organic semiconductor and an aqueous electrolyte, obtained by the coordinators group. PHOCS intends to combine the visible-light absorption properties of organics, together with the enhanced charge transport capabilities of inorganic semiconductors, in order to build a hybrid photoelectrode for hydrogen generation. New organic donor and acceptor materials (conjugated polymers and fullerenes derivatives) will be synthesized, properly tuning HOMO-LUMO levels position and energy gap extent for semi-water splitting purposes. In order to build properly-working photo-electrochemical cells, issues such as stability, wettability, catalytic functionality, electron transfer processes at the polymer/electrolyte interface will also be faced during the synthesis step. Multifunctional, high surface area, inorganic electrodes will be moreover developed, in order to increase surface area, provide ohmic contact to the organic active layer, 3D control of the donor-acceptor junction and advanced light management. Spectro-electrochemical characterization of organic/inorganic and organic/electrolytic solution interfaces will be continuously performed, in order to deep characterize charge transfer phenomena and improve the device performances. Final aim of PHOCS project is the realization of a scaled-up, 10x10 cm2, 1% solar-to-hydrogen energy conversion efficient device, as a tangible first step towards the new organic water splitting technology.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.3.4-01 | Award Amount: 3.98M | Year: 2011

The fishing industry in the EU and elsewhere produces an increasing mass of negative value crustacean shell waste (>6 MTPA), whose current disposal in landfills results in significant costs and risks to human health as well as to the environment. While in Asia small amounts of shrimp waste are processed to chitosan, the high CaCO3 content of EU crab shell waste has prevented cost effective conversion to value adding products. The project will develop an integrated biorefinery platform transforming the chemical constituents of EU, African and Asian crustacean shell waste into drop-in and novel chemical intermediates to produce high value, high performance bio-based polymers at high atom efficiencies. The innovative process comprises pretreatment steps to facilitate downstream enzymatic depolymerisation and conversion of sugars into chemical building blocks utilizing enzymatic and whole-cell biocatalysis routes. Biocatalyst development requires application of genomics techniques in combination with green-chemical and process-engineering know-how. Sustainable purification technologies will enable integration of monomers into current industrial polymerization processes. Biowaste streams will be valorised for the production of bioenergy to improve process efficiency and greenhouse gas footprint. The environmental impact of the process chain will be evaluated by a cradle-to-product life cycle analysis. Process scale-up will be linked with modelling and optimization studies to demonstrate economic viability. The consortium of 5 academic, 4 SME and 2 large industrial partners has the technical and management expertise to rapidly transfer laboratory scale results into novel industrial product lines at an accelerated pace. Key consortium members are from 5 different EU and 2 associated ICP states, which allows for strategic technology transfer from high- to low-tech driven countries, fostering the development of sustainable economies in the EU and beyond.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2011-1 | Award Amount: 1.51M | Year: 2012

The necessity for monitoring geo-risk areas such as rock slides is growing due to the increasing probability of such events caused by environmental change. Europe is one leader in survey technology, due to well-established providers of measurement systems and frameworks. In Europe, rock slides cause increasing damage particularly in alpine areas. DE-MONTES provides an efficient, highly automated, high-resolution, terrestrial, long range sensing measurement and analysis system which is able to monitor geo-risk (and related) objects by means of non-signalized natural target points - which is a key to such systems due to the lack of reachability and the required distance-to-the-object. Even novel sensor concepts such as terrestrial laser scanning can only cover a subset of the requirements, they limit the distance of application to 1-2 km and do not provide the ability to track individual surface points in high resolution - an important feature to detect regions of motion early enough for taking measures of protection, warning inhabitants, closing infrastructure or evacuation. It is mostly SMEs that run services in this area, reacting with a case-by-case strategy, using conventional technology. There is no well- established market yet on this family of applications, although the occurrence of dozens of events per year indicate that a mature observation system such as DE-MONTES is overdue. DE-MONTES is the first such system to cover long range applications and it would settle a new standard of reacting to this growing field of environmental misconduct. With the help of its research Partners, the DE-MONTES Project will build and test a productive prototype system for short-term exploitation of the SMEs involved in the Project, such that after project termination they immediately can use the system in their service portfolio, gain new business fields by exporting the system to related application areas, and can also use components of the system in related in-house R&D such as construction, archeological site survey, industrial inspection, or geo-monitoring. The project combines methods and techniques from standard surveying, computer vision, photogrammetry, mechatronics, software engineering, and geological sciences, well covered by the academic and research partners. The main step beyond currently available techniques lies in the introduction of a novel modular suite of terrestrial visual survey sensors, namely Image Assisted Total Stations (IATS, used to perform long-range high-resolution measurements on single points) and Terrestrial long-range laser scanners (TLS, used to survey large areas). The envisaged system, developed by the R&D partners, incorporates the sensors, their control & data processing, and a framework that enables an expert user (geodesist / geologist) to operate the software. Applications, test environments and verification procedures are provided by the SME partners.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: SFS-17-2014 | Award Amount: 2.33M | Year: 2015

High pressure and temperature (HPT) processing is a candidate technology for commercial food processing to obtain safer, high quality food products with extended shelf life, both chilled and shelf stable. Although it is accepted that HPT is environmentally friendly and can help to retain the fresh-like characteristics of foods better than conventional and other novel treatments, it has not yet been scaled-up and fully implemented into the food industry due to two major reasons: The lack of knowledge on the inactivation mechanisms and decision making tools enabling food industry to apply and control suitable treatments. In addition, its added value (best quality product) compared to current treatments must be demonstrated The unavailability of suitable industrial equipment and process parameters control tools. HIPSTER addresses the main barriers preventing the first market introduction and full deployment of HPT. The overall objective of the project is to develop and demonstrate fit for use knowledge, tools and industrial equipments in order to effectively implement this milder processing technology in the food industry. Specific objectives: - Development of affordable equipment at industrial scale suitable for the implementation of high pressure-temperature (HPT) processing - Definition of minimum process variables by means of the evaluation of microbiological risks for the main pathogenic and spoilage microorganisms of concern. A public database containing microbial kinetic parameters, determined under well-defined processing conditions will be generated. The database will include new knowledge and data already available. - Verification and validation of the solutions in an industrial environment, including compliance with legal requirements, economic feasibility, and sustainability HIPSTER will be implemented by an industry-driven consortium comprising 5 industries (both technology providers and end-users) and 4 RTD organisations.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.1-6 | Award Amount: 4.23M | Year: 2011

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased risk for pancreatic cancer indicate, that the tumour microenvironment is of particular importance for carcinogenesis in the pancreas. The long-term objective of this proposal is to increase survival of pancreatic cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments. For this purpose the clinical observation will be reverse-translated into innovative in-vitro and mouse models closely mimicking the human disease. This will allow a profound study of the mechanistic basis of treatment failure by deciphering the complex network between components of the microenvironment and cancer cells leading to increased resistance to chemotherapy and infiltrative growth along adjacent lymphatic and neural structures as well as metastatic spread. Identification of cancer (stem) cell-autonomous as well as stromal-derived mediators of invasion and chemoresistance will lead to novel drug targets to overcome the current therapeutic dilemma. The consortium has been specifically designed to include all required levels of expertise: 1) surgical and medical oncology groups conducting the largest clinical trials for pancreatic cancer in Europe, 2) expert pancreatic pathologists, 3) basic scientists focused on the study of carcinogenesis and tumour microenvironment interactions in the pancreas, 4) molecular oncology groups that have developed genetically engineered mouse models faithfully recapitulating human pancreatic cancer, as well as 5) pharmaceutical industry specialised on drug development.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2011.5.2-6. | Award Amount: 3.82M | Year: 2011

Europe needs a safe and cost effective transport network to encourage movement of goods and people within the EU and towards major markets in the East. This is central to European transport, economic and environmental policy. Many parts of Europes rail network were constructed in the mid 19th century long before the advent of modern construction standards. Historic levels of low investment, poor maintenance strategies and the deleterious effects of climate change (for example scour of bridge foundations due to flooding and rainfall induced landslides) has resulted in critical elements of the rail network such as bridges, tunnels and earthworks being at significant risk of failure. The consequence of failures of major infrastructure elements is severe and can include loss of life, significant replacement costs (typically measured in millions of Euros) and line closures which can often last for months. The SMART Rail project brings together experts in the areas of highway and railway infrastructure research, SMEs and railway authorities who are responsible for the safety of national infrastructure, The goal of the project is to reduce replacement costs, delay and provide environmentally friendly maintenance solutions for ageing infrastructure networks. This will be achieved through the development of state of the art methods to analyse and monitor the existing infrastructure and make realistic scientific assessments of safety. These engineering assessments of current state will be used to design remediation strategies to prolong the life of existing infrastructure in a cost-effective manner with minimal environmental impact.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.5-2 | Award Amount: 3.88M | Year: 2008

The inflammatory bowel diseases (IBD) which comprise Crohns disease and ulcerative colitis are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract. The frequency of these conditions has increased in recent decades, particularly in countries making the transition from developing to developed nation status. In western Europe, IBD now affects between 1/1000 and 5/1000 of the population, and the prevalence of the conditions in new EU accession countries appears to be growing as they develop. Few conditions in all of clinical medicine are linked with as much morbidity and potential mortality as IBD. Current treatment is based upon steroid therapy or neutralizing the effect of pro-inflammatory cytokines, especially TNFalpha. Despite their efficacy, many patients eventually require surgery for refractory disease or complications (stricture, perforation, abscess). In response to the call we have assembled a multidisciplinary team of international experts to delineate the role of intestinal proteases and their inhibitors in the pathophysiology of IBD. A particularly innovative aspect of our approach is the examination of both bacterial and host derived proteases and interactions between the two. The ultimate aim is develop novel therapeutics and increased understanding of the disease both of which will impact within the wider EU community and globally.

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives: 1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD), 2) nonclinically evaluate this system, 3) clinically validate the system after regulatory approval, & 4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment. The CosmoPHOS system consists of two interacting components: a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and b) medical devices. After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration. The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.2.1.6-1 | Award Amount: 8.85M | Year: 2011

The vital environmental and socio-economic role of European forests is well documented and acknowledged in policy documents of both the European Union and its member states. However, there are critical incoherencies within and between trans-national, national and local forest-related land use policies, the central issue being mismatches between the policies and their implementation at the landscape level. Hence, there is a need to improve existing policy and management approaches capable of delivering a better balance between multiple and conflicting demands for forest goods and services. Diminishing mismatches and providing a new policy and management approach that is sensitive to ecological, socioeconomic and political issues of are the main objectives of INTEGRAL. The objectives are achieved by following a research approach with 3 phases: diagnostic analysis of the status-quo (phase 1), participatory development and evaluation of scenarios (phase 2), and problem-solving oriented back-casting for policy development and evaluation (phase 3). The research design will be applied in a total of 20 landscapes in 10 European countries that differ in key characteristics, such as ownership, the importance of forestry and forest-based industries and the priorities of allocation and management of new and existing forest lands. The involvement of national and local stakeholder groups all the way through the project plays a decisive role in the project. The most important long term impact of INTEGRAL consists of the knowledge and competence base for integrating international, national and local levels in participatory decision and planning processes. This includes the development of manuals for how to conduct such processes, methods for utilizing quantitative decision support tools in the participatory process, and the establishment of a body of knowledge among those participating in the extensive case studies. Thus, the consistency of implemented forest policies can be enhanced.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2009-1-4-04 | Award Amount: 2.56M | Year: 2010

Well functioning factor markets are a crucial condition for the competitiveness and growth of agriculture and for rural development. At the same time, the functioning of the factor markets themselves are influenced by changes in agriculture and the rural economy, and in EU policies. Member state regulations and institutions affecting land, labour, and capital markets may cause important heterogeneity in the factor markets, which may have important effects on the functioning of the factor markets and on the interactions between factor markets and EU policies. The general objective of the Factor Markets project is to analyse the functioning of factor markets for agriculture in the EU-27, including the Candidate Countries. The Factor Markets project will compare the different markets, their institutional framework and their impact on agricultural development and structural change, as well as their impact on rural economies, for the Member States, Candidate Countries and the EU as a whole. The Factor Markets project will focus on capital, labour and land markets. The results of this study will contribute to a better understanding of the fundamental economic factors affecting EU agriculture, thus allowing better targeting of policies to improve the competitiveness of the sector.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-2.3.2. | Award Amount: 13.73M | Year: 2012

The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains. The first objective is to ensure that interoperable standards are available across all data resources and services shared by two of more ESFRI infrastructure. The identified standards will be implemented to enable data interoperation between ESFRI projects in biomedical sciences. Public data in life sciences will be freely accessible through these standard interoperable services. Private data, however, is a major concern in this domain, for medical information or for data with intellectual property issues. Where projects need to share sensitive data, standards for secure and restricted access will be identified and implemented. BioMedBridges is a practical solution to the data interoperability requirements of infrastructures in the biological and biomedical domains. A suite of use cases will guide the development and deployment of standards and services with emphasis on the issues arising between specific projects. These may cover the exchange of biomedical and genetic data, linking mouse model organism data with human clinical information, and the deposition of large volumes of data from one project to another. BioMedBridges is inclusive of emerging infrastructures which can contribute additional data classes and challenges such as bioimaging, ecosystems, small molecules and infectious diseases. The ESFRI infrastructures leading BioMedBridges are ELIXIR, BBMRI, EATRIS, ECRIN, InfraFrontier and INSTRUCT.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENERGY-2007-3.2-03 | Award Amount: 4.09M | Year: 2008

The transport sector represents a growing share of the total fossil fuel usage in the world. In order to fulfil the commitment to the Kyoto Protocol, the world usage of fossil oil in transport sectors must be reduced. One important approach to achieving this goal is to increase the share of renewable sources such as feedstocks in conversion routes. These biomass conversion routes involve a number of difficulties that should be attended to first by a suitable process configuration to avoid catalyst poisoning in production of syngas. Second, a major problem in the production of syngas-derived fuel from renewable sources is the presence of contaminates in the product gas from biomass gasifiers. These impurities that cause catalytic poisoning should be completely removed prior to the entry in catalytic systems that utilize in upgrading steps. With the evolution of these advanced uses of biomass derived syngas, it becomes necessary to develop progressively more stringent gas cleaning systems. Therefore, the projects key goal is development of a novel gas cleanup in order to reduce impurities from the gasifiers product gas to limits required for upgrading to syngas using as a feedstock in production of vehicle fuels. To accomplish this target that biomass conversion should preserve high energy efficiency in the subsequent synthesis steps and prevent catalytic poisoning, an alternative product route and more efficient gas cleaning systems are required. Nevertheless, biomass conversion processes offer many economical and environmental benefits, but it is clear that conversion technology should be able to compete with other conversion routes, for example via methane. Therefore, this RTD programme combines European expertise in the field of gasification, different proficiencies in cleaning technologies, high ranking catalyst expertise, catalyst company, and two research companies with R&D activities in the fields to expedite the development and commercialization of research outcomes.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.49M | Year: 2013

WoodSonics responds to a need in the EU sawmill sector to improve competitiveness by implementing machine strength grading of structural timber at SME sawmills. In the context of a serious crisis in the construction sector, significant savings in production costs and the optimisation of yield through the use of machine strength grading systems can help SME sawmills survive. However, the current cost of machine strength grading systems (from 100.000 - 500.000) is prohibitive for SMEs. WoodSonics proposes a cost-efficient machine grading system (60.000) using an innovative rolling ultrasonic transducer array which can be placed directly on the grading line to automatically grade the strength of the timber. Additionally, WoodSonics can detect and localise internal and external defects throughout the length of the board. The detection of localised defects allows sawmills to optimise their yield by removing defects and upgrading the quality of the timber, as well responding to specific client requests by separating defect-free wood within the same strength class. WoodSonics will be validated using spruce (the timber used in 90% of contruction) and chestnut, a high-value hardwood from the Mediterranean region.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-07 | Award Amount: 3.80M | Year: 2012

The sustainable provision of ecosystem services (ES) in and from mountain regions is of crucial importance to an array of stakeholders and society in general, going much beyond the interests of particular landowners in the mountain regions themselves. Mountain ecosystems can only continue to provide all these services in a rapidly changing world if a wide array of ES is considered in forest management at local, landscape and regional scales (multi-functionality). The project builds on seven case study regions in major mountain ranges throughout Europe covering a wide range of forest types, socio-economic conditions and cultural contexts and seeks to develop and evaluate strategies for their multifunctional management considering risks and uncertainty due to changing climatic and socio-economic conditions. The project addresses four main ES: timber production, protection against gravitational natural hazards, the role of forests in climate change mitigation via carbon sequestration as well as bioenergy production, and nature conservation and the maintenance of biodiversity. Non-timber forest products, recreation as well as use of forested landscapes by game and livestock species will be dealt with as well. To analyse conflicts and complementarities among ES from stand to landscape scales, improved models for the assessment and projection of ecosystem services as well as novel planning and decision support tools will be developed together with SMEs and applied in the case study regions. Stakeholder panels in all study regions will inform research activities and contribute to the development of improved mountain forest management approaches. SME partners play a key role in the development of new planning tools. Ultimately, ARANGE will translate project findings on the efficient provision of multiple ES from mountain forests into decision support for policy makers and forest practitioners, so as to improve the robustness of planning tools in real-world decision making.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2009.;ENV.2009. | Award Amount: 8.93M | Year: 2010

The GHG-Europe project aims to improve our understanding and capacity for predicting the European terrestrial carbon and greenhouse gas (GHG) budget by applying a systematic, comprehensive and integrative approach. GHG-Europe quantifies the annual to decadal variability of the carbon and GHG budgets of terrestrial ecosystems in EU27 plus Switzerland and in six data-rich European regions via data-model integration, diagnostic and predictive modelling. Models are calibrated by multi-site observations. Research includes CO2, CH4 and N2O in forests, croplands, grasslands, shrublands, peatlands and soils. Via an integrated approach, GHG Europe scales up consistently from local to regional and continental scale via scale dependent error propagation and systematic quantification of uncertainties, model validation at different scales and top-down verification by atmospheric inversion models. At regional and European scale lateral C transport by land use, trade and rivers are included. Variability in C and GHG budgets is attributed to natural (climate) and anthropogenic drivers (N deposition, land use, past and present management) by synthesis of past and emerging experiments, targeted observations in hot spots and hot moments and model sensitivity analyses. For this purpose, observations are extended to under-sampled regions and ecosystems with likely high importance for the European C budget: forests and land use change in Eastern Europe and Mediterranen shrublands. The future vulnerability of carbon pools and risks of positive feedbacks in the climate-carbon system are assessed by scenario analyses with biophysical models and by integrating feedbacks with socio-economic changes and EU climate and land use policies. GHG-Europe uses a bidirectional interaction with stakeholders to provide regular and timely scientific advice targeted to the emerging needs of the UNFCCC process and for implementing post-2012 climate commitments in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2010.2.3-02 | Award Amount: 12.29M | Year: 2011

The present proposal sees the development of business and value creation models as central to the development of personalised nutrition and thus it is intended to engage in a series of interviews with key stakeholders, which will generate a number of scenarios to be considered by these stakeholders. Parallel to that we will run some focus groups with consumers and develop a tool to ascertain consumer attitudes to personalised nutrition in 8 EU countries (1,000 per country) representing a breadth of gastronomic traditions. Within these 8 countries, we will recruit 1,280 subjects and offer 3 levels of personalised nutrition: 1 Personalised dietary advice alone; 2: personalised dietary advice based on biochemical phenotypic data; 3: the latter to include genomic data. These will be compared with a control group, which will be offered non-personalised dietary advice. All of the data on dietary intake and all of the advice will be Internet delivered and will last 6 months. Within each of the 3 levels of personalised nutrition groups, half will receive their feedback at months 0, 3 and 6 while the other half will have continuous feedback on demand with intensive coaching. The overall outcome measurement will be changes in a healthy eating index. The data gathered in this study will feed into the development of algorithms to provide automated feedback for future services delivering personalised advice on food choice. We will bring together an international group of experts to develop best practice in the application of all aspects of nutrigenomic research to personalised nutrition. We will also scope out existing and future technologies, particularly those involving biofeedback, which will help the development of personalised nutrition. Finally we develop position papers on the ethical and legal aspects of personalised nutrition. Permeating all of this work will be a wide-ranging communications programme aimed at all stakeholders of relevance to personalised nutrition.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.1-01 | Award Amount: 11.66M | Year: 2012

The goal of WATBIO is to use the power of next generation sequencing to develop an accelerated route for producing new germplasm with enhanced drought tolerance whilst maintaining biomass productivity and quality in water scarce, marginal environments unsuitable for food crops. This will be achieved for three non-food crops (Populus, Miscanthus and Arundo), suitable for growth on water scarce, marginal lands, through a 5-year translational research project. Populus and Miscanthus germplasm with increased drought tolerance will be produced within WATBIO whilst for Arundo its genetic diversity will be assessed and breeding tools developed. Twenty-two multidisciplinary partners (14 academics, and 7 SMEs) spanning the whole value chain for crop production will collectively achieve this innovation by 1) identifying key molecular, cellular and physiological traits for the maintenance of biomass production, lignocellulosic quality and water use efficiency in water-scarce environments; 2) linking these traits through modelling to underlying key genes, proteins and metabolite networks; 3) utilising a wide range of germplasm for screening in phenotyping platforms and field measurements at multiple sites to test importance of genotype x environment interactions in determining traits; 4) using sequence based gene expression data, identify 40 genes related to drought tolerance for testing proof of concept using GM approach; and 5) using sequence-based data for genome wide association and genetical genomic approaches, link physiology to traits of high heritability and to underlying genes. WATBIO will transfer knowledge of commercial significance using its industrial partners and stakeholders enabling the deployment of biotechnology to boost European competitiveness, without the necessity of GM. Through workshops, seminars and exchanges, WATBIO will train the next generation of multi-disciplinary professionals in the area of biomass crop production on marginal lands.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2012.3.5-04 | Award Amount: 7.76M | Year: 2012

The project GRACE will a) elaborate and sustainably implement a transparent framework for the review of GMOs or GM food and feed effects on environment, socio-economics and health and b) reconsider the design, execution and interpretation of results of animal feeding trials as well as in vitro studies for assessing the safety of GM food and feed. The framework will create high quality reviewing processes for different fields of GMO impact assessment and address the need for a well documented, transparent and sustainable representation of these reviewing processes. This will provide valuable and accessible information addressing the main issues associated with GMOs and enabling risk assessors, managers, scientists and the general public to reiterate and update their evaluations and conclusions on GMOs. It will adapt recently elaborated methodologies for (systematic) reviewing of the risk assessment information of GMOs and derived food and feed. The quality assessment for all reviewed papers and studies as well as the reviews conducted by the consortium, will be referenced by an open access database and one-stop-shop for data and information relevant to GMO risk assessment. Animal feeding trials and in vitro studies will clarify and compare the scientific added value of 90day feeding trials with whole foods with advanced state-of-the-art analytical, in vitro and in-silico tools. Suitable animal GMO-feeding models will be investigated, that are based on European (EFSA) and international guidance, and the project will provide guidance for relevant, alternative in vitro cell-based approaches for specific topics within the overall food and feed safety assessment. Available standard or scientifically approved protocols form the basis of the investigations also in the case of the analytical, in-vitro and second in-silico approaches. GRACE will provide guidance for the use and improvement of existing and suggested assessment tools in the field of food and feed safety.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: INFRA-2011-2.1.1. | Award Amount: 10.17M | Year: 2011

Key questions in physics can be answered only by constructing a giant underground observatory to search for rare events and study terrestrial and astrophysical neutrinos. The Astroparticle Roadmap of ApPEC/ASPERA strongly supports this, recommending that: a new large European infrastructure of 100000-500000 ton for proton decay and low-energy neutrinos be evaluated as a common design study together with the underground infrastructure and eventual detection of accelerator neutrino beams. The latest CERN roadmap also states: a range of very important non-accelerator experiments takes place at the overlap of particle and astroparticle physics exploring otherwise inaccessible phenomena; Council will seek with ApPEC a coordinated strategy in these areas of mutual interest. Reacting to this, uniting scientists across Europe with industrial support to produce a very strong collaboration, the LAGUNA FP7 design study has had a very positive effect. It enabled, via study of seven pre-selected locations (Finland, France, Italy, Poland, Romania, Spain and UK), a detailed geo-technical assessment of the giant underground cavern needed, concluding finally that no geo-technical show-stoppers to cavern construction exist. Building on this, the present design study will address two challenges vital to making a final detector and site choice: (i) to determine the full cost of construction underground, commissioning and long-term operation of the infrastructure, and (ii) to determine the full impact of including long baseline neutrino physics with beams from CERN.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST-2007-5.1-01 | Award Amount: 4.49M | Year: 2009

The automotive industry has recently seen a paradigmatic shift from design processes based on physical prototypes to a computationally aided product development process (PDP) based on virtual prototypes. To maintain the competitiveness of European car manufacturers, a significant reduction of lead development time is required. The main potential for improvement lies in further exploitation of virtual development and especially in further automation of these virtual processes through optimal design techniques. Optimal design techniques are mature and are being used in structural mechanics in the automotive industry, as well as in computational fluid dynamics (CFD) in the aeronautical industry. However, this potential has not yet been realised for CFD in the automotive industry. To integrate these methods into workflows within the routine PDP, the project will make advances with adjoint sensitivity methods, mesh-based and CAD-based shape optimisation, high-Reynolds number topology optimisation. Complete CFD optimisation workflows, i.e. chains of optimisation techniques adapted to the automotive processes for the early as well as later stages of development will be integrated into the PDP. Aspects of process stability, data management, storage, numerical efficiency will be addressed in conjunction with an analysis of current PDP practices. The current practices of organising the PDP will be analysed, the areas of potential for optimisation workflows identified and where necessary alterations of the PDP will be made. Key use cases within the design process defined by the two car manufacturers in the project will be demonstrated and the resulting reduction in lead time will be validated. European SMEs play a leading role in developing the software tools for the PDP and in supporting the car manufacturers in implementing these tools in their PDPs. Three SMEs with a track record of working with the automotive industry are partners in the project.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.2.2-02 | Award Amount: 7.84M | Year: 2012

NutriTech will build on the foundations of traditional human nutrition research using cutting-edge analytical technologies and methods to comprehensively evaluate the diet-health relationship and critically assess their usefulness for the future of nutrition research and human well-being. Technologies include genomics, transcriptomics, proteomics, metabolomics, laser scanning cytometry, NMR based lipoprotein profiling and advanced imaging by MRI/MRS. All methods will be applied in an integrated manner to quantify the effect of diet on phenotypic flexibility, based on metabolic flexibility (the capacity for the organism to adapt fuel oxidation to fuel availability). However, NutriTech will move beyond the state-of-the-art by applying these integrated methods to assess the underlying and related cell biological and genetic mechanisms and multiple physiological processes of adaptation when homeostasis is challenged. Methods will in the first instance be evaluated within a human intervention study, and the resulting optimal methods will be validated in a number of existing cohorts against established endpoints. NutriTech will disseminate the harmonised and integrated technologies on a global scale by a large academic network including 6 non-EU partners and by providing an integrated and standardised data storage and evaluation platform. The impact of NutriTech will be multifold and exploitation is crucial as major breakthroughs from our technology and research are expected. This will be achieved by collaboration with a consortium of 8 major food industries and by exploitation of specific technologies by our 6 SME partners. Overall, NutriTech will lay the foundations for successful integration of emerging technologies intro nutrition research.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2012.1.5 | Award Amount: 4.68M | Year: 2013

Project CATAPULT proposes to develop a radically new concept for automotive PEM fuel cell catalysts based on novel structures wherein platinum is deposited as an extremely thin layer ( <3 nm) on corrosion resistant supports of various morphologies, including particulate, nanofibrous and nanotubular, as well as nano-hierarchical combinations of these. In this approach, platinum is deposited using atomic layer deposition as thin, contiguous and conformal films that allow development of extended platinum or platinum alloy surfaces. Non-PGM catalysts will be developed via the tailored synthesis of metal-organic frameworks for their use either sacrificially to generate the C/N support for non-PGM species, or directly as a non-PGM catalyst. Hybrid ultra-low Pt/non-PGM catalysts and catalyst layers will also be investigated as a further novel approach. Increased fundamental understanding from supporting theoretical modelling will provide guidance to the strategies developed experimentally and to the down-selection of the new corrosion-resistant supports and their supported catalyst designs. Down-selected catalysts will be integrated into novel electrode designs and into MEAs incorporating state of the art membranes best adapted for automotive power trains, and evaluated according to protocols reproducing the stresses encountered in a drive cycle. The candidate MEA best satisfying performance and stability targets will be scaled-up for further assessment at large MEA and short stack levels. Techno-economic assessment will consider the scale up processability, and the impact of MEA performance and durability on stack costs. The well-balanced partnership, comprising two large industries (including an automotive OEM), two SMEs, two research organisations and two universities, will ensure close cooperation between industrial and institute partners, know-how, experience, research leadership, complementarity and industrial relevance.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2007-1-4-10 | Award Amount: 3.82M | Year: 2008

SharCo is aimed at helping the EU face the accession of Member States known as endemic of sharka disease by providing the EU with tools such as marker-assisted selection, PPV resistant plant materials, guidelines, warning systems, decision-support system. On that purpose, the project will, in the field of epidemiology, identify driving factors of PPV spread and diversification and develop novel and highthrough-put detection systems warning sharka outbreaks. In the field of genetics, it will provide molecular markers for the implementation of marker assisted selection of PPV resistant fruit varieties. In the field of biology, we will assess innovative biotechnological approaches to broaden resistance to PPV in different fruit tree species. Finally, in order to develop a PPV outbreak management, we will elaborate i) guidelines for endusers and policy makers concerning cultivation and risk management, ii) an early warning system coupled with a decision support system. All knowledge and tools developed by the project will be widely disseminated all over Europe with special attention made to PPV endemic countries.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.2.1 | Award Amount: 7.62M | Year: 2011

The ACTIVE project exploits ICT and other engineering methods and technologies for the design and development of an integrated redundant robotic platform for neurosurgery. A light and agile redundant robotic cell with 20 degrees-of-freedom (DoFs) and an advanced processing unit for pre- and intra-operative control will operate both autonomously and cooperatively with surgical staff on the brain, a loosely structured environment. As the patient will not be considered rigidly fixed to the operating table and/or to the robot, the system will push the boundaries of the state of the art in the fields of robotics and control for the accuracy and bandwidth required by the challenging and complex surgical scenario.\n\nTwo cooperating robots will interact with the brain that will deform for the tool contact, blood pressure, breathing and deliquoration. Human factors are considered by allowing easy interaction with the users through a novel haptic interface for tele-manipulation and by a collaborative control mode (hands-on). Force and video feedback signals will be provided to surgeons. Active constraints will limit and direct tool tip position, force and speed preventing damage to eloquent areas, defined on realistic tissue models updated on-the-field through sensors information. The active constraints will be updated (displaced) in real time in response to the feedback from tool-tissue interactions and any additional constraints arising from a complex shared workspace. The overarching control architecture of ACTIVE will negotiate the requirements and references of the two slave robots.\n\nThe operative room represents the epitome of a dynamic and unstructured volatile environment, crowded with people and instruments. The workspace will thus be monitored by environmental cameras, and machine learning techniques will be used for the safe workspace sharing. Decisions about collision avoidance and downgrading to a safe state will be taken autonomously, the movement of the head of the patient will be filtered by a bespoke active head frame, while fast and unpredictable patient motion will be compensated by a real-time cooperative control system. Cognitive skills will help to identify the target location in the brain and constrain robotic motions by means of on-field observations.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 25.61M | Year: 2013

In European robotics, ECHORD has successfully achieved integration on a large scale between industry and research that had never been done before. Capitalising on the major impact of ECHORD, the successor project ECHORD\\ (or E\\), will create new opportunities for European robotics researchers to work directly with SME/start-ups and new users/customers to create innovative markets.\n\nE\\ will continue ECHORDs two pillars, experiments and structured dialogue, taking advantage of experience and investment in the infrastructure. But E\\ will add another unique dimension: not only will we encourage ReIO and RoM to work together, but robot system customers and users will be involved connecting the suppliers directly with the market. To this end, there are two innovative new pillars: the Pre-Commercial-Procurement Pilots (PCPP) and the Knowledge and Innovation Centers (KIC). The PCPP will enable public procurers to become demanding buyers of new R&D. The complete PCP process will encompass robotics R&D for the first time, resulting in, demonstrable prototypes that can be evaluated together with the process at the end. The KICs are open experimental facilities that will that allow new robot customers and users to interact with roboticists with no entrance barrier and at very low cost so that new communities can form and radically new ideas can take shape. E\\s scientific work is structured in scenarios and research foci, directly derived from the SRA. They help steer the coordination between the experiments, KICs and PCPP to avoid unnecessary parallel work.\n\nE\\s implementation concept combines a team of excellent institutions with top-level researchers and the proven IT-backed processes. This will include highly effective quality management and monitoring.\n\nE\\ impact strategy is geared towards integration of stakeholder cooperation, SMEs, start-up sup-port and creating new markets ideally producing the next disruptive technologies.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 11.78M | Year: 2013

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.\nWe plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.\nWe will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 12.34M | Year: 2009

The Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy (NMI3) aims at the pan-European coordination of neutron scattering and muon spectroscopy, maintaining these research infrastructures as an integral part of the European Research Area. NMI3 comprehensively includes all major facilities in the field, opening the way for a more concerted, and thus more efficient, use of the existing infrastructure. Co-ordination and networking within NMI3 will lead to a more strategic approach to future developments and thus reinforce European competitiveness in this area. NMI3 is a consortium of 22 partners from 13 countries, including 10 research infrastructures. The objective of integration will be achieved by using several tools: * Transnational ACCESS will be provided by 10 partners offering more than 4000 days of beam time. This will give European users access to all of the relevant European research infrastructures and hence the possibility to use the best adapted infrastructure for their research. * Joint Research Activities focusing on six specific R&D areas will develop techniques and methods for next generation instrumentation. They involve basically all those European facilities and academic institutions with major parts of the relevant know-how. * Dissemination and training actions will help to enhance and to structure future generations of users. * Networking and common management will help strategic decision-making from a truly European perspective.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FI.ICT-2011.1.8 | Award Amount: 17.36M | Year: 2013

FI-STAR will establish early trials in the Health Care domain building on Future Internet (FI) technology leveraging on the outcomes of FI-PPP Phase 1. It will become self-sufficient after the end of the project and will continue on a sustainable business model by several partners. In order to meet the requirements of a global Health industry FI-STAR will use a fundamentally different, reverse cloud approach that is; it will bring the software to the data, rather than bringing the data to the software. FI-STAR will create a robust framework based of the software to data paradigm. A sustainable value chain following the life cycle of the Generic Enablers (GEs) will enable FI-STAR to grow beyond the lifetime of the project. FI-STAR will build a vertical community in order to create a sustainable ecosystem for all user groups in the global Health care and adjacent markets based on FI-PPP specifications. FI-STAR will deploy and execute 7 early trials across Europe, serving more than 4 million people. Through the trials FI-STAR will validate the FI-PPP core platform concept by using GEs to build its framework and will introduce ultra-light interactive applications for user functionality. It will pro-actively engage with the FI-PPP to propose specifications and standards.FI-STAR will use the latest digital media technology for community building and will proactively prepare for Phase 3 through targeted elicitation of new partners using open calls. Finally, FI-STAR will collaborate with other FI-PPP projects, through the mechanisms in place, by actively interacting with all necessary bodies. FI-STAR is a unique opportunity for implementing Future Internet Private-Public Partnership in the Health Care domain, by offering to the community standardised and certified software including a safe, secure and resilient platform, taking advantage of all Cloud Computing benefits and guaranteeing the protection of sensitive and personal data travelling in Public Clouds.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.2.1-3 | Award Amount: 14.90M | Year: 2010

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project will lead to evidence that is directly applicable to treatment guidelines, will explore the development of novel treatments and will identify potential mechanisms for new drug development. To achieve these goals we have assembled a European team of experts that is second to none in the world. Together we will pursue the following objectives: -To use MRI to optimise treatment outcome and to facilitate prediction of response to treatment; - To provide a rational basis for antipsychotic choices in the treatment of first episode schizophrenia or schizophreniform disorder; - To improve functional outcome and reduce drug discontinuation by means of psychosocial interventions. - To explore the potential of cannabidiol CBD, a modulator of endocannabinoid functioning, as an alternative to D2 based antipsychotics - To validate a new approach to improve cognitive performance in patients with cognitive deficits on the basis of their genetic make up; - To use theoretically driven neurochemical imaging (MRS) and empirically driven genetic/genomic markers as predictors of response to treatment.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-2.1-2014 | Award Amount: 3.92M | Year: 2015

The project provides solutions for common infrastructure problems encountered in diverse regions of Europe, e.g. deterioration and scour damage to bridges, slope instability, damage to switches and crossings and track performance. Whilst similar failure modes are seen around the EU, the triggers (precipitation, earthquake loading etc.) are regional. The DESTination RAIL project will develop management tools based on scientific principles for risk assessment using real performance measurements and other vital data stored in an Information Management System. This will allow for a step-change in the management of European rail infrastructure. The objectives will be achieved through a holistic management tool based on the FACT (Find, Analyse, Classify, Treat) principle. Find - Improved techniques for the assessment of existing assets will be developed. Analyse - Advanced probabilistic models fed by performance statistics and using databases controlled by an information management system. Classify - The performance models will allow a step-change in risk assessment, moving from the current subjective (qualitative) basis to become fundamentally based on quantifiable data. Treat - The impact of proposed remediation or reconstruction will be assessed using the a probabilistic whole life cycle model which includes financial and environmental costs and the impact of work on traffic flow. The FACT principles will be implemented in a holistic decision support tool for infrastructure managers. DESTination RAIL will result significant impact in relation to the objectives of the work programme. It will reduce the cost of investment by using the IMS to manage the network, (ii) Monitoring and real-times analyses will prevent unnecessary line restrictions and closures. (iii) Lower maintenance costs by optimisimg interventions in the life cycle of the asset and (iv) optimise traffic flow in the network.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2013.2.2-02 | Award Amount: 13.01M | Year: 2013

Emerging evidence indicates that the gut microbiome contributes to our ability to extract energy from the diet and influences development and function of the immune, endocrine and nervous systems, which regulate energy balance and behaviour. This has led to hypothesize that developing microbiome-based dietary interventions can be cost-effective measures to prevent diet-related and behavioural disorders. Yet this approach is restricted in practice by a lack of understanding of the specific species that contribute to these disorders and their interactions with host and lifestyle determinants. To progress beyond the state of the art, the MyNewGut proposal aims to: (1) shed light on the contribution of the human microbiome to nutrient metabolism and energy expenditure; (2) identify microbiome-related features that contribute to or predict obesity and associated disorders in human epidemiological studies; (3) understand how the microbiome is influenced by environmental factors and its role in brain and immune development and function in humans; and (4) provide proof-of-concept of the disease risk-reduction potential of dietary intervention with new foods/ingredients targeting the gut microbiome in humans. To this end, a translational multidisciplinary research strategy will be developed, combining experts in omic-technologies and all other scientific disciplines required. Consequently, the MyNewGut proposal will contribute to developing new approaches to prevent diet-related diseases (metabolic syndrome and obesity) and behavioural disorders through lifestyle changes, intake of pro- and prebiotics and semi-personalised and innovative food products. This will ultimately contribute to increasing the competitiveness of the European food industry and provide consumers with reliable claims on foods. Results will also help inform new strategies on public health, support EU legislation and improve the position of the EU in the field of food-related disease prevention.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 18.74M | Year: 2009

The Project promotes the access to five European Research Infrastructures, and it is structured intop eight Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities. The Project represents the continuation of the successful HadronPhysics project in FP6 and originates from the initiative of more than 2.500 European scientists working in the field of hadron physics. Hadron physics deals with the study of strongly interacting particles, the hadrons. Hadrons are composed of quarks and gluons. Their interaction is described by Quantum Chromo Dynamics, the theory of the strong force. Hadrons form more complex systems, in particular atomic. Under extreme conditions of pressure and temperature, hadrons may loose their identity and dissolve into a new state of matter similar to the primordial matter of the early Universe. The Networking Activities are related to the organization of experimental and theoretical collaborative work concerning both ongoing activities at present Research Infrastructures and planned experiments at future facilities. In hadron physics the close interaction between experimentalists and theoreticians is of paramount importance. The Joint Research Activities concentrate on technological innovations for present and future experiments. Applications in material science, medicine, information, technology, etc., represent natural fall-outs. The main objective of this Integrating Activity is to optimize the use and development of the Research Infrastructures existing in Europe working in the field of hadron physics. The Project aims as well at structuring, on European scale, the way Research Infrastructures operate, and at fostering their joint development in terms of capacity and performance. The approach used is the bottom up approach, to respond to the needs of the scientific community in all fields of science and technology.

News Article | October 6, 2016

The formation of quasiparticles, such as polarons, in a condensed-matter system usually proceeds in an extremely fast way and is very difficult to observe. In Innsbruck, Rudolf Grimm's physics research group, in collaboration with an international team of theoretical physicists, has simulated the formation of polarons in an ultracold quantum gas in real time. The researchers have published their findings in the journal Science. The concept of quasiparticles is a powerful tool to describe processes in many-body quantum systems, such as solid-state materials. For example, when an electron moves through a solid, it generates polarization in its environment because of its electrical charge. This "polarization cloud" moves together with the electron and the resulting "dressed electron" can be theoretically described as quasiparticle or a polaron. "You could picture it as a skier on a powder day," says Grimm. "The skier is surrounded by a cloud of snow crystals. Together they form a system that has different properties than the skier without the cloud." The challenge in an experiment is to measure the quasiparticles. "These processes last only attoseconds, which makes a time-resolved observation of their formation extremely difficult," explains Grimm. His research group uses ultracold quantum gases for simulations to study the many-body physics of complex quantum systems. Ultracold quantum gases are an ideal experimental platform to study physical phenomena in solid-state materials and also exotic states of matter, for example neutron stars. Because of the well-controlled environment, the scientists are able to create many-body states and manipulate interactions between particles in these gases. Rudolf Grimm's research group, working at the Institute for Quantum Optics and Quantum Information, Austrian Academy of Sciences, and the Institute for Experimental Physics, University of Innsbruck, is a leader in this research field. In collaboration with theoretical physicists from Harvard University, the TU Munich and Monash University in Australia, the researchers have now studied quasiparticle dynamics in real time. In a vacuum chamber, using laser trapping techniques, the researchers created an ultracold quantum gas made up of lithium atoms and a small sample of potassium atoms in the center. For both types of atoms they used isotopes of fermionic nature, which belong to the same fundamental class as electrons. Magnetic fields were used to tune interactions, which produced Fermi polarons, i.e. potassium atoms embedded in a lithium cloud. "In condensed matter, the natural time scale of these quasiparticles is on the order of 100 attoseconds," explains Grimm. "We simulated the same physical processes at much lower densities. Here, the formation time for polarons is a few microseconds." "We developed a new method for observing the 'birth' of a polaron virtually in real time," says quantum physicists Grimm. Looking into the future, he says: "This may turn out to be a very interesting approach to better understand the quantum physical properties of ultrafast electronic devices." More information: Ultrafast many-body interferometry of impurities coupled to a Fermi sea. Marko Cetina, Michael Jag, Rianne S. Lous, Isabella Fritsche, Jook T. M. Walraven, Rudolf Grimm, Jesper Levinsen, Meera M. Parish, Richard Schmidt, Michael Knap, Eugene Demler. Science.

News Article | December 1, 2016

« Toyota approves Mentor Graphics Volcano VSTAR AUTOSAR stack for ECU deployment in next-gen Toyota vehicles | Main | ORNL study finds even low penetration of CAVs delivers significant fuel economy benefits, but increases travel time slightly » Carbon specialist SGL Group is a development partner in the European joint development project INSPIRE (Integration of Novel Stack Components for Performance, Improved DuRability and LowEr Cost), which has been funded with a €7-million (US$7.4-million) award from Europe’s Fuel Cells and Hydrogen Joint Undertaking (FCH JU) and will run for three years. (Earlier post.) The aim of INSPIRE is to develop a new generation of fuel cells with higher performance and longer lifetime. SGL Group brings its long-established expertise as a component developer to the project, and is responsible for the development of the gas diffusion layers (GDL), which will be manufactured based on carbon fibers. The GDL in polymer electrolyte membrane (PEM) fuel cell provides a steady supply of gas to the catalyst layers, which are located on both sides of the ion exchange membrane and which convert hydrogen and oxygen into electrical energy and water. The GDLs also aid water vapor reaching the membrane (thereby increasing ionic conductivity) and also facilitate the removal of produced water. The reactants diffuse from the gas channels to the catalyst layer; the generated water must travel from the catalyst layer to the gas channels. GDLs are positioned between the catalyst layer in the cell and the gas flow channel; its structure controls catalyst utilization and overall fuel cell performance. In a 2012 review of GDL materials and designs, a team from the University of South Carolina noted that: The INSPIRE project, which kicked-off in May 2016, is being carried out under the coordination of Johnson Matthey, a leading manufacturer of catalyst coated membrane units, as well as other companies such as the BMW Group and Dana Holding Corporation (Neu-Ulm), along with several scientific research organizations (CNRS Montpellier, TU Berlin, TU Munich, University of Freiburg, VTT Espoo) and the SME Pretexo. Dana is developing an optimized design of metallic bipolar plate that delivers the hydrogen and air to the MEA and transmits the electricity generated to power the vehicle. BMW Group is setting out the requirements for the stack and will assemble the MEAs and bipolar plates into new stack designs aimed at achieving the cost, durability and volumetric power density targets required for mass market exploitation. CNRS Montpellier, VTT Technical Research Centre of Finland Ltd., Technical University of Munich, Technical University of Berlin and the University of Freiburg are working on next-generation catalysts, electrodes and membranes. Project management support is being provided by Pretexo. In addition to the focus on development, the partners will also be concentrating on establishing a common European supply chain for these critical components; namely the membrane, catalyst, gas diffusion layers and bipolar plates. With this step the capability of serial production will also be demonstrated. INSPIRE, with high-profile partners from the fields of science and industry, offers an excellent platform to accelerate the utilization of fuel cell technology with its innovative materials and components. For SGL Group, it highlights our entrepreneurial claim to play a key role in shaping developments in the megatrends of mobility and energy supply. These include not only graphite anode material for lithium ion batteries and carbon fiber composites for lightweight-construction passenger compartments, but also our gas diffusion layers for alternative drive technologies based on hydrogen. INSPIRE will make an invited presentation during the European Fuel Cell Car Workshop (EFCW2017), 1-3 March 2017, Orléans, France, organized by the FCH JU SMARTCat Project.

News Article | October 7, 2016

The formation of quasiparticles, such as polarons, in a condensed-matter system usually proceeds in an extremely fast way and is very difficult to observe. In Innsbruck, Rudolf Grimm's physics research group, in collaboration with an international team of theoretical physicists, has simulated the formation of polarons in an ultracold quantum gas in real time. The researchers have published their findings in the journal Science. The concept of quasiparticles is a powerful tool to describe processes in many-body quantum systems, such as solid-state materials. For example, when an electron moves through a solid, it generates polarization in its environment because of its electrical charge. This "polarization cloud" moves together with the electron and the resulting "dressed electron" can be theoretically described as quasiparticle or a polaron. "You could picture it as a skier on a powder day," said Grimm. "The skier is surrounded by a cloud of snow crystals. Together they form a system that has different properties than the skier without the cloud." The challenge in an experiment is to measure the quasiparticles. "These processes last only attoseconds, which makes a time-resolved observation of their formation extremely difficult," said Grimm. His research group uses ultracold quantum gases for simulations to study the many-body physics of complex quantum systems. Ultracold quantum gases are an ideal experimental platform to study physical phenomena in solid-state materials and also exotic states of matter, for example neutron stars. Because of the well-controlled environment, the scientists are able to create many-body states and manipulate interactions between particles in these gases. Rudolf Grimm's research group, working at the Institute for Quantum Optics and Quantum Information, Austrian Academy of Sciences, and the Institute for Experimental Physics, University of Innsbruck, is a leader in this research field. In collaboration with theoretical physicists from Harvard University, the TU Munich and Monash University in Australia, the researchers have now studied quasiparticle dynamics in real time. In a vacuum chamber, using laser trapping techniques, the researchers created an ultracold quantum gas made up of lithium atoms and a small sample of potassium atoms in the center. For both types of atoms they used isotopes of fermionic nature, which belong to the same fundamental class as electrons. Magnetic fields were used to tune interactions, which produced Fermi polarons, i.e. potassium atoms embedded in a lithium cloud. "In condensed matter, the natural time scale of these quasiparticles is on the order of 100 attoseconds," added Grimm. "We simulated the same physical processes at much lower densities. Here, the formation time for polarons is a few microseconds." "We developed a new method for observing the 'birth' of a polaron virtually in real time," said quantum physicists Grimm. Looking into the future, he says: "This may turn out to be a very interesting approach to better understand the quantum physical properties of ultrafast electronic devices."

News Article | November 15, 2016

For a long time, mathematical modelling of social systems and dynamics was considered in the realm of science fiction. But predicting, and at once influencing human behavior is well on its way to becoming reality. Scientists at the Technical University of Munich (TUM) are currently developing the appropriate tools. This will allow them to simulate and improve security at major events or increase the efficiency of evacuation measures. There is a long history of research aimed at predicting the behavior of groups and influencing them. But, it seems practically impossible to precisely predict the behavior of individuals, not least because of the myriad interactions between the physical, emotional, cognitive and social domains. But things look quite different when considering people in traffic, in social networks and at major events in which they do not appear as individuals, but rather as part of a crowd. "People in masses behave akin to particles in a fluid or gas," explains Professor Massimo Fornasier, chair of the Department of Applied Numerical Analysis at TU Munich. In physics, it is not necessary to know the properties of every individual particle to calculate with a high probability the direction of flow of a large number of gas molecules. It is enough to understand their mean motion properties. "We can take the same approach when looking at flows of human masses, animal swarms or interacting robots: Analogous to the force of attraction between molecules in a gas, we can describe generalized behavioral patterns as resulting from interacting social forces between individual agents and represent them in mathematical equations," says Fornasier, describing his approach. Professor Fornasier and his team have recently proven mathematical statements that demonstrate how surprisingly easy it is to automatically generate precise models for specific, relatively simple group interactions based on observed dynamics data. Using computer simulations, the mathematicians can describe potential collective behavioral patterns of a large number of individuals who mutually influence each other in a given situation. "In the next step we can then also make predictions about future behavior," says Fornasier. "And once we can calculate the behavior of a group of interacting agents in advance, we are only one small step away from controlling them." In an experiment conducted in May 2015 in collaboration with Consiglio Nazionale delle Ricerche (CNR) and the University of Rome "La Sapienza" in Italy, Fornasier and his team demonstrated that the process is in fact amenable to influencing group behavior. To this end, the researchers assigned two groups of 40 students each the task of finding a specific location in a building. The scientists planted two incognito informed agents into one of the groups. By merely moving very determinedly in a predefined direction, the agents were able to steer the group toward the target spot. This experiment demonstrates that taking control of self-organizing systems, which also include groups of individuals, is possible with surprisingly little effort. The mathematicians also confirmed that the results apply equally well to very large groups. "In fact, two to three agents per 100 individuals are sufficient," says Massimo Fornasier. The fact that his mathematical models are formulated in an entirely abstract environment makes them easily adaptable to a wide variety of situations. This facilitates finding efficient solutions for steering large masses of people though buildings in a stress-free manner or evacuating people in emergency situations. "But we can also apply our results to other interesting domains in society, like the behavior of investors in financial markets," says Fornasier. There, precisely coordinated activities by big investors can result in sizable market movements. Opinion forming in groups also builds on the interactions of people. In their models, the mathematicians demonstrated that it is most effective to concentrate on the most radical defenders of a given opinion. If you manage to convince them, the rest of the group will follow. "There is also a good model for this in nature," according to Fornasier. "To drive a herd of sheep in a desired direction, a good herding dog will always concentrate on the animal that is the farthest removed from the group. They achieve their goal by reining in the most stubborn animal." "For all the conceivably good application scenarios there remains, of course, the question of abuse," says Professor Fornasier. "The good news in this context is that we have also proven that behavior is not so easy to predict or control for all kinds of dynamics and situations." "An important prerequisite for for predictability and controllability is that the myriad possible interactions between the agents in a large group can be reduced to a small number of effective ones," says Massimo Fornasier. "Forecasts function well in groups that show generalized patterns of behavior." However, with competing interactions, when the energy of individual agents is too large an equilibrium and, thus, concerted movement of the group of agents can no longer be imposed using simple, sporadic interventions. "An extensive forecast of events like that accomplished by the mathematician Hari Seldon in Isaac Asimov's Foundation series or the all-encompassing control exercised in Aldous Huxley's 'Brave New World' will remain science fiction," says Professor Fornasier.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.4.4 | Award Amount: 3.46M | Year: 2012

Non-relational data management is emerging as a critical need for the new data economy based on large, distributed, heterogeneous, and complexly structured data sets. This new data management paradigm also provides an opportunity for research results to impact young innovative companies working on new RDF and graph data management technologies to start playing a significant role in this new data economy.Standards and benchmarking are two of the most important factors for the development of new information technology, yet there is still no comprehensive suite of benchmarks and benchmarking practices for RDF and graph databases, nor is there an authority for setting benchmark definitions and auditing official results. Without them, the future development and uptake of these technologies is at risk by not providing industry with clear, user-driven targets for performance and functionality.The goal of the Linked Data Benchmark Council (LDBC) project is to create the first comprehensive suite of open, fair and vendor-neutral benchmarks for RDF/graph databases together with the LDBC foundation which will define processes for obtaining, auditing and publishing results. The core scientific innovation of LDBC is therefore to define meaningful benchmarks derived from a combination of actual usage scenarios combined with the technical insight of top database systems researchers and architects in the choke points of current technology. LDBC will bring together a broad community of researchers and RDF and graph database vendors to establish an independent authority, the LDBC foundation, responsible for specifying benchmarks, benchmarking procedures and verifying/publishing results. The forum created will become a long-surviving, industry supported association similar to the TPC. Vendors and user organisations will participate in order to influence benchmark design and to make use of the obvious marketing opportunities.

News Article | November 14, 2016

For a long time, mathematical modelling of social systems and dynamics was considered in the realm of science fiction. But predicting, and at once influencing human behavior is well on its way to becoming reality. Scientists at the Technical University of Munich (TUM) are currently developing the appropriate tools. This will allow them to simulate and improve security at major events or increase the efficiency of evacuation measures. There is a long history of research aimed at predicting the behavior of groups and influencing them. But, it seems practically impossible to precisely predict the behavior of individuals, not least because of the myriad interactions between the physical, emotional, cognitive and social domains. But things look quite different when considering people in traffic, in social networks and at major events in which they do not appear as individuals, but rather as part of a crowd. "People in masses behave akin to particles in a fluid or gas," explains Professor Massimo Fornasier, chair of the Department of Applied Numerical Analysis at TU Munich. In physics, it is not necessary to know the properties of every individual particle to calculate with a high probability the direction of flow of a large number of gas molecules. It is enough to understand their mean motion properties. "We can take the same approach when looking at flows of human masses, animal swarms or interacting robots: Analogous to the force of attraction between molecules in a gas, we can describe generalized behavioral patterns as resulting from interacting social forces between individual agents and represent them in mathematical equations," says Fornasier, describing his approach. Professor Fornasier and his team have recently proven mathematical statements that demonstrate how surprisingly easy it is to automatically generate precise models for specific, relatively simple group interactions based on observed dynamics data. Using computer simulations, the mathematicians can describe potential collective behavioral patterns of a large number of individuals who mutually influence each other in a given situation. "In the next step we can then also make predictions about future behavior," says Fornasier. "And once we can calculate the behavior of a group of interacting agents in advance, we are only one small step away from controlling them." In an experiment conducted in May 2015 in collaboration with Consiglio Nazionale delle Ricerche (CNR) and the University of Rome „La Sapienza" in Italy, Fornasier and his team demonstrated that the process is in fact amenable to influencing group behavior. To this end, the researchers assigned two groups of 40 students each the task of finding a specific location in a building. The scientists planted two incognito informed agents into one of the groups. By merely moving very determinedly in a predefined direction, the agents were able to steer the group toward the target spot. This experiment demonstrates that taking control of self-organizing systems, which also include groups of individuals, is possible with surprisingly little effort. The mathematicians also confirmed that the results apply equally well to very large groups. "In fact, two to three agents per 100 individuals are sufficient," says Massimo Fornasier. The fact that his mathematical models are formulated in an entirely abstract environment makes them easily adaptable to a wide variety of situations. This facilitates finding efficient solutions for steering large masses of people though buildings in a stress-free manner or evacuating people in emergency situations. "But we can also apply our results to other interesting domains in society, like the behavior of investors in financial markets," says Fornasier. There, precisely coordinated activities by big investors can result in sizable market movements. Opinion forming in groups also builds on the interactions of people. In their models, the mathematicians demonstrated that it is most effective to concentrate on the most radical defenders of a given opinion. If you manage to convince them, the rest of the group will follow. "There is also a good model for this in nature," according to Fornasier. "To drive a herd of sheep in a desired direction, a good herding dog will always concentrate on the animal that is the farthest removed from the group. They achieve their goal by reining in the most stubborn animal." "For all the conceivably good application scenarios there remains, of course, the question of abuse," says Professor Fornasier. "The good news in this context is that we have also proven that behavior is not so easy to predict or control for all kinds of dynamics and situations." "An important prerequisite for for predictability and controllability is that the myriad possible interactions between the agents in a large group can be reduced to a small number of effective ones," says Massimo Fornasier. "Forecasts function well in groups that show generalized patterns of behavior." However, with competing interactions, when the energy of individual agents is too large an equilibrium and, thus, concerted movement of the group of agents can no longer be imposed using simple, sporadic interventions. "An extensive forecast of events like that accomplished by the mathematician Hari Seldon in Isaac Asimov's Foundation series or the all-encompassing control exercised in Aldous Huxley's 'Brave New World' will remain science fiction," says Professor Fornasier. The findings were presented at the European Congress of Mathematics in July 2016. They are results of the ERC-starting grant project "High-Dimensional Sparse Optimal Control" (HDSPCONTR) which was funded by the European Research Council (ERC). Besides members of the Fornasier group several researchers at TUM and cooperating international institutions have contributed to the results [in alphabetical order]: Dr. Giacomo Albi (TUM), Dr. Mattia Bongini (TUM), Dr. Marco Caponigro (Conservatoire National des Arts et Métiers, Paris, France), Dr. Emiliano Cristiani (Consiglio Nazionale delle Ricerche (CNR), IAC, Rome, Italy), Dr. Markus Hansen (TUM), Dr. Dante Kalise (Johann Radon Institute, ÖAW, Linz, Austria), Prof. Mauro Maggioni (Johns Hopkins University, Baltimore, USA), Prof. Benedetto Piccoli (Rutgers University, Camden, USA), Dr. Francesco Rossi (Aix-Marseille Université, Marseille, France), Dr. Francesco Solombrino (TUM), Prof. Emmanuel Trélat (Université Pierre et Marie Curie (Paris 6), France). M. Fornasier; Learning and sparse control of multiagent systems. In: Proceedings of the 7th European Congress of Mathematics, 2016 (in press) https:/ M. Bongini, M. Fornasier, M. Hansen and M. Maggioni. Inferring Interaction Rules from Observations of Evolutive Systems I: The Variational Approach; arXiv:1602.00342v2 [math.DS] 16 Feb 2016 https:/ M. Caponigro, M. Fornasier, B. Piccoli and E. Trélat. Sparse stabilization and control of alignment models, Mathematical Models and Methods in Applied Sciences, 25(03):521-564, 2015 https:/

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-01-2014 | Award Amount: 4.93M | Year: 2015

The proposed research effort provides methods for a faster and more efficient development process of safety- or operation-critical cyber-physical systems in (partially) unknown environments. Cyber-physical systems are very hard to control and verify because of the mix of discrete dynamics (originating from computing elements) and continuous dynamics (originating from physical elements). We present completely new methods for de-verticalisation of the development processes by a generic and holistic approach towards reliable cyber-physical systems development with formal guarantees. In order to guarantee that specifications are met in unknown environments and in unanticipated situations, we synthesise and verify controllers on-the-fly during system execution. This requires to unify control and verification approaches, which were previously considered separately by developers. For instance, each action of an automated car (e.g. lane change) is verified before execution, guaranteeing safety of the passengers. We will develop completely new methods, which are integrated in tools for modelling, control design, verification, and code generation that will leverage the development towards reliable and at the same time open cyber-physical systems. Our approach leverages future certification needs of open and critical cyber-physical systems. The impact of this project is far-reaching and long-term: UnCoVerCPS prepares the EU to be able to develop critical cyber-physical systems that can only be realised and certified when uncertainties in the environment are adequately considered. This is demonstrated by applying our ground-breaking methods to automated vehicles, human-robot collaborative manufacturing, and smart grids within a consortium that has a balanced participation of academic and industrial partners.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2009.2.1 | Award Amount: 2.37M | Year: 2010

Over the last few years successful coordination activities have been undertaken within the academic and industrial robotics\ncommunities (EURON and EUROP), but both communities still struggle with overcoming some remaining gaps: the\ncommunity-internal gaps of confusion about terminology, suboptimally coordinated transfer of research visions, technology\nand people, and the limited coordinated communication with both the general public and professional audiences. This\nincludes the popular science media, European Commission, national funding bodies, and representatives from neighbouring\ntechnology and market domains, such as cognitive science, mechatronics, automotive, aerospace, security, computer vision,\nembedded control systems.\nThis projects ambition is to create sustainable solutions to all of the above-mentioned gaps, following a policy of targeted\nstimulation of relevant grass-roots initiatives that both communities have already experimented with during the last couple of\nyears, but that have previously seen little success because of a lack of committed, professional and coordinated support. The\ndriver behind these stimulations will always be the robotics industry (since its needs for innovation and strong positioning in\nthe worldwide robotics market are greatest), but the academic research community will be heavily involved via a system of\nflexible, targeted expert contributions whose short-term benefits are easy to identify and communicate.\nThe following activities are planned: improved industry-academia cooperation by giving more structure to commonly\norganised events (administration, annual meetings, web portal on Robotics in Europe, advanced training, roadmapping,\nand entrepreneurship advocacy) and by coordinated communication to the general public (press releases, visibility at major\nrobotics events worldwide, robotics competitions related to the shared research and development roadmap, laymans\nexplanation of robotics technology in combination with semantic search support on the web portal).

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.6.1 | Award Amount: 21.87M | Year: 2010

The eCoMove project will create an integrated solution for road transport energy efficiency by developing systems and tools to help drivers sustainably eliminate unnecessary fuel consumption (and thus CO2 emissions), and to help road operators manage traffic in the most energy-efficient way. By applying this combination of cooperative systems using vehicle-infrastructure communication, the project aims to reduce fuel consumption by 20% overall. This target can be achieved by:\n\n Saving unnecessary kilometers driven (optimising routes)\n Helping driver to save fuel (optimising driver behaviour)\n Managing traffic more efficiently (optimising network management)\n\nThe eCoMove concept rests on the idea that, for a given trip by a particular driver in a particular vehicle, there is some least possible fuel consumption that could be achieved by the perfect eco-driver travelling through the perfectly eco-managed road network. In reality, both drivers and traffic management systems fall short of this ideal, and much fuel is wasted and CO2 emitted unnecessarily.\nThe eCoMove innovations will target the two sources of this avoidable fuel consumption: private trips and freight/logistics trips.\n\nThis integrated project (IP) will structure into six different sub-projects:\n1. Coordination and Management.\n2. Core Technology Integration both to develop common core technologies and to ensure strong technical coordination across the IP.\n3. ecoSmartdriving to develop solutions for eco-driving support for car drivers,\n4. ecoFreight & Logistices, for both eco-driving support for trucks and eco-freight and logistics management.\n5. ecoTrafficManagement & Control to develop applications for cooperative eco-traffic network management.\n6. Validation & Evaluationto validate the performance and effectiveness of all applications in a number of urban, non-urban and motorway environments.\n\nKey objectives of eCoMove innovation are to develop and validate the following applications:\n ecoSmartDriving to improve driver eco-performances, including: ecoTripPlanning, on trip dynamic green routing, ecoDriving support, ecoPostTrip and ecoMonitoring;\n ecoDriver Coaching System and in-vehicle Truck eCoNavigation for good vehicle drivers\n cooperative ecoFleet Planning and Routing for environmental sound ecoFreight & Logistics\n ecoAdaptive Balancing & Control system as well as cooperative Fuel-efficient Motorway system as means for ecoTrafficManagement & Control.\n\nThese important eCoMove innovations are enabled by the use of cooperative information exchange, such as vehicle fuel consumption data & route destination by the traffic system, the traffic lights phase data, speed and route recommendations by the vehicle.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.2.2 | Award Amount: 25.84M | Year: 2009

The European robotics industry plays a key role in maintaining our continents industrial base. The robotics industry is strong, but fragmented and dispersed. In the future, cutting-edge technology resulting from top-level research will be the decisive factor for success. Europe not only has a powerful robotics industry, but can also boast superb research. By drawing on these resources, ECHORD aims at producing new knowledge through advancing the state of the art in selected research foci and developing novel technology from which new products can be derived. Within ECHORD, opportunities for knowledge advancement and technology transfer between academia and industry will be created across the whole continent. This will be achieved through the solicitation of focused, small-size RTD projects, so-called experiments, which can be rapidly negotiated, funded and executed. Via these experiments, ECHORD will bring about a large-scale introduction of robotic equipment into research institutions. This is expected to result in both tangible and measurable out-comes in terms of the accelerated development of technologies, as well as the deployment of robotics technology into new scenarios for the direct application of research results. For ECHORD, three such scenarios have been defined: human-robot co-working, hyper flexible cells, and cognitive factories. The foremost purpose of the scenarios is to define an environment that is both scientifically challenging to research institutions and commercially relevant to robot manufacturers.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2008-2.5-1 | Award Amount: 4.41M | Year: 2009

Improving tool behaviour can optimise forming processes undergoing severe thermomechanical solicitations which are used to obtain high performance components. FGM are particularly appropriate for developing high performance tools since they allow this optimization through a graded variation of their properties. This project aims to develop a new generation of FGM with: Functionally graded thermal conductivity and wear resistance for hot stamping, forging and casting dies to enable controlled cooling in different regions of the die. In hot stamping it will allow obtaining microstructurally tailored components, with an improved performance and crash performance with optimized weight for safety related automotive components. In die casting it is expected to increase tool life and improve the mechanical properties of the casting. Improved fracture toughness and wear resistance for cold forming through a gradual variation of the hard particles content. It will be done by an optimization of the properties of the microstructural constituents, i.e. hard particles and the metallic matrix, separately. FGM with surfaces tailored to have high load bearing capability as a substrate for hard coatings. These aims will be achieved by: Microstructural design considering the thermomechanical requirements acting on tools, obtained from simulation of the heat transfer and stresses acting on each microstructural constituent. Investigation into the relationship between the properties of the microstructural constituents and the macroscopic mechanical behaviour. A detailed investigation on the properties, size, morphology and surface modification of the hard particles will be made. Thermomechanical laboratory tests to screen the developed materials. Materials will be characterised in terms of thermal conductivity, thermal fatigue, fracture and fatigue resistance and wear behaviour. Process related experiments, including NDT will be carried out for upscaling to industrial use

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: REGIONS-2012-2013-1 | Award Amount: 2.31M | Year: 2013

To master increasingly complex and multidisciplinary technology and business chains in ICT, partnering, risk-sharing and mobilisation of critical mass across the Union are needed. CLINES cluster partnership will address many of the difficulties facing innovative research and business actors.The CLINES partnership builds on the cooperation and experience of four European Research Driven Regional clusters with proven track records. The partnership involves Brainsbusiness ICT cluster in North Jutland, Denmark, BICCnet in Bavaria, Germany, DSP Valley in Leuven, Belgium, and GAIA in the Basque Country, Spain. Each participating cluster builds on strong and committed triple helix partnerships. The mission of the CLINES partnership is to develop a sustainable, well-organized European key technology intercluster, where the outcome of the partnership will increase the coordination of trans regional innovation investments and ensure an efficient development, exploitation and dissemination of the ICT applications. CLINES project results will lead to increased European excellence within key enabling technologies and foster pertinent regional digital agendas. It will furthermore provide a framework for cluster cooperation to unlock novel business opportunities on global markets beyond Europe. By the end of the project period, CLINES will present: A strategic research agenda for the involved institutions including both selected research challenges as well as selected, potential application areas. A strategy for public & private funding which is coordinated with the strategic research agenda. A strategy for innovation activities with relevant partners and based on smart specialization strategy. A strategy for internationalization, to boost competitiveness. A dissemination strategy for attracting companies and investors which is using a variety of media and which is based on selected showroom demonstrators illustrating research and innovation results.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: INFRA-2007-2.1-01 | Award Amount: 2.46M | Year: 2008

Key questions in particle and astroparticle physics can be answered only by construction of new giant underground observatories to search for rare events and to study sources of terrestrial and extra-terrestrial neutrinos. In this context, the European Astroparticle Roadmap of 03/07, via ApPEC and ASPERA, states: We recommend a new large European infrastructure, an international multi-purpose facility of 105-106 ton scale for improved studies of proton decay and low-energy neutrinos. Water-Cherenkov, Liq. Scintillator & Liq. Argon should be evaluated as a common design study together with the underground infrastructure and eventual detection of accelerator neutrino beams. This study should take into account worldwide efforts and converge by 2010... Furthermore, the latest particle physics roadmap from CERN of 11/06 states:A range of very important non-accelerator experiments takes place at the overlap of particle and astroparticle physics exploring otherwise inaccessible phenomena; Council will seek with ApPEC a coordinated strategy in these areas of mutual interest. Reacting to this, uniting scientists across Europe, we propose here a design study, LAGUNA, to produce by 2010 a full conceptual design sufficient to provide policy makers and funding agencies with enough information for a construction decision. Has Europe the technical and human capability to lead future underground science by hosting the next generation underground neutrino and rare event observatory? We aim to answer this question. Certainly construction will exceed the capacity of any single European nation - to compete with the US and Asia unification of our scattered efforts is essential. Failure to plan now risks not only that our picture of Natures laws remain fundamentally incomplete but also that leadership in the field enjoyed by Europe for 20 years falls away. EU FP7 input now is timely and will have major strategic impact, guaranteeing coherence and stimulating national funding.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: Fission-2007-3.1-01 | Award Amount: 6.70M | Year: 2008

Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular disease. In addition, radiation may increase atherosclerotic lesions in the coronary arteries. The aim of this collaborative research project is to elucidate the pathogenesis of early and late alteration in the microcirculation of the heart and of atherosclerotic lesions in arteries after exposure to low radiation doses in comparison to high radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences. To achieve this goal, in vivo as well as ex vivo and in vitro studies will be performed. A central component of the project will be the local irradiation of the heart with subsequent isolation of cardiomyocytes and cardiac endothelial cells to provide all participating groups with the same biological material for further study. In addition, structural, morphological and molecular studies will be complemented by functional assays and imaging methods.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: HEALTH-2007-2.4.5-7 | Award Amount: 1.39M | Year: 2008

Hearing loss is one of the most common chronic health conditions in the elderly population with important implications for patient quality of life. The diminished ability to hear and to communicate is frustrating in and of itself, but the strong association of hearing loss with depression and functional decline adds further to the burden on individuals who are hearing impaired. Hearing loss can limit communications skills: not to hear means not to understand what is being said. Hence deafness does not produce compassion but do often produce a sense of irritation. Despite the prevalence and burden of hearing loss, hearing impairment is largely underdiagnosed in older persons and undertreated. The reason for this is that one of the most conspicuous signs of a hearing loss is that it cannot be seen! Actually, this is the reason why deafness does not receive the necessary attention. Too often, the public and still too many health care professionals underestimate the dramatic effects of deafness. Novel strategies should be explored to make screening and early intervention a feasible part of routine care. Project AHEAD III has been specifically designed to: - Provide evidence of the effects of hearing impairment in adults and particularly in the elderly - Analyse costs associated with the implementation of integrated large scale programmes of hearing screening and intervention in the elderly - Provide quality standards and minimum requirements for screening methods and related diagnostic techniques - Develop guidelines and recommendations on how to implement successful screening programmes to be tuned to the local, social, and economical conditions of a country.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 2.14M | Year: 2009

There is a consensus today that supplying a growing world population with energy is one of the biggest if not the biggest challenge mankind is facing in the 21st century. The reasons for this are numerous and are among others related to the observation that energy is critical to human development, including economic growth, equity and employment, and that fossil fuels our current energy backbone are slowly but inevitably declining. This generates an increasing demand of well-educated young scientists knowledgeable in materials science for energy conversion and storage, because a central problem for all forms of energy is their efficient generation or conversion as well as energy storage with sufficiently high density (e.g., hydrogen or biofuels). In this broader context, the proposed Marie Curie Initial Training Network (ITN) MATCON will concentrate on the following topics of fundamental importance: Photo-electrochemical generation of hydrogen by water splitting Bio-inspired and biomimetic energy conversion Thermoelectric and thermoionic heat conversion For all of these topics, alternative or new materials and materials combinations will be necessary to improve the efficiency of energy conversion or to overcome existing problems with stability. Therefore, the Network will also put considerable emphasis on the tailoring and development of specific materials for electrodes, substrates and functional interfaces. This expertise will be of central importance for the successful implementation of the different research topics outlined above and, at the same time, provide an ideal basis for the training of the young researchers in state of the art materials science and semiconductor technology.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.00M | Year: 2012

This network brings together an exceptionally strong group of world leading experts in nano-science and technology in order to achieve breakthroughs in understanding and successful utilisation of nanoscale systems in future devices. The focus of the consortium is on few spin nano-systems in solid-state materials including III-V semiconductors and Carbon-based structures: carbon nano-tubes, graphene and diamonds. Such wide material base emphasizes the truly intersectoral character of this collaboration opening opportunities for crossing the boundaries between several areas of solid-state physics and technology. In order to ensure the highest impact of this collaboration in the emerging supra-disciplinary field of physics and applications of spin nano-systems, we bring together the expertise of the world top class research institutions and industry from 4 European countries. The network will deliver top international level multidisciplinary training to 11 early stage researchers and 5 experienced researchers, offering them, in particular, an extended program of multinational exchanges and secondments. The research and development under this network will undertake a broad scope of tasks important for implementation of spin nano-systems in future devices, such as non-volatile ultra-compact memories, nano-magnetometers, spin qubits for quantum information, and high-efficiency single photon sources. The objectives of the network include: (1) Realization and optical control of coherent single spins in nanostructures; (2) Spin-orbit interaction and spin-orbit qubits in nanostructures; (3) Advanced techniques for manipulation of nuclear spins on the nanoscale; (4) Generation of long-distance entanglement between single spins.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.75M | Year: 2011

The FlowAirS proposal is collaborative training research network. It will be focused on the generation, propagation and reduction of sound in flow ducts for transport, buildings and power generation. There is a real need for a European-wide training in this field: the FlowAirS general objective is to train by research a new generation of young researchers with multi-disciplinary skills and able to make research careers more attractive and will enhance their own career opportunities. To achieve this goal, a partnership has been established between seven academic research centres of excellence, five industrial world leaders in their respective sectors, one innovative SME and four private research institutes or consulting engineering company: the collaboration between academia and private sector representatives is a key element of the FlowAirs training research programme. The work programme is divided in 8 Work Packages (WPs). The first 2 WPs deal with sound sources mechanisms. WP3 will be focused on innovative solutions for noise reduction. Three other WPs are concerned by the different numerical procedures and system identifications that are used in flow duct systems. One of the WP deals with the dissemination of the results to European citizens, researchers and industries. The last WP is on management and training. Training activities will be organized along three main axes: 1) training through research; 2)formal training giving all the important skills needed by researchers in the field of sound in flow duct systems and 3)training through practical experience on industrial sites. By participating to FlowAirS young researchers will gain a multi-disciplinary and appropriate background in generation, propagation andreduction of sound in flow ducts. The FlowAirS project will bring to European citizens innovative solutions to reduce the noise pollutionwhich is one of the key solutions for enhancing people quality of life and health in the European Union.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.2 | Award Amount: 7.14M | Year: 2010

The SOLID concept is to develop small solid-state hybrid systems capable of performing elementary processing and communication of quantum information. This involves design, fabrication and investigation of combinations of qubits, oscillators, cavities, and transmission lines, creating hybrid devices interfacing different types of qubits for quantum data storage, qubit interconversion, and communication. The SOLID main idea is to implement small solid-state pure and hybrid QIP systems on common platforms based on fixed or tunable microwave cavities and optical nanophotonic cavities. Various types of solid-state qubits will be connected to these hubs: Josephson junction circuits, quantum dots and NV centres in diamond. The approach can immediately be extended to connecting different types of solid-state qubits in hybrid devices, opening up new avenues for processing, storage and communication. The SOLID objectives are to design, fabricate, characterise, combine, and operate solid-state quantum-coherent registers with 3-8 qubits. Major SOLID challenges involve: Scalability of quantum registers; Implementation and scalability of hybrid devices; Design and implementation of quantum interfaces; Control of quantum states; High-fidelity readout of quantum information; Implementation of algorithms and protocols. The SOLID software goal is to achieve maximal use of the available hardware for universal gate operation, control of multi-qubit entanglement, benchmark algorithms and protocols, implementation of teleportation and elementary error correction, and testing of elementary control via quantum feedback. An important SOLID goal is also to create opportunities for application-oriented research through the increased reliability, scalability and interconnection of components. The SOLID applied objectives are to develop the solid-state core-technologies: Microwave engineering; Photonics; Materials science; Control of the dynamics of small, entangled quantum systems

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 11.57M | Year: 2011

Recent progress in physical Human-Robot Interaction (pHRI) showed that active and safe workspace sharing becomes possible in principle. Inspired by these results, SAPHARI will perform a fundamental paradigm shift in robot development in the sense that we place the human as the centre of the entire design. We address all essential aspects of safe, intuitive physical interaction between humans and complex, human-like robotic systems in a strongly interconnected manner. While encompassing safety issues based on biomechanical analysis, human-friendly hardware design, and interaction control strategies, the project will develop and validate perceptive and cognitive key components that enable robots to track, understand and predict human motions in a weakly structured dynamic environment in real-time. Apart from developing the necessary capabilities for interactive autonomy, we will tightly incorporate the human safety also at the cognitive level. This will enable the robots to react or physically interact with humans in a safe and autonomous way. Biomechanical knowledge and biologically motivated variable compliance actuators will be used to design bimanual manipulation systems close to human properties and performance. Planning motions and tasks of such complex systems in real-time require new concepts, including tight coupling of control and planning, that lead to new reactive action generation behaviours. Moreover, self explaining interaction and communication frameworks will be developed to enhance the system usability. The project focuses on two industrial use cases that explicitly require contacts and force exchange in human-robot co-work, as well as on professional service scenarios in hospitals, in which a medical staff and an assisting robot interact closely during daily work. Results of this project are expected to strongly impact all applications where interactive robots can assist humans and release them from dangerous or routine tasks.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.78M | Year: 2013

Organic Bioelectonics is a new discipline which holds promise to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. At the moment Europe has a unique leading position in this area, being almost all the world-leading groups in this field located in Europe and constituting the core of this international training network. However, realizing the promise of Organic bioelectronics requires research and training not only crossing disciplines, such as electrical engineering, biology, chemistry, physics, and materials science, but also crossing our European countries. The EU will add value on the global scene only if it acts jointly. OrgBIO is at the core of European technological innovation and will become an indispensable part of the educational canon. It will establish a world-class training platform spreading around the highly interdisciplinary / intersectorial European-led area of organic bioelectronics. Education along with science and entrepreneurial mindsets and attitudes is the core of the OrgBIO training programme, which aims at excellence and innovation, at all level. Excellence in science is guaranteed by the world-leading groups which founded this research area. Innovation in education is guaranteed by the involvement of researchers on education, business experts. Using different sensors, actuators, electronic and interconnect technologies the network will develop multifunctional systems based on organic devices and materials with high sensitivity that are also flexible, conformable and present over large areas for various biomedical / biological applications in the life science. Multi-analyte and disposable analytical systems manufactured by large-area printing methods will provide services to the individuals and healthcare community. Targeted implemented interactions with a wide network of venture capitals and business actors will immediately transfer the research outcome to the European Industry.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.6 | Award Amount: 7.23M | Year: 2011

Experimentally-driven research is key to success in exploring the possible futures of the Internet. An open, general-purpose, shared experimental facility, both large-scale and sustainable, is essential for European industry and academia to innovate today and assess the performance of their solutions. OpenLab brings together the essential ingredients for such a facility. We extend early prototypes of testbeds, middleware, and measurement tools so as to provide more efficient and flexible support for a diverse set of experimental applications and protocols. The prototypes include a set of demonstrably successful testbeds: PlanetLab Europe, with its 153 partner/user institutions across Europe; the NITOS and w-iLab.t wireless testbeds; two IMS (IP Multimedia Subsystem) telco testbeds for exploring merged media distribution; a green networking testbed; the ETOMIC high precision network measurement testbed; and the HEN emulation testbed. Associated with these testbeds are similarly successful control- and experimental-plane software. OpenLab advances these prototypes with key enhancements in the areas of mobility, wireless, monitoring, domain interconnections, and the integration of new technologies such as OpenFlow. These enhancements will be transparent to existing users of each testbed, while opening up a diversity of new experiments that users can perform, extending from wired and wireless media distribution to distributed and autonomous management of new social interactions and localized services, going far beyond what can be tested on the current Internet. OpenLab results will advance the goal of a unified Future Internet Research and Experimentation (FIRE) facility. In addition, OpenLab can provide models for the Future Internet Public Private Partnership (FI-PPP). Finally, OpenLab will issue open calls to users in industry and academia to submit proposals for innovative experiments using the OpenLabs technologies and testbeds, and will devote one million euros to funding the best of these proposals.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.39M | Year: 2013

The introduction of new technologies in the fabrication of light-weight high-performance materials for civil-engineering applications opens many new possibilities for the design of extremely lightweight structures. In particular, the inclusion of photo-voltaic cells together with the use of carbon-fiber cables will allow new design concepts combining an extreme lightness with an excellent structural performance while preserving the sustanability. Even if the new technology constitutes a potential breakthrough, in order to allow a successful impact on the market the properties of the novel materials need to be investigaded in detail so to understand their behaviour with respect to fatigue, aging, or other long-term effects. The wide adoption of such new solutions, will on the other hand imply the definition of an improved computer-based design approach. New tools will be needed to allow modeling to structural behaviour of ultra-lightweight structures and to realize them in conceptual designs.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.07M | Year: 2013

DNA Nanotechnology is an emerging interdisciplinary area that will underpin the development of future nanoscience-based technologies for areas such as medicine, diagnostic tools, optics and electronics. DNA nanotechnology is based on the unique self-assembly properties of DNA which allow the rational design and synthesis of complex nanoscale structures with predictable form and function. Many other materials can be integrated in such DNA structures to create highly functional nanodevices. The Marie Curie ITN EScoDNA will establish a sustainable European School of DNA Nanotechnology. By providing high quality training to young scientists, EScoDNA will improve their career prospects in both public and private sectors; it will also strengthen the competitive position of European research and industry in this promising strategic field. A network of leading European researchers, two SMEs and a major commercial research institute will work together to foster the development of a new generation of scientists with the skills required to meet future challenges in DNA nanotechnology, from fundamental science to novel applications. The training program will involve collaborative research projects, including international secondments and exchange of data through a web-based Lab-Wiki Journal, and through summer schools and workshops. The industrial partners will be integrated in the training programme, and the two SMEs will coordinate training related to the commercial exploitation of new technologies, management and entrepreneurial skills. They will also take a lead in managing the protection and commercialization of new technologies arising from research with the ITN. The programme is designed to create a pool of highly qualified researchers prepared for a wide range of careers in bionanotechnology and nanofabrication and, especially, capable of contributing to the development of a strong European centre for the scientific and commercial development of DNA nanotechnology.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-14-2014 | Award Amount: 6.34M | Year: 2015

With anticipated exponential growth of connected devices, future networks require an open solutions architecture facilitated by standards and a strong ecosystem. Such devices need an easy interface to the connected network to request the kind of communication service characterized by guarantees about bandwidth, delay, jitter, packet loss or redundancy. In response, the network should grant the requested network resources automatically and program the intermediate networking devices based on device profile and privileges. Similar requirement also comes from business applications where application itself asks for particular network resources based on its needs. Software Defined Networking (SDN) and Network Function Virtualisation (NFV) provide promising combination leading to programmable connectivity, rapid service provisioning and service chaining. As a part of 5G PPP programme, VirtuWind will develop and demonstrate SDN & NFV ecosystem, based on open, modular and secure framework showcasing a prototype for intra-domain and inter-domain scenarios in real wind parks as a representative use case of industrial networks, and validate the economic viability of the demonstrated solution. The wind park control network has been chosen as a professional application in VirtuWind as wind energy has now established itself as a mainstream of sustainable energy generation. By envisioning lower capital expenditure and operational expenditure costs in control network infrastructure, VirtuWind will play important role in assisting wind energy sector to achieve cost reductions. Further applicability of VirtuWind solution in other industrial domains will bring multifold benefits in their communication networks. The VirtuWind consortium consists of strong industry and academic partners covering the whole value chain of programmable networks. The consortium is striving for a common vision of creating industrial capability of SDN/NFV in Europe.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.97M | Year: 2016

This network brings together world-leading experts in nano-science and technology from 6 European countries in order to achieve breakthroughs in understanding and successful utilization of nanoscale solid-state spin systems in emerging quantum technologies. The proposed innovative science in the supra-disciplinary field of physics and applications of spin nano-systems will underpin breakthrough developments in quantum computing, quantum communications and networks, and nano-imaging. Important innovative step consolidating the joint effort of the whole consortium is the focus on crystalline solids where magnetic interactions of electron spins with lattice nuclei are negligible and well-controlled. We will develop electrically-controlled spin-quantum-bits (qubits) in Si-Ge quantum dots and nanowires; will optically manipulate spin impurities in diamond in applications for quantum computing and networks and in nano-magnetometry; will achieve new understanding of quantum phenomena due to the spin-valley coupling in atomically thin 2D semiconductors, an emerging class of materials with a promise for quantum technologies. Research training to 15 early stage researchers will be delivered by 14 academic and 7 industrial groups. Network-wide training course in transferable skills will be specially developed and delivered by the Think Ahead (Sheffield), an award winning initiative at the University of Sheffield (award by the Times Higher Education, 2014). Current proposal is designed to advance this multi-disciplinary research field significantly beyond the state-of-the-art, and train a new cohort of researchers capable of developing spin-based solid-state quantum technologies towards real-life applications in the next 5 to 10 years.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: GV-1-2014 | Award Amount: 7.25M | Year: 2015

SPICY is a collaborative research project associating 5 industrials partners (3 large groups and 2 SME) with 8 academic and research centres to the multidisciplinary development of a new generation of Li-ion batteries meeting the expectations of electrical vehicle end-users, including performances, safety, cost, recyclability and lifetime. For this purpose, SPICY will consider the development of new chemistry materials, cell architectures and packaging with the support of understanding and modelling activities. SPICY will address the whole value chain until the implementation of manufacturing. SPICY will focus on polyanionic phosphates for the cathode material. LiFePO4 is well known as a safer and more durable cathode material. Unfortunately, its energy density is low due to the electrochemical potential of Fe. One objective of SPICY will be to bind metals having a higher potential than Fe, allowing an increase of the material potential, and thus a higher energy. Regarding the anode material, SPICY will study two chemistries. Graphite is used in current Li-ion cells and remains one of the major anode materials for the next generation of Li-ion cells. Silicon is appropriate for high energy cell applications but has lower cyclability. Silicon will be investigated through new synthesis process methods providing nanoparticles and core-shell structures to improve particle stability. Active and passive components will be harmonized for a higher energy density i.e: polyanionic phosphate /graphite up to 200 Wh/kg, and polyanionic/Si up to 230 Wh/kg. In addition, three cells architectures and packaging will be investigated. The thermal behaviour of these cells will be studied in ageing tests in order to model Li-ion cells. Finally, the industrial environment will be considered and SPICY solution will be assessed so as to optimise cost and to integrate eco-design, thereby supporting the future development of a strong industrial base in this field.

Fujitsu Limited and TU Munich | Date: 2010-06-02

A method for evaluating a target molecule 7 bound to a probe molecule 1 provided with a marker 3 includes: applying an AC voltage between a working electrode 2 provided on a substrate and a counter electrode 8, and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, or a binding rate constant therebetween, a dissociation rate therebetween, or a dissociation rate constant therebetween.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.2-6 | Award Amount: 3.43M | Year: 2009

The main purpose of the EVINCI-study is to test the impact of combined anatomo-functional non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of anatomic imaging, by multislice computerized tomography, combined with functional tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive anatomo-functional imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from anatomo-functional cardiac imaging and clinical-biohumoral data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2010.6.3-3;SEC-2010.6.4-1 | Award Amount: 4.47M | Year: 2011

The Task of VALUESEC is defining, context modeling, weighting and quantifying attributes of costs and benefits, advantages and disadvantages of security measures, and demonstration of an application tool evaluating the different effects and the aggregated value of security measures. It will generate a knowledge base of the status and trends in theory and in practical applications of methods of economics applied to security decision making. The great challenge will be to combine economical (mostly quantitative) and societal effects (mostly qualitative) of security measures into a value function, one methodology framework and integrate it into a toolkit which will be flexible and user friendly, and applicable to a large spectrum of possible decisions in the security domain. Decisions supported by this tool will be more transparent and better rationalized than present. Project approach: - Problem Analysis and Requirements: Which typical problem classes should be addressed? Analyze and describe decision making processes and requirements for improvement. - Theories, Methodologies, Components: Which existing approaches to value and utility functions can be exploited to security decisions? Identification of innovation potential. - Design and usability: Which functions should the tool be capable to perform to provide for effective decision support? Define functionality, attributes and usable models and map them against identified problem classes - Development: How will the system work? Transformation of the models and utility function into applicable tools. - Evaluation: How do the implemented tools really work and help? Proof of the power and applicability of the tools in realistic use cases. - Dissemination and exploitation: How will findings and results be propagated and brought to practical use? How should research on security economics continue? Help pave the way to a future with more transparent and valuable security decisions.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 412.30K | Year: 2011

The goal of the DCP-PhysBio exchange program is to bring together several European teams (France, Germany, UK), Israel, as well as partners from Russia and Ukraine. We want to use our combined expertise to study various challenging dynamical and cooperative phenomena taking place in complex physical and biological systems. All the teams have a track record of research in these areas concentrating on particular numerical or theoretical facets, such that the network will synergistically amplify their strengths. The staff exchanges will include both a team research work on specific work packages which will further consolidate the research partnership, and a transfer of knowledge component of workshops, schools and seminars which will ensure an effective dissemination of results and foster interactions amongst the young researchers. If the aims of our proposal are to be achieved, then not only that a long-term research network will emerge but a number of PhD students and early career researchers will have had been mentored into, and intensively exposed to, a culture of international collaborative research.

The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research. 12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside. The fellows will be mentored by world-leading experts to shape a new generation of European leaders in biomedical science and overcome current fragmentation in Europe. The research is at the forefront of biomedical science because of the UK genome-wide association study in 2000 myocardial infarction (MI) patients and our EU-FP6 integrated projects Bloodomics and Cardiogenics. We will exploit our knowledge about the genetic architecture of MI to investigate the hypothesis whether sequence variation of genes encoding network hubs poses a greater risk for network destabilisation compared to genes encoding regular nodes. Focusing on three hub genes we postulate that genetic/bio-markers associated with hubs can be integrated in algorithms for MI/CAD risk prediction. Success will critically depend on new developments in computing, machine learning, pattern recognition and advanced data mining and statistical analysis. To have a free development path from basic discovery to health care improvement young scientists must be taught to cross the classic barriers between academic disciplines. We offer a timely and necessary alternative to Europes classic PhD programmes by providing a seamlessly integrated multi-disciplinary environment in an academic-private sector partnership free of boundaries. Our aim is a targeted strategy for prevention and treatment based on a better understanding of the genetic and molecular mechanism of disease. This will deliver major advances in public health and patient care, which can only be achieved if a new scientific cadre is developed.

The objective of the SOMATCH is to improve the competitiveness of EU SMEs in Textile and Clothing (T&C) and design focused sectors by the collection, definition and visualization by ad hoc interfaces of fashion trends. SOMATCH will provide creative designers with detailed and reliable trends estimations and forecasts of user acceptance. Its goal will be achieved by the creation of an innovative tool for the mining and visualization of large sets of unstructured data, related to the use and preferences of fashion products by consumers, supporting T&C companies quick reaction to the market dynamics and better adaptation of design to real consumers demand. SOMATCH faces this complex and challenging deal by the combined development and application of SoA advanced image analysis technology, unexploited and innovative in clothing and fashion, combined with social network analysis. Its results will be presented to interested end users by dedicated interfaces and instruments: mobile devices as well as ad hoc visualization tools will be explored for this purpose. The visualisation of the generated data will be performed from off-line statistics, generated after data processing, and by new real-time instruments for image collection and evaluation of designs. They will be targeted also by the integration of the systems with new SoA mobile and wearable (for ex. Google Glass) devices to collect information and to visualise trend interpretation. This approach will open a vast field of new approaches for the fashion designers, supporting final users involvement into the whole trend evaluation and a close interaction with them. To reach this purpose Somatch consortium includes research centres expert in image and content analysis (TUM, UPC), software providers experts in data management, platform development and fashion tools (Holonix. Sparsity, Ideal), end users from SME textile industry and retail (DENA) and social networking and e-commerce (Weblogs, NJAL).

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2013-7 | Award Amount: 11.42M | Year: 2013

Factory-in-a-Day aims at improving the competitiveness of European manufacturing SMEs by removing the primary obstacle for robot automation; installation time and installation cost. The high costs result in payback periods, making the investment in robotized automation economically unattractive. Factory-in-a-Day will reduce the installation time (and the related cost) from months to one single day. The project follows the steps of such an installation day. (1) New standardized arms, mobile platforms, and hands are combined with 3D printed custom parts to be designed in a matter of hours from novel design templates. (2) Robots are placed in an unaltered production location, where new self-calibration routines and a novel software framework allow effortless interconnection of robot components and existing machinery. (3) For selected application domains (e.g. mould finishing and assembly) a set of novel learnable skills (cf. Apps) allow rapid teaching of the production tasks. (4) The robots collaborate safely with humans in a shared un-fenced workspace due to safe robot arms with dynamic obstacle avoidance, made possible by novel proximity-sensing skin and online path re-planning algorithms. Augmented reality lets the robots project their intended motion plans to inform the workers. (5) Finally, Factory-in-a-Day also innovates the organizational aspects of robot installation. The project is driven by Europes top robotics researchers (e.g. TUD, KUL, TUM, Fraunhofer) and industry players (Philips, Universal Robotics, Siemens, Materialise). The second-largest temp agency Randstad and its participating client SMEs will test hybrid human-robot teams performing short-batch production work. Together with novel certification procedures proposed in Factory-in-a-Day and strong , Europe-wide dissemination targeted at manufacturing industry, the technological and organizational innovations are poised to radically change the robot automation sector.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-21-2016 | Award Amount: 1.35M | Year: 2017

The objective of Morpheos is to create in EU a centralized open ecosystem based on consumer morphology where creative enterprises can have access to knowledge about customers expectations and need (customization knowledge in the following) to enhance their creativity and design processes. It will address the needs of EU creative SME manufacturers, consumers and creative web developers and entrepreneurs. Based on the analysis of actual solutions limits, Morpheos offers a different disruptive approach, exploiting actually available KET (smart mobile, 4G broadband), open ecosystem approach and social interaction not possible in the past. Specific objectives are: deployment of MORPHEOS PLATFORM for item suggestion based on unique identification of the customer and morphotype DB, in form of plug&play addons for major e-commerce platforms (Wordpress, Joomla, Magento, Prestashop) to be affordable, accessible to SMEs and fit for high design goods produced in EU; SMARTHPONE AND MOBILE MEASURE COLLECTION exploiting in commercial environment mobile camera potential to collect consumer measures, fully integrated with the addons; refinement, validation and implementation of the self-learning MATCHER algorithm for item personalized indication; DEMO AND SCALE-UP use in operational environment, paving the way to commercial exploitation; creation of a standardized unique BIG DATA of morphotypes of all geographical groups of on-line world consumers and products; the MORPHEOS ECOSYSTEM ready for third party additional solutions and apps by web entrepreneurs to exploit the potential of the sw with new functionalities and to expand its use to other sectors. The final objective is to realize a beta version of the platform and of add-ons for the major ecommerce platforms, validated in real business environment by SME vendor end users and consumers in fashion and interior design sectors, to prove the validity of the solution in 2 major creative EU manufacturing sectors.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.63M | Year: 2011

The coordination action CA-RoboCom will design and describe the FET Flagship initiative Robot Companions for Citizens (RCC) including its: S&T framework, governance, financial and legal structure, RTD organization, funding scheme, competitiveness strategy and risk analysis. FET-Fi RCC will realize a multi-disciplinary science and engineering program supporting a radically new approach towards machines and how we deploy them in our society. RCC is an ecology of soft and sentient machines that will help and assist humans in the broadest possible sense to support and sustain our welfare. RCC will have soft bodies based on the novel integration of solid articulated structures with flexible properties and display soft behavior based on new levels of perceptual, cognitive and emotive capabilities. RCC will be cognizant and aware of their physical and social world and respond accordingly. RCC will attain these properties because of their grounding in the most advanced sentient machines we know: animals. Conversely, RCC will validate our understanding of the general design principles underlying biological bodies and brains, establishing a positive feedback between science and engineering. The driving metaphor of RCC is that of the robot dancing partner who will be able to autonomously dance together with a human at a high-level of performance a range of styles. Driven by the vision and ambition of RCC, CA-RoboCom will by means of an appropriate outreach strategy, involve all pertinent stakeholders: science and technology, society, finance, politics and industry. Other than the commitment of its Consortium, CA-RoboCom will involve a wide range of external experts in its working groups, its advisory board, and in its European and International Cooperation board. The CA-RoboCom consortium believes that given the potential transformative and disruptive effects of RCC in our society their development and deployment has to be based on a the broadest possible support platform.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.17. | Award Amount: 15.90M | Year: 2012

Advanced solutions to the challenges that confront our technology-based society from energy and environment to health are crucially dependent on advanced knowledge of material properties down to the atomic scale. Neutron and Muon spectroscopy offer unique analytical tools for material investigation. They are thus an indispensible building block of the European Research Area and directly address the objectives of the Innovation Union Flagship Initiative. The knowledge creation via neutron and muon spectroscopy relies on the performance of a closely interdependent eco-system comprising large-scale facilities and academic and industrial users. The Integrated Infrastructure Initiative for Neutron and Muon Spectroscopy (NMI3) aims at a pan-European integration of the main actors within this eco-system. The NMI3 coordination effort will render public investment more efficient by harmonizing and reinforcing the services provided to the user community. It will thus directly contribute to maintaining Europes world-leading position. NMI3 is a comprehensive consortium of 18 partners from 11 different countries that includes all major providers of neutrons and muons in Europe. NMI3 exploits all tools available within I3s to realize its objectives. - Transnational Open Access will build further capacity for European users. It will foster mobility and improve the overall creation of scientific knowledge by providing the best researchers with the opportunity to use the most adapted infrastructures. - Joint Research activities will create synergies in innovative instrument development that will feed directly into improved and more efficient provision of services to the users. - Networking activities will reinforce integration by harmonizing procedures, setting standards and disseminating knowledge. Particular attention is given to train young people via the European Neutron and Muon School as well as through an e-learning platform.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: GALILEO-2-2015 | Award Amount: 1.16M | Year: 2016

The goal of AUDITOR is the implementation of novel precise-positioning techniques based on augmentation data in custom GNSS receivers to improve the performance of current augmentation services and reducing costs. These techniques are already patented by the consortium and proven to offer better accuracy with faster convergence times than solutions commercially available. More sophisticated atmospheric models will be implemented to provide better corrections of ionospheric errors and further increase accuracy. All these advances will be integrated in a software demonstrator that will use public data from GNSS networks to generate these correction data streams. These new receivers will enable cost-effective precision agriculture services to farmers, especially those with small and medium-sized businesses in areas of Europe. The custom dual-frequency receiver module will follow an innovative approach by porting a GNSS software-defined receiver to an embedded system that will integrate hardware accelerators to enable real-time operation in a low power system. The form factor and capabilities of the resulting receiver will be comparable to those of existing professional receivers in the market, while retaining all the advantages of software receivers: modularity, scalability, upgradability, and flexibility. Besides providing multi-frequency multi-constellation support, this advanced receiver will allow very low level access to key internals even at sample level, enabling the integration of other complementary techniques like interference analysis and monitoring or authentication using remote servers for encrypted bands. The fact that the software layer will be the evolution of an existing and successful open-source project, GNSS-SDR, will allow GNSS developers and researchers to customize the code of the receiver to tailor it to their own applications or test their algorithms using this flexible receiver module, from reflectometry to ultra-tight coupled GNSS/INS systems.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.2.1 | Award Amount: 2.91M | Year: 2008

The project intends to establish a link between fundamental sensing tasks and automated cognition processes that concern the understanding a short-term prediction of human behaviour as well as complex human interaction. The analysis of human behaviour is unrestricted environments, including localization and tracking of multiple people and recognition of their activities, currently constitutes a topic of intensive research in the signal processing and computer vision communities. This research is driven by diferent important applications, including unattended surveillance and intelligent space monitoring. \nThe overall goal of the project is the development of principled methods to link fundamental sensing tasks using multiple modalities, and automated cognition regarding the understanding of human behaviour in complex indoor environments, at both individual and collective levels. Given the two above principles, the consortium will conduct research on three core scientific and technological objectives: \n1) sersor modelling and information fusion from multiple, heterogeneous perceptual modalities \n2) modelling, localization, and tracking of multiple people \n3) modelling, recognition, and short-term prediction of continuous complex human behaviour

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-4.0-2 | Award Amount: 12.21M | Year: 2009

The project addresses from one site the most critical and costly step to produce liquid fuel from natural gas using conventional routes, e.g. the stage of syngas production, and from the other side explores alternative routes to convert natural gas to liquid transportable products. The general objective is to explore novel and innovative (precompetitive) routes for transformation of natural gas to liquid products, particularly suited for remote areas to facilitate the transport. The aim is an integrated multi-disciplinary approach to develop in a long term vision the next-stage catalysts and related precompetitive technologies for gas to liquid conversion, in fully consistence with the indications of the call. For this reason, we have excluded to consider as part of the project catalytic technologies, such as FT synthesis and hydrocracking. In addition, we have excluded to investigate coal to liquid, both due to environmental impact of the use of coal, and to focus R&D. We have thus focused the project on three cluster lines: 1. new, not conventional routes for catalytic syngas formation from natural gas which include steps of separation by membrane and eventual reuse of byproducts; 2. direct catalytic conversion of methane to methanol/DME; 3. direct catalytic conversion of methane to aromatics under non-oxidative conditions followed by upgrading of the products by alkylation with ethane/propane.

TU Munich and Orcan Energy | Date: 2011-11-16

The present invention provides a device which comprises: a heat exchanger (1) for transferring heat of a heat-supplying medium to a working medium which differs from said heat-supplying medium, a first supply device designed to provide a flow of the heat-supplying medium at a first temperature from a heat source to the heat exchanger, and a second supply device which is designed to deliver the heat-supplying medium after it has passed through the heat exchanger, and/or a further medium at a second temperature lower than the first temperature, to the flow of the heat-supplying medium at the first temperature.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-4.0-1 | Award Amount: 13.81M | Year: 2011

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3\), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.3-2 | Award Amount: 9.96M | Year: 2011

The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen, Enerbck & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (diabesity), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.4-4 | Award Amount: 5.16M | Year: 2012

NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) are physically robust. Coupling between electronic devices and neurons was recently studied using soft, nanocrystalline diamond-based micro-electrode arrays, evaluated in laboratory animals for retinal stimulation. These diamond implants considerably reduced gliosis, enabled stimulation currents to be raised by more than one order of magnitude before causing visible chemical alteration, and enabled long lasting operation with reduced biofouling. Our previous experience with nanocrystalline diamond will be directly built upon through the introduction of atomic layers of graphene to diamond surfaces. NeuroCare will specifically focus on: Carbon-biointerface development offering reduced biofouling over the state-of-the-art, as set by the DREAMS project and improved biocompatibility Interfacing of rigid MEAs and FETs with cells and organs to improve bidirectional communication with neurons for in vitro research and pharmacological applications Nanoscale surface engineering and flexible macroscale implant materials for optimal contact to biological tissue Making and testing implantable MEAs and FETs for complex multichannel neuronal communication - targeting the specificity in vivo of the implantable devices for 3 high-impact clinical applications Neurocare partners will test interfaceable and implantable devices via in vitro and in vivo testing. NeuroCare federates 12 partners: CEA (LIST and CLINATEC), Ecole Suprieure dIngnieurs en Electronique, Forschungszentrum Jlich, Ayanda Biosystems SA, University College London (London Centre for Nanotechnology), Johannes

The clinical evidence indicates that the number of people with all levels of hearing impairment and hearing loss is rising mainly due to a growing global population and longer life expectancies. Hearing loss caused by pathology in the cochlea or the cochlear nerve is classified as sensorineural hearing loss. The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible.\nSIFEM focuses on the development of a Semantic Infostructure interlinking an open source Finite Element Tool with existing data, models and new knowledge for the multi-scale modelling of the inner-ear with regard to the sensorineural hearing loss. The experts will have access to both the data (micro-CT images, histological data) and inner ear models, while the open-source developed tools and the SIFEM Conceptual Model will be contributed to the VPH toolkit enhancing their reusability. These SIFEM open source tools and services enhance and accelerate the delivery of validated and robust multi-scale models by focusing on: (i) Finite Element Models manipulation and development, (ii) cochlea reconstruction and (iii) 3D inner ear models visualization.\nThe final outcome is the development of a functional, 3D, multi-scale and validated inner-ear model that includes details of the micromechanics, cochlea geometry, supporting structures, surrounding fluid environment and vibration patterns. In the open context that the project addresses the results can be used to better identify the mechanisms that are responsible for the highly sensitive and dynamic properties of hearing loss. These result to the description of alterations that are connected to diverse cochlear disorders and assist the experts to better assess each patients condition leading to more efficient treatment and rehabilitation planning and, in long-term, to personalized healthcare.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: Fusion-2007-7.2 | Award Amount: 3.23M | Year: 2008

The timely availability of qualified materials for use in fusion power reactors is a necessity for the fast deployment of fusion power. 27 European institutions have joined together in the FEMaS-CA to advance fusion materials science in Europe and in close cooperation with EFDA, the European Fusion Development Agreement. The overarching objective of this Coordination Action is: The FEMaS-CA will create a European research environment in which fusion materials science for the realization of fusion power can be carried out with optimum effect. To enforce this objective, the goals of the are 1. It will strengthen the application of advanced materials characterization methods which is an essential ingredient for the successful development of fusion reactor materials in Europe. 2. It will form a strong European network involving institutions and large scale facilities outside of the present fusion programme 3. Within this network bi- and multilateral collaborative activities shall be carried out. 4. Together with EFDA activities it will contribute to the formation of lasting and efficient European structure for fusion materials science and development.

Agency: European Commission | Branch: FP7 | Program: JTI-CS | Phase: JTI-CS-2011-1-SGO-02-026 | Award Amount: 291.89K | Year: 2011

The modelling language Modelica and libraries based upon it are excellently suited for model-based design of future aircraft systems, e.g. more electric aircraft or sustainable air-conditioning systems. To enable those design tasks, Modelica Libraries for media models, electromagnetic devices such as transformers and electrical machines and for wavelet analysis shall be developed or extended by a consortium of three partners. XRG Simulation will provide two fluid property models according to the Modelica.Media specification, one model for R134a and one model for humid air. Both models shall be used for complex air conditioning system simulation e.g. of aircraft. Technische Universitt Dresden, where the Modelica.Magnetic.FluxTubes library was originally developed, will extend this library with hysteresis models. Simulation of static (ferromagnetic) and dynamic (eddy current) hysteresis allows for estimation of iron losses in transformers and electrical machines and hence, e.g., for subsequent simulation of heating. In addition, Modelica models of one- and three-phase transformers will be developed. Compared to the simple transformer models already included in the Modelica Standard library, the models to be developed include a transformers magnetic subsystem and hence consider saturation and core losses. The developed hysteresis and transformer models will be validated with in-house measurements. Furthermore, the Modelica.Magnetic library will be extended by electrical machine models based on look-up tables. These models allow for dynamic simulation of machines with saturation and non-linear torque-current-angle characteristics. Technische Universitt Mnchen will develop a Modelica Wavelet library for capture, identification and analysis of processes. This library will allow new signal processing methods for analysis, reconstruction and modelling of signals. That will improve the power quality assessment in physical systems, e.g. in electrical systems of aircraft.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.1.1-2 | Award Amount: 3.22M | Year: 2013

Creativity is a fundamental transformative mechanism of the European economy. To study this mechanism, this project brings together 11 of Europes leading innovation research centres, and is structured around six themes: 1. Mapping and measuring the creative-cultural industries and their impacts; 2. Understanding and modelling creativity and design; 3. Entrepreneurship and industrial dynamics in the creative-cultural industries; 4. Digital ecosystems, user participation and the blurring of production and consumption; 5. Intellectual property, IP rights and innovation in creative-cultural activities, and, 6. Policy issues and recommendations. Together, and through nearly 25 person years of research, we will make substantial progress in methodologies and provide fresh and integrated approaches in the study of creativity and innovation, as well as in the dynamics of these industries. This will result in new data sets, policy briefs and tools, as well as academic articles and books. Above all, the project will substantially enhance the state of knowledge and understanding of the nature and characteristics of creativity and innovation, the cultural-creative industries, and their role in shaping the future European economy and society. It will also provide important and reliable evidence regarding the emergence, promotion and stimulation of creativity in relation to innovation in Europe, and how creativity-based entrepreneurship contributes to economic growth and wellbeing. The project will also be a highly valuable and original source of knowledge and understanding for the research, business and policymaking communities at both the EU and national / regional levels. The project will also help build a European research community focused on creativity and innovation, and will contribute to building research capacity by providing opportunities for early career researchers. It will also seek to advance the role of women researchers and research managers in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.1-7 | Award Amount: 4.11M | Year: 2008

This project aims at improving drug delivery to cancer cells by developing targeted radiotherapy with alpha-emitting radionuclides. Alpha particles emitted by radionuclides have short tracks (about 100 microns) in body tissues. As a result, they should be most appropriate to treat small-size tumours and isolated cancer cells. This project proposes the development of improved vectors and targeting technology based on specific targeting agents (recombinant antibody fragments and synthetic peptides), pretargeting approaches and nano-colloids especially designed to deliver alpha-emitting radionuclides to cancer cells after local or systemic administration. The concept of in situ generator, that allows the use of longer half-life parents of alpha-emitting radionuclides will be developed. Several approaches to prevent the release of radionuclides after parent isotope disintegration, including encapsulation in nano-colloids, are proposed. Improved targeting methods will be tested in animal models of small-size tumours and associated dosimetry (including micro-dosimetry) and toxicity studies will be performed. The final goal of the project will be to propose one or several new products for targeted delivery of alpha-emitting radionuclides for clinical development.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-2 | Award Amount: 8.00M | Year: 2013

Schizophrenia is a severe mental disorder that manifests early in life and imposes a high social and economic burden on European societies. An imaging tool that enables the diagnosis of schizophrenia during early development is extremely desirable and is requested by the clinical community in order to make the management of the disease more effective. TRIMAGE aims to optimise and validate an integrated diagnostic solution including simultaneous PET/MR/EEG imaging and specific biomarkers to provide the clinicians an effective tool for the diagnosis and choice of treatment of schizophrenia and other mental health disorders. Specific biomarkers using information from PET/MR, fMRI/EEG and PET/MR/EEG will be used to define the signature of the disease. The imaging hardware will be engineered with the intent of making the instrument a cost-effective and beyond the state of the art commercial product so as to provide a toolset for the diagnosis of patients in most clinical psychiatric centres. The instrument will comprise a 1.5 T cryogen-free, very compact superconducting magnet, a PET insert based on silicon photomultiplier with better performances (2 mm FWHM spatial resolution, 14% sensitivity at the center of the field of view) than any available clinical PET scanner and a fully integrated EEG. The adopted technology will reduce cost, simplify safety management, improve patient comfort and boost performance with respect to state of the art MRI and PET brain imagers. The tool design and construction requires scientific and technological developments in both the physical and medical fields: the work plan counts on the cooperation of highly qualified academic institutions and research centres with a major R&D contribution coming from four high technology European SMEs and Large Companies.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.2 | Award Amount: 5.29M | Year: 2012

Project aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients. The new device will allow the automatic measurements of therapeutic drugs and metabolites characterized by a narrow therapeutic range and serious potential side effects. Clinical benefit will be an optimized dosage of the respective therapeutical drug. The patient will be connected to the device by an intravenous microdialysis catheter to allow 48-h online measurements. Based on this minimally-invasive approach, the therapeutic drugs and related metabolites will be monitored at short time intervals. The need of mixing the dialysate with the chemical reagents and the necessity of incubation times for the bioassay implementation, unavoidable procedure for bioanalyte detection, implies that a continuous measurement of such analytes is impossible, but the miniaturisation down to micro- and nano-scales will lead to very short time intervals, of the order of a few minutes. Heart of the device will be a multi-parametric optical chip, which will make use of the recent developments in nanotechnology to convert the concentration changes of the analytes in detectable luminescent signals. Essential sections of the device will be also:\ni) the microfluidic circuit before the chip, where the dialysate is mixed with the reagents necessary for the implementation of the biological assay;\nii) the optical detection system which must be characterised by high efficiency and strong compactness;\niii) the compact hardware control unit and user interface that allow instrument control and data handling.\nThe integration of all these sections within the POCT stand-alone device requires the convergence of competences ranging from chemistry and biochemistry to optics and medicine as well as the convergence of micro and nanotechnologies, such as micro/nanofluidics,microdialysis and micro/nanosensing.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FoF.ICT.2010.10.1 | Award Amount: 3.82M | Year: 2010

The project entitled Highly Customizable and Flexible Packaging Station for mid- to upper sized Electronic Consumer Goods using Industrial Robots (CustomPacker) aims at developing and integrating a scalable and flexible packaging assistant that aids human workers while packaging mid to upper sized and mostly heavy goods.Electronic consumer goods, e.g. TV sets, have a large number of variants and are packaged manually. Only in single-variant production lines with high lot sizes, an automation of the packaging step has been introduced. However, automating the packaging process will decrease the production cycle time and costs also for mixed variant production lines, thus allowing that several production lines can be merged to a reduced number of flexible packaging stations. This also allows an optimization with regard to the actual demands of the (various) goods (i.e. number of items produced per day). In order to achieve the realization of these challenging goals for a highly flexible packaging station, CustomPacker will bring together the highly adaptable skills of a human worker together with the precision and ability of robots to carry heavy goods.The main goal of CustomPacker is to design and assemble a packaging workstation mostly using standard hardware components resulting in a universal handling system for different products. Ideally one setup for packaging a high variety of products and components can be implemented, which can be achieved by a teachable system architecture. This will open a new dimension of todays way in how industrial robots are deployed, namely the collaboration of human workers together with robot co-workers. Only by driving the reliability and precision of todays available technology to the limits and by additionally forcing the use of highly sophisticated software modules for worker detection and intention recognition, the cycle times can be reduced in order to justify the investment costs for additional complexity.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-1.3-3 | Award Amount: 3.78M | Year: 2008

The goal of the OpenTox project is to develop a predictive toxicology framework with a unified access to toxicological data, (Q)SAR models and supporting information. It will provide tools for the integration of data from various sources (public and confidential), for the generation and validation of (Q)SAR models, libraries for the development and integration of new (Q)SAR algorithms, and validation routines. OpenTox will attract toxicological experts without (Q)SAR expertise as well as model and algorithm developers. It will move beyond existing attempts to solve individual research issues, by providing a flexible and user friendly framework that integrates existing solutions and new developments. OpenTox will be relevant for REACH as it gives risk assessors simple access to experimental data, (Q)SAR models and toxicological information that adheres to European and international regulatory requirements. OpenTox will be published as an open source project to allow a critical evaluation of its algorithms, to promote dissemination, and to attract external developers. Facilities for the inclusion of confidential in-house data and for accessing commercial prediction systems will be included. OpenTox will contain high-quality data and (Q)SAR models for chronic, genotoxic and carcinogenic effects. These are the endpoints with the greatest potential to reduce animal testing. The impact of OpenTox will however go beyond REACH and long-term effects, because it will be straightforward to create models for other endpoints (e.g,. sensitisation, liver-toxicity, cardio-toxicity, ecotoxicity). The proposed framework will support the development of new (Q)SAR models and algorithms by automating routine tasks, providing a testing and validation environment and allowing the easy addition of new data. For this reason we expect, that OpenTox will lead to (Q)SAR models for further toxic endpoints and generally improve the acceptance and reliability of (Q)SAR models.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.2.2-3 | Award Amount: 18.59M | Year: 2014

Highly efficient Power Electronics (PE) employed in power generation, transmission, and distribution is the prerequisite for the Europe-wide penetration of renewable energies; improves the energy efficiency; increases the power quality and enables continuous voltage regulation, reactive power compensation and automated distribution. It also facilitates the integration of distributed resources like local energy storages, photovoltaic generators, and plug-in electric vehicles. The development of a new generation of high power semiconductor devices, able to operate above 10kV, is crucial for reducing the cost of PE in the above-mentioned applications. The material properties of SiC, clearly superior to those of Si, will lead to enhanced power devices with much better performance than conventional Si devices. However, todays SiC PE performs rather poorly compared to the predictions and the production costs are by far too high. Pooling world-leading manufacturers and researchers, SPEED aims at a breakthrough in SiC technology along the whole supply chain: Growth of SiC substrates and epitaxial-layers. Fabrication of power devices in the 1.7/>10kV range. Packaging and reliability testing. SiC-based highly efficient power conversion cells. Real-life applications and field-tests in close cooperation with two market-leading manufacturers of high-voltage (HV) devices. Known and new methodologies will be adapted to SiC devices and optimized to make them a practical reality. The main targets are cost-savings and superior power quality using more efficient power converters that exploit the reduced power losses of SiC. To this end, suitable SiC substrates, epitaxial-layers, and HV devices shall be developed and eventually be implemented in two demonstrators: A cost-efficient solid-state transformer to support advanced grid smartness and power quality. A windmill power converter with improved capabilities for generating AC and DC power.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.4 | Award Amount: 2.79M | Year: 2008

The objective of the GENESYS project is to develop a cross-domain reference architecture for embedded systems that can be instantiated for different application domains to meet the requirements and constraints documented in the ARTEMIS strategic research agenda. These requirements are composability, networking, security, robustness, diagnosis, integrated resource management and evolvability. The reference architecture will address common issues, such as complexity management, separation of communication and computation, support for different levels of quality of service, security, model-based design, heterogeneity of subsystems, legacy integration, optimal power usage, and diagnosis. It will provide domain-independent services that can be customized to the needs of a particular application domain. Domain-specific platform services will be converged such that components from different application domains can be consistently integrated while preserving relevant properties. The project will result in a conceptualization of the cross-domain architecture, a specification of cross-domain core services and optional services for the selected application domains, and four exploratory prototypes that will demonstrate and help to evaluate the feasibility of selected central architectural concepts in the different application domains. The expected impact of GENESYS is a reduction of development costs and a speed-up of the time-to-market of embedded system development in different application domains, thereby strengthening the European presence in the competitive world-wide embedded systems markets. The support for cross-domain reuse of components is of particular relevance to innovative European SMEs that plan to enter those markets with high-tech products under increasing time pressure. The consortium consists of many major European embedded system suppliers and OEMs encompassing a broad range of application domains, supported by leading research and academic organizations.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 12.08M | Year: 2015

Todays society is being transformed by new materials and processes. Analytical techniques underpin their development and neutrons, with their unique properties, play a pivotal role in a multi-disciplinary, knowledge-based approach. Industry and the neutron research community must however work together more closely to enhance their innovation potential. Neutrons are only available at large scale facilities (LSFs), presenting specific challenges for outreach. National and European initiatives have combined to create a user community of almost 10000, mainly academia-based users, which is supported by an ecosystem of about 10, often world-class national facilities and the European facility, the Institute Laue Langevin. Europe leads neutron science and is investing almost 2B in the European Spallation Source (ESS), its construction, like Horizon 2020, spanning the period 2014-2020. SINE2020, world-class Science and Innovation with Neutrons in Europe in 2020, is therefore a project with two objectives; preparing Europe for the unique opportunities at ESS in 2020 and developing the innovation potential of neutron LSFs. Common services underpin the European research area for neutrons. New and improved services will be developed in SINE2020, by the LSFs and partners in 13 countries, in a holistic approach including outreach, samples, instrumentation and software. These services are the key to integrating ESS in the European neutron ecosystem, ensuring scientific success from day one. They are also the basis for facilitating direct use of neutron LSFs by industry. Particular emphasis is placed on the industry consultancy, which will reach out to industry and develop a business model for direct, industry use of LSFs in 2020, and data treatment, exploiting a game-changing opportunity at LSFs to adopt a common software approach in the production of scientific results.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.2.1 | Award Amount: 3.16M | Year: 2014

TACMAN addresses the key problem of developing an information processing and control technology enabling robot hands to exploit tactile sensitivity and thus become as dexterous as human hands. The current availability of the required technology now allows us to considerably advance in-hand manipulation. TACMANs goal is to develop fundamentally new approaches which can replace manual labor under inhumane conditions by endowing robots with such tactile manipulation abilities, by transferring insights from human neuroscientific studies into machine learning algorithms.\n\nTACMAN will provide an innovative new technology that is key for bringing industrial manufacturing back to Europe. Consider the case of the iPhone, where most mechanical manipulation of the major components is achieved by manual human labor under terrible work conditions and not by advanced industrial robots--despite that millions of iPhones are industrially assembled per month. The reason for this absence of appropriate automation is the lack of manipulation skills of current robots.\n\nCommercially available robotic hand-arm systems move more accurately and faster than humans, and their sensors see more and at a higher precision--even the smallest forces and torques can be detected. Despite these impressive sensori-motor abilities, current robots are terrible at manipulation when compared to humans. Neuro- science provides a clear reason for the superiority of human hands: During manipulation, humans make substantial use of the data from tactile sensors, i.e., the information obtained through the feeling in the humans fingers. Robot hands are lacking this key ability! Hence, the rationale of TACMAN is that this performance gap in manipulation ability can be filled by (1) making such tactile sensory comprehensible, and (2) use the information provided by such sensors intelligently for behavior generation.\n\nTACMAN aims to integrate the most robust available tactile sensors into the control of existing modern robot hands, and, based on this control law, develop tactile sensor-based manipulation solutions. To make this innovation tractable in a three year project, we aim only on recognising and handling objects that are already in the hand. The structure of the project is designed to allow quick scaling from straightforward, well-captured scenarios employing a single finger to complex multi-fingered manipulation.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: EE-02-2015 | Award Amount: 4.22M | Year: 2015

In ZERO-PLUS, a comprehensive, cost-effective system for Net Zero Energy (NZE) settlements will be developed and implemented. The system will be composed of innovative solutions for the building envelope, for building energy generation and management, and for energy management at the settlement level. A reduction of operational energy usage to an average of 0-20 kWh/m2 per year (compared with the current average of 70-230 kWh/m2) will be achieved through a transition from single NZE buildings to NZE settlements, in which the energy loads and resources are optimally managed. A primary objective of the project will be to develop a system whose investment costs will be at least 16% lower than current costs. In order to reduce balance of system costs, an approach of mass customization will be employed. Mass produced technologies will be integrated in a system that is optimally designed according to the local climate and site of each project in which it is implemented. To this end, a structured process will be developed and applied for the integration, optimization and verification of the design. The projects work programme will ensure a rapid market uptake, within its four-year scope, of the innovative solutions that will be developed. These solutions will be implemented in four different demonstration projects throughout the EU, with varying climates and building types. The results of their implementation will be monitored, analyzed and disseminated. A comprehensive market analysis and business plan will support the commercial exploitation of the projects results. The project will be carried out by a consortium that includes universities, project owners, technology providers and organizations, which will closely collaborate in all the projects phases.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: FoF-09-2015 | Award Amount: 8.87M | Year: 2015

HORSE aims to bring a leap forward in the manufacturing industry proposing a new flexible model of smart factory involving collaboration of humans, robots, AGVs (Autonomous Guided Vehicles) and machinery to realize industrial tasks in an efficient manner. HORSE proposes to foster technology deployment towards SMEs by developing a methodological and technical framework for easy adaptation of robotic solutions and by setting up infrastructures and environments that will act as clustering points for selected application areas in manufacturing and for product life cycle management (production and/or maintenance and/or product end of life). The main strategy builds on existing technology and research results in robotics and smart factories and integrates them in a coherent framework. The suitability of the resulting framework is not only driven by but will be validated with end-users - manufacturing companies- in two steps: In the first, the joint iterative development of the framework together with selected end-users will take place (Pilot Experiments). In the second, its suitability and transferability to further applications will be validated with new end users, which are recruited by an Open Call mechanism. The novel approaches of HORSE are the integration of concepts such as (physical) human-robot interaction, intuitive human-machine interfaces, and interaction between different robots and machines into an integrated environment with pre-existing machines and workflows. Safety of the human worker as well as reduction of health risks through physical support by the robotized equipment will contribute to better overall manufacturing processes. In these, pre-defined workflows to be customized are the basis for servitisation, for the entire value chain that allow rapid reconfiguration of the robots based collaborative production processes. HORSE aims to foster advanced manufacturing technology deployment by industries and especially SMEs.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-03-2014 | Award Amount: 9.73M | Year: 2015

General X-ray image sensing is undergoing a major transition away from analog solutions towards Direct Radiography using digital Flat-Panel Detector (FPD) technology, offering immediate imaging, large productivity, lower dose and portability. LORIX will develop, prototype and demonstrate large area X-ray FPD detectors enabled by TOLAE technology by combining a printed Organic Photo Diode (OPD) with existing Thin Film Transistors active matrices (TFT), in security, health and Non Destructive Testing applications. LORIX will consider two complementary technology routes for effective market introduction: - The short term (2020), low risk route, based on Organic Detector On Glass (oDOG) concept, integrates printed OPD layer on a-Si active matrix on glass, used for displays. This will result in highly competitive organic FPDs with higher performance at lower manufacturing cost. - The medium (2022) term route, relying on Organic Detector On Foil (oDOF) concept, integrates a printed OPD on an organic TFT active matrix on foil. This full organic sensor on foil with improved mechanical robustness and lightweight will enable an easier penetration into nomadic X-ray markets and later will pave the way for dynamic, curved and flexible image sensors. LORIX partners are complementary and cover the full TOLAE value chain: material supplier, equipment manufacturers, companies & research organisations for OPD & OTFT design & integration, companies for production of sensors and full systems. Major OLAE European pilot facilities, PICTIC in Grenoble, Plastic Logic in UK & Germany, will be used for effective industrial exploitation of the products in Europe. Entering an existing business, LORIX will have direct access to end users in the targeted applications. LORIX innovations will strengthen the European industries leadership on X-ray market and will contribute to build a complete value chain with manufacturing capabilities in Europe for large area organic sensors applications.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: GV-8-2015 | Award Amount: 8.20M | Year: 2016

Batteries are not yet the ideal energy container they were promised to be. They are expensive, fragile and potentially dangerous. Moreover the current EV cannot compete yet with traditional vehicles when it comes to driving range and flexibility. EVERLASTING intends to bring Li-ion batteries closer to this ideal by focusing on the following technology areas. Predicting the behavior of battery systems in all circumstances and over their full lifetime. This enables accurate dimensioning and choice of the correct battery type, leading to lower cost. It also facilitates the development of a powerful battery management system during all stages of its evolution from idea to fully tested product. Sensing signals beyond the standard parameters of current, voltage and temperature. This multi-sensing approach provides more varied and in-depth data on the status of the battery facilitating a pro-active and effective management of the batteries, preventing issues rather than mitigating them. Monitoring the status of the battery by interpreting the rich sensor data. By intelligently combining this information with road, vehicle and driver data we intend to offer accurate higher-level driver feedback. This induces a bigger trust and hence a lower range anxiety. Managing the battery in a proactive way, based on a correct assessment of its status. Efficient thermal management and load management results in increased reliability and safety and leads to lower overall cost through an increased lifetime. Defining a standard BMS architecture and interfaces and gathering the necessary support in the market. This allows an industry of standard BMS components to flourish which will result in lower cost.

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.3 | Award Amount: 5.79M | Year: 2010

The objective of Novel EXplorations Pushing Robust e-VLBI Services (NEXPReS) is to offer enhanced scientific performance for all use of the European VLBI Network (EVN) and its partners. The proposed activities will allow the introduction of an e-VLBI component to every experiment, aiming for enhanced robustness, flexibility and sensitivity. This will boost the scientific capability of this distributed facility and offer better data quality and deeper images of the radio sky to a larger number of astronomers. In the past years, e-VLBI has been successfully introduced for real-time, high-resolution radio astronomy. Due to limitations in connectivity, bandwidth and processing capacity, this enhanced mode cannot be offered to all astronomers yet, in spite of its obvious advantages. By providing transparent buffering mechanisms at telescope and correlator it will be possible to address all the current and future bottlenecks in e-VLBI, overcoming limited connectivity to essential stations or network failures, all but eliminating the need for physical transport of magnetic media. Such a scheme will be far more efficient, and ultimately greener, than the current model, in which complex logistics and a large over-capacity of disks are needed to accommodate global observations. It will require high-speed recording hardware, as well as software systems that hide all complexity. Real-time grid computing and high bandwidth on demand will be addressed as well, to improve both the continuous usage of the network and prepare the EVN for the higher bandwidths which will ensure it will remain the most sensitive VLBI array in the world. The proposed programme will strengthen the collaboration between the European radio-astronomical and ICT communities. This will be essential to maintain Europes leading role in the global SKA project.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 3.42M | Year: 2015

Wireless Chip-to-Chip (C2C) communication and wireless links between printed circuit boards operating as Multiple Input Multiple Output devices need to become dominant features of future generations of integrated circuits and chip architectures. They will be able to overcome the information bottleneck due to wired connections and will lead the semiconductor industry into a new More-Than-Moore era. Designing the architecture of these wireless C2C networks is, however, impossible today based on standard engineering design tools. Efficient modelling strategies for describing noisy electromagnetic fields in complex environments are necessary for developing these new chip architectures and wireless interconnectors. Device modelling and chip optimization procedures need to be based on the underlying physics for determining the electromagnetic fields, the noise models and complex interference pattern. In addition, they need to take into account input signals of modern communication systems being modulated, coded, noisy and eventually disturbed by other signals and thus extremely complex. Recent advances both in electrical engineering and mathematical physics make it possible to deliver the breakthroughs necessary to enable this future emerging wireless C2C technology by creating a revolutionary electromagnetic field simulation toolbox. Increasingly sophisticated physical models of wireless interconnects and associated signal processing strategies and new insight into wave modelling in complex environments based on dynamical systems theory and random matrix theory make it possible to envisage wireless communication on a chip level. This opens up completely new pathways for chip design, for carrier frequency ranges as well as for energy efficiency and miniaturisation, which will shape the electronic consumer market in the 21st century.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 2.96M | Year: 2016

2D-INK is targeted at developing inks of novel 2D semiconducting materials for low-cost large-area fabrication processes on insulating substrates through a new methodology, which will exceed the properties of state-of-the-art graphene- and graphene oxide based inks. Achieving this would represent an important step forward in the processing of 2D semiconducting materials and will provide the key parameters for fabricating the next generation of ultrathin electronic appliances. The inherent high-risk of 2D-INK is countered by a strongly interdisciplinary research team composed of 9 partners (8 academics \ 1 SME) with demonstrated experience in their corresponding fields and with different yet highly complementary backgrounds. Therefore only together and in synergy they will be able to address the challenges of the multiple research and innovation aspects of 2D-INK that cover the entire value chain from materials design and synthesis, characterisation, formulation and processing to device implementation. In addition 2D-INK has the potential to revolutionise research on 2D semiconducting materials way beyond the current interests on synthesis (high impact), since the efficient dispersion and formulation of 2D semiconducting materials into inks enables the applications of 2D semiconducting materials over different scientific and technological disciplines, such as electronics, sensing, photonics, energy storage and conversion, spintronics, etc. Overall, 2D-INK addresses perfectly the challenge of this call as it is an archetype of an early stage, high risk visionary science and technology collaborative research project that explores radically new manufacturing and processing technologies for novel 2D semiconducting materials.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 2.87M | Year: 2015

Many aspects of our life, but also cutting-edge research questions, hinge on the solution of large systems of partial differential equations expressing conservation laws. Such equations are solved to compute accurate weather forecast, complex earthquake physics, hematic flows in patients, or the most catastrophic events in the universe. Yet, our ability to exploit the predictive power of these models is still severely limited by the computational costs of their solution. Thus, the simulation of earthquakes and their induced hazards is not yet accurate enough to prevent human losses. And our ability to model astrophysical objects is still insufficient to explain our observations. While exascale supercomputers promise the performance to tackle such problems, current numerical methods are either too expensive, because not sufficiently accurate, or too inefficient, because unable to exploit the latest supercomputing hardware. Exascale software needs to be redesigned to meet the disruptive hardware changes caused by severe constraints in energy consumption. We thus develop a new exascale hyperbolic simulation engine based on high-order communication-avoiding Finite-Volume/Discontinuous-Galerkin schemes yielding high computational efficiency. We utilize structured, spacetree grids that offer dynamic adaptivity in space and time at low memory footprint. And we consequently optimise all compute kernels to minimise energy consumption and exploit inherent fault-tolerance properties of the numerical method. As a general hyperbolic solver, the exascale engine will drive research in diverse areas and relieve scientist from the burden of developing robust and efficient exascale codes. Its development is driven by precise scientific goals, addressing grand challenges in geo- and astrophysics, such as the dynamic rupture processes and subsequent regional seismic wave propagation, or the modeling of relativistic plasmas in the collision of compact stars and explosive phenomena.

The invention relates to a method for lubricating an expansion machine (30) in a thermodynamic cycle device, wherein the thermodynamic cycle device comprises the expansion machine, a feed pump (50), a lubricant separator (10) and a working medium containing a lubricant, and wherein the method comprises the following steps: The working medium is subjected to pressure by means of the feed pump. The pressurised working medium is delivered by the feed pump to the lubricant separator. At least part of the lubricant is separated from the working medium by means of the lubricant separator. At least part of the separated lubricant is delivered by the lubricant separator to the expansion machine. The invention further relates to a thermodynamic cycle device comprising a working medium that contains a working fluid and a lubricant, an expansion machine, a feed pump for subjecting the working medium to pressure, and a lubricant separator for separating at least part of the lubricant from the working medium, wherein the cycle device is designed to deliver at least part of the separated lubricant from the lubricant separator to the expansion machine.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2010-8 | Award Amount: 14.36M | Year: 2011

Transportation based on cars, aircraft and ships is a key factor for modern human societies. Human operators have historically been in charge of the two main facets of transportation: vehicle control and traffic control. Technological innovations have progressively allowed the introduction of advanced automated assistance systems leading to a complex interplay of humans and automation which has been shown to lead in many cases to new types of human errors, incidents and sometimes accidents. It has been recognized that further automation alone cannot solve the problem and the crucial issue is how to achieve an adequate level of human-machine cooperation with shared authority. The proposal addresses missing key enablers for market penetration of innovative dynamic Distributed Cooperative Human-Machine Systems (DCoS). The proposal intends to develop affordable methods, techniques and tools which go beyond assistance systems and consequently address the design, development and evaluation of cooperative systems from a multi-agent perspective where human and machine agents are in charge of common tasks, assigned to the system as a whole. A high quality user interface is inevitable to meet user expectations and to gain market acceptance of cooperative systems with increased levels of automation. Already today the development of a user interface of Embedded Systems is a substantial cost driver that is constantly increasing. The proposal strives to boost cost efficiency of highly innovative DCoS with several interactive Embedded Systems. This will be achieved by supporting and closing the industrial development process chain from (1) DCoS composition over (2) interaction design to (3) system design and (4) interface design and by allowing to evaluate the overall system safety, efficiency and effectiveness already in early process phases. An Innovation Eco System for cooperative embedded HMI will be established during the project and will be maintained afterwards.

Home > Press > Nanodevice, build thyself: Researchers in Germany studied how a multitude of electronic interactions govern the encounter between a molecule called porphine and copper and silver surfaces Abstract: As we continue to shrink electronic components, top-down manufacturing methods begin to approach a physical limit at the nanoscale. Rather than continue to chip away at this limit, one solution of interest involves using the bottom-up self-assembly of molecular building blocks to build nanoscale devices. Successful self-assembly is an elaborately choreographed dance, in which the attractive and repulsive forces within molecules, between each molecule and its neighbors, and between molecules and the surface that supports them, have to all be taken into account. To better understand the self-assembly process, researchers at the Technical University of Munich have characterized the contributions of all interaction components, such as covalent bonding and van der Waals interactions between molecules and between molecules and a surface. "In an ideal case, the smallest possible device has the size of a single atom or molecule," said Katharina Diller, who worked as a postdoctoral researcher in the group of Karsten Reuter at the Technical University of Munich. Reuter and his colleagues present their work this week in The Journal of Chemical Physics, from AIP Publishing. One such example is a single-porphyrin switch, which occupies a surface area of only one square nanometer. The porphine molecule, which was the object of this study, is even smaller than this. Porphyrins are a group of ringed chemical compounds which notably include heme - responsible for transporting oxygen and carbon dioxide in the bloodstream - and chlorophyll. In synthetically-derived applications, porphyrins are studied for their potential uses as sensors, light-sensitive dyes in organic solar cells, and molecular magnets. The researchers from TU Munich assessed the interactions of the porphyrin molecule 2H-porphine by using density functional theory, a quantum mechanical computational modelling method used to describe the electronic properties of molecules and materials. Their simulations were performed at the high-performance supercomputer SuperMUC at Leibniz-Rechenzentrum in Garching. The metallic substrates the researchers chose for the porphyrin molecules to assemble on, the close packed single crystal surfaces of copper and silver, are widely used as substrates in surface science. This is due to the densely packed nature of the surfaces, which allow the molecules to exhibit a smooth adsorption environment. Additionally, copper and silver each react differently with porhyrins - the molecule adsorbs more strongly on copper, whereas silver does a better job of keeping the electronic structure of the molecule intact - allowing the researchers to monitor a variety of competing effects for future applications. In their simulation, porphyrin molecules were placed on a copper or silver slab, which was repeated periodically to simulate an extended surface. After finding the optimal geometry in which the molecules would adsorb on the surface, the researchers altered the size of the metal slab to increase or decrease the distance between molecules, thus simulating different molecular coverages. The computational setup gave them a switch to turn the energy contributions of neighboring molecules on and off, in order to observe the interplay of the individual interactions. Diller and Reuter, along with colleagues Reinhard Maurer and Moritz Müller, who is first author on the paper, found that the weak long-range van der Waals interactions yielded the largest contribution to the molecule-surface interaction, and showed that the often employed methods to quantify the electronic charges in the system have to be used with caution. Surprisingly, while interactions directly between molecules are negligible, the researcher found indications for surface-mediated molecule-molecule interactions at higher molecular coverages. "The analysis of the electronic structure and the individual interaction components allows us to better understand the self-assembly of porphine adsorbed on copper and silver, and additionally enables predictions for more complex porphyrine analogues," Diller said. "These conclusions, however, come without yet considering the effects of atomic motion at finite temperature, which we did not study in this work." About American Institute of Physics The Journal of Chemical Physics publishes concise and definitive reports of significant research in the methods and applications of chemical physics. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

News Article | December 5, 2016

How much electricity flows through the grid? When and where? Where are the bottlenecks? What happens when wind turbines and solar cells feed in additional energy? The answer to these questions are essential for the global energy turnaround. However, for a valid planning, one first needs a solid understanding of the infrastructure. Researchers at the Technical University of Munich (TUM) are now collecting information via an open source platform accessible to everyone. Hundreds of volunteers are already underway, and their numbers are growing every day. Armed with the OpenGridMap app on their smart phones, they meander through Munich, Berlin, Tokyo and even Teheran. Just another cell phone game? "No, we aren't chasing Pokémons," reassures Jose Rivera, director of the OpenGridMap project. "What we are interested in is the electrical infrastructure: High-voltage and low-voltage power lines, transformer sub-stations, wind turbines and solar power plants." Users of the app share photos and locations with a server housed in the Department of Computer Science at TU Munich. There, the information is analyzed, evaluated and ultimately loaded into the open source OpenStreetMap map system. The goal is a map of electric power grids worldwide. "This is a prerequisite for the energy turnaround - not only here in Germany, but in all countries around the world. You can only plan the restructuring of the energy supply if you know exactly where powerlines are located and at which locations power from high-voltage lines is transformed and fed into the low-voltage networks," explains Prof. Hans-Arno Jacobsen, director of the Department of Energy Informatics and Middleware at TUM. Building on this foundation, it is possible, for example, to simulate how feeding in renewable energy will affect the grid and where bottlenecks or surplus capacity will arise and where it might make sense to build storage facilities. What is lacking thus far is a solid pool of data, says Rivera: "Of course every power utility knows its own grids, but there are many power companies but very few open their data to the public. This is compounded in emerging markets by the fact that the information is frequently not even digitized. Contracting a company to compile the infrastructure for an entire country, or even the entire world would not be affordable for the researchers." The cost-effective alternative: crowd sourcing. The TU Munich team did not have to start at zero: A community of volunteers has been collecting data for the Wiki global map OpenStreetMap for over 10 years. This publicly accessible data set also contains information on electric power grids. "However, it they are neither complete nor verified," explains Rivera. "And that is precisely what we are now hoping to change:" Half a year ago the researcher from the Department of Energy Informatics and Middleware published his OpenGridMap app on the Google Playstore. Since then he has been looking for volunteers to map wind turbines, solar power plants, transformer sub-stations and power lines using their mobile phones. Rivera verifies the information - is a transformer sub-station indeed a transformer sub-station? - and uploads the data to the open source map. There the network of verified grids in becoming increasingly denser. Red lines traverse the map like a mesh of arteries. The denser the mesh of mapped points, the more information can be generated. In Garching, for example, where a particularly large number of volunteers are active, the researcher has successfully calculated the location of subterranean power lines leading to houses using a novel algorithm. The idea is to make data from the project available to engineers and scientists around the world. "There are many potential applications for the OpenGridMap," Professor Jacobsen emphasizes. "You could investigate the feasibility of making a state like Bavaria energy autonomous." And someone attempting to improve the infrastructure a developing or emerging country could easily recognize how far a given town is removed from the nearest powerline. It is no wonder that there is great interest in the OpenGridMap project: Siemens is a project mentor and the World Bank also supports the undertaking. The project receives further funding from the German Federal Ministry for Education and Research (BMBF) and the Alexander Humboldt Foundation. Jose Rivera, Johannes Leimhofer, and Hans-Arno Jacobsen. OpenGridMap: towards automatic power grid simulation model generation from crowdsourced data. Computer Science-Research and Development (2016): 1-11 - DOI: 10.1007/s00450-016-0317-4

Agency: European Commission | Branch: H2020 | Program: IA | Phase: EE-01-2014 | Award Amount: 4.93M | Year: 2015

About 40% of the overall energy consumption in Europe is related to the building sector and represents about 1/3 of Europes CO2 emissions. The successful accomplishment of the emission reduction target by 2050, involves the need to increase the rate of retrofitting of the inefficient building stock up to 2.9%. In order to increase the renovation rate, more efficient renovation processes from design to manufacturing phase are needed. The use of prefabricated modules for renovation reduces on-site works, installation time, works intrusiveness, minimising the consumption of raw material; however there is a need to define holistic methodologies to adapt prefabrication processes to individual renovation solutions as well as to mass production, linked to computer design tools. Giving answer to the mentioned needs BERTIM will provide: (1) High energy performance prefabricated modules for deep renovation, integrating windows, insulation materials, collective HVAC systems, renewable energy systems and energy supply systems. The modules will be based in timber and recyclable materials for a low carbon foot print. The assembly system will guarantee a very little time in the installation and low disturbance to tenants. (2) An innovative holistic renovation process methodology based on a digital workflow from design to installation phase. In order to support the renovation process, a renovation project design tool oriented to SME integrating BIM with CAD/CAM tools and assuring the interoperability with CNC machines for mass manufacturing processes will be developed and implemented in three industrial settings. (3) Affordable business opportunities for different stakeholders as potential leaders in the launching of the renovation process. The whole renovation process and the developed timber modules will be validated in a full-scale research infrastructure, and then, they will be demonstrated in two real buildigns in two different climatic zones (South and North Europe).

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT.2011.4.4-5. | Award Amount: 34.53M | Year: 2011

The All-Electric Aircraft is a major target for the next generation of aircraft to lower consumption of non-propulsive power and thus fuel burn. To eliminate hydraulic circuits, pumps and reservoirs, Electro Mechanical Actuators (EMA) are mandatory but now need to meet cost, reliability and weight requirements from the airframers. ACTUATION 2015 aims to develop and validate a common set of standardised, modular and scalable EMA resources for all actuators (flight control, high lift, main landing gear, door, thrust reverser) and all types of aircraft (business/regional/commercial airplanes and helicopters). Compared to the A320, ACTUATION 2015 will reduce the overall Life Cycle Costs of actuators by 30%, improve reliability by 30% and reduce aircraft weight by 500kg. The project relies on recent advances made in EU and national projects to integrate the required technologies (solid state power distribution, power electronics, operation in harsh conditions, jam tolerant EMA) to overcome the current barriers to EMA and mature EMA technologies to TRL 5. Standardising EMA modules (motors, power drive electronics, mechanics, sensing) will be a key enabler to succeed in achieving cost objectives and developing the supply chain. Standardisation will start during the project with the support of a standardisation body (CEN). The technical approach will be to gather detailed airframes requirements, specify a set of standard modules and develop prototypes for assessment at component and actuator level through rig tests and the virtual validation of modules. In parallel, a unified EMA design process supported by standard methods and tools will also be developed. ACTUATION 2015 will complement existing projects, notably CLEAN SKY SGO with an EMA solution, and pave the way towards the ACARE 2020 All-Electric Aircraft. ACTUATION 2015 is a 4,5 year integrated project comprising 54 partners representing the European stakeholders of the actuation and airframe sectors from 12 countries

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT.2011.4.4-4. | Award Amount: 37.57M | Year: 2011

The ESPOSA project will develop and integrate novel design and manufacture technologies for a range of small gas turbine engines up to approx. 1000 kW to provide aircraft manufacturers with better choice of modern propulsion units. It will also deal with engine related systems which contribute to the overall propulsion unit efficiency, safety and pilot workload reduction. Through the newly developed design tools and methodologies for the engine/aircraft integration the project will also contribute to the improved readiness for new turbine engines installation into aircraft. New technologies and knowledge gained through the ESPOSA project will provide European general aviation industry with substantially improved ability to develop and use affordable and environmentally acceptable propulsion units and reliable aircraft systems minimizing operating costs, while increasing the level of safety. The new engine systems and engine technologies gained from ESPOSA should deliver 10-14% reduction in direct operating costs (DOC) and reduce significantly the pilot workload. The ESPOSA project is oriented on turbine engine technologies tailored for a small aircraft up to 19 seats (under CS-23/FAR23) operated on the scheduled and non-scheduled flights. The research work comprises performance improvements of key engine components, their improved manufacture in terms of costs and quality. New engine component technologies will be backed by novel modern electronic engine control based on COTS, pioneering the engine health monitoring for small engines and providing new more electric solutions for fuel and propeller control systems. Project activities will include extensive validation on the test rigs. The most appropriate technologies according to value/cost benefit will be selected and integrated into functional complexes and further evaluated on the engine test beds. The functionality of certain project outcomes will also be demonstrated and validated in-flight conditions.

Bornkessel-Schlesewsky I.,University of South Australia | Bornkessel-Schlesewsky I.,University of Marburg | Schlesewsky M.,Johannes Gutenberg University Mainz | Small S.L.,University of California at Irvine | And 2 more authors.
Trends in Cognitive Sciences | Year: 2015

Here, we present a new perspective on an old question: how does the neurobiology of human language relate to brain systems in nonhuman primates? We argue that higher-order language combinatorics, including sentence and discourse processing, can be situated in a unified, cross-species dorsal-ventral streams architecture for higher auditory processing, and that the functions of the dorsal and ventral streams in higher-order language processing can be grounded in their respective computational properties in primate audition. This view challenges an assumption, common in the cognitive sciences, that a nonhuman primate model forms an inherently inadequate basis for modeling higher-level language functions. © 2014 Elsevier Ltd.

Gerlach C.,Bavarian Academy of science and Humanities | Rummel R.,TU Munich
Journal of Geodesy | Year: 2013

One of the main objectives of ESA's Gravity Field and Steady-State Ocean Circulation mission GOCE (Gravity field and steady-state ocean circulation mission, 1999) is to allow global unification of height systems by directly providing potential differences between benchmarks in different height datum zones. In other words, GOCE provides a globally consistent and unbiased geoid. If this information is combined with ellipsoidal (derived from geodetic space techniques) and physical heights (derived from leveling/gravimetry) at the same benchmarks, datum offsets between the datum zones can be determined and all zones unified. The expected accuracy of GOCE is around 2-3 cm up to spherical harmonic degree nmax ≈ 200. The omission error above this degree amounts to about 30 cm which cannot be neglected. Therefore, terrestrial residual gravity anomalies are necessary to evaluate the medium and short wavelengths of the geoid, i. e. one has to solve the Geodetic Boundary Value Problem (GBVP). The theory of height unification by the GBVP approach is well developed, see e. g. Colombo (A World Vertical Network. Report 296, Department of Geodetic Science and Surveying, 1980) or Rummel and Teunissen (Bull Geod 62:477-498, 1988). Thereby, it must be considered that terrestrial gravity anomalies referring to different datum zones are biased due to the respective datum offsets. Consequently, the height reference surface of a specific datum zone deviates from the unbiased geoid not only due to its own datum offset (direct bias term) but is also indirectly affected by the integration of biased gravity anomalies. The latter effect is called the indirect bias term and it considerably complicates the adjustment model for global height unification. If no satellite based gravity model is employed, this error amounts to about the same size as the datum offsets, i. e. 1-2 m globally. We show that this value decreases if a satellite-only gravity model is used. Specifically for GOCE with nmax ≈ 200, the error can be expected not to exceed the level of 1 cm, allowing the effect to be neglected in practical height unification. The results are supported by recent findings by Gatti et al. (J Geod, 2012). © 2012 Springer-Verlag.

Li J.,TU Munich | Li J.,California Institute of Technology | Richter K.,TU Munich | Reinstein J.,Max Planck Institute for Medical Research | Buchner J.,TU Munich
Nature Structural and Molecular Biology | Year: 2013

Heat-shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that associates dynamically with various co-chaperones during its chaperone cycle. Here we analyzed the role of the activating co-chaperone Aha1 in the progression of the yeast Hsp90 chaperone cycle and identified a critical ternary Hsp90 complex containing the co-chaperones Aha1 and Cpr6. Aha1 accelerates the intrinsically slow conformational transitions of Hsp90 to an N-terminally associated state but does not fully close the nucleotide-binding pocket yet. Cpr6 increases the affinity between Aha1 and Hsp90 and further stimulates the Hsp90 ATPase activity. Synergistically, Aha1 and Cpr6 displace the inhibitory co-chaperone Sti1 from Hsp90. To complete the cycle, Aha1 is released by the co-chaperone p23. Thus, at distinct steps during the Hsp90 chaperone cycle, co-chaperones selectively trap statistically distributed Hsp90 conformers and thus turn Hsp90 into a deterministic machine. Copyright © 2013 Nature America, Inc.

Shahzad M.,TU Munich | Zhu X.X.,German Aerospace Center
IEEE Transactions on Geoscience and Remote Sensing | Year: 2015

With data provided by modern meter-resolution synthetic aperture radar (SAR) sensors and advanced multipass interferometric techniques such as tomographic SAR inversion (TomoSAR), it is now possible to reconstruct the shape and monitor the undergoing motion of urban infrastructures on the scale of centimeters or even millimeters from space in very high level of details. The retrieval of rich information allows us to take a step further toward generation of 4-D (or even higher dimensional) dynamic city models, i.e., city models that can incorporate temporal (motion) behavior along with the 3-D information. Motivated by these opportunities, the authors proposed an approach that first attempts to reconstruct facades from this class of data. The approach works well for small areas containing only a couple of buildings. However, towards automatic reconstruction for the whole city area, a more robust and fully automatic approach is needed. In this paper, we present a complete extended approach for automatic (parametric) reconstruction of building facades from 4-D TomoSAR point cloud data and put particular focus on robust reconstruction of large areas. The proposed approach is illustrated and validated by examples using TomoSAR point clouds generated from a stack of TerraSAR-X high-resolution spotlight images from ascending orbit covering an approximately 2-$\hbox{km}^{2}$ high-rise area in the city of Las Vegas. © 2014 IEEE.

Abdi M.,TU Munich | Hartmann M.J.,Heriot - Watt University
New Journal of Physics | Year: 2015

We study entanglement of the motional degrees of freedom of two tethered and optically trapped microdisks inside a single cavity. By properly choosing the position of the trapped objects in the optical cavity and driving proper modes of the cavity, it is possible to equip the system with linear and quadratic optomechanical couplings. We show that a parametric coupling between the fundamental vibrational modes of two tethered microdisks can be generated via a time-modulated input laser. For a proper choice of the modulation frequency, this mechanism can drive the motion of the microdisks into an inseparable state in the long time limit via a two-mode squeezing process. We numerically confirm the performance of our scheme for current technology and briefly discuss an experimental setup that can be used for detecting this entanglement by employing the quadratic coupling. We also comment on the perspectives for generating such entanglement between the oscillations of optically levitated nanospheres. © 2015 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 4.95M | Year: 2015

BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at boosting and accelerating implementation of BBMRI-ERIC and its services. Its main deliverables are designed to complete or launch the construction of key Common Services of the Research Infrastructure as required for ESFRI-projects under implementation, reflecting the targets of the European Research Area (ERA). One of the challenges in the post-genomic era is the research on common complex diseases, such as cancer, diabetes and Alzheimers disease. Revealing these diseases will depend critically on the study of human biological samples and data from large numbers of patients and healthy individuals. The EUs ageing population is will result in an increase in many of those diseases and consequently an increased healthcare expenditure for senior citizens. BBMRI-ERIC is a specific European asset having become a fundamental component in addressing the ongoing and future requirements particularly of Europes health service frameworks, including competitiveness and innovativeness of health-related industries. Its implementation is essential for the understanding of the diversity of human diseases, biological samples and corresponding data, which are required for the development of any new drug or diagnostic assay and are, therefore, critical for the advancement in health research, ultimately leading to personalised medicine. BBMRI-ERIC will provide a gateway access to the collections of the European research community, expertise and services building on the outcome of ADOPT BBMRI-ERIC.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-24-2015 | Award Amount: 8.36M | Year: 2016

Due to an aging population and the spiralling cost of brain disease in Europe and beyond, EDEN2020 aims to develop the gold standard for one-stop diagnosis and minimally invasive treatment in neurosurgery. Supported by a clear business case, it will exploit the unique track record of leading research institutions and key industrial players in the field of surgical robotics to overcome the current technological barriers that stand in the way of real clinical impact. EDEN2020 will provide a step change in the modelling, planning and delivery of diagnostic sensors and therapies to the brain via flexible surgical access, with an initial focus on cancer therapy. It will engineer a family of steerable catheters for chronic disease management that can be robotically deployed and kept in situ for extended periods. The system will feature enhanced autonomy, surgeon cooperation, targeting proficiency and fault tolerance with a suite of technologies that are commensurate to the unique challenges of neurosurgery. Amongst these, the system will be able to sense and perceive intraoperative, continuously deforming, brain anatomy at unmatched accuracy, precision and update rates, and deploy a range of diagnostic optical sensors with the potential to revolutionise todays approach to brain disease management. By modelling and predicting drug diffusion within the brain with unprecedented fidelity, EDEN2020 will contribute to the wider clinical challenge of extending and enhancing the quality of life of cancer patients with the ability to plan therapies around delicate tissue structures and with unparalleled delivery accuracy. EDEN2020 is strengthened by a significant industrial presence, which is embedded within the entire R&D process to enforce best practices and maximise translation and the exploitation of project outputs. As it aspires to impact the state of the art and consolidate the position of European industrial robotics, it will directly support the Europe 2020 Strategy.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 3.73M | Year: 2017

Two-dimensional materials (2DMs) such as graphene, hexagonal boron nitride, silicene and others, are currently amongst the most intensively studied classes of materials that hold great promise for future applications in many technological areas. However, the main hurdle against practical utilization of 2DMs is the lack of effective mass production techniques to satisfy the growing qualitative and quantitative demands for scientific and technological applications. The current state-of-the-art synthesis method of 2DMs involves the dissociative adsorption of gas-phase precursors on a solid catalyst. This process is slow by nature, inefficient, and environmentally unfriendly. Our analysis and recent experimental evidence suggest that using liquid metal catalysts (LMCats) instead of solid ones bears the prospect of a continuous production of 2DMs with unprecedented quality and production speed. However, the current knowledge about the catalytic properties of LMCats is extremely poor, as they had no technological significance in the past. In fact, there exist no well-established experimental facilities, nor theoretical frameworks to study the ongoing chemical reactions on a molten surface at elevated temperatures and under a reactive gas atmosphere. Our aim is to establish a central lab under supervision/collaboration of several scientific/engineering teams across Europe to develop an instrumentation/methodology capable of studying the ongoing chemical reactions on the molten catalyst, with the goal to open two new lines of research, namely in situ investigations on the catalytic activity of LMCats in general, and unravelling the growth mechanisms of 2DMs on LMCat surfaces in specific. The gained knowledge will be used to establish the first efficient mass production method for 2DMs using the new LMCat technology. This will open up the possibility of exploiting the unique properties of 2DMs on an industrial scale and in every day devices.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2011.6.3-1. | Award Amount: 3.70M | Year: 2011

This proposal is all about the introduction and airworthiness of cruiser-feeder operations for civil aircraft. Cruiser-feeder operations are investigated as a promising pioneering idea for the air transport of the future. The soundness of the concept of cruiser-feeder operations for civil aircraft is explained in the proposal, taking air-to-air refuelling operations as an example. A comprehensive estimate is given, which shows a fuel burn reduction potential and a CO2 emission reduction of 31% for a typical 6000 nautical miles flight with a payload of 250 passengers. This reduction potential is known to be large by any standard.The top level objective of the proposal is to demonstrate on a preliminary design level that cruiser-feeder operations (as a concept to reduce fuel burn and CO2 emission levels) can be shown to comply with the airworthiness requirements for civil aircraft. The subsequent Scientific and Technological (S&T) objectives are presented in the proposal. In the project, airworthy operational concepts for cruiser-feeder operations are determined and studied. The benefits in terms of CO2 emission reduction are derived and quantified. This is conducted in three integrating work packages, which are underpinned by research conducted in three disciplinary work packages. A conceptual and preliminary design study of aircraft required will be made, as well as automatic flight control concepts necessary to reduce the workload of the pilots and concepts to transfer passengers, supllies and waste. Finally, flight simulations will be conducted to investigate the cruiser-feeder operations concept. Impact of the RECREATE project will be generated by disseminating the results to the general public, to advisory groups and policy makers and to the aeronautical sciences community.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.1 | Award Amount: 3.32M | Year: 2008

N-CRAVE will deliver a proof-of-concept for network coding as the major enabler in dynamic wireless network environments with multiple communicating peers, where robustness is a key challenge. The simple, yet disruptive idea of network coding is that nodes are allowed to not only forward but also process and mix the incoming independent information flows. The objective is to develop solutions for architecting and controlling wireless networks in performance-challenged and resource-constrained environments. N-CRAVE will advance knowledge of fundamentals of network coding for improving attainable performance limits of networked systems for capacity, throughput, latency, complexity and energy with a view towards practically encountered scenarios. Key protocol components of the access, transport and network layers that operate hand-in-hand with network coding will be developed. In doing so, novel lightweight techniques will be designed based on convex optimization, linear algebra and backpressure control principles for transporting maximal amount of data over the network. Emphasis will be placed on advanced modes of information transport such as multi-cast and group-to-group communication with multiple simultaneous sessions in highly volatile environments. Innovative content distribution and storage methods will be developed for various wireless architectures and application-driven performance metrics, such as throughput, delay and fairness. A major goal will be to make the techniques viable in dynamically changing, volatile environments by preserving low computational complexity and signaling load. Besides inherent benefits of network coding in capacity provisioning and robustness, positive ramifications in security will be used to fortify confidentiality, secrecy and resilience to data corruption and other threats. Finally N-CRAVE will deliver an experimental wireless test-bed on which various network coding techniques will be implemented and validated.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT-2007-1.1-01;AAT-2007-4.2-01 | Award Amount: 4.56M | Year: 2008

ACFA 2020 deals with innovative active control concepts for ultra efficient 2020 aircraft configurations like the blended wing body (BWB) aircraft. The objective of the designed controllers is an ambitious improvement of ride comfort and handling qualities, as well as load reduction on BWB type aircraft. Due to the unconventional placement of control surfaces, BWB type aircrafts require multi-channel control architectures for manoeuvres as well as for active rigid body and vibration control. This is regarded as technology step compared to state-of-the-art single-channel controllers generally used for conventional aircraft configurations. Moreover promising algorithms such as adaptive feed-forward control and neural network control for active control of BWB type aircrafts will be investigated in ACFA 2020. These multi-channel algorithms will be applied to the large flying wing aircraft designed in the VELA and NACRE project as well as to a newly designed ultra efficient 450 passenger aircraft. For this 450 passenger aircraft design a flying wing and an ultra wide body fuselage aircraft with carry-through wing box will be compared and the configuration which promises highest efficiency with respect to fuel burn will be retained for a more detailed design. Based on the attained loads reduction due to the developed active control systems, the structure of this new 450 passenger aircraft will be resized with the goal of an ambitious weight saving for further improvement of fuel efficiency. To summarise, the main objectives of ACFA 2020 are to provide robust as well as adaptive multi-channel control architectures for loads alleviation and improvement of ride comfort and handling qualities on BWB type aircrafts, as well as the design of a new ultra efficient 450 passenger BWB type aircraft.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 4.26M | Year: 2013

SPENCER will break new ground for cognitive systems in populated environments. While there is an increasing focus on making robots more socially aware, related approaches are still limited in their capacity to perceive, model and learn human social behavior and respond with appropriate actions in real-time from mobile platforms. SPENCER will systematically address these problems and advance the fields of perception of individual humans and groups, normative human behavior learning and modeling, socially-aware mapping, and socially-aware task, motion and interaction planning under real-world conditions. In particular, by addressing these problems simultaneously in a multi-disciplinary project team, we will exploit synergies which will enable us to design cognitive systems that reach new levels of autonomy, efficiency, robustness, and safety in populated environments, optimizing the trade-off between objective and subjective performance measures. The project is motivated by an end-user market-pull and a technology-push. End-users seek innovative solutions to guide people and efficient mobile information provision. Robotics research meanwhile, has become suitably advanced to start considering humans as more than objects but as people with relationships, social rules and culturally diverse backgrounds. To this end, SPENCER will combine robotics research with social signal processing and socio-psychological user studies that will guide the learning process of socially normative robot behaviors into the relevant directions. The SPENCER consortium includes a large European airline as end-user that will deploy the SPENCER robotic demonstrator for the purpose of smart flow management of transfer passengers at the Amsterdam Schiphol Airport. This deployment has a large exploitation potential and is an excellent benchmark of the research developed in SPENCER given the demanding nature of airports as highly populated real-world environments.

Agency: European Commission | Branch: FP7 | Program: JTI-CS | Phase: JTI-CS-2011-1-SAGE-04-013 | Award Amount: 455.00K | Year: 2011

The strong need for higher efficiency, reduced CO2, NOX emissions, weight and noise reduction in aircraft engines leads to a demand of innovative materials with optimized mechanical and physical properties. The special design of new generation geared turbofan aircraft engines with their faster rotating LPT leads to higher temperatures in the turbine, casing and engine mount and thus requires parts with increased high temperature properties. High temperature strength means in most cases bad forgeability and weldability as well as combined with high toughness challenging machinability. Thus, beside of new designs the production processes have to be altered to get high quality parts. The overall goal of this project is an improved understanding of thermomechanical processing and its effect on residual stresses and distortion as well as microstructure and mechanical properties of forgings used for improved temperature exhaust cases. The proposed project consortium has significant experience with regard to nickel base superalloys with higher temperature capability than Inconel718 like Udimet720, Waspaloy, Allvac718Plus, RENE65 and Haynes282. Together with the know-how on residual stress simulation and measurement established in several projects since 2001 a successful realization of this project is possible. Beside project management according IPMA standards six further work packages have been defined. One for radial forging and one for closed die forging will be used to optimise thermomechanical processes based on simulation and to produce demonstrator parts. Open die forgings are used for residual stress and microstructure investigations. Material data for finite element simulation and residual stress modelling will be generated in on work package and verified together with the customer in an other. Residual stress modelling will be verified by neutron diffraction measurements and other methods in the final work package.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.2 | Award Amount: 6.51M | Year: 2010

Quantum entanglement has the capacity to enable disruptive technologies that solve outstanding issues in: - Trust, privacy protection, and security in two- and multi-party transactions; - Novel or enhanced modes of operation of ICT devices; - Reference standards, sensing, and metrology. The development of entanglement-based strategies addresses these challenges and provides the foundations for quantum technologies of the 21st century. The practical exploitation of entanglement requires groundbreaking levels of robustness and flexibility for deployment in real-world environments. This ambitious goal can be reached only through radically new designs of protocols, architectures, interfaces, and components. Q-ESSENCE will achieve this by a concerted application-driven effort covering relevant experimental, phenomenological, and fundamental aspects. Our consortium will target three main outcomes: 1) Development of entanglement-enabled and entanglement-enhanced ICT devices: atomic clocks, quan