Dresden, Germany
Dresden, Germany

The Technische Universität Dresden is the largest institute of higher education in the city of Dresden, the largest university in Saxony and one of the 10 largest universities in Germany with 37,134 students as of 2013. The name Technische Universität Dresden has only been used since 1961; the history of the university, however, goes back nearly 200 years to 1828. This makes it one of the oldest colleges of technology in Germany, and one of the country’s oldest universities, which in German today refers to institutes of higher education which cover the entire curriculum. The university is member of TU9, a consortium of the nine leading German Institutes of Technology. The university is one of the eleven German universities which succeeded in the Excellence Initiative in 2012, thus getting the title of a "University of Excellence". The TU Dresden succeeded in all three rounds of the German Universities Excellence Initiative . Wikipedia.

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A method for generating random numbers on multiprocessor systems and a multiprocessor system for generating true random numbers, using the method, generate truly random numbers with high entropy in a multiprocessor system with little additional effort to chip area and power dissipation. The method includes the steps of: measuring a phase error signal of a clock generator circuit of a first and a second processing unit respectively, forwarding the phase error signal of the respective clock generator circuit of the first and second processing unit to a true random network, combining the phase error signal of the clock generator circuit of the first processing unit and the phase error signal of the clock generator circuit of the second processing unit in the true random network to random bit streams, picking-up a random bit stream of the true random network, passing the respective random bit stream back to a random generator of the respective processing unit for outputting true random.

Zollner D.,TU Dresden | Rios P.R.,Federal University of Fluminense
Acta Materialia | Year: 2017

Curvature driven grain growth proceeds by the motion of curved grain boundaries in polycrystals leading to a decrease in the total interfacial free energy. However, grain growth cannot occur without the so-called topological transitions. Indeed, it is a mathematical impossibility that a decrease in the number of grains per unit volume may take place without the topological transition that corresponds to the grain disappearance. Nonetheless, despite their importance, no previous work has studied the topological transitions in detail that take place during the transient as well as the self-similar state of coarsening. In the present work, the three classical topological changes are tracked during 2-d grain growth simulated by a Monte Carlo method. It is shown and discussed how topological transitions reach a self-similar state together with the grain size and the number of edges (faces) per grain distribution. © 2017 Acta Materialia Inc.

Michetti P.,TU Dresden | Timm C.,TU Dresden
Physical Review B - Condensed Matter and Materials Physics | Year: 2017

The topological nature of Weyl semimetals (WSMs) is corroborated by the presence of chiral surface states, which connect the projections of the bulk Weyl points by Fermi arcs (FAs). We study a bilayer structure realized by introducing a thin insulating spacer into a bulk WSM. Employing a self-consistent mean-field description of the interlayer Coulomb interaction, we propose that this system can develop an interlayer electron-hole pair condensate. The formation of this excitonic condensate leads to partial gapping of the FA dispersion. We obtain the dependence of the energy gap and the critical temperature on the model parameters, finding, in particular, a linear scaling of these quantities with the separation between the Weyl points in momentum space. A detrimental role is played by the curvature of the FAs, although the pairing persists for moderately small curvature. A signature of the condensate is the modification of the quantum oscillations involving the surface FAs. © 2017 American Physical Society.

Zlotnikov I.,TU Dresden | Zolotoyabko E.,Technion - Israel Institute of Technology | Fratzl P.,Max Planck Institute of Colloids and Interfaces
Progress in Materials Science | Year: 2017

The mechanical behavior of materials depends to a large extent on their properties at the nanoscale and, therefore, novel characterization techniques with sub-micron spatial resolution were developed in the last decades. Among them are the variety of tools for probing local elastic and viscoelastic properties of materials, the methods such as nanoindentation and AFM- and nanoindenter-based measurements using force modulation. In this review, we describe the nanoindenter-based nanoscale modulus mapping technique, which emerged as an extremely powerful tool for providing quantitative information on the storage and loss moduli distributions in complex nanocomposites. Since the tip penetrates only a few nanometers into the materials, this technique provides a superior lateral resolution in the order of 20 nm. All aspects of the method are covered, including a historical perspective, theoretical analysis, instrumentation, and examples of its application for studying multiphase structures and interfaces. The main focus of this review is the challenging field of natural bio-composites, which consist of stiff and compliant components, often with nanometric dimensions. Gradients of mechanical properties across the nm-sized features in biological materials are of upmost importance for their mechanical performance. Quantitative information on the nano-scale moduli distributions in these structures can hardly be achieved by other means. © 2017 Elsevier Ltd

Bon V.,TU Dresden
Current Opinion in Green and Sustainable Chemistry | Year: 2017

Current micro review describes the recent progress in the energy-related MOF applications. The most outstanding research papers and reviews, which report the application of Metal-Organic Frameworks for gas storage, adsorption heat transformation, solar cells, fuel cells, hydrogen evolution reaction and supercapacitors are highlighted. © 2017 Elsevier B.V.

Leichsenring P.,TU Dresden | Wallmersperger T.,TU Dresden
Smart Materials and Structures | Year: 2017

Ionic hydrogels belong to the class of polyelectrolyte gels, also known as ionic gels. Their ability to swell or shrink under different environmental conditions such as change of pH, ion concentration or temperature make them promising materials for new sensoric or actuatoric devices. Numerical simulations play a crucial role for further developing hydrogel based devices. In the present contribution, a thermodynamically consistent continuum model based on the theory of porous media is derived. The governing field equations are solved on a one-dimensional domain by applying the finite element method. For the time discretization an Euler backward algorithm is implemented. The hydrogel swelling behavior is triggered by a chemical stimulus and is analyzed in space and time. Two mechanical configurations are considered: the hydrogel free swelling behavior and a mechanically clamped configuration, where the hydrogel swelling is hindered, are evaluated in detail. The presented results lead to a precise understanding of the chemo-electro-mechanical behavior and the driving pressure contributions. © 2017 IOP Publishing Ltd.

Rudolph S.,TU Dresden
Principles of Knowledge Representation and Reasoning: Proceedings of the 15th International Conference, KR 2016 | Year: 2016

Recently, the field of knowledge representation is drawing a lot of inspiration from database theory. In particular, in the area of description logics and ontology languages, interest has shifted from satisfiability checking to query answering, with various query notions adopted from databases, like (unions of) conjunctive queries or different kinds of path queries. Likewise, the finite model semantics is being established as a viable and interesting alternative to the traditional semantics based on unrestricted models. In this paper, we investigate diverse database-inspired reasoning problems for very expressive description logics (all featuring the worrisome trias of inverses, counting, and nominals) which have in common that role paths of unbounded length can be described (in the knowledge base or of the query), leading to a certain non-locality of the reasoning problem. We show that for all the cases considered, undecidability can be established by very similar means. Most notably, we show undecidability of finite entailment of unions of conjunctive queries for a fragment of SHOIQ(the logic underlying the OWL DL ontology language), and undecidability of finite entailment of conjunctive queries for a fragment of SROIQ (the logical basis of the more recent and popular OWL 2 DL standard). Copyright © 2016, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

Introduction The introduction of the new law GKV-FQWG strengthens the competition between statutory health insurance. If incentives for risk selection exist, they may force a battle for cheap customers. This study aims to document and discuss incentives for regional risk selection in the German risk structure compensation scheme. Method Identify regional autocorrelation with Moran's l on financial parameters of the risk structure compensation schema. Results Incentives for regional risk selection do indeed exist. The risk structure compensation schema reduces 91% of the effect and helps to reduce risk selection. Nevertheless, a connection between regional situation and competition could be shown (correlation: 69.5%). Only the integration of regional control variables into the risk compensation eliminates regional autocorrelation. Discussion The actual risk structure compensation is leading to regional inequalities and as a consequence to risk selection and distortion in competition. Copyright ©, Georg Thieme Verlag KG. All rights reserved.

Seidel N.,TU Dresden
ACM International Conference Proceeding Series | Year: 2016

Video-based learning plays an important role in many blended and distance learning courses. The same is true for assessment as a key element in individual and collaborative learning scenarios. In this paper we discuss nine patterns on how to integrate assessment into video learning environments. Thus, we aim to provide solutions that go beyond the receptive and passive usage of instructional video material. The presented patterns describe common solutions of recurring problems at the intersection of user interface design and the instructional design regarding video-based learning. © 2016 ACM.

Braun R.,TU Dresden
Lecture Notes in Informatics (LNI), Proceedings - Series of the Gesellschaft fur Informatik (GI) | Year: 2016

The semantic specification of Enterprise Modeling Languages (EMLs) is a challenging task that is primarily caused by the immanent subjectivity in the context of enterprise modeling. This covers the interpretation of respective meta model constructs due to their references to the reality. In contrast, EMLs may also contain formal semantics in regard of automating specific parts. Despite the generally accepted relevance of semantics for the application of EMLs, current research lacks in the provision of appropriate description means and largely omits semantic investigations. This paper therefore proposes a multi-faceted framework for the analysis and description of EML semantics in order to increase the awareness of relevant influences. The framework consists of an ontic and epistemological dimension in its core, as material semantics finally address such fundamental aspects. On this basis, several wrapping dimensions are outlined: Conceptualization dimension, pragmatic dimension, representation dimension and the final consensus dimension.

Mamino M.,TU Dresden
Theoretical Computer Science | Year: 2017

We prove that to find optimal positional strategies for stochastic mean payoff games when the value of every state of the game is known, in general, is as hard as solving such games tout court. This answers a question posed by Daniel Andersson and Peter Bro Miltersen. © 2017 Elsevier B.V.

Zopf C.,TU Dresden | Kaliske M.,TU Dresden
Computers and Structures | Year: 2017

This research paper contributes to the model-free characterisation of elastic and inelastic materials. The introduced material description is based on neural networks for the constitutive stress-strain-relationship and is an alternative to a classical constitutive material description. This approach is an efficient method to represent the material behaviour numerically. The performance of the novel model-free formulation is exemplary shown for uncured natural rubber. One major advantage of the presented approach is the capability to use it for the representation of a wide range of materials. The novel model-free characterisation consists of a neural network that is coupled to the so-called micro-sphere approach. This formulation was developed for the characterisation of rubber like materials and takes the micro-structure of the material into account. As a benefit of this coupling, the neural networks, representing the stress-stretch-dependency, have to be exploited analysed only in onedimensional direction. In the first instance, the derivation is introduced for an Artificial Neural Network to yield a pure elastic description. Subsequently, the model-free approach is expanded in order to represent inelastic material behaviour as well. This extended formulation is obtained via a Recurrent Neural Network. Finally, uncured natural rubber material is described by the derived numerical approach. The model-free characterisation is validated by the finite element simulation of material tests. A complex forming of a rubber block into a mould is basis for a final validation of the model-free description. © 2017 Elsevier Ltd

Li Y.,Leuphana University Loneburg | Krober W.,Martin Luther University of Halle Wittenberg | Bruelheide H.,Martin Luther University of Halle Wittenberg | Hardtle W.,Leuphana University Loneburg | Von Oheimb G.,TU Dresden
Journal of Plant Ecology | Year: 2017

Aims Growth rates of plants are driven by factors that influence the amount of resources captured and the efficiency of resource use. In trees, the amount of light captured and the efficiency of light use strongly depends on crown characteristics and leaf traits. Although theory predicts that both crown and leaf traits affect tree growth, few studies have yet to integrate these two types of traits to explain species-specific growth rates. Using 37 broad-leaved tree species of subtropical forests in SE China, we investigated how interspecific differences in wood volume growth rates were affected by crown and leaf traits. We tested the hypotheses that (i) larger crown dimensions promote growth rates, (ii) species-specific growth rates are positively related to leaf stomatal conductance, leaf water potential and leaf chemical components, and negatively related to leaf C/N and leaf toughness and (iii) the two sets of traits better explain growth rates in combination than either alone. Methods Our study was conducted in a large-scale forest Biodiversity and Ecosystem Functioning experiment in China (BEF-China), located in a mountainous region in Jiangxi Province. We related 17 functional traits (two crown dimension and three crown structure traits; six physiological and six morphological leaf traits) to the mean annual growth rate of wood volume of young trees of the studied species. Interrelationships between crown and leaf traits were analyzed using principal component analysis. Simple linear regression analysis was used to test the effect of each trait separately. We used multiple regression analysis to establish the relationship of growth rate to each set of traits (crown traits, physiological and morphological leaf traits) and to the combination of all types of traits. The coefficients of determination (R2 adj) of the best multiple regression models were compared to determine the relative explanatory power of crown and leaf traits and a combination of both Important Findings The species-specific growth rates were not related to any of the single crown traits, but were related positively to leaf stomatal conductance and leaf water potential individually, and negatively to leaf toughness, with approximately 13% variance explained by each of the traits. Combinations of different crown traits did not significantly explain the species-specific growth rates, whereas combinations of either physiological or morphological leaf traits explained 24% and 31%, respectively. A combination of both crown and leaf traits explained 42% of variance in species-specific growth rates. We concluded that sets of traits related to carbon assimilation at the leaf-level and to overall amount of leaves exposed at the crownlevel jointly explained species-specific growth rates better than either set of traits alone. © The Author 2017. Published by Oxford University Press on behalf of the Institute of Botany, Chinese Academy of Sciences and the Botanical Society of China All rights reserved.

Siegert F.,TU Dresden
Journal of Physics G: Nuclear and Particle Physics | Year: 2017

The production of prompt photons is one of the most relevant scattering processes studied at hadron-hadron colliders in recent years. This article will give an overview of the different approaches used to simulate prompt photon production in the Sherpa event generator framework. Special emphasis is placed on a complete simulation of this process including fragmentation configurations. As a novel application a merged simulation of γ γand γ γ+jet production at NLO accuracy is presented and compared to measurements from the ATLAS experiment. © 2017 IOP Publishing Ltd.

Sommer J.-U.,Leibniz Institute of Polymer Research | Sommer J.-U.,TU Dresden
Macromolecules | Year: 2017

We study the properties of a polymer brush exposed to a mixture of two solvents where one component, called the co-nonsolvent (CNS), has a stronger preference with respect to the polymer. The concept of preferential adsorption of CNS onto the polymer, as recently proposed by Mukherhi, Kremer, and Marques [ Nat. Commun. 2014, 5, 4882 ], is combined with the mean-field Alexander-de Gennes approach for the polymer brush. The key assumption is that CNS can form bridges between two monomers which is associated with a further gain in free energy, thus leading to an effective monomer-monomer attraction. The adsorption equilibrium of CNS at a given value of the monomer concentration results in a concentration-dependent X-function for the polymer brush which describes the effective interactions between the monomers in the mixed solvent. This in turn can lead to a discontinuous collapse transition and to a corresponding reentry transition at higher CNS concentrations. The problem can be analytically treated for a minimal model where the increase of self-volume of the monomers due to adsorption of CNS is neglected. In this case the collapse and the reswelling transition have the same signature. For low brush densities in the noncollapsed state we give an analytic approximation for the spinodal of the collapse. This also allows to define two scaling variables instead of the three control parameters which are the grafting density, the CNS-monomer selectivity, and the volume faction of CNS. The proposed effective free energy contribution resulting from the CNS adsorption equilibrium can be transferred to other systems such as to gels or dendrimers. © 2017 American Chemical Society.

Strasser A.,TU Dresden
Pacific Asia Conference on Information Systems, PACIS 2016 - Proceedings | Year: 2016

Delphi is a frequently used research method in the IS field. The last years have seen many variants of the Delphi Method being proposed and used in IS research. However, these variants seem not to be properly derived: while all variants share certain characteristics, their reasoning for differentiation varies inconsistently. It seems that researchers tend to create presumably "new" Delphi Method variants although the underlying modification of the Delphi Method is in fact minor. This leads to a heterogeneity of Delphi Method variants and undermines scientific rigor when using Delphi. The study addresses this deficit and (1) identifies variants of Delphi that are differentiated and determines their characteristics, (2) critically reflects to what extent a clear distinction between these variants exists, and (3) develops a taxonomy proposal of Delphi Method variants. The proposed taxonomy helps to clearly differentiate Delphi Method variants and enhances methodological rigor when using the Delphi Method.

Seifert L.,TU Dresden | Miller G.,New York University
Clinical Cancer Research | Year: 2017

Necroptosis is a caspase-8-independent cell death that requires coactivation of receptor-interacting protein 1 (RIP1) and receptor-interacting protein 3 (RIP3) kinases. The necrosome is a complex consisting of RIP1, RIP3, and Fas-associated protein with death domain leading to activation of the pseudokinase mixed lineage kinase like followed by a rapid plasma membrane rupture and inflammatory response through the release of damage-associated molecular patterns and cytokines. The necrosome has been shown to be relevant in multiple tumor types, including pancreatic adenocarcinoma, melanoma, and several hematologic malignancies. Preclinical data suggest that targeting this complex can have differential impact on tumor progression and that the effect of necroptosis on oncogenesis is cell-type and context dependent. The emerging data suggest that targeting the necrosome may lead to immunogenic reprogramming in the tumor microenvironment in multiple tumors and that combining therapies targeting the necrosome with either conventional chemotherapy or immunotherapy may have beneficial effects. Thus, understanding the interplay of necroptotic cell death, transformed cells, and the immune system may enable the development of novel therapeutic approaches. © 2016 American Association for Cancer Research.

We propose applications that utilize the infimum and the supremum of closure operators that are induced by structures occuring in the field of Description Logics. More specifically, we consider the closure operators induced by interpretations as well as closure operators induced by TBoxes, and show how we can learn GCIs from streams of interpretations, and how an error-tolerant axiomatization of GCIs from an interpretation guided by a hand-crafted TBox can be achieved. © 2016, CEUR-WS. All rights reserved.

Herrmann J.,TU Dresden | Guenther E.,TU Dresden
Journal of Cleaner Production | Year: 2017

Enterprises face changing climate conditions within their daily business. Thus, they are affected directly through climate change impacts on their operations or indirectly by climate change impacts on the supply chain. Even if enterprises are aware of the relevance of adapting to climate change, there exist barriers that impede organizational change strategies. In order to mainstream research on barrier categorization of climate change adaptation, we want to explore a scale of organizational barriers for enterprises' climate change adaptation strategies. By developing a barrier scale, we contribute to future research by allowing conclusive causal explanations for the occurrence of barriers and how they can be overcome. As barriers are context-specific, we decided for an empirical setting in a specific context regarding organizational climate change adaptation. In this study, we focus on multinational enterprises' supply chains, especially the stakeholder group of small and medium-sized suppliers. As small and medium-sized enterprises are stakeholders of multinational enterprises, their adaptation to climate change is relevant for multinational enterprises as well. The value of our study is threefold: First, we present the first empirically explored scale of organizational barriers for enterprises' climate change strategies by factor analysis. Second, we describe what multinational enterprises should learn for their strategic practices concerning an effective and efficient climate change adaptation in the supply chain. And third, even if we confirm that barriers are contextspecific, we would suggest our explored scale for organizational barriers for other context-specific changes strategies. © 2017 Elsevier Ltd.

Dargie W.,TU Dresden
IEEE International Conference on Multisensor Fusion and Integration for Intelligent Systems | Year: 2017

Wireless electrocardiograms are useful for several practical applications in the healthcare domain. However, their usefulness is often limited by the quality of data that can be extracted from them. One of the main factors affecting the quality of ECG data is the inclusion of movement induced artefacts. In this paper we propose an adaptive filter to improve the quality of measurements. We propose to use motion or inertial sensors to capture the movements which affect the electrodes of a wireless ECG. Thus, we regard measurements from a 3D accelerometer and a 3D gyroscope as indication of the magnitude of noise artefacts in the outputs of a wireless ECG and use them to estimate and remove the movement artefacts. The paper presents the design and implementation of the filter, which we used to improve actual measurements we took whilst different subjects carried out various everyday activities (walking, running, riding a bicycle, and climbing up and down a staircase). © 2016 IEEE.

Lavrov E.V.,TU Dresden
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2017

The results of combined IR absorption and photoconductivity studies on hydrogen donors in ZnO and TiO2 are presented. It is shown that hydrogen donors in ZnO and rutile TiO2 can be detected as Fano resonances in the photoconductivity spectra at the frequencies corresponding to the vibrational modes of these defects. In the case of anatase TiO2 IR absorption lines at 3412 and 3417 cmâ'1are assigned to the stretching local vibrational modes of a donor in the neutral and the positive charge states, respectively. Interstitial hydrogen is suggested as a tentative model for the defect giving rise to these vibrational modes. © 2017 SPIE.

We present a minor modification of of the stabilisation term in the local projection stabilisation (LPS) method for stabilising singularly perturbed problems on layer-adapted meshes, such that the error can be estimated uniformly and in optimal order in the associated LPS-norm, which is stronger than the standard energy norm. Numerical results confirm the theoretical findings. © 2017 Springer Science+Business Media Dordrecht

Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are “rare subtypes” of chorioretinal neovascularisation and are distinguished by their distinct morphology and the sometimes worse response to therapy. Chorioretinal anastomosis, severe exsudates with serosanguinous pigment epithelial detachment and, in PCV, orange-red lesions in the papillomacular bundle can be diagnostic. Indocyanine green angiography (ICGA) is considered the gold standard for diagnosis of PCV and delivers important information for RAP too. Typical characteristics of PCV include foci of hyperfluoresence, with pulsatile filling in the early phase. This characterises choroidal polypoidal lesions, often in connection with an abnormal choroidal vascular network. In RAP, typical retino-retinal anastomosis can be identified, in particular in areas with pigment epithelial detachment. Optical coherence tomography (OCT) can complement diagnostic testing. In cases of RAP, early therapy initiation with intravitreal anti-VEGF is crucial for the prognosis of visual acuity. PCV can exhibit spontaneous regression. In active disease, photodynamic therapy (PDT) is efficient in the closure of PCV polyps. In association with CNV, it makes sense to combine PDT and intravitreal anti-VEGF medication. In spite of the initial increase in visual acuity, this state is normally “only” stabilised in the long term. In patients with idiopathic secondary CNV membranes (high myopia, post-inflammatory, post-traumatic changes or in hereditary connective tissue diseases), small “classical” type 2 membranes are mostly involved. Hence, these are strictly speaking not directly rare subtypes. Nevertheless, these patients are mostly younger, with less protracted illness and limited available regeneration ability of the retinal pigment epithelium (RPE): they may therefore differ favourably from the courses with nAMD, with earlier inactivation and with fewer required anti-VEGF injections. CNV with angioid streaks are a special case in this group. Unfortunately, these lesions have a recurrent, protracted and, in the end, mostly frustrating course. Copyright © 2016, Georg Thieme Verlag KG. All rights reserved.

Reimann M.,TU Dresden
International Journal of Obesity | Year: 2017

Background and Objective:Although there is strong evidence linking obesity with increased sympathoneural activity, involvement of the adrenal medulla is less clear. We therefore investigated adrenal medullary function under fasting and feeding conditions in normal weight (NW, n=33), overweight (OW, n=28) and obese (OB, n=36) adults (59% women).Subjects and Methods:Ninety-seven healthy adults participated in a cross-sectional study with recruitment stratified according to BMI. Plasma for catecholamines and metanephrines was sampled in the fasting state, at 30-min intervals during a 120-min glucose tolerance test and during an euglycaemic-hyperinsulinaemic clamp (40 mU m-2 min-1 insulin dose). Body composition was determined by leg-to-leg bioelectrical impedance analysis.Results:Obese subjects had the lowest fasting plasma concentrations of epinephrine (NW: 0.17, 95% confidence interval (CI): 0.14–0.20 nmol l-1; OW: 0.16, 95% CI: 0.12–0.19 nmol l-1; OB: 0.11, 95% CI: 0.08–0.13 nmol l-1; P=0.018) and metanephrine (NW: 0.17, 95% CI: 0.15–0.19 nmol l-1; OW: 0.15, 95% CI: 0.13–0.16 nmol l-1; OB: 0.13, 95% CI: 0.12–0.15 nmol l-1; P=0.022), the latter reflecting adrenal medullary store size. Fasting plasma epinephrine (r=−0.437; P<0.001) and metanephrine (r=−0.477; P<0.001) concentrations were additionally inversely correlated with whole-body fat percentage. Suppression of epinephrine secretion in response to carbohydrate ingestion was significantly blunted in overweight and obese subjects compared with the normal weight subjects (Pinteraction=0.045). Most of the variance in basal epinephrine was related to whole-body fat percentage (β=−0.389, 95% CI: −0.09 to −0.69; P=0.012) that explained the lower concentrations of epinephrine and metanephrine in women than men.Conclusions:We provide evidence that adrenomedullary dysfunction is a characteristic feature of obesity that involves both reduced adrenal secretion of epinephrine and size of adrenal medullary epinephrine stores.International Journal of Obesity advance online publication, 28 February 2017; doi:10.1038/ijo.2017.36. © 2017 Macmillan Publishers Limited, part of Springer Nature.

Altman E.,Weizmann Institute of Science | Sieberer L.M.,University of Innsbruck | Chen L.,China University of Mining and Technology | Diehl S.,University of Innsbruck | And 2 more authors.
Physical Review X | Year: 2015

Fluids of exciton polaritons, excitations of two-dimensional quantum wells in optical cavities, show collective phenomena akin to Bose condensation. However, a fundamental difference from standard condensates stems from the finite lifetime of these excitations, which necessitates continuous driving to maintain a steady state. A basic question is whether a two-dimensional condensate with long-range algebraic correlations can exist under these nonequilibrium conditions. Here, we show that such driven two-dimensional Bose systems cannot exhibit algebraic superfluid order except in low-symmetry, strongly anisotropic systems. Our result implies, in particular, that recent apparent evidence for Bose condensation of exciton polaritons must be an intermediate-scale crossover phenomenon, while the true long-distance correlations fall off exponentially. We obtain these results through a mapping of the long-wavelength condensate dynamics onto the anisotropic Kardar-Parisi-Zhang equation.

Ganz J.,University of Oregon | Brand M.,TU Dresden
Cold Spring Harbor Perspectives in Biology | Year: 2016

Teleost fish have a remarkable neurogenic and regenerative capacity in the adult throughout the rostrocaudal axis of the brain. The distribution of proliferation zones shows a remarkable conservation, even in distantly related teleost species, suggesting a common teleost ground plan of proliferation zones. There are different progenitor populations in the neurogenic niches—progenitors positive for radial glial markers (dorsal telencephalon, hypothalamus) and progenitors with neuroepithelial-like characteristics (ventral telencephalon, optic tectum, cerebellum). Definition of these progenitors has allowed studying their role in normal growth of the adult brain, but also when challenged following a lesion. From these studies, important roles have emerged for intrinsic mechanisms and extrinsic signals controlling the activation of adult neurogenesis that enable regeneration of the adult brain to occur, opening up new perspectives on rekindling regeneration also in the context of the mammalian brain. © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

Trolle M.L.,University of Aalborg | Seifert G.,TU Dresden | Pedersen T.G.,University of Aalborg
Physical Review B - Condensed Matter and Materials Physics | Year: 2014

Recent experimental results have demonstrated the ability of monolayer MoS2 to efficiently generate second harmonic fields with susceptibilities between 0.1 and 100 nm/V. However, few theoretical calculations exist with which to interpret these findings. In particular, it is of interest to theoretically estimate the modulus of the second harmonic response since experimental reports on this differ by almost three orders of magnitude. Here, we present calculations of the second harmonic response based on a tight-binding band structure and implementation of excitons in a Bethe-Salpeter framework. We compare directly with recent experimental findings demonstrating a good agreement with the excitonic theory regarding, e.g., peak position. Furthermore, we predict an off-resonance susceptibility on the order of 0.1 nm/V, while on-resonance values rise to 4 nm/V. © 2014 American Physical Society.

Haroske G.,TU Dresden
Current Opinion in Rheumatology | Year: 2011

Purpose of review: To describe current progress in understanding pyoderma gangraenosum, illustrate clinical observations and discuss therapeutic interventions. Recent findings: The proline-rich, glutamic acid-rich, serine-rich and threonine-rich (PEST) family of protein tyrosine phosphatases is a critical regulator of adhesion and migration. PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. This pathway seems to be involved in diseases related to pyoderma gangraenosum such as chronic inflammatory bowel disease and aseptic abscesses syndrome. Pyoderma gangraenosum is one of the most common extra-intestinal manifestations of chronic inflammatory bowel disease. In multivariate analyses, pyoderma gangraenosum was significantly and independently associated with black African origin, familial history of ulcerative colitis, uninterrupted pancolitis as the initial location of inflammatory bowel disease, permanent stoma, eye involvement and erythema nodosum. The treatment of choice for idiopathic pyoderma gangraenosum is systemic corticosteroids but cyclosporine A, mycophenolate mofetil and tumour necrosis factor-alpha inhibitors have been successful to control pyoderma gangraenosum as second line or adjuvant options. In addition, small studies have been published with successful therapeutic intervention using alefacept, visilizumab or anakinra but controlled trials are warranted. Although systemic immunosuppressants remain the choice therapy for most cases of pyoderma gangraenosum, a local approach should be considered in localized disease. Recently, topical tacrolimus has successfully been used as an off-label drug in localized disease. Summary: By a better understanding of the underlying pathology and recent drug developments patients with pyoderma gangraenosum will benefit. For several new drugs, however, controlled trials are warranted. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Lupo A.,TU Dresden | Coyne S.,Leibniz Institute for Natural Product Research and Infection Biology | Berendonk T.U.,TU Dresden
Frontiers in Microbiology | Year: 2012

The environment, and especially freshwater, constitutes a reactor where the evolution and the rise of new resistances occur. In water bodies such as waste water effluents, lakes, and rivers or streams, bacteria from different sources, e.g., urban, industrial, and agricultural waste, probably selected by intensive antibiotic usage, are collected and mixed with environmental species. This may cause two effects on the development of antibiotic resistances: first, the contamination of water by antibiotics or other pollutants lead to the rise of resistances due to selection processes, for instance, of strains over-expressing broad range defensive mechanisms, such as efflux pumps. Second, since environmental species are provided with intrinsic antibiotic resistance mechanisms, the mixture with allochthonous species is likely to cause genetic exchange. In this context, the role of phagesand integrons for the spread of resistance mechanisms appears significant. Allochthonous species could acquire new resistances from environmental donors and introduce the newly acquired resistance mechanisms into the clinics. This is illustrated by clinically relevant resistance mechanisms, such as the fluoroquinolones resistance genes qnr. Freshwater appears to play an important role in the emergence and in the spread of antibiotic resistances, highlighting the necessity for strategies of water quality improvement. We assume that further knowledge is needed to better understand the role of the environment as reservoir of antibiotic resistances and to elucidate the link between environmental pollution by anthropogenic pressures and emergence of antibiotic resistances. Only an integrated vision of these two aspects can provide elements to assess the risk of spread of antibiotic resistances via water bodies and suggest, in this context, solutions for this urgent health issue. © 2012 Lupo, Coyneand Berendonk.

Eke I.,National Center for Radiation Research And Technology | Cordes N.,National Center for Radiation Research And Technology | Cordes N.,TU Dresden
Radiotherapy and Oncology | Year: 2011

Translational research is essential to find new therapeutic approaches to improve cancer patient survival. Despite extensive efforts in preclinical studies, many novel therapies fail to turn out to be translational from bench to beside. Therefore, new models better reflecting the conditions in vivo are needed to generate results, which transfer reliably into the clinic. The use of three-dimensional (3D) cell culture models has provided new emerging insights into the understanding of cellular behavior upon cancer therapies. Interestingly, cells cultured in a 3D extracellular matrix are more radio- and chemoresistant than cells grown under conventional 2D conditions. In this review, we summarize and discuss underlying mechanisms of this phenomenon including integrin-mediated cell-matrix interactions, cell shape, nuclear organization and chromatin structure. Identifying the molecular differences between 2D and 3D cultured cells will offer the opportunity to improve our research and widen our therapeutic possibilities against cancer. © 2011 Elsevier Ireland Ltd. All rights reserved.

Eke I.,National Center for Radiation Research And Technology | Cordes N.,National Center for Radiation Research And Technology | Cordes N.,TU Dresden
Radiotherapy and Oncology | Year: 2011

Purpose: Epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK) show frequent overexpression and hyperactivity in various human malignancies including head and neck squamous cell carcinomas (HNSCC). To examine effects of dual EGFR/FAK inhibition on cellular radiosensitivity of HNSCC cells in a more physiological environment, we employed a previously established laminin-rich extracellular matrix (lrECM) based three-dimensional (3D) cell culture model. Materials and methods: UTSCC15 and SAS HNSCC cell lines stably transfected with EGFR-CFP or CFP were used. Single or combined EGFR (Cetuximab, siRNA) and FAK (TAE226, siRNA) inhibition were accomplished prior to measuring clonogenic survival and protein expression and phosphorylation. Immunofluorescence enabled visualization of EGFR-CFP and FAK. Results: Cetuximab resulted in higher radiosensitization in EGFR-CFP overexpressing cell lines than CFP controls. Single EGFR or FAK inhibition mediated radiosensitization, while dual EGFR/FAK targeting further augmented this effect. Despite signaling alterations upon Cetuximab and siRNA knockdown, analysis of protein expression and phosphorylation indicates EGFR and FAK signaling coexistence without obvious overlap. Conclusions: Combined EGFR/FAK targeting yielded stronger radiosensitization than either approach alone, which might be based on non-overlapping downstream signaling. Whether dual targeting of EGFR and FAK can reasonably be combined with radiotherapy and chemotherapy needs clarification. © 2011 Elsevier Ireland Ltd. All rights reserved.

Balasuriya S.,University of Adelaide | Padberg-Gehle K.,TU Dresden
Physica D: Nonlinear Phenomena | Year: 2014

We outline a method for controlling the location of stable and unstable manifolds in the following sense. From a known location of the stable and unstable manifolds in a steady two-dimensional flow, the primary segments of the manifolds are to be moved to a user-specified time-varying location which is near the steady location. We determine the nonautonomous perturbation to the vector field required to achieve this control, and give a theoretical bound for the error in the manifolds resulting from applying this control. The efficacy of the control strategy is illustrated via a numerical example. ©2014 Elsevier B.V. All rights reserved.

Kamphuisen P.W.,University of Groningen | Beyer-Westendorf J.,TU Dresden
Thrombosis Research | Year: 2014

Patients with cancer have an increased risk of bleeding complications, of which some are fatal. This risk is influenced by chemotherapy, cancer type and stage, thrombocytopenia, renal function, and previous bleeding. Since many cancer patients receive anticoagulant treatment for prophylaxis or treatment of venous thromboembolism (VTE), bleeding complications are a challenge in clinical practice. This review article focuses on the overall bleeding risk of cancer patients and the risk of major and clinically relevant bleeding associated with anticoagulant treatment, such as vitamin K antagonists, LMWH and the direct oral anticoagulants. It also describes strategies for individual risk assessments. © 2014 Elsevier Ltd. All rights reserved. © 2014 Elsevier Ltd.

Beyer-Westendorf J.,TU Dresden
Journal of Thrombosis and Haemostasis | Year: 2011

Currently, few topics in the field of anticoagulant therapy are as intensely discussed as the question: which is the best new oral anticoagulant? The most advanced substances in this field are the oral direct factor Xa-inhibitors rivaroxaban, apixaban and edoxaban and the oral direct thrombin inhibitor dabigatran. All of these substances are currently being tested in very similar phase III trials or are in the process of approval. In these trials, open-label or double-blind double-dummy designs are being used to evaluate the efficacy and safety in prevention and treatment of venous thromboembolism or stroke prevention in atrial fibrillation in several thousands of patients. As a consequence, an intense discussion of the advantages and disadvantages of open-label or double-blind trials is currently under way and interpretation of trial results is often focused on this matter. In general, a blinded trial is regarded as being less subject to bias than an open trial because it minimizes the impact of knowledge of treatment allocation on post-randomized treatment decisions and on reporting of outcomes. However, a blinded trial is not always feasible. Thus, in some respects, the two trial designs offer complementary strengths and weaknesses. This review addresses the risks of bias for internal and external validity of open-label and double-blind anticoagulation trials to help to objectify this debate. © 2011 International Society on Thrombosis and Haemostasis.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.6.2 | Award Amount: 4.79M | Year: 2011

The objective of ISES is to develop ICT building blocks to integrate, complement and empower existing tools for design and operation management to a Virtual Energy Lab (VEL). This will allow evaluating, simulating and optimizing the energy efficiency of products for built facilities and facility components in variations of real life scenarios before their realization, acknowledging the stochastic life-cycle nature.\nThe focus is on buildings, factories and warehouses because in buildings about 40% of the global energy is used and 30% of CO2 emissions and solid waste is created. There is a huge market for more energy-efficient design of new buildings and for refurbishing of the huge building stock through energy-efficient component products.\nThe goal of the project is to increase, by an order of magnitude, the quality of energy-efficiency in design through the development of an In-Silico Energy Simulator Laboratory, based on an interoperable ontology-supported platform.\nThe focus of the RTD work is on multi-model design and testing, stochastic lifecycle analysis/simulation in combination with new supporting ontology and interoperability tools and services, and respective re-engineering of existing tools, making them more intelligent and smartly interoperable. Further goals are the combination of energy profile models with product development STEP models and building and facility BIM models.\nThe VEL will be configured as an ontology-controlled SOA system with distributed services, distributed modelling and analysis/simulation tools and distributed data sources. This will allow concentrating the RTD work on ICT gaps, whereas existing, market-proof services, tools and data sources can be incorporated nearly development-free. The extended focus is on: (1) the development of optimal support for inventing and using innovative faade elements, and (2) the elaboration of the optimal computable stochastic model in relation to the design phase in order to make stochastic considerations applicable in daily practice.

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 74.61M | Year: 2013

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.\nOur main scientific and technological objectives in the different tiers of the value chain are to develop material technologies for ICT and beyond, identify new device concepts enabled by graphene and other layered materials, and integrate them to systems that provide new functionalities and open new application areas.\nThese objectives are supported by operative targets to bring together a large core consortium of European academic and industrial partners and to create a highly effective technology transfer highway, allowing industry to rapidly absorb and exploit new discoveries.\nThe Flagship will be aligned with European and national priorities to guarantee its successful long term operation and maximal impact on the national industrial and research communities.\nTogether, the scientific and technological objectives and operative targets will allow us to reach our societal goals: the Flagship will contribute to sustainable development by introducing new energy efficient and environmentally friendly products based on carbon and other abundant, safe and recyclable natural resources, and boost economic growth in Europe by creating new jobs and investment opportunities.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-3.3-3 | Award Amount: 4.01M | Year: 2009

AMPHORA is a Europe wide project involving researches and research institutions from 14 European countries, and counterparts and organizations from all 27 Member States, that will provide new scientific evidence for the best public health measures to reduce the harm done by alcohol through addressing social and cultural determinants, marketing and advertising, taxes and pricing, availability and access, early diagnosis and treatment of disease, interventions in drinking environments, and safer untaxed alcohol products. Cost effectiveness analyses will be undertaken in multiple settings, geographical regions, and for different gender and age groups to guide integrated policy making to reduce the harm done by alcohol. Using time series analysis, longitudinal intervention research, policy mapping, cost effectiveness analyses, and other policy relevant research methodologies, recent and current alcohol policy changes will be evaluated throughout European Member States. Current alcohol policy related infrastructures will be documented and their impact on effective policy development and implementation analyzed. The interaction between social and cultural determinants of alcohol policy and policy and preventive measures will be studied to determine the extent to which the implementation and impact of effective alcohol policies is culturally determined. Methodologies will be developed to allow tools for benchmarking and comparative analysis at the European level, advancing the state of the art in alcohol policy research and enhancing cooperation between researchers in Europe and other geographic regions to promote integration and excellence of European research in alcohol policy. AMPHORA will provide the evidence base to inform policy and decision makers at European, national and local levels to implement effective interventions to reduce the harm done by alcohol throughout a wide range of policies implemented in different sectors and settings.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 15.49M | Year: 2010

QoSMOS is a 3-year Integrated Project that aims at researching, developing and integrating a Cognitive Radio (CR) framework to enable mobile broadband systems to improve utilisation of licensed and/or unlicensed bands, by adding dynamic exploitation of under-utilised spectrum. The technical focus is on opportunistic use of spectrum combined with managed Quality of Service (QoS) and seamless mobility.\n\nEfficient use of spectrum and energy, co-existence with and protection of other services, a good and affordable user experience, and opening up of the mobile markets are the driving forces behind QoSMOS. A new two-tier process is proposed for spectrum management to simplify, and hence reduce the cost of, the access network management system and yet provide managed QoS. New dynamic spectrum sensing and usage metrics are required so that decisions can be taken on spectrum occupancy. Mobility is enhanced by new hand-off processes that can include pre-assignment of resources. System simulations and test-beds will be used for proving and assessing the cognitive algorithms and wireless hardware technology innovations. The result will be the availability of a CR framework with rules that can be adapted for different regulatory regimes and stakeholders prepared for its exploitation.\n\nQoSMOS is timely because spectrum policy is becoming increasingly liberalised and stakeholders are pressing for its exploitation. Regulators, government, manufacturers, network operators, service providers and users are expecting an impact from the technology. The 2011 World Radio Conference is mid-way through the project where exploitation decisions for Europe will be taken.\n\nThe framework and mechanisms developed in QoSMOS will adapt to the different regulatory domains across Europe. Barriers to new mobile markets will be lowered, enabling new business opportunities right across the value chain from vendors to service providers, which will be equally beneficial to all European countries.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2013.2.2-4 | Award Amount: 5.43M | Year: 2013

The multidisciplinary consortium of the NanoCaTe project will develop a more efficient thermoelectric- and storage material based on nanocarbon (e.g. graphene and CNT) to reclaim waste heat by thermoelectric generators and to storage the energy in super capacitors or secondary batteries for manifold applications like pulsed sensors or mobile electronic devices. The integration of the developed materials into harvester and storage devices is a further step to characterize the performance of the innovative materials. Finally, a demonstrator consisting of harvester, storage and energy management represents a self-sustaining, universally usable, and maintenance-free power supply. The project will substantially strengthen the position of Europe in the field of thermoelectric and storage materials by developing devices with increased lifetime produced by cost-efficient technologies and therefore contributing to a further promotion of cleaner energy technologies.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-2.2-1 | Award Amount: 27.17M | Year: 2009

The call 4.2.2-1 organic materials for electronics and photonics is based on the observation that the limited availability of high-performance multi-functional materials is a roadblock to further industrial progress. To address the wide scope of the call, we have identified specific materials bottlenecks to the fields of electronics and photonics. They constitute the focal points of our project. One-P main objective is: to invent, design, synthesize, characterize, process, and to supply the missing materials in the fields of organic electronics and photonics and to develop appropriate patterning methods for micro- and nano-structuring of these materials that can be up-scaled to roll-to-roll technologies. The work plan is composed of five technical workpackages, each one addressing current materials challenges: 1) charge transport and injection, 2) detection and sensing, 3) light emission, 4) functional self-assembled monolayers, 5) continuous processing and technology. Computer-aided design of materials and the use of advanced characterization tools are transversal activities that are integrated in technical workpackages. The sixth workpackage is devoted to dissemination, exploitation, and management of intellectual properties that are essential for the project success. To carry out this multi-disciplinary project, a cross-sectorial consortium has been formed at the European level. It is composed of strong academic and industrial teams with necessary and complementary expertises to cover all scientific, technological and exploitation aspects. The project will generate fundamental knowledge and help to develop unprecedented technologies. They will have a positive impact on competitiveness of European industries, environment, job creation, health, security, safety, and welfare of European citizens

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST-2007-4.1-05 | Award Amount: 5.18M | Year: 2008

The European Urban Guided Transport sector (Light rails, Metros, but also Tramways and Regional Commuter trains) is still characterized by a highly diversified landscape of Safety Requirements, Safety Models, Responsibilities, Roles, Safety Approval, Acceptance and Certification Schemes. While a certain convergence in architectures and systems can be observed the safety life cycle still differs from country to country and in some cases even within one country. Furthermore security items occur more and more as vital for the urban transport sector. In some cases these items are linked to the safety of the urban transport systems. In this context safety is seen as everything dealing with the methods and techniques to avoid accidents. Security is concerned with the protection of persons and the system from criminal acts. The state of the art will be analysed, merged into harmonized and agreed joint safety packages and extended by still missing elements to strengthen excellence of European surface transport. The MODSafe consortium aims at providing for the first time a coherent and agreed Hazards Analysis and Risk Analysis. Also, beyond todays scattered landscape the MODSafe partners will for the first time define agreed safety requirements for the safety related functions of an urban guided transport system. In order to achieve such a safety requirements allocation it is necessary to construct a functional and Object Safety Model of an urban guided transport system. This model will be based on currently running and previous European projects. It will thereby utilise and test the existing knowledge and R&D results. Finally, MODSafe will develop an agreed process and layout for generic safety proofs for urban guided transport safety systems in order to improve future cross acceptances.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.3-1 | Award Amount: 7.79M | Year: 2008

The earliest currently identifiable process in the pathogenesis of type 1 diabetes (T1D) is the development of autoimmunity to islet beta cells in the form of autoantibodies. Hindering attempts to prevent autoimmune T1D, the aetiology and pathogenesis of the islet auto-immunization, including whether it is preceded by metabolic abnormalities and cell-mediated autoimmunity, is still poorly understood. To overcome this, DIAPREPP will focus on the early auto-immunization against islet antigens, in particular to disclose events preceding current autoantibody markers. The concept is that events prior to auto-immunization govern the likelihood and signature of immunization, which in turn determines progression to disease. The overall objective is to determine mechanisms of islet autoantigen immunization. In a truly collaborative manner, and through five S/T workpackages plus three dedicated to dissemination, training, and management, DIAPREPP will 1. provide a unique set of clinical material that includes a case-control cohort representative of the worlds largest studies of pre-T1D, with follow-up and samples from birth, and pancreatic islets and lymph nodes from patients; 2. investigate the effects of environmental exposure to infections on islet cells and immune cells; 3. perform extensive metabolomic analysis of pre-autoimmune samples and in relevant animal models to test mechanistic hypotheses of auto-immunization; 4. carry out detailed analyses of early autoimmune responses with a special focus on autoreactive CD8\ T cells; and 5. apply findings to ongoing prevention studies. The expected impact of DIAPREPP is new fundamental knowledge regarding how 1. immunization against islet autoantigens can occur; 2. signs of self-immunization can be exploited for prediction and monitoring of disease; and 3. the immunization or its progression to islet beta cell destruction and T1D development can be prevented.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-17-2014 | Award Amount: 6.90M | Year: 2015

ALISE is a pan European collaboration focused on the development and commercial scale-up of new materials and on the understanding of the electrochemical processes involved in the lithium sulphur technology. It aims to create impact by developing innovative battery technology capable of fulfilling the expected and characteristics from European Automotive Industry needs, European Materials Roadmap, Social factors from vehicle consumers and future competitiveness trends and European Companies positioning. The project is focused to achieve 500 Wh/Kg stable LiS cell. The project involves dedicated durability, testing and LCA activities that will make sure the safety and adequate cyclability of battery being developed and available at competitive cost. Initial materials research will be scaled up during the project so that pilot scale quantities of the new materials will be introduced into the novel cell designs thus giving the following advancements over the current state of the art. The project approach will bring real breakthrough regarding new components, cell integration and architecture associated. New materials will be developed and optimized regarding anode, cathode, electrolyte and separator. Complete panels of specific tools and modelling associated will be developed from the unit cell to the batteries pack. Activities are focused on the elaboration of new materials and processes at TRL4. Demonstration of the lithium sulphur technology will be until batteries pack levels with validation onboard. Validation of prototype (17 kWh) with its driving range corresponding (100 km) will be done on circuit. ALISE is more than a linear bottom-up approach from materials to cell. ALISE shows strong resources to achieve a stable unit cell, with a supplementary top-down approach from the final application to the optimization of the unit cell.

Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-02-2014 | Award Amount: 87.61M | Year: 2015

The key objective of PowerBase Enhanced substrates and GaN pilot lines enabling compact power applications is to ensure the availability of Electronic Components and Systems (ECS) for key markets and for addressing societal challenges, aiming at keeping Europe at the forefront of the technology development, bridging the gap between research and exploitation, creating economic and employment growth in the European Union. The project PowerBase aims to contribute to the industrial ambition of value creation in Europe and fully supports this vision by addressing key topics of ECSEL multi annual strategic plan 2014. By positioning PowerBase as innovation action a clear focus on exploitation of the expected result is primary goal. To expand the limits in current power semiconductor technologies the project focuses on setting up a qualified wide band gap GaN technology Pilot line, on expanding the limits of todays silicon based substrate materials for power semiconductors, improving manufacturing efficiency by innovative automation, setting up of a GaN compatible chip embedding pilot line and demonstrating innovation potential in leading compact power application domains. PowerBase is a project proposal with a vertical supply chain involved with contributions from partners in 7 European countries. This spans expertise from raw material research, process innovation, pilot line, assembly innovation and pilot line up to various application domains representing enhanced smart systems. The supporting partners consist of market leaders in their domain, having excellent technological background, which are fully committed to achieve the very challenging project goals. The project PowerBase aims to have significant impact on mart regions. High tech jobs in the area of semiconductor technologies and micro/nano electronics in general are expressed core competences of the regions Austria: Carinthia, Styria, Germany: Sachsen, Bavaria and many other countries/ regions involved.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EE-03-2014 | Award Amount: 5.33M | Year: 2015

RIBuild will strengthen the knowledge on how and under what conditions internal thermal insulation is to be implemented in historic buildings, without compromising their architectural and cultural values, with an acceptable safety level against deterioration and collapse of heavy external wall structures. The general objective of RIBuild is to develop effective, comprehensive decision guidelines to optimise the design and implementation of internal thermal insulation in historic buildings across the EU. RIBuild focuses on heavy external walls made of stone, brick and timber framing, as most historic buildings are made of these materials. The general objective is achieved through three main activities To obtain a thorough knowledge level to characterise the eligibility of the building for a deep internal thermal insulation renovation. This knowledge is obtained through screening of historic buildings, investigation of material properties and threshold values for failure To determine the conditions under which different internal insulation measures are reliable and affordable measures based on probabilistic modelling of the hygrothermal performance, the environmental impact and the cost/benefit To develop a set of comprehensive decision guidelines, which are demonstrated in a number of buildings. RIBuild addresses the most difficult retrofitting measure of historic buildings: internal thermal insulation. The adaption of knowledge developed by RIBuild contributes to sustainable historic buildings with improved energy efficiency implying an easier conversion of energy supply from inefficient fossil fuels to efficient renewable energy sources. RIBuild also assesses the hygrothermal performance of the building construction, thus no collateral damage occurs; in case of failure an easy roll back of the measures is possible. The guidelines developed in RIBuild strongly support the deep and holistic retrofitting approach which historic buildings face in the coming years.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2010.2.1.2-3 | Award Amount: 3.88M | Year: 2010

SYSPATHO focuses on the development of novel and generally applicable mathematical methods and algorithms for systems biology. These methods and algorithms will be applied to study the complex interactions of hepatitis C virus (HCV), a human-pathogenic virus of high medical relevance, with its host at the systems level. Using a multidisciplinary, integrative approach, PATHOSYS will (a) develop methods to analyze and integrate a wide variety of data from wet lab experiments, databases and biological literature, (b) develop and apply machine learning tools to reconstruct and study intracellular interaction networks from experimental data, (c) develop new and improve existing algorithms and mathematical methods for bottom-up modelling, to fit models to data, and to analyze the dynamic behaviour of models (d) generate new experimental data to gain novel insights into hepatitis C virus host interactions, and (e) use the newly developed methods and data to model and analyze HCV-host interactions at the systems level. Guided by biological data, PATHOSYS focuses on the design of novel algorithms and mathematical methods for systems biology, with the aim to provide generally applicable tools to elucidate biological processes. Based on developed models and using systems analysis, PATHOSYS will elucidate virus host interactions of Hepatitis C virus at an unprecedented level. As a direct spin-off, models and analysis methods developed in PATHOSYS will lead to the identification of new candidate host cell target genes applicable for the design of novel anti-viral drugs against hepatitis C. Targeting of host cell factors will reduce the likelihood for the development of therapy resistance and increase the chance for broad-spectrum antivirals. Inclusion of two SME partners will ensure exploitation of results generated in PATHOSYS and their transfer into industrial and pharmaceutical applications, thus strengthening economy and health care system in Europe.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: HEALTH-2007-3.4-1 | Award Amount: 877.37K | Year: 2009

Bipolar (BP) disorder is characterized by recurrent manic and depressive episodes, affecting more than 1% of the EU population. Delay in the diagnosis (based only on clinical features), uncertainties in the definition of episodes and on the treatment strategy best adapted to each patient lead to devastating socio-economic, professional and family consequences that be reverted by optimized diagnostic and treatment procedures. ENBREC is designed to build an EU-wide network of expert centres specialising in research and care on BP disorder, in order to integrate research efforts on the mechanism of disease, and on optimized diagnostic and treatment. Common tools and practice, training and information will help structuring the EU BP research community and translate research outcome into healthcare, as listed in the work packages: WP1: Management of the project WP2: Developing common tools for diagnosis and multinational cohort follow-up WP3: Developing common tools for cognitive assessment WP4: Assessment of common biomarkers and genetic markers WP5: Development of standards for imaging WP6: Treatment optimisation, definition of subgroups of responders WP7: Supporting multinational clinical research and data management WP8: Education, information, dissemination, translation of research outcomes into healthcare WP9: Extension to new countries and within the countries The consortium currently covers networks of BP expert centres reaching the critical mass in Germany, Italy, Norway, Spain, UK, and France (representing more than 300 Millions EU citizens), and plans to extend to other EU member states. It also includes ECRIN, the FP7 infrastructure providing support to multinational clinical studies. Integration of EU research and care on BP disorder will benefit EU patients and citizens, restore EU leadership in BP research, strengthen drug development in the EU, in line with the expectations of the Innovative Medicines Initiative strategic research agenda.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.4 | Award Amount: 4.56M | Year: 2008

ICT-eMuCo addresses the platform architecture of future mobile devices. This comprises the relevant controller elements as well as the operating system and application layers. It is expected that the computational performance needed by these devices will grow exponentially due to the growing number of features implemented and the advances in the wireless communication standards. The fast growing number of applications and the resulting diversification requires a co-existence of open and protected environments.It is therefore proposed to choose a multi-core architecture to get the best ratio of performance and power consumption while maintaining a high flexibility and scalability in the system through variations in number of cores, cache sizes, clock speeds etc. Existing multi-cores are taken as a starting point for the controller architecture. The actual implementation of e.g. the cache and memory system will be optimized to the specific needs as well as the extension by hardware accelerators for dedicated tasks.Virtualization technology will be employed to abstract the applications including potential legacy operating systems from the hardware architecture. This provides the means to separate real-time from non-real-time and secure from open domains. To account for the embedded nature of mobile devices and its limitations in performance and power consumption the virtualisation functionalities are supported by hardware where appropriate.The awareness for the existence of multi-cores must also arise at the programmers level. This is taken care of by a model-driven code generation technology based on SDL for typical communications protocol tasks and UML for the application development and modelling.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 14.80M | Year: 2010

Telecommunication networks and in particular mobile communications are increasingly contributing to global energy consumption. The EARTH proposal tackles the important issue of energy saving by enhancing the energy efficiency of mobile broadband systems thereby reducing CO2 emissions. It is a highly ambitious and unique proposal, applying an integrated approach to investigate the energy efficiency of mobile systems. EARTH has mobilized a consortium of all major stakeholders with serious efforts committed to the development of a new generation of energy efficient products, components, deployment strategies and energy-aware network management solutions. The target of EARTH is to enhance the energy efficiency of mobile systems by a factor of at least 50% compared with the current ones. It will investigate the energy efficiency limit that is theoretically and practically achievable whilst providing high capacity and uncompromised QoS. The proposal is primarily focused on mobile cellular systems, LTE and its evolution LTE-A, where potential impact on standardization is envisaged but it will also consider 3G (UMTS/HSPA) technology for immediate impact.\nThe tangible results of the EARTH project are: 1) Energy efficient deployment strategies, 2) Energy efficient network architectures, 3) New network management mechanisms, adaptive to load variations with time 4) Innovative component designs with energy efficient adaptive operating points, 5) New radio and network resource management protocols for multi-cell cooperative networking.\nThe new techniques will be validated using sophisticated simulation tools and in a mobile network test plant.\nTechnologies developed by EARTH will enable wireless communications systems with unprecedented energy efficiency, significant reduction in environment pollution and operating cost. EARTH plans to provide valuable and timely contributions to standardization, regulations processes and place Europe in a strong IPR position.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: HEALTH.2011.3.3-4 | Award Amount: 2.27M | Year: 2011

On the regional level, Europe has one of the highest levels of resources for mental health care. Despite this, the high burden and impact of mental disorders in Europe is expected to rise. ROAdmap for Mental health Research (ROAMER) is designed to develop a comprehensive, consensus-based roadmap to promote and integrate mental health and well-being research in Europe. Research advances and innovations are to be devoted to decreasing the burden of mental disorders and increasing the mental health and well-being of Europeans. ROAMER will combine a neutral, fact-based methodology with extensive stakeholder involvement in consultation and dissemination. During the kick-off phase, the methodology (including comprehensive EU-wide indicators to assess the current state of the art, gaps and advances) and the desired situation (scoping and objectives) will be finalised. Secondly, the current state of the art will be examined, using these tools. In the third phase, the desired situation will be compared with the current situation to identify gaps and advances. Phase four prioritises these gaps and advances, as well as solutions. In the fifth phase, this information is translated into roadmaps covering infrastructures, capacity building and funding strategies for scientific areas relevant to mental health and well-being: biomedical, psychological, social, economic and public health. Geographical, interdisciplinary, developmental, gender and age perspectives will be taken into account. To achieve consensus among a broad group of scientists, service users, carers, government and funding institutions and other stakeholders, ROAMER uses web-based surveys, scientific workshops, scientific advisory board meetings, stakeholder meetings, consensus meetings, and policy meetings. The consortium consists of leading experts in the field, and is well balanced in terms of geographical distribution and complementary expertises across all relevant aspects of mental health research.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: EeB.NMP.2013-5 | Award Amount: 6.47M | Year: 2013

17 partners from11 countries covering all building life cycle will develop an innovative Integrated Evolutionary Design Methodology that can allow the stakeholders to predict the current and future energy efficiency of buildings (both at individual level and neighbourhood level) and make better informed decision in optimising the energy performance at building life cycle level, including operation and maintenance. If we want to create long term energy efficient building we must not only consider the present building life cycle scenario but also VISUALIZE THE FUTURE. Visualizing the future will help us to design energy efficient building not only for the present but also for the future, ensuring an Energy Efficient Life Cycle of the building. Design4energy project will take this into consideration and will develop tools and methodologies that can help designing energy efficient buildings that can consider both short term performance as well as future scenarios, considering important factors such as deterioration curves, technology evolution, climate change effect, users, energy neighbourhood configuration, continuous commissioning alternatives while evaluating their impact in the Building Life Energy Performance. The continuous commissioning will include strategies as preventive maintenance,renovation of energy systems technologies (HVAC, RES, .) etc, including deep retrofitting strategies. The proposed methodology will be based on a sophisticated technology platform that will make use of energy attributes of building components, deterioration of building components and systems, neighborhood energy systems, energy related parameters, energy simulation tools and current usage parameters of the tenants , derived from maintenance and operation data. The technology platform developed within the Design4energy project will allow the stakeholders to explore various design options and make validated and qualified choices as early as possible, giving due consideratio

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 10.27M | Year: 2010

The number of networked humans will reach saturation by the middle of the next decade, while the number of networked devices will continue to increase dramatically for some time to come. The Wireless World Research Forum (WWRF) has set out a vision of the future where 7 trillion wireless devices will be serving 7 billion people by 2017. The vast majority of wireless traffic will be between machines in remote locations. However, wireless communication networks have been designed mainly with human users in mind. And while scale and type of M2M applications are growing rapidly over todays cellular networks, they are still defined following mainly humans communication requirements. To meet the requirements of M2M applications, a new kind of network is needed to serve efficiently a huge number of devices which may have rather modest communications needs.\nThe project will work towards meeting following main aims:\n To develop and provide a new architecture to support efficient and cost-effective wireless M2M communications.\n To provide energy efficient wide area coverage for M2M applications such as wireless sensor networks.\n To extend the scalability of the LTE infrastructure with the aim to extend the range of applications to very cost sensitive mobile narrowband applications.\n To develop a cost, spectrum and energy efficient radio access technology for M2M applications, adapted to coexist within a high capacity LTE network.\n To increase energy efficiency of devices, as they may need to be autonomous for months or years. New sleep mode optimization and wake-up mechanisms will be developed within the LTE extensions.\nAchieving these aims, EXALTED will impact both the network and service infrastructure, and also the use and exploitation of LTE networks, thus boosting the European manufacturers and operators.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.1.1 | Award Amount: 11.35M | Year: 2014

Providing broadband wireless communications to a majority of European citizens is a major objective of the EC at the horizon of 2020. With a current annual growth rate in the range of 70%, the mobile data traffic of smartphones, tablets, machine-to-machine and other portable devices dramatically challenges the 4G wireless cellular network currently under deployment. To sustain this growth, high data-rate millimetre-wave (mmW) technologies, that demonstrate striking capabilities for short- and medium-range wireless communications, can bring a tremendous performance improvement.MiWaveS will develop the key technologies for the implementation of mmW wireless access and backhaul in future 5th Generation heterogeneous cellular mobile networks, taking advantage of the wide unlicensed or light-licensed frequency bands available to allow flexible spectrum usage as well as peak capacities above 10 Gbit/s aggregated throughput, well beyond the LTE-Advanced system. Installed in dense urban environments, miniature mmW small-cell access-points connected to the cellular network through optical fibre or mmW wireless backhaul will support massive data exchanges for mobile users with low latency, low interferences, high QoS and low power consumption per bit. They will also contribute to a reduced exposure of the public to electromagnetic fields (EMF) thanks to lower transmitted power and reduced skin penetration at mmW, steerable directive antennas focusing the signals in the directions of interest, and reduced data traffic through the lower frequency legacy base-stations.To lead this research in Europe, the MiWaveS consortium groups major network operators, equipment/component providers, OEMs, research institutes and academic institutions with world-known expertise in the relevant areas for designing and demonstrating heterogeneous cellular networks with mmW access and backhaul.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: EeB.NMP.2013-4 | Award Amount: 9.92M | Year: 2013

Today, Building Energy Performance Simulation (BEPS) analysis tends to show a large discrepancy with real energy performance. Most cases are due to gross mistakes rather than fundamental inadequacy of available technology and methods. The reasons are manifold. Highly simplified calculation methods are used far beyond their domain of validity. Assumed boundary conditions such as occupant behaviour are not in accordance with actual usage; gross malfunctions in control and HVAC systems are left undetected in the commissioning process, while thermal bridges and distribution system losses are left without attention. Moreover, metered and sub-metered data are not used efficiently in calculation tools and engineering based simulation models during the Measurement and Verification (M&V) phase. TRIBUTE aims at minimizing the gap between computed and measured energy performances through the improvement of the predictive capability of a state-of-the-art commercial BEPS. TRIBUTE will extend the use of this tool to the commissioning and operation stages of a building. For existing buildings, M&V techniques will be developed and deployed to connect the BEPS model in real time to the pivotal wireless sensing and control systems of a monitored building. This involves modelling building systems to a higher fidelity than done today, developing technology for on-line identification of building key parameters, and automatically adapting the on-line, real time BEPS to the actual buildings state. In addition, BHM and EFM application will compare measured data to the then improved predicted metrics and will enable detecting building deviations. Advanced data mining methods will help evaluate these deviations. Subsequent Energy Efficiency Diagnostic Rules and optimization methods will provide cost effective and corrective retrofit actions accordingly. The methodology and tools will be evaluated in the context of three different building types and locations.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.91M | Year: 2015

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics and engineering aiming at an in depth understanding of fundamental cellular mechanochemical principles. BIOPOL combines exactly this required expertise in one joint training program for young researchers. BIOPOL has assembled a unique multidisciplinary consortium bringing together top scientists from the fields of molecular/developmental cell biology, membrane physics, engineering as well as specialists from the private sector. The scientific objectives focus on understanding of fundamental mechanisms of cellular mechanosensing in health and disease, the role of external forces in cell division and mechanochemical regulation of cell polarity including tissue formation. Finally, part of BIOPOLs research program is the further development of cutting edge technologies like advanced atomic force microscopy, novel photonic tools like optical stretcher or innovative organ on a chip technology, exploiting physical cellular properties. BIOPOLs collaborative cutting edge research program is integral part of its training program provided to early stage researcher and is further translated into seven state of the art experimental training stations representing the consortiums expertise. In addition, BIOPOL has developed a 3 years modular curriculum including workshops, summerschools, Business plan competitions and conferences with a specific agenda of transferable skill training elements highly relevant for scientific communication, translational research and in particular entrepreneurship.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-21-2015 | Award Amount: 3.92M | Year: 2016

Transition from healthy status to Parkinsons Disease (PD) is vaguely tractable, since symptoms can be so subtle in the early stages that they go unnoticed. Lack of biomarkers and/or findings on routine MRI and CT scans, PD is left undiagnosed for years, gradually affecting the life of over 6.5 million of older adults (>55-60 yrs) worldwide, increasing the risk of their health deterioration. Epidemiological studies conclude that early intervention could have an inverse relation with the PD-related risks of progressive frailty, falls and emotional shift towards depression. Based on this evidence, the cardinal objective of i-PROGNOSIS is the development of (i) an ICT-based behavioural analysis approach for capturing, as early as possible, the PD symptoms appearance, and (ii) the application of ICT-based interventions countering identified risks. To achieve this, awareness initiatives will be employed, so as to construct i-PROGNOSIS community, targeting > 5000 older individuals within the duration of the project, in order to unobtrusively sense large scale behavioural data from its members, acquired from their natural use of mobile devices (smartphone/smartwatch). Ensuring anonymisation and secure Cloud archiving, i-PROGNOSIS will develop and employ advanced big data analytics and machine learning techniques, in a distributed and privacy aware fashion, so as to instantiate a PD Behavioural Model and construct reliable early PD symptoms detection alarms. To those identified and clinically validated as early stage PD patients, ICT-based interventions will be provided via the i-PROGNOSIS Intervention Platform, including: a) a Personalised Game Suite (ExerGames, DietaryGames, EmoGames, Handwriting/VoiceGames) for physical/emotional support, b) targeted nocturnal intervention to increase relaxation/sleep quality and c) assistive interventions for voice enhancement and gait rhythm guidance. In this way, i-PROGNOSIS will constructively contribute to active and healthy ageing.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-18-2015 | Award Amount: 6.31M | Year: 2016

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe. Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal intensive care, 45-50% of affected children die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective interventions, beside hypothermia, are warranted to further improve their outcome. Allopurinol is a xanthine oxidase inhibitor and reduces the production of oxygen radicals and brain damage in experimental, animal, and early human studies of ischemia and reperfusion. This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. Beyond this primary objective, the project will provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates. Furthermore it will give the opportunity to further develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions. Finally, this trial will extend our knowledge about incidence of and risk factors for perinatal asphyxia and HIE possibly enabling generation of more preventive strategies for the future.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ICT-38-2015 | Award Amount: 1.16M | Year: 2016

The aim of the 30-months PICASSO project is (1) to reinforce EU-US collaboration in ICT research and innovation focusing on the pre-competitive research in key enabling technologies related to societal challenges - 5G Networks, Big Data, Internet of Things and Cyber Physical Systems, and (2) to support the EU-US ICT policy dialogue by contributions related to e.g. privacy, security, internet governance, interoperability, ethics. PICASSO is oriented to industrial needs, provides a forum for ICT communities and involves 24 EU and US prominent specialists in the three technology-oriented ICT Expert Groups and an ICT Policy Expert Group, working closely together to identify policy gaps in the technology domains and to take measures to stimulate the policy dialogue in these areas. A synergy between experts in ICT policies and in ICT technologies is a unique feature of PICASSO. An analysis of the industrial drivers, societal needs, and priorities for EU-US ICT collaboration will be done, and policy gaps will be highlighted. An Opportunity Report will point out new avenues for EU-US research, innovation and policy collaboration. An ICT Industry Toolkit app will support companies and academia in exploiting collaboration opportunities. Policy briefs focusing on specific aspects of identified policy gaps will provide visibility for EU policies and propose ways forward. Strategic initiatives will be investigated and discussed, and a White Paper will be prepared. The outreach campaign will include 30\ events, success stories factsheets, info sessions and webinars. PICASSO will directly contribute to the strengthening of the European industrial leadership in ICT. PICASSOs approach will be integrative, inclusive, industry-driven, societally responsible and beneficial for both EU and US. It is supported by NIST, National Institute of Standard and Technology, US, and the European Cluster Alliance.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST-2007-4.1-01;SST-2007-4.1-02 | Award Amount: 5.28M | Year: 2009

Powered Two Wheeler (PTW) users are greatly over-involved in serious and fatal crashes. They have between 5 and 25 times the risk of having a fatal crash compared to car drivers, depending on the country. The number of PTWs on European roads has more than doubled over the last two decades. The recent MAIDS (Motorcycle Accident In-Depth Study) study of PTW crashes in Europe found that behavioural and ergonomic issues were major contributing factors to PTW crashes: the primary accident cause for PTW crashes was the failure of drivers to perceive two-wheelers; and human error was a major contributing factor to most crashes, for both PTW and car drivers. The majority of PTW crashes involved a collision with a car. Many large-scale research programs have been undertaken to understand the behavioural and ergonomic factors that contribute to crashes involving 4-wheeled vehicles. These have been effective in informing countermeasure development, which has led to significant reductions in crashes. To our knowledge, no comparable human factors and behavioural research programs have been initiated in the PTW domain, in Europe or elsewhere. The high rate of motorcycle-related deaths and injuries calls for new and refined countermeasures, deriving from solid behavioural and ergonomics research. In this proposal we outline an innovative program of research, involving partners from Europe, Israel and Australia, that directly targets those behavioural and ergonomic factors cited in the MAIDS study as contributing to PTW crashes. This includes research on crash causes and human error, the worlds first naturalistic riding study involving instrumented PTWs, research on motorcycle rider risk awareness and perception, the development of new research tools to support the research program, in-depth research on the factors that underlie driver failures to see PTWs and their riders, and the development of recommendations for practical countermeasures for enhancing PTW rider safety.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.2 | Award Amount: 3.96M | Year: 2008

A growing number of applications require the ability to analyze massive amounts of streaming data in real time. Examples of such applications are: market data processing, anti-spam and anti-virus filters for e-mail, network security systems for incoming IP traffic in organisation-wide networks, automatic trading, fraud detection for cellular telephony to analyze and correlate phone calls, fraud detection for credit cards, and e-services for verifying SLAs. Typically, such applications require strong analysis and processing capabilities, i.e., data mining, to discover facts of interest. Data analysis happens today on clusters of workstations using specialized middleware and applications. Although solutions for real-time processing of information flows already exist, current platforms and infrastructures phase three main limitations: (a) scalability, (b) autonomy, and (c) performance. STREAM aims at scaling system size by an order of magnitude, to 100s of nodes, achieving real-time processing of information flows, and providing unsupervised and autonomous operation. This will allow for much broader deployment of such products and services to new areas that need to manipulate large information flows in a cost-effective manner, and in particular, the Telecom, Financial, and E-services sectors.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST-2007-1.2-01;SST-2007-1.2-02 | Award Amount: 3.21M | Year: 2009

The majority of the European roads are paved with asphalt material. The dismantling and end of life strategies for these pavements are very divergent among the EU member states and the associated countries. In general the share of recycling the reclaimed asphalt in new asphalt courses is rather lower than it could be technically. The Re-road project aims to address these problems with a holistic approach to the technical and environmental aspects of all steps in the recycling procedures of asphalt material. The overall objectives of the project is to o be able to raise the level of re-use of asphalt concrete to 99% with a minimum of downgrading of the material and a minimal introduction of virgin material into the mixes made with reclaimed asphalt.

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-3.2-6 | Award Amount: 3.92M | Year: 2008

Reliable data on the prevalence and incidence of the spectrum of mental disorders in older people are currently lacking for the EU. Despite the availability of some national and a few cross-national cross-sectional studies with quite variable results, the size and burden of mental disorders in the elderly remains unclear. This has been attributed to a number of methodological factors (e.g. lack of appropriate diagnostic instruments). In addition patterns of incidence and of the natural course and prognosis of mental and physical disorders in people above 65 years are lacking nationally and cross-nationally in the EU, with only a few notable exceptions. Furthermore, there are no cross-national studies investigating the interaction of mental disorders and the utilisation of treatment under specific consideration of the severity and the impairment of activities and participation, in terms of ICF-categories, of older people in different European countries. Therefore, the objective of the proposed study is to (1) develop, respectively to adapt existing instruments and (2) to collect data on the prevalence, the incidence and on the natural course and prognosis of mental disorders, and to do this in sufficiently powered representative samples of older people living in the community across different European countries. This includes assessing health service needs, investigating to what extent existing services are used by older people and which specific barriers to utilisation may exist. Thereby, the implementation of the study will enable the further development and improvement of harmonised instruments for the assessment of impairments of activities and participation in older adults, to adapt already existing instruments, and to facilitate results that are comparable across cultures. Results will help to change health care in direct contact with people, and beyond this, they offer starting points for structural changes initiated on the level of health politics.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.6.5 | Award Amount: 4.54M | Year: 2010

The MIRABEL projects main goal is to develop a conceptual and infrastructural approach that allows energy distribution companies to efficiently manage higher amounts of renewable energy and balance supply and demand. Currently, most renewable energy sources (RES; e.g. windmills, solar panels) pose the challenge that the production depends on external factors, such as wind speed and direction, the amount of sunlight, etc. Hence, available power from RES can only be predicted but not planned, which makes it difficult for energy distributors to efficiently include RES into their daily schedules. As an unfortunate consequence, power from RES often has to be given away for free due to a lack of demand.\n\nThe objectives of the MIRABEL consortium are as follows:\n1. We will develop a model of actors with certain roles in the energy market and specify data to be exchanged between these actors.\n\n2. We will develop a concept of micro-requests to handle the energy demand and supply on a household level, together with methods\n- to forecast demand and supply based on historical and additional data, such as weather forecasts (both on a small scale, i.e. for households, and on a larger scale), and to update these predictions over time,\n- to aggregate and disaggregate the micro-requests on a regional level, and\n- to schedule energy production and consumption based on aggregated requests.\n\n3. We will design a distributed, decentralised and scalable infrastructure to handle the high data load from the mass of households. A prototypical system architecture and its revision will be developed.\n\n4. In order to test and demonstrate our approach, we will implement a demonstration system with the help of concrete trial scenarios and real-world data. These include a Transmission System Operator trial, a Local Distributor of Energy trial, and a community consumer trial.\n\n5. Standardised data exchange is required between consumers and brokers; between producers and brokers; among brokers themselves; and between brokers, large producers/consumers and grid operators. Standardisation is pursued throughout the project.\n\nThe project is led by SAP Research (Germany), a group that is very active in the area of advanced analytics and infrastructure development. SAP Research is associated to SAP, the worlds leading provider of BI solutions. With Aalborg Universitet (Denmark), TU Dresden (Germany), and the Joef Stefan Institute (Slovenia), the consortium includes two academic partners with a strong research background in data management and one leading research institute for applied research. The use case partners Energie Baden-Wrttemberg AG (Germany) and CRES (Greece) provide real data and facilities for testing. INEA (Slovenia) acts as a technology provider and contributes strong expertise in the energy sector. TNO (Netherlands) is a research organisation with experience in standardisation and utilities projects.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: EeB.ENV.2010.3.2.4-1 | Award Amount: 6.70M | Year: 2010

The project 3ENCULT bridges the gap between conservation of historic buildings and climate protection, which is not an antagonism at all: historic buildings will only survive if maintained as living space. Energy efficient retrofit is useful for structural protection as well as for comfort reasons - comfort for users and comfort for heritage collections. The joint task of conservation and energy efficient retrofit is highly interdisciplinary. The 3ENCULT consortium consists of scientists and stakeholders, especially on the level of SMEs, from the fields of diagnostics, conservation, building physics, sustainability, architecture and lighting up to cybernetics, thus guaranteeing both, the development of sustainable solutions and the impact on European economy. Eight case studies will demonstrate and verify solutions that are applicable to the majority of European built heritage in urban areas. Building owners and local historic preservation agencies are integrated in local case study teams. 3ENCULT will demonstrate the feasibility of Factor 4 to Factor 10 reduction in energy demand, depending on the case and the heritage value. The main objectives are the development of passive and active solutions for conservation and energy efficient retrofit including available products as well as new developments by involved SMEs, the definition of diagnosis and monitoring instruments, the long term monitoring (also for IEQ controlling) and the planning and evaluation tools and concepts supporting the implementation, the quality assurance and control of success of the energy retrofit measures. Guidelines will be disseminated to the scientific and public community. Finally, position papers will be issued suggesting possible integrations and/or implementations of the present regulation framework for improving energy efficiency of historic buildings in urban areas and in particular EPBD and Environmental Impact Assessment as well as Aalborg Commitments and Leipzig Charter.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: GC-ICT-2013.6.7 | Award Amount: 14.95M | Year: 2013

Modern societies are eagerly looking for the integration of mobility and their urban living area to enable reliable and safe transportation, better efficiency and cost, comfort and low emissions for the environment. The trends are obvious, however, providing a hybrid/electrical car is only one part of the full picture. The standard customer is still very reluctant to buy a full electrical vehicle (FEV). The reasons are manifold but the most important is unpredictable mileage and limited autonomy. The prediction of the cruising range without any restrictions in terms of safety and comfort is a key point: essential is D-P-C (Drive safely, Park easily and Charge conveniently).\n\nToday a nominal 100km range might vary from 50 to 130km in reality, depending on various conditions such as temperature and profile of the route. Increasing the capacity of the battery is no viable option because it results in a drastically increase in cost and weight of the car. Through eDAS we will limit the negative impact of high and low environment temperatures from -50% today to a maximum of -20% of the reachable range in electric vehicles, which corresponds to an improvement of 60% compared to state of the art. We will bring the infrastructure of the EV to the optimum operating temperature range for faster fast charging, pre-conditioned passenger compartment and battery, also safety and convenience features, such as de-iced windows during winter time based on the available infrastructure without adding cost and weight based on new designs and architecture combining battery, e-motor, electronics, charger and energy management.\n\nAddressing this challenge of the architecture of all subsystems of the complete EV requires a wide area of expertise, and in consequence leads to a large consortium. To develop and demonstrate the innovative hardware and software solutions, including new materials, adequate resources and budget are required.

The European electricity system is facing major challenges to implement a strategy for a reliable, competitive and sustainable electricity supply. The development and the renewal of the transmission infrastructure are central and recognised issues in this strategy. Indeed the transmission system is a complex and strongly interconnected infrastructure that offers a wide range of benefits like reliability improvement, promotion of competitive electricity markets and of economic growth, support for development of new generation and for exploitation of renewable resources. Within this context, the objective of REALISEGRID is to develop a set of criteria, metrics, methods and tools (hereinafter called framework) to assess how the transmission infrastructure should be optimally developed to support the achievement of a reliable, competitive and sustainable electricity supply in the European Union (EU). The project encompasses three main activity-packages: 1) identification of performances and costs of novel technologies aimed at increasing capacity, reliability and flexibility of the transmission infrastructure; 2) definition of long term scenarios for the EU power sector, characterized by different evolutions of demand and supply; 3) implementation of a framework to facilitate harmonisation of pan-European approaches to electricity infrastructure evolution and to evaluate the overall benefits of transmission expansion investments. The expected output of the project is fourfold: - Implementation of the framework to assess the benefits provided by transmission infrastructure development to the pan-European power system. - Preparation of a roadmap for the incorporation of new transmission technologies in the electricity networks. - Analysis of impacts of different scenarios on future electricity exchanges among European countries. - Testing and application of the framework for the cost-benefit analysis of specific transmission projects.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-2.4-1 | Award Amount: 7.65M | Year: 2009

The discovery of porous hybrid materials constructed from inorganic nodes and organic multifunctional linkers has established a new area of inorganic-organic hybrids (Metal-Organic Frameworks, MOFs) with extraordinary performance as compared to traditional porous solids such as zeolites and activated carbon. NanoMOF will focus beyond discovery and integrate MOFs into products with industrial impact within a strong cooperation of established MOF research institutions and industrial end users. The extraordinary properties of MOFs are expected to lead to a significant ecologic and economic impact in three areas: 1) Clean air, pollution, and toxicity risks of gaseous chemicals are environmental concerns with specific materials needs for selective adsorption in porous materials and advanced filter systems. Industrial feed gases and exhaust gases require a high purity to ensure durable processes and avoid pollution. The integration of MOFs into textile products will be used to develop air permeable personal protective clothing. For industrial and house-hold fuel cell reformer units novel MOF-based sulphur removal systems will be developed. 2) Safe delivery of highly toxic electronic grade gases (etching gases, dopants) is crucial for tool operation in semiconductor and solar industry. 3) Catalysis is an ecologically relevant and economically attractive technology. The replacement of liquid acids by solid state catalysts avoids the production of toxic liquid waste. MOF catalysts for (trans)esterification processes are designed for the conversion of fatty acids and triglycerides into valuable products for the oleochemical industry. The integration of MOFs into industrial relevant processes and products is supported by advanced modelling, simulation and process monitoring techniques. The project aims for a higher integration of MOFs into products with a high added value in order to propel Europe into an internationally leading position in the industrial use of MOFs.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2010.2.1-1 | Award Amount: 40.00M | Year: 2011

SECUR-ED Project federates, with a delegated management and in a balanced manner, major operators and top industrial integrators to enhance the security of urban public transportation in medium and large cities, through live demonstrations. Based on the best practices, in a very diverse societal and legacy environment, SECUR-ED will aggregate a consistent and interoperable mix of technologies and processes, covering all aspects, from risk assessment to complete training packages. SECUR-ED rationale is to create a global European improvement in mass transportation security through the development of packaged modular solutions validated through the demonstrations, and made available to the full community of operators. The process will follow a strict methodology to translate the threats into a system-of-systems architecture and interoperability language, as well as in assessing the results obtained. The different modules (made up of best practices, procedures, training and hardware and software) are selected and packaged with standard interfaces, ready to be integrated. Similarly standard interfaces are developed to host such modules in the legacy transport infrastructures. With a good coverage of the diverse priorities, integration is performed in the networks of four cities (Madrid, Paris, Milan and Berlin), validating the security enhancement packages, becoming a showcase of this unique European initiative. This is only the start point: a set of medium size cities will then use the above tool-kit to assess their risks and design their own solutions through adapted demonstrations, staff training to best practices, technical upgrades To amplify the process, with the support of the professional associations, the Advisory Groups (Operators, First responders and Authorities) will conduct an active dissemination of the project results to the community of urban transport stakeholders in Europe.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2009.1.1 | Award Amount: 4.15M | Year: 2010

Wireless communications, perpetually a source of innovation, is entering new and uncharted territory. In order to enhance system performance and cater for the services and applications of the future, there is the need for cooperative and cognitive communications paradigms that support advanced coexistence technologies for radio optimization. In short, wireless communications is moving towards a disruptive phase, where the speed and capability of interdisciplinary knowledge integration, for systems cooperation and coexistence, becomes a requirement for survival. This needs new thinking, and the development of architectures and facilitators for novel flexible radio technologies. To account for this paradigm shift and position Europe to benefit most from it, experts in areas of cooperation and coexistence, comprising but not limited to realms such as cognitive radio, cognitive networking and flexible networking, must integrate and harmonize their agendas. Through this approach, to paraphrase a common adage, the whole will become stronger than the sum of the parts. Moreover, there is the need to produce a next generation of European researchers, with the right skills-sets to solve the challenges of optimisation for cooperative and coexisting wireless systems. The ACROPOLIS NoE is specifically designed to meet these challenges; it has a strong, interdisciplinary, joint-research agenda, fostering rapid innovation that is of the highest quality and is able to bridge the gaps in European research. Its structure allows it to react rapidly to changes in the research landscape, where integration of research activities to achieve critical mass, and spreading of excellence throughout industry, other research organisations and elsewhere, are at the very heart of its formulation and ideals. To summarise, ACROPOLIS fosters relevant European excellence in research and education, and through the amalgamation of this strives to achieve new heights that would otherwise be impossible.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.82M | Year: 2011

The vision on a future high-precision radiation therapy utilizing either particle or photon beams is a treatment on a technological level which allows for: (1) obtaining information on relevant tumour parameters (volume, position, topology, density - also of the surrounding tissue) during every moment of therapeutic irradiation; (2) adapting the treatment plan in real time; and (3) initiating the appropriate control of the irradiation device to compensate for any deviations from the original treatment plan that compromise a tumour conformal dose delivery. The European training network in digital medical imaging for radiotherapy (ENTERVISION) will be established in response to the critical need for reinforcing research in online 3D digital imaging and the training of professionals in order to deliver some of the key elements and building blocks for realizing the vision for early detection and more precise treatment of tumours. This is an interdisciplinary (physics, medicine, electronics, informatics, radiobiology, engineering) multinational initiative, which has the primary goal of training researchers who will help technical developments at a pan-European level, for the benefit of all of Europe. ENTERVISION brings together ten academic institutes and research centres of excellence and the two leading European companies in particle therapy, IBA and Siemens. All partners are known worldwide in the diverse but complementary fields associated with technological development for improving health. Thus the network covers a unique set of competencies, expertise, infrastructures and training possibilities. The network will train 12 ESR and 4 ER during a 48 month period. The context of a new technique and a dynamic research program in an area of great societal demand offers outstanding training opportunities for future careers of the young researchers.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-12-2015 | Award Amount: 2.71M | Year: 2016

The elastic Wireless Networking Experimentation (eWINE) research project will realize elastic networks that can scale to a high number of users in a short timespan through the use of an agile infrastructure (intelligent software and flexible hardware), enabling: (1) dynamic on-demand end-to-end wireless connectivity service provisioning, (2) elastic resource sharing in dense heterogeneous and small cell networks (HetSNets), and (3) intelligent and informed configuration of the physical layer. eWINE will develop and validate algorithms for advanced Cognitive Networking (context determination & sensing, optimization & negotiation techniques, and online learning algorithms) through experimentally-driven research on top of existing FIRE/FIRE\ facilities (CREW, WiSHFUL, FLEX). Several partners are involved in these facility projects. The consortium includes both academic researchers and industrial developers (3 SMEs \ 1 multinational company). The uptake of the project results will be promoted by making openly available the Intelligence Toolbox and organizing the eWINE Grand Challenge; through Open Calls of WiSHFUL; and by educating the wireless community via FORGE, VideoLectures.net and YouTube. To cope with the increasing density of wireless devices, eWINE will primarily address the EUs need for intelligent solutions to mitigate the spectrum scarcity and network configuration problems and strengthen the competitiveness of European companies (reducing development costs, speeding product validation and shortening time-to-market) in developing innovative products able to increase wireless capacity and energy efficiency, and lower electromagnetic exposure. The project results will lead to improved European innovation in several domains (secured & robust communication, IoT, 5G, etc.). eWINE will leverage research to exploit the full potential of the coordinated use of heterogeneous wireless networks, and as such will contribute significantly to regulatory policies and standardization.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: EeB-07-2015 | Award Amount: 6.14M | Year: 2015

As occupant behaviour can be considered as one of the main drivers of the performance gap, TOPAs will focus on reducing the gap from an operational perspective, hence supporting Post Occupancy Evaluation. Quantifying the performance gap is non-trivial, the performance gap is dependent on time and contextual factors, and individual buildings will have a particular performance gap. The delivery of energy efficiency projects through energy performance contracts and ESCOs is widely seen as a way of addressing sub-optimal post installation performance of energy efficiency technologies. Since this model is very attractive from many perspectives and is identified as a central route to delivery of energy efficiency gains in the EPBD, methods and models for the accurate measurement and verification of energy savings are essential to the growth of the ESCO market. The energy audit process is generally done for a fixed duration at a specific point in time. A key outcome is the identification and root cause analysis of energy inefficiencies and as a result a plan is put in place to minimise these inefficiencies. This can be very effective at reducing energy consumption in a building. However, from an implementation perspective, it can be difficult to identify all issues (in some cases conflicting system level goals) and the persistence of savings can be poor and as a consequence inefficiencies re-appear. Continuous energy auditing takes this one-off process and makes it a constant rolling cycle where a detailed overview of the building performance is consistently available making it possible to refine the energy management plan. TOPAs adopts the principle of continuous performance auditing and considers not only energy use but also an understanding of how buildings are used and their climatic state, thus providing a holistic performance audit process through supporting tools and methodologies that minimise the gap between predicted and actual energy use.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INSO-4-2015 | Award Amount: 3.47M | Year: 2016

MOVING is an innovative training platform that enables users from all societal sectors to fundamentally improve their information literacy by training how to use, choose, reflect and evaluate data mining methods in connection with their daily research tasks and to become data-savvy information professionals. The platform provides users with technical support as well as social advice and learning input to organise, filter and exploit information in a more efficient and sustainable way. Thus, we tackle the core challenge of knowledge society to manage large amounts of information in a professional way. The ability for understanding, using and developing data mining strategies will become a basic cultural technique. In fact, information management is one of the basic competences today. The open innovation training platform MOVING is both: a working environment for the quality analysis of large data collections with data mining methods and a training environment with information, learning and exchange offers for digital information management. This connection of technical application and curriculum does overcome any artificial distinction in training and practice. The MOVING platform provides beyond state-of-the-art semantic search and analysis of large data sets. It makes its own functioning understandable to the users and offers individually configurable training programmes and guidance based on a proved qualification concept. The MOVING platform will be implemented in two use cases: (i) EY provides the use case of compliance officers with worldwide 60.000 public administrators. (ii) TUD provides a use case on educating young researchers on how to apply and interpret data-intensive research tasks. Here, we address 100.000 students. The exploitation is two-fold, a business-plan strategy for EY and a public-financed and tailoring of services-based strategy for the researcher use case. This will have decisive impact on the innovative capacity of the European society.

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of radiation observed at distance from the irradiated metastatic site(s), and the effect of the tumour-specific immunocytokine L19-IL2 (watch our animation explaining the concept at https://youtu.be/6wDE6RkrikA). Palliative treatment is the current standard of care for patients with metastatic non small cell lung cancer (NSCLC), unless there is an actionable mutation. By using the concept of limited metastatic disease (10 sites, WHO 0-1: oligo\) we aim to develop a therapy with curative intent. IMMUNOSABR will gather evidence for the clinical efficacy of our bi-modal treatment strategy in a multicentre randomised phase II study (clinicaltrials.gov no. NCT02735850) in patients with limited metastatic NSCLC. IMMUNOSABR is complemented by two strong biomarker work packages which focus on developing an ambitious personalised biomarker strategy, to identify patients who can benefit from the novel treatment strategy. This includes promising non-invasive imaging techniques and state-of-the-art immunological monitoring approaches on tumour tissue and blood. IMMUNOSABR will spur further development of L19-IL2 as a commercial drug and translate the bi-modal treatment strategy towards clinical implementation.

Vehlow A.,National Center for Radiation Research And Technology | Cordes N.,National Center for Radiation Research And Technology | Cordes N.,TU Dresden | Cordes N.,Helmholtz Center Dresden
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2013

The survival of cancer patients suffering from glioblastoma multiforme is limited to just a few months even after treatment with the most advanced techniques. The indefinable borders of glioblastoma cell infiltration into the surrounding healthy tissue prevent complete surgical removal. In addition, genetic mutations, epigenetic modifications and microenvironmental heterogeneity cause resistance to radio- and chemotherapy altogether resulting in a hardly to overcome therapeutic scenario. Therefore, the development of efficient therapeutic strategies to combat these tumors requires a better knowledge of genetic and proteomic alterations as well as the infiltrative behavior of glioblastoma cells and how this can be targeted. Among many cell surface receptors, members of the integrin family are known to regulate glioblastoma cell invasion in concert with extracellular matrix degrading proteases. While preclinical and early clinical trials suggested specific integrin targeting as a promising therapeutic approach, clinical trials failed to deliver improved cure rates up to now. Little is known about glioblastoma cell motility, but switches in invasion modes and adaption to specific microenvironmental cues as a consequence of treatment may maintain tumor cell resistance to therapy. Thus, understanding the molecular basis of integrin and protease function for glioblastoma cell invasion in the context of radiochemotherapy is a pressing issue and may be beneficial for the design of efficient therapeutic approaches. This review article summarizes the latest findings on integrins and extracellular matrix in glioblastoma and adds some perspective thoughts on how this knowledge might be exploited for optimized multimodal therapy approaches. © 2013.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-1.2-4 | Award Amount: 9.31M | Year: 2010

Following the pioneering experiences which lasted several decades, particle therapy has become a recognized way of curing cancer. 2 new European dual-ion facilities (Heidelberg, Pavia) will soon become operational, followed by several others which are today at different stages of planning and construction. Hadron therapy faces the challenge of improving treatment outcomes with tools able to provide on-line a 4 dimensional feedback of the irradiation to enhance the dose conformation to the cancer volume and improve the treatment of moving organs. ENVISION is set up by 15 leading European research organisations, and 1 leading industrial partner IBA , to respond to these challenges. CERN is project coordinator and the majority of the key European experts in this field are involved, as well as the Hadron Research Facilities (Heidelberg, Pavia) who will immediately benefit from the developments foreseen in this project. A valorisation committee with members of the industrial partners has been established to maximally exploit the results. ENVISION tackles the problems of on-line Dose Monitoring and of performing accurate Quality Assurance tests by developing novel imaging modalities related to dose deposition and allow assessing the treated volume and deriving reliable indicators of the delivered dose. It concentrates on the detection of nuclear reaction products produced by the interaction of the beam with atomic nuclei of the tissue (positron emitting nuclides for ibPET, photons or light charged particles for ibSPAT). The methods are applicable to all therapy relevant ion species. The application of TOF techniques with superior time resolution to beam delivery integrated double head ibPET scanners has the potential for improving ibPET image quality. Furthermore, the real-time observation of the dose delivery process will become feasible for the 1st time, substantially reducing intervention times in case of treatment mistakes or incidents.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-3.4-1 | Award Amount: 9.01M | Year: 2011

The MAPICC 3D project and concept aims at developing manufacturing system for 3D shaped, multilayered products based on flexible materials. The ultimate goals are: > The development of integrated and automated process chain able to produce from hybrid thermoplastic yarn to 3D complex shaped thermoplastic composite structure in single step thermoplastic consolidation process. > The development of flexible industrial tools, able to produce customized final composites: possibility to reinforce the preform by coating, weaving multilayers, by injection of foam, by introduction of sensors (control quality of preform during the production or monitor the integrity of composite during use) > The development of modelling tool in order to help understanding of the mechanisms involved in the new technologies and to prototype virtually 3D preform, predictive tools to evaluate the physical and mechanical properties of final 3D preform and final composites structure and at the last step reverse engineering. The speed of production and the cost of manufacturing the 3D preform will be in accordance with the transport, building and energy thanks to: The use of raw materials at low cost based on thermoplastic polymer, or regenerated fibres, A decrease of production time. The polluting, labour-intensive and expensive steps of cutting, forming and joining, of current composites production could be avoiding. A dynamic quality control during the production to improve the process robustness, A decrease of quantity of wastes in comparison to current 2D preform based composite structures manufacturing. The consortium allows integrating the entire process chain and involves the industrial stakeholders from machine tools, automation and modelling processing of flexible materials, yarn and textiles, composites and end users for transport: industry insures the leadership of the project.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SST-2007-6.0-04 | Award Amount: 634.71K | Year: 2009

U-STIR defines the know-how and technologies addressing Europes surface transport problems beyond 2050. A lead user centred approach will stimulate the development and capture of radical new technological concepts. Local connecting offices will analyse deficits and establish activities reaching out for fundamentally new solutions for the mobility and transport demands, improving environmental, economical and social quality in one step. WP1 co-ordinates the work progress, supporting the partners, advising on contingency plans and also fulfilling administrative project tasks. In WP2 the working methodology will be refined. This involves Innovation Incubators, which will exploit ideas collected and employ Delphi panels, analysing the technological drivers for 2050 and beyond. WP3 is the workhorse of the project fostering the creative thinking. Creativity tools and ideas from partners will start the creative process implemented as workshops. The Innovation Pump will do the same for the Internet, offering ideas and tools to improve creativity. Diligent research and incubation process will help defining the technological gaps. Incentives and methodological help stems from WP2. Participating universities will allow access to their research facilities for the incubation. WP4 will create an innovation friendly climate, motivating researchers, industry and users to participate in the innovation process and giving stakeholders ideas at hand to support this process of innovative excellence. A Delphi process will define the technological roadmap. WP5 Evaluation/Monitoring will be assessing the work in parallel to WP3 and WP4 intervening in case the performance or quality does not meet the defined threshold. WP6 - dissemination will be implemented as a service to the whole project, producing the dissemination products, developing on-line tools, and will reaching the target groups using a full fledged repertoire of dissemination products.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.3-04 | Award Amount: 11.20M | Year: 2013

The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a significant extent primarily due to lack of biocatalysts with the required selectivity, availability and compatibility with the rigorous process conditions. Selected industrial oxidation and oxyfunctionalization target reactions form the basis for the INDOX screening and optimization of new biocatalysts, including: i) Intermediates for agrochemicals/APIs; ii) Polymer precursors and functionalized polymers; and iii) Intermediates for dye-stuffs. The project flow comprises: i) Recovery of selective biocatalysts from the groups of heme-peroxidases/peroxygenases, flavo-oxidases and copper-oxidoreductases from fungal genomes and other sources; ii) Improvement of their oxidative activity and stability by protein engineering (using rational design, directed evolution and hybrid approaches combined with computational calculations) to fulfill the operational and catalytic conditions required by the chemical industry; and iii) Optimization of reaction conditions and reactor configurations (including immobilization technologies and new enzymatic cascade reactions). Finally the cost efficiency compared to chemical processing will be evaluated. The INDOX approach is supported by a highly-specialized consortium of SMEs, large companies and research/academic institutions. Production of the new optimized biocatalysts and their introduction into the chemical market will take advantage from the participation of the world-leading company in the sector of industrial enzymes, together with several chemical companies willing to implement the new medium- and large-scale biotransformation processes.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 5.80M | Year: 2008

Membrane proteins (MPs) are known to be key molecules in cellular communications, from signal transduction to transport of ions, metabolites and other molecules. They also participate in the synthesis of ATP, the import of soluble or MPs from the cytosol, and they protect living organisms from toxic factors. The proposal consists in a joint training effort involving the major biophysical methods that are -or soon will be- the major techniques used in the field of structural biology of MPs. A collaborative effort is essential for the training of the future generation of biologists dedicated to membrane proteins. It will pave the way to an integrative approach for the study of structure-function relationships of membranes. It will therefore open new strategies for structure-based drug design, in particular toward G-protein coupled receptors (GPCR), which are major drug targets (GPCRs represent 30% of current drug targets). The training proposed in this program will not only form high-level academic researchers but will also largely contribute in forming the main actors of the future developments in biotechnology and personalized medicine. This network combines 12 academic research groups and 3 industrial companies interested in collaborating with these groups and involved in drug discovery or scientific equipment for SBMP. These groups are internationally recognized for analysing the structure and dynamics of membrane proteins by a combination of experimental and theoretical approaches: in vivo and in vitro expressions systems, functional/biochemical/biophysical characterisation, X-Ray diffraction, electron microscopy (EM), atomic force microscopy (AFM), single-molecule force spectroscopy (SMFS), liquid and solid state NMR, numerical simulations. Seven partners from 6 different countries are involved: France, Poland, Portugal, Switzerland, Germany and the Netherlands.

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.4-3 | Award Amount: 9.29M | Year: 2013

Nanotechnology is a key enabling technology. Still existing uncertainties concerning EHS need to be addressed to explore the full potential of this new technology. One challenge consists in the development of methods that reliably identify, characterize and quantify nanomaterials (NM) both as substance and in various products and matrices. The European Commission has recently recommended a definition of NM as reference to determine whether an unknown material can be considered as nanomaterial (2011/696/EU). The proposed NanoDefine project will explicitly address this question. A consortium of European top RTD performers, metrology institutes and nanomaterials and instrument manufacturers has been established to mobilize the critical mass of expertise required to support the implementation of the definition. Based on a comprehensive evaluation of existing methodologies and a rigorous intra-lab and inter-lab comparison, validated measurement methods and instruments will be developed that are robust, readily implementable, cost-effective and capable to reliably measure the size of particles in the range of 1100 nm, with different shapes, coatings and for the widest possible range of materials, in various complex media and products. Case studies will assess their applicability for various sectors, including food/feed, cosmetics etc. One major outcome of the project will be the establishment of an integrated tiered approach including validated rapid screening methods (tier 1) and validated in depth methods (tier 2), with a user manual to guide end-users, such as manufacturers, regulatory bodies and contract laboratories, to implement the developed methodology. NanoDefine will be strongly linked to main standardization bodies, such as CEN, ISO and OECD, by actively participating in TCs and WGs, and by proposing specific ISO/CEN work items, to integrate the developed and validated methodology into the current standardization work.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2011.2.2.1-3 | Award Amount: 8.07M | Year: 2011

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.4-1 | Award Amount: 13.40M | Year: 2013

In this proposed integrating project we will develop innovative in-line high throughput manufacturing technologies which are all based on atmospheric pressure (AP) vapour phase surface and on AP plasma processing technologies. Both approaches have significant potential for the precise synthesis of nano-structures with tailored properties, but their effective simultaneous combination is particularly promising. We propose to merge the unique potential of atmospheric pressure atomic layer deposition (AP-ALD), with nucleation and growth chemical vapour deposition (AP-CVD) with atmospheric pressure based plasma technologies e.g. for surface nano-structuring by growth control or chemical etching and, sub-nanoscale nucleation (seed) layers. The potential for cost advantages of such an approach, combined with the targeted innovation, make the technology capable of step changes in nano-manufacturing. Compatible with high volume and flexible multi-functionalisation, scale-up to pilot-lines will be a major objective. Pilot lines will establish equipment platforms which will be targeted for identified, and substantial potential applications, in three strategically significant industrial areas: (i) energy storage by high capacity batteries and hybridcapacitors with enhanced energy density, (ii) solar energy production and, (iii) energy efficient (lightweight) airplanes. A further aim is to develop process control concepts based on in-situ monitoring methods allowing direct correlation of synthesis parameters with nanomaterial structure and composition. Demonstration of the developed on-line monitoring tools in pilot lines is targeted. The integrating project targets a strategic contribution to establishing a European high value added nano-manufacturing industry. New, cost efficient production methods will improve quality of products in high market value segments in industries such as renewable energy production, energy storage, aeronautics, and space. DoW adaptations being made responding on requests from Phase-2 Evaluation Report In Phase-2 of the evaluation process, a number of points were noted by the evaluators where the project had insufficient information or could benefit from upgrading or justification. Our response and actions against each point raised has been summarized and send to the project officer, Dr. Rene Martins, in a separate document.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2011.1.1 | Award Amount: 5.55M | Year: 2012

NEWCOM# is a Network of Excellence (NoE) proposal submitted in response to challenge FP7-ICT-2011-8 1.1, Future Networks. A group of 14 partners in 14 different countries (12 of which come from the former FP7 NoE NEWCOM\\) decided to capitalize on the high degree of integration in research they already at-tained to build an NoE with the following objectives: i) to produce medium to long term results in the area of design and performance evaluation of wireless networks; ii) to strengthen the integration of partners re-search activities and agendas, both at the theoretical and experimental levels; iii) to foster Industry-academia cooperation, dissemination, and liaison by making academic research closer to industrial needs and interests; iv) to provide a unique training environment for a new generation of researchers in both theo-retical and experimental research; v) to contribute to the long-term sustainability of the NoE by creating a permanent environment for cooperative research.\nIn a Theoretical Research track, the NEWCOM# researchers will pursue long-term, interdisciplinary re-search on the most advanced aspects of wireless communications like Finding the Ultimate Limits of Com-munication Networks, Opportunistic and Cooperative Communications, Energy- and Bandwidth-Efficient Communications and Networking. A second track will be devoted to the EUropean lab of Wireless commu-nications for the future INternet, a federation of three sites in three European Countries that will host re-searchers working on a few general themes like Radio Interfaces, Internet of Things, and Flexible Communi-cation Terminals. The third track will have a number of initiatives to foster excellence like the creation of seasonal schools, a series of publication on journals and books, and an action directed towards strengthen-ing relations with European companies, which will participate to the NoE as Affiliate Partners, through a number of in-company dissemination events.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.1-5 | Award Amount: 8.12M | Year: 2011

Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis. Due to this poor clinical outcome, concomitant hormone dysregulation and limited treatment options the two cancer entities severely impact on affected patients. However, the rarity of the tumors also impedes clinical studies which are affected by fragmentation and low cohort sizes. The European Network for the Study of Adrenal Tumors (ENS@T) has recently implemented a collection of adrenal tumor related databases and defined an associated network of Biological Resource Centers devoted to research on adrenal tumors. The concurrence of recent achievements of this evolving network, the progress in the understanding of molecular mechanisms and increasing availability of specific diagnostic and therapeutic tools for adrenal cancers provides the unique opportunity to achieve unmatched progress in the implementation of both translation and clinical research dedicated to ACC and MPH. Specifically, the newly formed ENS@T-CANCER consortium will address the following topics: 1. Structuring European clinical and translational research through implementation of a virtual research environment, 2. Improving clinical outcome of patients with adrenal cancer by conducting interventional trials carried out by European centers of excellence, 3. Improvement of differential diagnosis and risk stratification of adrenal cancer, 4. Identification and validation of tools for follow-up of patients with adrenal cancer, 5. Identification of novel biomarkers for treatment response. The ultimate aim of the ENS@T-CANCER Consortium is to develop research in the field of adrenal cancers to improve diagnosis and treatment abilities. The Network will allow recruiting sufficient patients in all relevant European centers, to harmonize diagnosis criteria and to use the various technological approaches of a number of laboratories.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 2.80M | Year: 2016

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), molecular motors, and MT-binding factors, some of which show astounding complexity. The mitotic spindle is the one of the cellular structures that best represents the ability of biological matter to self-organize though arrays of dynamic protein-protein interactions. It rapidly assembles when cells enter mitosis, and it disassembles, after sister chromatid separation and mitotic exit. The complexity and dynamic behaviour of the mitotic spindle captures the imagination of synthetic biologists and modellers. These molecular engineers try to understand and harness the principles of self-organization to generate new biological structures endowed with the most typical features of biological matter, the ability to harness energy to do mechanical or chemical work. The emerging discipline of synthetic biology aims to bring together modellers, physicists, and chemists, with biochemists, structural biologists and cell biologists. So does DivIDe, which will train a new generation of molecular engineers endowed with a strong basis in quantitative computational and biochemical methods, and therefore capable of addressing cellular and molecular mechanisms. Furthermore, molecular engineering harbours industrial applications, and DivIDe will continuously provide results for potential exploitation by the three SME partners. Training in management skills, conceptual and ethical thinking, communication and networking will complement the scientific offer. In summary, DivIDe will be able to teach an integrated package of skills and will train the molecular biologists of the future.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.8.1 | Award Amount: 9.94M | Year: 2013

Computer games represent a vast economic market, a key driver of technology, and an increasingly powerful medium for a broad range of applications. The latest wave of innovation for computer games is mobile and, more precisely, location-based. These outdoors mobile experiences are radically different from traditional computer games or their mobile equivalent. They focus the players attention on the real world around them as much as on the digital world of the game, aiming to create a powerful juxtaposition of the two.\nAlthough location-based gaming is an industry on the verge of explosive growth, the creation and deployment of such experiences, especially those involving multiple participants, is simply out of reach for the vast majority of creative industries and authors because of the blend of many cutting-edge technologies they require, their hard to master limitations, and the complex gaming concepts they employ.\nThe first objective of MAGELLAN is to deliver an unprecedented authoring environment based on visual authoring principles in order to enable non-programmers, as well as more advanced users, to cost-effectively author and publish multi-participant location-based experiences. The second objective is to deliver a scalable web platform featuring social networking means and supporting the publication, browsing and execution of a massive number of such experiences. Finally, MAGELLAN will produce a series of guides for authors of location-based experiences that will constitute a reference for interested people as well as a foundational document for future research in the field.\nTo achieve this, MAGELLAN will adopt a holistic approach integrating interdisciplinary research involving a complementary group of world-class experts from multiple scientific and technological domains. A user-centred approach will be adopted in order to place end-users, represented by the 5 SMEs partners and the open User Group members, at the heart of the project.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SST-2007-1.2-01;SST-2007-1.2-02 | Award Amount: 1.25M | Year: 2009

The DIREC_MAT project objective is to share, at a European scale, knowledge and practices on recycling road and road-related waste in the aim of ensuring an environmentally-friendly and sustainable end-of-life for road infrastructure. Road material recycling processes have previously been studied in national and European research projects and have led to various levels of practical implementation; unfortunately, the national experiences developed across Europe almost never benefit other European countries. This is especially true for the newer Member States. Furthermore existing knowledge and practices are presently scattered. Reliable practice-oriented data on all types of road materials and waste will be identified and compiled by skilled experts working in both research and construction capacities. Field experience and relevant research issues will be integrated into a Web database to provide the European road community with unrestricted access to updated online data on end products that have been classified, assessed and illustrated with jobsite practices for dismantling and recycling applications. This database will not only offer information to stakeholders on facilitating the correct re-use of road and road-related waste products back into roads without generating health impacts, but will also provide technical and scientific information for CEN Technical Committees. Lastly, such a tool will make it possible to better identify outstanding research needs in this area. Best practice guides on green techniques for recycling road and road-related waste back into roads will be delivered; benchmarking processes will be detailed and shared by all stakeholders in order to achieve a road material recyclability level of nearly 100%. FEHRL (Forum of European Highway Research Laboratories) will contribute by performing decisive clustering tasks and engaging in a comprehensive dissemination plan to promote the required knowledge sharing for end-users

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.96M | Year: 2016

WiBEC (Wireless In-Body Environment Communications) is an Innovative Training Network for 16 young researchers, who will be recruited and trained in coordinated manner by Academia, Industry, and Medical Centres. This training will address the Social, Health, and Technology challenges of the H2020:Wireless In-Body Devices. WiBECs main objective is to provide high quality and innovative doctoral training to develop the wireless technologies for novel implantable devices that will contribute to the improvement in quality and efficacy of healthcare. Two devices will be used as a focus for the individual researchers projects; cardiovascular implants and ingestible capsules to investigate gastro intestinal problems. These devices will enable medical professionals to have timely clinical information at the point of care. The medical motivation is to increase survival rates and improvement of health outcomes with easy and fast diagnosis and treatment. The goal for homecare services is to improve quality of life and independence for patients by enabling ambient assisted living (AAL) at home. In this particular ETN, inter-sectoral and multi-discipline work is essential, as the topic requires cooperation between medical and engineering institutions and industry. This aspect is fulfilled with the participation of two reference hospitals, two medical device manufacturers and three top ranked universities in Europe, covering complementary aspects of the in-body wireless device field. Concerning future employment perspectives; surgery and medical assistance is rapidly becoming more technological than it is today, and a large number of experts combining engineering and medical skills will be required in Europe to enable novel paradigms like AAL to be realised. The ESRs who join this ETN will acquire diverse skills that will enable them to occupy privileged positions to join and promote EU leadership in ICT for Health.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: Fission-2008-3.2.1 | Award Amount: 3.92M | Year: 2009

Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of normal healthy tissue damage that are not yet well understood in both conventional treatment techniques and emerging techniques (protons, heavy ions). The project will include measurement of radiation doses outside the treatment volume and investigation of the accuracy of methods of dose calculation in this region. The extensive existing databases of radiation treatments and outcomes will be used to investigate models of normal tissue damage and second primary cancer. The measurements and data analysis will be supported by theoretical modelling and surveys to develop the link between radiobiological mechanisms and empirical normal tissue complication (NTCP) models, and to extend conventional models to apply to the emerging techniques. The project is restricted to two years, so there will be a limit to the amount of new research possible. Therefore an essential part of the project will be to engage a forum of experts to redefine the current knowledge on normal tissue damage following radiotherapy, identify gaps in the knowledge and make recommendations for future research, data collection, and technological developments. The final report will consist of a series of focused documents directed to clinicians (for the application of normal tissue risks in treatment optimisation), equipment manufacturers (recommendations on safety design), and the research community (summary of knowledge and recommendations on data collection and project proposals).

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENERGY-2007-9.1-01 | Award Amount: 3.77M | Year: 2008

The SECURE project will build a comprehensive framework that considers all the issues related to the topic of security of supply, including geopolitics, price formation and the economic and technical design of energy markets inside and outside the EU. Tools, methods and models will be developed to measure and assess EU security of energy supply both outside the EU and inside the EU. The objective is to evaluate the vulnerability of the EU to the different risks which affect energy supplies in order to help optimizing the Unions energy insecurity mitigation strategies, including infrastructure investment, demand side management and dialogue with producing countries. This project will develop energy security indicators for all the major energy sources in order to identify the risk factors and quantify the EU exposure to volume and price risks in the short and long terms, including impacts of severe accidents and terrorist threats. Costs and benefits (both measurable and perceived) of energy security will be evaluated for different energy supply/demand scenarios to help policy makers providing the most appropriate institutional, political and industrial solutions. All major energy sources and technologies (oil, natural gas, coal, nuclear, renewables and electricity) will be addressed from upstream to downstream with both a global and sectoral analysis studying in depth issues such as technical, economic/regulatory and geopolitical risks. The analysis will also integrate demand as a key issue related to energy security. The SECURE project has both a strong quantitative and qualitative component and will at the end not only provide a comprehensive methodological and quantitative framework to measure energy security of supply, but it will also propose policy recommendations on how to improve energy security taking into account costs, benefits and risks of various policy choices.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-14-2014 | Award Amount: 7.89M | Year: 2015

Superfluidity is a state in which matter behaves like a fluid with zero viscosity. Our project aims at achieving superfluidity in the network: the ability to instantiate services on-the-fly, run them anywhere in the network (core, aggregation, edge) and shift them transparently to different locations. The SUPERFLUIDITY project tackles crucial shortcomings in todays networks: long provisioning times, with wasteful over-provisioning used to meet variable demand; reliance on rigid and cost-ineffective hardware devices; daunting complexity emerging from three forms of heterogeneity: heterogeneous traffic and sources; heterogeneous services and needs; and heterogeneous access technologies, with multi-vendor network components. The SUPERFLUIDITY solution is based on: a decomposition of network components and services into elementary and reusable primitives; a native, converged cloud-based architecture; the virtualization of radio and network processing tasks; platform-independent abstractions, permitting reuse of network functions across heterogeneous hardware platforms, while catering to the vendors need for closed platforms/implementations; and high performance software optimizations along with leveraging of hardware accelerators. As a result, the 5G network will benefit from: i) location-independence: network services deployable in heterogeneous networks; ii) time-independence: near instantaneous deployment and migration of services; iii) scale-independence: transparent service scalability; and iv) hardware-independence: development and deployment of services with high performance irrespective of the underlying hardware. Through these properties, SUPERFLUIDITY will provide a converged cloud-based 5G concept that will enable innovative use cases in the mobile edge, empower new business models, and reduce investment and operational costs. The SUPERFLUIDITY consortium gathers an impressive and uncommon blend of Telco and IT players that can make its vision a reality.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-5.3-2014 | Award Amount: 3.98M | Year: 2015

CREATE addresses the task Tackling Urban Road Congestion, taking a long-term view of how this can be achieved, especially in cities experiencing rapid growth in car ownership and use. It deals with most of the issues set out in the recent Urban Mobility Package. Objectives: Rigorously and systematically develop practical definitions of urban road congestion and of network performance, and identify factors influencing conditions in different cities. Work with Western European (WE) cities that have succeeded in decoupling traffic growth from economic growth, to analyse quantitatively the objective factors which have contributed to this, and the qualitative factors which have enabled a policy evolution from supporting traffic growth to encouraging sustainable mobility. Develop concrete guidance and provide capacity building for cities in Central and Eastern Europe (CEE), and the EuroMed region, enabling them to move rapidly to develop a feasible, effective and deliverable Sustainable Urban Mobility Plan (SUMP). Anticipating future pressures on city transport systems (congestion and overcrowding), to investigate how new transport technologies might increase transport efficiency, and how non-transport technologies and changes in business and social practices could reduce pressures on transport systems. These objectives will be achieved by: Analysing congestion and network performance data provided by INRIX and WE cities. Using detailed household travel data from repeat surveys in WE cities since the 1970s/1980s and complementary data on network, economic and demographic conditions; and documents setting out historical policy development. Preparing detailed guidance and training for our CEE cities, which will then be delivered to a much larger set of cities. Working with leading technology providers, businesses and futurists, to explore what options there might be to provide high quality mobility in cities facing increasing population and employment.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.3 | Award Amount: 3.91M | Year: 2011

Large scale embedded Monitoring and Control (M&C) systems in energy management, transporta-tion, security and safety often co-exist alongside each other with little cooperation within and among heterogeneous systems which hampers the increasing demand to operate the whole system optimally. A good example is building management, a market worth in excess of $36 billion annually by 2015, where a wide range of vendor specific, heterogeneous M&C systems for HVAC, access control, fire and safety, etc. are in use. This stove pipe system approach limits optimal solutions to energy-efficiency, occupant comfort, or fire safety, especially as most systems need to evolve over time and have to deal with unexpected or unpredictable dynamics such as fire.SCUBA will create a novel architecture, services, and engineering methodologies for robust, adaptive, self-organising, and cooperating monitoring and control systems to address the current problems of heterogeneity and interoperability, installation and commissioning complexity, and adaptability and robustness in the building monitoring and control space. SCUBA will develop semantic models for devices, systems and building management applications and will contribute to their standardisation to improve interoperability. SCUBA will provide a proof of concept of this approach by demonstrating how self-organisation will lead to simpler engineering, commissioning, and maintenance and how cooperation among heterogeneous, multi-vendor building monitoring and control systems will make the system more adaptive and robust in real building management applications.SCUBA addresses the challenges of the call including development of systems capable of dealing with complex, distributed and/or uncertain dynamics, development of self-organising, monitoring and control systems, providing methods for adjusting to/ recovering from failures, and standardisation of configuration interfaces and exchange platforms.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-17-2015 | Award Amount: 9.63M | Year: 2016

The share of renewable energy is growing rapidly driven by the objective to reduce greenhouse gas emissions. The amount of electric power which can be supplied to the grid depends on the time of the day and weather conditions. A conventional fleet of thermal power plants is required to compensate for these fluctuations before large scale energy storage technologies will be mature and economically viable. All power market projections expect this to be the case for the next 50 years at least. For a strong expansion of renewables, this fleet has to operate flexibly at competitive cost. Current power plants cannot fill this role immediately without impeding their efficiency and engine lifetime through increased wear and damage induced by the higher number of (shorter) operating/loading cycles. New technologies need to be introduced to balance demand peaks with renewable output fluctuations at minimal fuel consumption and emissions without negative effects on cycling operation. The FLEXTURBINE partners have developed a medium to long term technology roadmap addressing future and existing power plants. The FLEXTURBINE project presented hereafter is the first step in such technology roadmap and consists of: (1) new solutions for extended operating ranges to predict and control flutter, (2) improved sealing and bearing designs to increase turbine lifetime and efficiency by reducing degradation/damages, and (3) an improved lifecycle management through better control and prediction of critical parts to improve competitive costs by more flexible service intervals and planned downtime, and by reducing unplanned outages. In all areas, individual technologies will be developed from TRL 3 to TRL 4-6. FLEXTURBINE brings together the main European turbine manufacturers, renowned research institutes and universities. It involves plant and transmission system operators to include user feedback and to prepare the take-up of the FLEXTURBINE technologies in power plants world-wide.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 707.70K | Year: 2013

This is a project for a partnership between leading Brazilian and European research groups in dynamical systems, a prominent subject in mathematics. An extensive consortium of European and Brazilian institutions will collaborate to provide world leading critical mass and support for research on the very forefront of the field. Work Packages reflect parallel priorities in the research. Transfer of knowledge is facilitated by two large conferences and five smaller workshops. The project has excellent strategic value in view of the development of closer ties in higher education and research between the European Research Area and Brazil.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: LCE-02-2016 | Award Amount: 11.23M | Year: 2016

The GOFLEX project will innovate, integrate, further develop and demonstrate a group of electricity smart-grid technologies, enabling the cost-effective use of demand response in distribution grids, increasing the grids available adaptation capacity and safely supporting an increasing share of renewable electricity generation. The GOFLEX smart grid solution will deliver flexibility that is both general (across different loads and devices) and operational (solving specific local grid problems). GOFLEX enables active use of distributed sources of load flexibility to provide services for grid operators, balance electricity demand and supply, and optimize energy consumption and production at the local level of electricity trading and distribution systems. Building on top of existing, validated technologies for capturing and exploiting distributed energy consumption and production flexibility, GOFLEX enables flexibility in automatic trading of general, localized, device-specific energy as well as flexibility in trading aggregated prosumer energy. Generalized demand-response services are based on transparent aggregation of distributed, heterogeneous resources to offer virtual-power-plant and virtual-storage capabilities. The sources of load flexibility include thermal (heating/cooling) and electric storage (electric vehicles charging/discharging). A backbone data-services platform offers localised estimation and short-term predictions of market and energy demand/generation, and flexibility in order to support effective data-driven decisions for the various stakeholders. Smart-grid technologies, such as increased observability and congestion management, contribute to the platform. Over 36 months, GOFLEX will demonstrate the benefits of the integrated GOFLEX solution in three use-cases, covering a diverse range of structural and operational distribution grid conditions in three European countries.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.3.4 | Award Amount: 12.93M | Year: 2013

Data-centres form the central brains and store for the Information Society and are a key resource for innovation and leadership. The key challenge has recently moved from just delivering the required performance, to include consuming reduced energy and lowering cost of ownership. Together, these create an inflection point that provides a big opportunity for Europe, which holds a leading position in energy efficient computing and market prominent positions in embedded systems.\n\nEUROSERVER is an ambitious and holistic project aimed to arm Europe with leading technology for conquering the new markets of cloud computing:\n\n1. Capitalise on the European strength in embedded and low power computing to provide an innovative combined architecture-and-technology integration platform that enables the reuse of highly-integrated, high-performance, energy-efficient component subsystems in a micro-server solution suitable across both cloud data-centres and embedded application workload.\n\n2. Perform a combined architecture-technology exploration that creates the hardware and the software for micro-server based computing in support of cloud-based and embedded applications.\n\n3. Evidence this architecture in a data-centre grade low-power physical micro-server prototype solution utilizing advanced ARM IP, industry leading FD-SOI fabrication technology, and state of the art 2.5D device integration technologies and prove the advantages of these European technologies as the enabler of next generation, low-cost, power-efficient, high-density compute.\n\nThe EUROSERVER consortium brings together world-class leaders in their own fields and creates the critical-mass required to deliver More than Moore solutions. A unique differentiator of EUROSERVER is its broad access to the required industrial technologies and specialised academic support. The potential impact of EUROSERVER is therefore very high to competitively accelerate and improve the delivery of energy-efficient computing worldwide.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.1 | Award Amount: 9.79M | Year: 2008

Current two big trends in wireless communications are the development of new broadband component and the integration of heterogeneous wireless networks, to achieve the vision f the so-called 4G network.\nThe FUTON project addresses both issues by proposing the development of a hybrid fiber-radio infrastructure transparently connecting remote antenna units to a central unit where a joint processing can be performed. This allows the development of virtual MIMO concepts to achieve broadband wireless transmission, and also inter-cell interference cancellation. Furthermore the fact that several heterogeneous systems are co-localized enables the development of efficient Common Radio Resource Management procedures.\nThe focus of the project includes two main components: one, the dominant, dealing with technical aspects and a second addressing business / deployment models related with the techniques under study.\nAt the technical level the main goals are\n- Specify, design, implement and provide proof of concept for a hybrid optical-radio infrastructure enabling the integration of heterogeneous systems including the broadband component of future wireless systems \n- Exploit the potentialities offered by the transparent infrastructure to specify and develop the PHY and MAC layer of the broadband wireless system based on distributed processing.\n- Exploit the potentialities offered by the infrastructure for distribution of heterogeneous radio services and develop mechanisms for inter-system coordination and optimum usage of the radio resources and provide the proof of concept.\nAnd in terms of deployment/ business models\n- Evaluate the implications on the current wireless architecture models of the FUTON concept, determine cost models for upgradeability / replacement and provide roadmaps for evolution and standardization.\nThe FUTON consortium brings together expertise from the areas of wireless and optical communications, allowing synergies between these two areas.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.83M | Year: 2016

Organic solar cells (OSCs) have the potential to become an environmental friendly, inexpensive, large area and flexible photovoltaics technology. Their main advantages are low process temperatures, the potential for very low cost due to abundant materials and scalable processing, and the possibility of producing flexible devices on plastic substrates. To improve their commercialization capacity, to compete with established power generation and to complement other renewable energy technologies, the performance of state-of-the-art OSCs needs to be further improved. Our goals within SEPOMO Spins in Efficient Photovoltaic devices based on Organic Molecules are to bring the performance of OSCs forward by taking advantage of the so far unexplored degree of freedom of photogenerated species in organic materials, their spin. This challenging idea provides a unified platform for the excellent research to promote the world-wide position of Europe in the field of organic photovoltaics and electronics, and to train strongly motivated early stage researchers (ESRs) for a career in science and technology oriented industry that is rapidly growing. Our scientific objectives are to develop several novel routes to enhance the efficiency of OSC by understanding and exploiting the electronic spin interactions. This will allow us to address crucial bottlenecks in state-of-the-art OSCs: we will increase the quantum efficiency by reducing the dominant recombination losses and by enhancing the light harvesting and exciton generation, e.g. by means of internal upconversion of excited states. Our ESRs will be trained within this interdisciplinary (physics, chemistry, engineering) and intersectoral (academia, R&D center, enterprise) consortium in highly relevant fundamental yet application-oriented research with the potential to commercialise the results. The hard and soft skills learned in our network are central for the ESRs to pursue their individual careers in academics or industry.

Agency: European Commission | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2011-2 | Award Amount: 3.32M | Year: 2012

The objective of the Lynceus project is to investigate and demonstrate ultra-low power wireless body-area-network technologies for enabling unobtrusive localisation and tracking of people for onboard and overboard search and rescue as well as for safe evacuation of ships during emergency. The Lynceus technology aims to revolutionise current emergency management and ship evacuation practice through the development of beyond the state-of-the-art real-time emergency management and safe evacuation systems which will significantly contribute towards early localisation and rescue of people in danger located onboard a ship or in the sea. The Lynceus novel technology will be transferred into the SME-driven market segments of smoke alarm/fire detection systems, lifesaving equipment, emergency management decision support systems and assistive search and rescue equipment. The proposed research will generate high societal and market impact for the European SMEs, and will enable major technological breakthroughs in the areas of ultra-low power wireless systems, wearable antennas, wireless and sensor electronics, digital signal processing and decision support systems.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SiS-2010- | Award Amount: 1.82M | Year: 2010

The EU lags behind its global competitors when it comes to the number of MST graduates. A special effort is required to close this gap. The overall aim of the SECURE project is to make a significant contribution to a European knowledge-based society by providing relevant research data that can help policy makers to improve MST curricula and their implementation throughout the EU in order to prepare children from an early age on for future careers in MST, whilst at the same time making MST more accessible and enjoyable for all children so that they will keep a vivid interest in science and technology, and understand the importance of their societal role. SECURE will focus on the 5 13 age group, because the foundation for a revived interest in MST can best be laid at an early age, when children are most susceptible for the wonders of the world that surrounds them. A rigorous research programme conducted by the SECURE consortium will scrutinise and compare current MST curricula for pupils aged 5, 8, 11 and 13 in the member states as they are intended by the authorities, implemented by the teachers and perceived by the learners. The instruments used to this end will consist of a transnational comparative screening instrument for MST curricula, of teacher and learner questionnaires and of a lesson observation instrument. The cornerstone of the valorisation strategy of the research outcomes will be the direct and active involvement of a transnational expert group of research and curriculum development institutions that will provide feedback as well as a direct access to policy makers.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2008. | Award Amount: 1.20M | Year: 2009

Many potentially hazardous compounds are traded as chemicals or incorporated as additives in products. Their release to the environment has been a concern of EC, UNO, WHO and OECD. The discussion of the assessment and management of chemicals and products led to the OECD program Globally Harmonised System of Classification and Labelling of Chemicals (GHS). The World Summit encouraged countries to implement GHS with a view of having the system operating by 2008. The need to form GHS on a global scale is part of EU policy. GHS aims to have the same criteria worldwide to classify the responsible trade and handling of chemicals and at the same time protect human health. The EU will ensure transition from the current EU Classification & Labelling (C\L) to the GHS which harmonizes with REACH. Countries like Japan and the USA announced to implement GHS in the near future. UNITAR supports other countries. However, a complete picture on the global state of implementation is not available. With the growing level of worldwide trade we however face unsafe products on the marked. Only last year reports about toys releasing hazardous components made it to headlines. Vietnam reported that all kind of plastic gets recycled and sold back to the market. This shows that global trade in a circular economy is not acceptable without globally agreed assessment methods and harmonised C\L. A ECB study revealed that the EU regulation REACH will require 3.9 mill. additional test animals if no alternative methods are accepted. The number of additional tests are unknown when GHS is implemented in a global scale. The CA RISKCYCLE will include experts from OECD, UNEP, SusChem, country experts from Asia, America and Europe. The overall objective of the project is to define with international experts future needs of R\D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2009-4.2-01 | Award Amount: 12.54M | Year: 2010

The E-SPONDER is a suite of real-time data-centric technologies which will provide actionable information and communication support to first responders that act during abnormal events (crises) occurring in critical infrastructures. This information will enable improved control and management, resulting in real time synchronization between forces on the ground (police, rescue, firefighters) and out-of-theater command and control centers (CC). The approach guiding the E-SPONDER project is based on the fusion of variable forms of field-derived data within a central system which will then provide information analysis and decision support applications at designated CC locations in order to provide in situ support to first responders that operate in Critical Infrastructures. Statistics show that efficient emergency system can reduce accident losses to 6%, compared with situations without emergency system . As a result, an efficient emergency system is a key to cope with all kinds of sudden events and improve safety of cities and countries. To do this, E-SPONDER will achieve the following objectives: i) Improvement of front end data collection technologies installed both on portable and fixed platforms, providing a flexible yet comprehensive coverage of the affected area; ii) this data will then be fused and analyzed to provide real-time decision support; iii) E-SPONDER will make these resources readily available to commanders through the use of easily accessible web-portals but lastly and most important it will provide significant support based on Information and Communication Technologies to the First Responders. Thus, E-SPONDER will minimize the uncertainty that characterizes crisis events, thereby limiting their scope. Once E-SPONDER elements are ready for deployment they will be integrated and extensively field tested.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2008.10.1.2;NMP-2008-2.6-1 | Award Amount: 3.43M | Year: 2009

A.1.2. Project summary The overall objective of the MAHEATT project is to develop a prototype cost-effective lithium-ion high energy battery technology with electrode performances well beyond the current state-of-the-art, with automotive applications (hybrid vehicles and electric traction) and hand held tools as application target areas. This will be achieved by innovative synthesis and design of radically improved cathode materials and by optimizing kinetics and stability through nanostructuring of all electroactive materials (EAMs) and components. Main objectives are: To design synthesis routes and novel electroactive materials for the cathode and for the anode with a much higher specific capacity compared to present EAMs; To design the EAMs in nanoscopic form to provide a faster kinetics; To coat the EAMs by a porous conductive layer to suppress undesired (electro-)catalysis and to enhance electronic conductivity; To optimize binding and assembly of the EAMs into a nanoporous network forming an excellent percolation system for Li-ions and for the electrolyte. The approach is highly cross-disciplinary, with partnership of leading research institutions and leading European industry. The solution to the materials challenges will benefit from integrated feedback between advanced characterization, theory, modelling, synthesis and up-scaling. The key objective for our target materials and systems in relation to electric traction in the automotive sector is a battery that utilizes at least 1.5 times (i.e. 240 mAh/g) larger charge density than current state-of-the art cathode materials.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2007-5.2-01;SSH-2007-4.2-01 | Award Amount: 1.50M | Year: 2008

This proposal aims to investigate the ways the destruction and subsequent selective reconstruction of the cultural heritage impact identity formation. Recent conflicts in Europe, as well as abroad, has brought the deliberate destruction of the heritage of others, as a means of inflicting pain, to the foreground. With this has come the realisation that the processes involved and thus the long-term consequences are poorly understood. Heritage reconstruction is not merely a matter of design and resources - at stake is the re-visioning and reconstruction of peoples identities! Through five regional case studies, this project seeks to illuminate both the empircal and theoretical relationship between cultural heritage, conflict ,and identity. In particular, it will examine how destruction as well as reconstruction affect notions of belonging and identies at different scales ranging from the individual to the pan-national. The five regional studies will ensure historical depth, variation, and different trajectories, while the shared methodologies and axes of investigation will ensure comparative measures are reached. The regional work packages will use case studies to collect data and conduct analysis that collectively will aim to answer 1) what conditions and ideologies inspire the destruction of cultural heritage and what is selected for destruction?, and 2) what are the consequences at local, national and regional levels of such destruction and the subsequent reconstruction of parts of peoples heritage. The project will vastly enhance insights into the crucial relationship between heritage and identity, and on this basis it will provide much needed knowledge of use to policy-makers .

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 8.50M | Year: 2013

Chronic kidney disease is world wide a major cause of end-stage renal disease (ESRD). 800.000 patients in Europe and in the US, respectively, require long-term treatment initially with peritoneal dialysis, followed by hemodialysis and kidney transplantation. Each ESRD patient on hemodialysis costs 40000 to 80000 per year, has extremely poor quality of life and an average life expectancy of only 4 years. Kidney transplantation totally changes life for an ESRD patient who can then return to normal life, but this treatment is hampered by the low number of available kidney grafts. All these treatments are, however, associated with severe adverse reactions that cause damaging thromboinflammation, triggered by the intravascular innate immune system, which lead to poor results and non-function. The overall aim of this project is to clarify the mechanisms and identify natures own specific control points of regulation in these adverse reactions in order to be able to significantly improve the quality of hemodialysis devices and kidney grafts by applying these concepts of regulation in hemodialysis and kidney transplantation. We envisage that conveying a novel soluble complement inhibitor to the clinical stage via phase 1/2a clinical studies, creation of nano-profiled surfaces with low activating properties and generation of easy-to-apply one step-coatings for treatment of biomaterials (hemodialysis) and endothelial cell surfaces (kidney grafts) will revolutionize the treatment modalities of ESRD. The feasible hemodialysis treatment periods are anticipated to be extended, combined with an improved quality of life and in kidney transplantation attenuation of innate immune reactions will prolong the life expectancy of the graft and make kidneys more accessible for transplantation. All the novel techniques can be applied to other types of implantations, extracorporeal treatments and transplantation and in the future be used in xenotransplantation and stem cell therapies.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.2 | Award Amount: 11.23M | Year: 2009

ULICE is a 4-year project set up by 20 leading European research organisations, including 2 leading European industrial partners (Siemens and IBA), to respond to the need for greater access to hadron therapy facilities for particle therapy research. Project coordinator is the Italian Research Infrastructure Facility CNAO (Milan). Both existing European Hadron Research Facilities in Heidelberg and Milan are partner and together with the next operational centre (Philipps-Universitt Marburg; yr4) they will provide 624 hours of beam-time (141 users, 52 projects) to external researchers. Future facilities like MedAustron, Etoile and Archade also participate in ULICE, which will result in a strong integrated network. Full exploitation of all different resources, unrestricted spread of information and the improvement of existing and upcoming facilities are provided by using grid-based data sharing. The project is built around 3 pillars with measurable outputs. These outputs will be exploited by the (future) facilities and (partly by) the industrial partners: 1. JRA - focus on development of instruments and protocols: new gantry design, improvement of four-dimensional particle beam delivery, adaptive treatment planning, mechanisms for patient selection to the whole European Community and database development for specific tumours which can best be treated using carbon ion. 2. Networking - increasing cooperation between facilities and research communities wanting to work with the research infrastructure. Outputs will be (among others): a report on recommendations for strategically optimal locations for future RIs throughout Europe, training to new users 3. Transnational access: 2-step approach, using a combination of pre-defined (within ULICE) clinical trial programmes to allow researchers with patients to visit the facility, and radiobiological and physics experiments to take place.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENERGY.2011.2.1-2;NMP.2011.1.2-1 | Award Amount: 12.88M | Year: 2012

In recent years, the effort in thin-film silicon (TFSi) was made at solving industrialization issues. In 2010, several companies demonstrated 10% stable modules (> 1 m). The major bricks for efficient production are now in place. Next challenges are linked to the fact that TFSi multi-junction devices, allowing for higher efficiency, are complex devices, in which the substrate geometry and each layer have an impact on the full device. This explains why the first industrializations focused on single technology roads (e.g., Jlich-AMAT or EPFL-Oerlikon approaches). This project focuses at bringing the next-generation technology to the market, using newly developed state-of-the art knowledge to solve the complex puzzle of achieving at the same time strong light in-coupling (high current) and good electrical properties (open-circuit voltage and fill factor). In a unique collaborative effort of the leading EU industries and research institutions in the field, the consortium will go beyond the current technology status by Introducing novel materials, including multi-phase nanomaterials (such as doped nc-SiOx, high crystallinity nc-Si materials), stable top cell materials, nanoimprinted substrates and novel or adapted transparent conductive oxides; Designing and implementing ideal device structures, taking into account the full interaction of layers in multi-junction devices; Controlling the growth of active layers on textured materials; Working at processes that could allow a further extension of the technology such as very high rate nc-Si deposition or multi-step superstrate etching; Transferring processes, including static and dynamic plasma deposition, from the laboratory to pilot scale, with first trials in production lines. The targets of the project is to achieve solar cells with 14% stable efficiency, leading to the demonstration of reliable production size prototypes module at 12% level. Potential cost below 0.5/Wp should be demonstrated.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.3-1 | Award Amount: 8.25M | Year: 2012

Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia. Although many trials have demonstrated the efficacy of lifestyle and pharmaceutical interventions in diabetes prevention, no trial has evaluated the extent to which mid- and long-term complications can be prevented by early interventions on hyperglycaemia. Aims: To assess the long-term effects on multiple complications of hyperglycaemia of early intensive management of hyperglycaemia with sitagliptin, metformin or their combination added to lifestyle intervention (LSI) (diet and physical activity), compared with LSI alone in adults with non-diabetic intermediate hyperglycaemia (IFG, IGT or both). Study Design: Long-term, multi-centre, randomised, partially double blinded, placebo controlled, phase-IIIb clinical trial with prospective blinded outcome evaluation. Participants will be randomised to four parallel arms: 1) LSI \ 2 placebo tablets/day; 2) LSI \ 2 Metformin tablets of 850 mg/day; 3) LSI \ 2 Sitagliptin tablets of 50 mg/day; 4) LSI \ 2 tablets of a fixed-dose combination of Sitagliptin 50mg and Metformin 850 /day. Active intervention will last for at least 3 years, and additional follow-up up to 5 years. Setting and population: Males and Females with pre-diabetes (IFG, IGT or both) aged 45 to 74 years selected from primary care screening programs in 15 clinical centres from 12 countries: Australia, Austria, Bulgaria, Germany, Greece, Italy, Lithuania, Poland, Serbia, Spain, Switzerland and Turkey. (N=3000) Main Outcomes: The primary endpoint is a combined continuous variable: the microvascular complication ndex (MCI) composed by a linear combination of the Early Treatment Diabetic Retinopathy Study Scale (ETDRS) score (based on retinograms), the level of urinary albumin to creatinine ratio, and a measure of distal small fibre neuropathy (sudomotor test by SUDOSCAN), measured during baseline visit and at 36th and 60th month visits after randomisation. In addition, this project will include the evaluation of early novel serological biomarkers of systemic inflammation, early micro-vascular damage, non-alcoholic fatty liver disease, insulin sensitivity and insulin secretion, and measures of quality of life, sleep quality (somnograms) and neuropsychological evaluation. Vascular function and structure will be evaluated in a subset of participants (n=1000), including cIMT and microvascular endothelial function measured by EndoPAT. Expected results: By evaluating the effect of aggressive treatments in pre-diabetes for the early prevention of diabetes complication, this project has the potential of changing the current paradigm of early management of hyperglycaemia. The ultimate goal is the development of a standardized core protocol for the early prevention of microvascular and other complications, impacting social cost as a result not only in health care, but also in disabilities at work.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2012.4.2-2 | Award Amount: 13.14M | Year: 2013

The dynamic capture of situational awareness concerning crowds in specific mass gathering venues and its intelligent enablement into emergency management information systems, using smart communication devices and spaces is critical for achieving rapid, timely guidance and safe evacuation of people out of dangerous areas. Humans could be overwhelmed by fast changes of potentially dangerous incidents occurring at confined environments with mass-gathering. They could fail to make objective decisions to find their way to safety. This condition may lead to mass panic and make emergency management more challenging. In eVACUATE, the intelligent fusion of sensors, geospatial and contextual information, with advanced multi-scale crowd behaviour detection and recognition will be developed. The structured fusion of sensing information with dynamic estimated uncertainties on behaviour predictions will advance eVACUATE crowd dynamic models; and virtual reality simulations of crowds in confined environments. A service oriented Decision-Support System shall be developed to dynamically distribute on-demand evacuation information to emergency management actors as the crisis unfolds. Decision-makers at the command posts, first responders, front-line stewards and volunteers receive real-time situation aware information of updated evacuation strategies using robust and resilient eVACUATE information and communication infrastructure. Smart spaces of electronic, audio and other mobile devices shall be connected to the integrated system to provide safer evacuation routings for people. The eVACUATE system performance and scalability will be validated in five distinct scenarios involving incidents with large crowd at various venues with the requirements of evacuation time reductions and increases of safety and security. These are: 1) Underground stations in Bilbao and 2) Marseille; 3) Real Sociedad Footbal Stadium in San Sebastian, 4) Athens International Airport and 5) a STX Cruiseship.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT-2007-1.4.01 | Award Amount: 39.99M | Year: 2008

Since the publication of the ACARE goals, the commercial and political pressure to reduce CO2 has increased considerably. DREAM is the response of the aero-engine community to this pressure. The first major DREAM objective is to design, integrate and validate new engine concepts based on open rotor contra-rotating architectures to reduce fuel consumption and CO2 emissions 7% beyond the ACARE 2020 objectives. Open rotors are noisier than equivalent high bypass ratio turbofan engines, therefore it is necessary to provide solutions that will meet noise ICAO certification standards. The second major DREAM objective is a 3dB noise emission reduction per operation point for the engine alone compared to the Year 2000 engine reference. These breakthroughs will be achieved by designing and rig testing: Innovative engine concepts a geared and a direct drive contra-rotating open rotor (unducted propulsion system) Enabling architectures with novel active and passive engine systems to reduce vibrations These technologies will support the development of future open rotor engines but also more traditional ducted turbofan engines. DREAM will also develop specifications for alternative fuels for aero-engines and then characterise, assess and test several potential fuels. This will be followed by a demonstration that the selected fuels can be used in aero-engines. The DREAM technologies will then be integrated and the engine concepts together with alternative fuels usage assessed through an enhanced version of the TERA tool developed in VITAL and NEWAC. DREAM is led by Rolls-Royce and is made of 47 partners from 13 countries, providing the best expertise and capability from the EU aeronautics industry and Russia. DREAM will mature technologies that offer the potential to go beyond the ACARE objectives for SFC, achieving a TRL of 4-5. These technologies are candidates to be brought to a higher TRL level within the scope of the CLEAN SKY JTI.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.22. | Award Amount: 9.76M | Year: 2012

ESTEEM2 is an integrated infrastructure of electron microscopy facilities providing access for the academic and industrial research community in the physical sciences to some of the most powerful characterization techniques available at the nanoscale. Transnational access to ESTEEM2 centres is obtained through a transparent, simple peer review process based on merit and scientific priorities. Service to users is supported by a networking programme which addresses key issues such as specimen preparation, data interpretation through theory and simulation, and standardization of protocols and methodologies. A series of schools and workshops provide training in innovative methods in electron microscopy and a forum for discussing emerging (cutting-edge) techniques. Directed research programmes focus on the further development of electron diffraction, imaging and spectroscopy and the advancement of 3D methods and time resolved experiments. In all, ESTEEM2 establishes a strategic leadership in electron microscopy to guide future developments and promote electron microscopy to the wider research community at large.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SEC-2013-1.6-3 | Award Amount: 14.16M | Year: 2014

The advancement of 24/7 surveillance systems for the security of WideZones with multiple assets at localized scales is of extreme strategic relevance to European economies, industries, authorities and Citizens. Nevertheless, the cost for large deployments and maintenance of ground sensing networks for local surveillance across these WideZones is extremely high. Hence, large areas of high economic importance, particularly those situated at Member States cross-borders, may be exposed to undetected local illicit activities. These could lead to large systemic failures of the processes operating in wider zones, while economic stability, safety and security in Europe can be potentially compromised. Hence, the integration of affordable ground and airborne sensor observation technologies for the critical surveillance of large spatial areas of high economic values in Europe needs to be imminently prioritized. Secure and interoperable observation data and information management services using open standards shall be deployed in ZONeSEC with the aim of cost-effectively reusing them in the surveillance of many other European WideZones. These services are part of an advanced Knowledge Base (KB) and primarily focused on large scale surveillance with high performance detection of localized abnormal activities and alerts. Semantically enriched domain knowledge representations shall be stored in the KB for supporting high level data fusion and reasoning with reduced uncertainties and false alerts. Surveillance professionals will securely subscribe to the scalable KB services of the ZONeSEC system of systems with customisable visualization features. Several pilots specializing in the detection of illegal unauthorized entrances to or trespassing premises; or actions to damage to or deployment of harmful devices on installations shall be fully demonstrated. These concern Water, Oil and Transnational Gas Pipelines; Highways and Rail tracks conveyed in six European countries.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-05-2014 | Award Amount: 8.44M | Year: 2015

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension. Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushings syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life. This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: MG-4.2-2014 | Award Amount: 10.16M | Year: 2015

Maritime disasters in recent years are a stark reminder of the imperative need for timely and effective evacuation of large passenger ships during emergency. The Lynceus2Market project addresses this challenge through delivering a revolutionary operational system for safe evacuation based on innovative people localisation technologies. The system consists of: 1) Localisable life jackets that can provide passenger location in real-time during emergency 2) Smart smoke detectors that also act as base stations of an on-board localisation system 3) Innovative localisable bracelets able to send activity data to the emergency management team 4) Low cost fire and flooding escalation monitoring sensor notes 5) novel mustering handheld devices for automatic identification and counting of passengers during evacuation 6) Smart localisable cabin key cards 7) Intelligent decision support software able to fuse all localisation, activity and disaster escalation data to provide an integrated real-time visualisation, passenger counting and evacuation decision support 8) Innovative shore or ship-launched Unmanned Aerial Vehicle for localising people in the sea in short time and assisting search and rescue operations when accident occurs in extreme weather, during the night or in a remote location 9) Low-cost rescue-boat mounted radars for people localisation in the vicinity of the boat. The proposed project is based on the promising results developed in the FP7 LYNCEUS project where the innovative technologies were tested in lab and in small scale pilots. Lynceus2Market brings together European global players in the field, such as cruise ship owners, operators, ship builders, maritime equipment manufacturers, a classification society, industry associations and important technology organisations with the aim to implement the first market replication of these technologies and products. The Lynceus2Market will create significant impact by saving passenger lives during maritime accidents.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 5.71M | Year: 2012

Motivation. The last decades brought an exponential increase in mobile traffic volume. This will continue and a 1000-fold increase by 2020 has been forecasted. Small-cells promise to provide the required data rates through an increased spatial utilisation of the spectrum.Problem statement. Due to strong inter-cell interference, small-cell deployments will require a high degree of coordination as offered by centralised processing. Furthermore, heterogeneous backhaul solutions will be used to connect small-cells and core network. So far, access and backhaul are individually designed and therefore not optimised. In order to support centralised processing and a heterogeneous backhaul, challenges on access and backhaul must be simultaneously tackled.Approach. iJOIN introduces the novel concept RAN-as-a-Service (RANaaS), where RAN functionality is flexibly centralised through an open IT platform based on a cloud infrastructure. iJOIN aims for a joint design and optimisation of access and backhaul, operation and management algorithms, and architectural elements, integrating small-cells, heterogeneous backhaul, and centralised processing. Additionally to the development of technology candidates across PHY, MAC, and the network layer, iJOIN will study the requirements, constraints, and implications for existing mobile networks, specifically 3GPP LTE-A.Results. iJOIN will design new network operation and management algorithms in the context of RANaaS, show their implications on 3GPP LTE, and evaluate the derived technologies with respect to four quantitative key objectives:1) system throughput2) energy-efficiency3) cost-efficiency4) utilisation-efficiencyiJOIN will further impact1) the research community by identifying new challenges,2) business opportunities through new concepts for implementing mobile networks, and3) standardisation through strong industry participation of all major stakeholders.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: NMP-2007-2.1-3;NMP-2007-1.2-4 | Award Amount: 1.50M | Year: 2009

Nanotechnology has the ability to become the most promising technology advance for the 21st Century. It offers a huge potential of applications and economic benefits, which may contribute to the European economy. Scientifically and economically, nano-metrology is an indispensible part for nanotechnology which must develop hand in hand with the developments of nano-science and technology. The programme of work set out in this project will address the need within Europe to develop the required measurement frame to successfully support the development and economic exploitation of nanotechnology. A pan-European coordinated response to the emerging needs of nanotechnology defined required from the National Metrology Institutes to provide a suitable measurement framework for the effective commercial development of nanotechnology. To address this requirement a European Strategy Plan for Nanometrology will be delivered in consultation with key stakeholders. 5 European Action Groups in Nanometrology will be implemented to address the need to put in place a process chain for the dissemination of metrology techniques as well as traceability to national standards and internationally harmonised standard methods specific to the particular nanotechnology area addressed. Educational programmes addressing nanometrology across Europe will be reviewed, a future training needs analysis completed and recommendations for training curricula made. Training will be provided in basic nano metrology concepts as well as standardisation. European capabilities review will be completed and a directory published. Exisitng and future requirements for large infrastructures as well as capbility gaps will be assessed. Traceability and metrology in industry will also be addressed. This project will take input from a range of stakeholders including National Metrology Institutes, research institutes, industry, regualtory and standards bodies as well as the EC.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SPIRE-01-2014 | Award Amount: 5.88M | Year: 2015

The Process Industries require a high degree of automation, monitoring, and advanced simulation and control for their often complex manufacturing processes and operations. Emphasis is on continuous or batch production, mixing, reaction and separation of materials of higher value. Indeed, increased globalisation and competition are drivers for process analytical technologies (PAT) that enable seamless process control, greater flexibility and cost efficiency. ProPAT aims to develop novel sensors and analysers for providing measurements on composition, particle size and local bulk properties, as well as more traditional but smart sensors for measuring other process parameters, such as temperature, flowrate, pressure, etc., and integrate them into a versatile global control platform for data acquisition, data processing & mining and User Interface in order to measure properties of process streams and products, accurately and in real-time. The platform also provides self-learning and predictive capabilities aimed for dramatically reducing overcosts derived from even slight deviations from the optimum process. Low cost MEMS-NIR spectroscopic and granulometric analysers, smart sensors for in batch and in continuous processes will be developed and integrated into the global control platform with the chemometric tools and the predictive software to deliver an integrated process control platform. ProPAT will enable near real time closed-loop process control to operate industrial processes at their optimum, both economically and environmentally, while ensuring high levels of quality. It will also allow the uptake of the Quality by Design for continuous process improvement. The project results will be validated in different processes and applications including milling of minerals, ceramics, metals, mixing and granulation of pharma products and polymerization of resins, and will represent a major step forward towards more efficient, reliable and sustainable industrial operation

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.5.1 | Award Amount: 11.78M | Year: 2008

TheraEDGE is an industry-driven effort to accelerate the adoption of theranostics applications in Primary Care by pushing Point of Care Test (POCT) technology far beyond its current state-of-the-art and by delivering clinical, analytical and operational breakthroughs.\nTheraEDGE is built around the high-incidence clinical case of early-diagnosing lower respiratory tract infections in Primary Care. Simultaneous testing for different pathogens and their antibiotic resistance will have a huge European impact:\nbetter clinical outcomes and standards of care through more effective and timely diagnosis and treatment\nimproved health economics through optimization of antibiotics prescription, infection control practices and reduction of clinical visits or hospital stays\nsubstantial business for the In Vitro Diagnostics industry through the standardisation and commercialization of innovative POCT products and systems\nTheraEDGE consists of three multidisciplinary platforms:\na core Lab-On-a-Chip supporting multi-marker assays and using Single Molecule Detection (SMD) as an alternative to PCR-based molecular diagnostics. SMD removes the need for amplification and has the potential to become a key enabler for Nucleic Acid Testing at the Point of Care by providing less complex, faster, more sensitive and more specific assays\nan architecture that provides Plug and Play semantic interoperability and creates opportunities for the standardisation of POCT instruments and information systems, offering radical usability, robustness and vendor interoperability improvements. Practitioners will be able to run out-of-the-box multiple compliant devices from one single PDA-based operator interface\na set of applications built on a convergent ITC platform that supports General Practitioners in their patient management and clinical decision-making, and provides therapeutic services for patient education and compliance monitoring in order to fight antibiotic misuse and abuse.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.1.1 | Award Amount: 4.42M | Year: 2013

Current communication standards and systems are not optimally prepared for their application in unpredictable environments which occur for example in serious disaster scenarios such as earthquakes or tsunamis. Cellular communications systems are planned using accurate/strict link budget allocation mechanisms, in order to keep the probability of outage in an acceptable range. The whole communication chain (coding, signalling chain, but as well as higher layer protocols) is optimized for the operation in this range. Therefore, communication services perform poorly or fail completely in unpredictable environments. Future networks will most likely be heterogeneous and dense, a structure which can be exploited if communication schemes are constructed on an appropriate the theoretical, technological, and practical basis. In order to establish this basis, RESCUE proposes the integrated concept links on the fly which encompasses the key technologies of distributed joint source/channel coding in lossy wireless networks, exploitation of multi-path information transfer in wireless mesh networks, distributed and centralized MAC/network protocols for channel access, and routing, cross-layer design for interference management and error control.This will allow to achieve successful and robust information transfer through multi-path networks that are constructed from lossy point-to-point links, adaptability of information quality to the specific quality of service (QoS) requirements of applications and devices for higher spectrum and energy efficiency and the integration of diverse communication infrastructure such as base stations, relays, and satellites, and terminals for network robustness and fast provision of communication. In practice, such situations are frequent in todays wireless networks with mobility of nodes, high density cells, dynamic and opportunistic frequency management that has impact on the on-going communications and future 5G networks challenges.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH-2010-3.2-1 | Award Amount: 10.21M | Year: 2011

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors will be studied through a foresight approach to inform a redesign of effective addictions governance. Ownership will be described by an historical study of addiction through the ages, an analysis of public and private stakeholder views, and through image analyses, of professional and citizenship views. A study of how addictions are classified and defined will be followed by estimates of their health, social and economic impact. Determinants of addiction will be investigated through a coordinated and cohesive social, economic and biological analysis of initiation, transition into problem use and transition into and out of dependence. The business of addiction will be analyzed through studies of revenues, profits and participants in legal and illegal trade, the impact of suppliers on addictive substance use and behaviours, and analyses of webs of influence on policy responses. Addictions governance will be studied by describing the views and forces that determine the ways societies steer themselves and by stock taking of present governance practices to old and emerging addictions. Youth as customers will be analyzed through considering the impacts of new technologies on promoting and mitigating use, by studying the interrelations of culture and biology, and by determining features that promote resilience and nudge young people to reduce problematic use. The programme itself will be professionally managed from a partnership perspective to promote a coordinated and integrated approach to the high volume of research and its policy implications.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT.2012.1.4-2. | Award Amount: 30.14M | Year: 2012

Future aero engines will need to be more efficient and contribute to the reduction on environmental impact of air transportation. They must reach some standards of performance by reducing emissions and creating some savings on operation costs. EIMG consortium has launched since several years some initiatives to develop future engines in the frame of the European Committee research programmes. Within different project such as DREAM, VITAL, NEWAC or LEMCOTEC, EIMG is ensuring the development of innovative technologies in order to further reduce the fuel burn, emissions and noise. In order to ensure the technological breakthrough, future aero-engines will have higher overall pressure ratios (OPR) to increase thermal efficiency and will have higher bypass ratios (BPR) to increase propulsive efficiency. These lead to smaller and hotter high pressure cores. As core engine technologies have been addressed in the previous project, E-BREAK project will ensure the mandatory evolution of sub-systems. It is indeed required for enabling integration of engine with new core technologies to develop adequate technologies for sub-systems. E-BREAK will aim to adapt sub-systems to new constraints of temperature and pressure. The overall picture of these initiatives bring all technology bricks to a TRL level ensuring the possibility to integrate them in a new aero engines generation before 2020. In its 2020 vision, ACARE aims to reduce by 50% per passenger kilometer CO2 emissions with an engine contribution targeting a decrease by 15 to 20% of the SFC. NOX emissions would have to be reduced by 80 % and efforts need to be made on other emissions. E-BREAK will be an enabler of the future UHOPR integrated engine development, completing efforts done in previous or in on-going Level 2 programs.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 14.40M | Year: 2010

The first 3GPP Long Term Evolution standard version is complete and ready to be deployed. Although it increases peak data rate and spectral efficiency compared to legacy techniques, cell-edge and average user throughputs are still significantly lower than the peak rates. In the LTE-Advanced Study Item, ways to extend LTE are being explored. However, some of the considered techniques are complex and significant research efforts are needed to bring these techniques to reality.\n\nThe main ARTIST4G project objective is to improve the ubiquitous user experience of cellular mobile radio communications systems by satisfying the following requirements:\n\tHigh spectral efficiency and user data rate across the whole coverage area\n\tFairness between users\n\tLow cost per information bit\n\tLow latency\n\nThis objective will be achieved by developing innovative concepts out of promising ideas from the research ecosystem, and benchmarking them with the state-of-the-art. The technologies identified to fulfil the above requirements are:\n\tInterference avoidance\n\tInterference exploitation\n\tAdvanced relay techniques\n\nARTIST4G will build upon projects such as EASY-C, where first steps towards integration of these technologies in cellular systems have been made, but also address new aspects like:\n\tAdvanced multi-cell scheduling for adaptive and efficient usage of interference management and relaying techniques in appropriate scenarios\n\tImpact of the innovative concepts on the network architecture\n\nARTIST4G will not only use theoretical analysis and simulations to develop and validate innovative concepts based on these technologies, but also enable proof-of-concept via hardware prototypes and field trials in a representative testbed.\n\nIt is expected that ARTIST4G will create a major impact on standardization and provide the partners with a technological head-start that will strengthen the European position in cellular communications.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT.2011.1.4-2. | Award Amount: 67.80M | Year: 2011

The main objective of the LEMCOTEC project will be the improvement of core-engine thermal efficiency by increasing the overall pressure ratio (OPR) to up to 70 leading to a further reduction of CO2. Since NOx increases with OPR, combustion technologies have to be further developed, at the same time, to at least compensate for this effect. The project will attain and exceed the ACARE targets for 2020 and will be going beyond the CO2 reductions to be achieved by on-going FP6 and FP7 programmes including Clean Sky: 1.) CO2: minus 50% per passenger kilometre by 2020, with an engine contribution of 15 to 20%, 2.) NOx: minus 80% by 2020 and 3.) Reduce other emissions: soot, CO, UHC, SOx, particulates. The major technical subjects to be addressed by the project are: 1.) Innovative compressor for the ultra-high pressure ratio cycle (OPR 70) and associated thermal management technologies, 2.) Combustor-turbine interaction for higher turbine efficiency & ultra-high OPR cycles, 3.) Low NOx combustion systems for ultra-high OPR cycles, 4.) Advanced structures to enable high OPR engines & integration with heat exchangers, 5.) Reduced cooling requirements and stiffer structures for turbo-machinery efficiency, 6.) HP/IP compressor stability control. The first four subjects will enable the engine industry to extend their design space beyond the overall pressure ratio of 50, which is the practical limit in the latest engines. Rig testing is required to validate the respective designs as well as the simulation tools to be developed. The last two subjects have already been researched on the last two subjects by NEWAC. The technology developed in NEWAC (mainly component and / or breadboard validation in a laboratory environment) will be driven further in LEMCOTEC for UHPR core engines. These technologies will be validated at a higher readiness level of up to TRL 5 (component and / or breadboard validation in a relevant environment) for ultra-high OPR core-engines.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2011.2.4.3-4 | Award Amount: 3.89M | Year: 2012

Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the diabetes epidemic is in South Asia and this is reflected in the migrant populations in Europe. Current prevention strategies are focused on adult life and target over-nutrition in high-risk adults. However, for many population groups across the globe, these strategies ignore many key principles that underlie the increasing global prevalence of these diseases. A substantial portion of the South Asian people, living in their home countries experience nutrition deprivation, while after migration to Europe, may encounter nutritional abundance resulting in imbalance during their lifecourse. These conditions are of particular importance during foetal and early developmental stages where environmental insults may interact with genetic risk to induce foetal programming of adult metabolic disease. Few groups have targeted early life programming as an opportunity for the prevention of diabetes/obesity in childhood and subsequent adult life and there are limited guidelines on this topic. The proposed grant will bring together a unique group of investigators in South Asia (India, Bangladesh and Pakistan) and Europe (UK, Norway, Germany and Finland) with SMEs of complementary expertise (Germany and Spain) combining prevention strategies, state-of-the-art genomics, social sciences and public health that focus on these early life predictors of disease. The major objective behind this collaborative and multi-disciplinary approach is to combine knowledge from the work packages on lifestyle, nutrition and genomics to both inform public health policy through guideline development and design a large-scale pragmatic intervention to prevent the metabolic syndrome, obesity and diabetes in South Asian populations aimed at early life taking into account multi-generational effects.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.2 | Award Amount: 3.88M | Year: 2008

White Organic Light Emitting Diodes (OLEDs) are potentially highly efficient large area light sources that can be used for general lighting applications in hitherto unprecedented ways, such as light-emitting flexible foils. In the past years, the luminous efficacy of prototype white OLEDs has shown a very fast, fivefold, increase. In principle, there seems to be no fundamental obstacle towards 100 lm/W efficiency, beyond that of fluorescent lamps. However, in practice the ever-increasing complexity of OLEDs (20 layers or more) now hampers further progress towards that goal, in part because reaching this efficiency goal is only of practical interest in combination with durability, colour stability and tunability, mechanical stability and ease of fabrication. For the further development of efficient white OLEDs, the availability of an experimentally validated opto-electronic device model will be crucial. Todays first generation models, based on conventional understanding of transport and photo-physical processes, are at least incomplete for realistic OLED materials. The AEVIOM project aims at enabling a breakthrough in white OLED efficiency and lifetime by the development and application of an integrated second generation OLED model. After experimental validation, the model will provide a quantitatively correct physical description of the effects of disorder on the transport and photo-physical processes. The model will be the basis for numerical methods that properly include the entire chain of electrical and optical effects inside the organic semiconductor, as well as the optical out-coupling. Finally, experimentally validated recommendations will be given towards the realization of a breakthrough in white OLED efficiency and lifetime, and also in device manufacturing (simplified optimal layer structure).

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.1 | Award Amount: 24.95M | Year: 2010

The European Middleware Initiative is a collaboration of the three major middleware providers in Europe, ARC, gLite and UNICORE, and other consortia. EMI aims to deliver a consolidated set of middleware components for deployment in EGI, PRACE and other DCIs; extend the interoperability between grids and other computing infrastructures; strengthen the reliability of the services; and establish a sustainable model to maintain and evolve the middleware, fulfilling the requirements of the user communities.\nEuropean scientific research has benefited recently from the increasing availability of computing and data infrastructures with unprecedented capabilities for large scale distributed initiatives. These infrastructures are largely defined by enabling middleware. After the necessary initial period of research and consolidation that has taken place in the past several years, the growing usage of these resources now requires the transformation of the computing infrastructures into a professionally managed and standardized service. It is of strategic importance for the establishment of permanent, sustainable research infrastructures to lower the technological barriers still preventing resource owners from federating the resources, and potential communities of tens of thousands of researchers from using grids as a commodity tool in their daily activities.\nThe EMI project will make the realization of this vision possible by addressing a number of problems that still prevent users from easily accessing and using the whole capacity of the existing computing infrastructures. It will focus on improving the usability and accessibility for scientific users and the interoperability and manageability for service providers. The sustainability of the grid services will be directly addressed by replacing wherever possible proprietary technology with off-the-shelf components, improving their standardization and implementing industry standard quality assurance methodologies.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.2.4.2-1 | Award Amount: 14.96M | Year: 2012

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke. Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so its social and economic burden will grow with the ageing of the European population. Current treatment options for the 80 to 85% of all strokes due to cerebral ischaemia - around. 900,000 events in Europe every year, or one every 40 seconds - are extremely limited. Systematic review of experimental studies suggests that hypothermia is the most promising intervention identified to date. Therapeutic cooling is effective in reducing ischaemic brain injury following cardiac arrest, and hypothermia is therefore considered by experts the most promising treatment for patients with acute ischaemic stroke, next to reperfusion strategies. The EuroHYP-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit or harm of therapeutic cooling in 1500 awake adult patients with acute ischaemic stroke. In addition to efficacy and safety, the economic impact of therapeutic hypothermia will be assessed, along with several sub-studies involving imaging, ultrasound, and biomarker methods. The investigators involved in the EuroHYP-1 consortium are leading European experts in statistical design and analysis, therapeutic hypothermia, imaging, health economics, ultrasound, biomarkers, and trial execution (implementation and monitoring). Moreover in addition to these academic experts the consortium also involves European patient and family advocacy groups and small and medium-size enterprises, and the joint endeavours of this extended team will ensure the successful enrolment of patients at eighty hospitals across 25 countries in Europe.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.3 | Award Amount: 10.94M | Year: 2011

With ComVantage we envision an interorganisational collaboration space turning todays organisation-centric manufacturing approach into a product-centric one. Manufacturers will benefit from a flexible, efficient platform that helps them to operate as one virtual factory and thus gain competitive advantages in their markets. Based on best practises of Web 2.0 technologies the collaboration space will be an extension to existing business and engineering software. It will allow to share, administrate and monitor focused information throughout a products life cycle in a de-centralised manner. The close collaboration on the B2B and B2C levels will foster existing trends such as Open Innovation or Crowd Sourcing.\nThe framework of the virtual factory will encompass a secure access control that is founded on dynamic workflow models and flexible user roles accounting for large enterprises, SMEs and for end-customers. It will enable temporary and de-centralised access management for ad-hoc collaboration between geographically distributed experts.\nTo adhere to changing working situations, to efficient communication, and to rich interaction technologies ComVantage will focus on mobile devices. Intuitive and trustful mobile apps shall support users in fast decision making and problem solving. Information from different sources across the organisations is provided and maintained via Linked Data . The integration of sensor data allows for products to be members of the collaboration space.\nA continuous evaluation of the ICT and business model considering use cases throughout the project will verify the added-value of ComVantage for the European industry. The utilisation of existing technologies, a close user approach, and an incremental project set-up will provide sound concepts ready for fast productisation. Thus implementing ComVantage will increase lean communication, agile and highly efficient production processes, cost control and a low carbon footprint.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SST.2013.2-2. | Award Amount: 15.00M | Year: 2013

In 2011, the White Paper on European Transport reasserted how fundamental transport was for society, for the mobility of European citizens and for the growth and vitality of the European economy. CAPACITY4RAIL will deliver research that is innovative, prepares rail for the future and takes into account results from previous research projects and programmes. The project builds on previous useable results and will deliver both technical demonstrations and system wide guidelines and recommendations that will be the basis for future research and investment, increasing the capacities of rail networks in the future. The time used for infrastructure monitoring, maintenance and renewal means down time. New concepts for low maintenance infrastructure, using standardized and plug-and-play concepts will be proposed. Non-intrusive innovative monitoring techniques or self-monitoring infrastructure will be investigated, allowing low or no impact on train operations. The fragility of some key component of the infrastructure system (especially in extreme weather conditions) such as switches may impact the efficiency of the whole system. The resilience of switches to any kind of known failure will be reinforced, as well as the ability of the operation system to recover from incidents. Capacity enhancements will also be achieved by higher speed freight vehicles, allowing an optimized interleaving of freight trains into mixed traffic, and improved planning models for operation. Intermodal integration within the global transport system will be improved through enhanced transhipment of passengers and freight. CAPACITY4RAIL will also look towards 2030/2050, by proposing guidelines for future deployments in the mid-term, recommendations for technologies to de developed and deployed in the long term and investigating the key opportunities for funding these within national and EU funding schemes.

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2007.6.3 | Award Amount: 2.02M | Year: 2008

The aim of the REEB project is to facilitate co-creation of a Strategic Research Agenda (SRA) and a supporting Implementation Activity Plan (IAP) for sustainable and energy-efficient smart building constructions by and through the establishment of and federation of dialogue between interactive and complimentary communities of practice from energy, environment, and building construction domains. REEB will establish a community operating method that will allow these communities to act as breeding and nurturing grounds for innovation in bringing together the relevant organisations and stakeholders for the purpose of starting up innovation cycles in ICT-based environment management and energy efficiency in smart building constructions. The main outcomes will be (i) a SRA and detailed IAP for RandD and innovation in ICT supporting energy-efficient smart facilities, (ii) a comprehensive coordination of information exchange and dissemination between energy-related ICT projects in various EU, national, and global programs/initiatives, in terms of on-going research, developed solutions, standardisation efforts, etc.. This will include organising events and communication channels for identifying, defining, promoting and stimulating the innovative use of ICT in the Sustainability and Energy Efficiency area to reach the widest audience and bring together all stakeholders from the enlarged EU and relevant global communities. The REEB consortium involves 8 partners with complementary expertise drawn from 6 European countries (France, Finland, Spain, Ireland, UK, Germany). Moreover, the core partners, in their effort to build up the REEB community and develop the vision, roadmap and implementation plan, are supported by this Special Interest Group (SIG) whose members (both RTD and industry) will participate in community discussions and decisions, and provide active feedback to studies and analyses.

Agency: European Commission | Branch: H2020 | Program: ECSEL-RIA | Phase: ECSEL-01-2014 | Award Amount: 52.90M | Year: 2015

The 3Ccar project will provide highly integrated ECS Components for Complexity Control in thereby affordable electrified cars. The new semiconductors for Complexity management (Control, reduction) will offer the next level of energy efficiency in transportation systems. 3Ccars impact is maximizing pragmatic strategy: Use semiconductor technology innovations to manage functionality & complexity increase. This leads also to cheaper, efficient, robust, comfortable, reliable and usable automotive systems. This strengthens Europe as a whole (OEM, Tier1, Semiconductor) generating economic growth and new jobs in Europe. The impact of 3Ccar is driven vertically by innovations and horizontally enabling growth and deployment in the industry based on what we see as European Values. We recognized that European engineers develop for highest efficiency, convergence and manageable complexity. Our society appreciates long life products to avoid waste. 50 partners and 55 Mio budget give the mass for innovative products such as functional integrated powertrains, smart battery cells with unique selling features allowing Europe to advance to global leadership. An important feature of the project has been the recognition and exploitation of synergies with other EV projects, enabling fast innovation cycles between such aligned projects. With 55 Mio budget and 10 b impact the R&D expenditure ratio is 200 which is 10x higher than the semiconductor average and corresponds to very strong innovation potential which will be translated into automotive and semiconductor industry. The technologies developed in 3Ccar will be commercialized all over the world while giving advantages to Europes OEMs willing to manufacture in Europe. 3Ccar will be involved in standardization needed to ensure that large vertical supply chains can be established. The 3Ccar project shows that collaboration between industry, research institutes, governments and customers is pivotal for excellence in Europe.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2013.7.2.3 | Award Amount: 62.80M | Year: 2014

A group of eight Transmission System Operators with a generator company, manufacturers and research organisations, propose 5 demonstration projects to remove, in 4 years, several barriers which prevent large-scale penetration of renewable electricity production in the European transmission network. The full scale demonstrations led by industry aim at proving the benefits of novel technologies coupled with innovative system integration approaches: - A scaled down model of generators connected to a HVDC link is used within a new testing facility to validate novel control strategies to improve the interaction between HVDC links and wind turbine generators - The implementation of a full scale, hardware-in-the-loop test setup in collaboration with worldwide market leaders of HVDC-VSC technology explores the interactions of HVDC VSC multiterminal control systems to validate their interoperable operations - Strategies to upgrade existing HVDC interconnectors are validated with the help of innovative components, architecture and system integration performances, to ensure higher RES penetration and more efficient cross border exchanges. - Full scale experiments and pilot projects at real life scale of both installation and operation of AC overhead line repowering technologies are carried out to show how existing corridors can see their existing capacity increase within affordable investments. - The technical feasibility of integrating DC superconducting links within an AC meshed network (using MgB2 as the critical material) will be tested at prototype scale, thus proving that significant performance improvements have been reached to enable commercialization before 2030 The experimental results will be integrated into European impact analyses to show the scalability of the solutions: routes for replication will be provided with benefits for the pan European transmission network and the European electricity market as soon as 2018, in line with the SET plan objectives

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.6 | Award Amount: 6.76M | Year: 2010

The main target of CREW is to establish an open federated test platform, which facilitates experimentally-driven research on advanced spectrum sensing, cognitive radio and cognitive networking strategies in view of horizontal and vertical spectrum sharing in licensed and unlicensed bands.\nThe CREW platform incorporates 5 individual wireless testbeds (heterogeneous ISM @ iMinds-Gent, heterogeneous licensed @ TCD-Dublin, cellular @ TUD-Dresden, wireless sensor @ TUB-Berlin, outdoor heterogeneous ISM/TVWS @ JSI-Ljubljana) augmented with SoA cognitive sensing platforms from IMEC (Belgium) and TCS (France).\nCREW will physically and virtually federate components by linking together software and hardware entities from different partners using a standardized transceiver API, realizing advanced cognitive sensing functionality. In addition, the CREW federation will establish a benchmarking framework, enabling experiments under controlled and reproducible test conditions and providing methodologies for automated performance analysis, allowing a fair comparison between different cognitive concepts or between subsequent developments. Data sets created under benchmarked conditions according to a common data structure enable the emulation of CREW components in other experimental or simulation environments.\nThe basic CREW federation will be operational at the end of the first year for external use. Through three open calls (at month 12, month 24 and month 36) external experimenters will be attracted for using the CREW platform, leading to an open and demand-driven expansion of the federation and its usage.\nAlong with the federation activities, a strong interaction with the FIRE coordination and support actions will be realized, hereby ensuring maximal compliance of the CREW platform to the overall vision of the FIRE facilities.\nFinally, the CREW project will implement a sustainability business model for exploitation of the federated testbed from year 4 on and beyond the project.

Schlierf M.,TU Dresden | Ha T.,University of Illinois at Urbana - Champaign
Cell | Year: 2012

DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time. © 2012 Elsevier Inc.

Roerecke M.,Center for Addiction and Mental Health | Roerecke M.,University of Toronto | Rehm J.,Center for Addiction and Mental Health | Rehm J.,University of Toronto | Rehm J.,TU Dresden
International Journal of Epidemiology | Year: 2014

Background: Alcohol use disorders (AUD) are highly disabling. Recent studies reported much higher relative risks for all-cause mortality in AUD patients compared with earlier studies. Systematic evidence regarding cause-specific mortality among AUD patients has been unavailable to date.Methods: Studies were identified through MEDLINE, EMBASE and Web of Science up to August 2012. Following MOOSE guidelines, prospective and historical cohort studies assessing cause-specific mortality risk from AUD patients at baseline compared with the general population were selected. Data on several study characteristics, including AUD assessment, follow-up period, setting, location and cause-specific mortality risk compared with the general population were abstracted. Random-effect meta-analyses were conducted.Results: Overall, 17 observational studies with 6420 observed deaths among 28 087 AUD patients were included. Pooled standardized mortality ratios (SMRs) after 10 years of follow-up among men were 14.8 (95% confidence interval: 8.7-24.9) for liver cirrhosis, 18.0 (11.2-30.3) for mental disorders, 6.6 (5.0-8.8) for death by injury and around 2 for cancer and cardiovascular diseases. SMRs were substantially higher in women, with fewer studies available. For many outcomes the risk has been increasing substantially over time.Conclusions: Cause-specific mortality among AUD patients was high in all major categories compared with the general population. There has been a lack of recent research, and future studies should focus on the influence of comorbidities on excess mortality risk among AUD patients. Efforts to reduce these risks should be a priority, given that successful treatment reduces mortality risk substantially for a relatively common psychiatric disease. © The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

BACKGROUND: Alcohol consumption is a major global risk factor for mortality and morbidity. Much discussion has revolved around the diverse findings on the complex relationship between alcohol consumption and the leading cause of death and disability, ischemic heart disease (IHD).METHODS: We conducted a systematic search of the literature up to August 2014 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify meta-analyses and observational studies examining the relationship between alcohol drinking, drinking patterns, and IHD risk, in comparison to lifetime abstainers. In a narrative review we have summarized the many meta-analyses published in the last 10 years, discussing the role of confounding and experimental evidence. We also conducted meta-analyses examining episodic heavy drinking among on average moderate drinkers.RESULTS: The narrative review showed that the use of current abstainers as the reference group leads to systematic bias. With regard to average alcohol consumption in relation to lifetime abstainers, the relationship is clearly J-shaped, supported by short-term experimental evidence and similar associations within strata of potential confounders, except among smokers. Women experience slightly stronger beneficial associations and also a quicker upturn to a detrimental effect at lower levels of average alcohol consumption compared to men. There was no evidence that chronic or episodic heavy drinking confers a beneficial effect on IHD risk. People with alcohol use disorder have an elevated risk of IHD (1.5- to 2-fold). Results from our quantitative meta-analysis showed that drinkers with average intake of <30 g/day and no episodic heavy drinking had the lowest IHD risk (relative risk = 0.64, 95% confidence interval 0.53 to 0.71). Drinkers with episodic heavy drinking occasions had a risk similar to lifetime abstainers (relative risk = 1.12, 95% confidence interval 0.91 to 1.37).CONCLUSIONS: Epidemiological evidence for a beneficial effect of low alcohol consumption without heavy drinking episodes is strong, corroborated by experimental evidence. However, episodic and chronic heavy drinking do not provide any beneficial effect on IHD. Thus, average alcohol consumption is not sufficient to describe the risk relation between alcohol consumption and IHD. Alcohol policy should try to reduce heavy drinking patterns.

Cai W.,TU Dresden | Chen L.,Robert Koch Institute | Chen L.,Max Planck Institute for the Physics of Complex Systems | Ghanbarnejad F.,Robert Koch Institute | And 3 more authors.
Nature Physics | Year: 2015

The spreading of contagions can exhibit a percolation transition, which separates transitory prevalence from outbreaks that reach a finite fraction of the population. Such transitions are commonly believed to be continuous, but empirical studies have shown more violent spreading modes when the participating agents are not limited to one type. Striking examples include the co-epidemic of the Spanish flu and pneumonia that occurred in 1918 (refs,), and, more recently, the concurrent prevalence of HIV/AIDS and a host of diseases. It remains unclear to what extent an outbreak in the presence of interacting pathogens differs from that due to an ordinary single-agent process. Here we study a mechanistic model for understanding contagion processes involving inter-agent cooperation. Our stochastic simulations reveal the possible emergence of a massive avalanche-like outbreak right at the threshold, which is manifested as a discontinuous phase transition. Such an abrupt change arises only if the underlying network topology supports a bottleneck for cascaded mutual infections. Surprisingly, all these discontinuous transitions are accompanied by non-trivial critical behaviours, presenting a rare case of hybrid transition. The findings may imply the origin of catastrophic occurrences in many realistic systems, from co-epidemics to financial contagions. © 2015 Macmillan Publishers Limited. All rights reserved.

Heitkam S.,University Paris - Sud | Heitkam S.,TU Dresden | Drenckhan W.,University Paris - Sud | Frohlich J.,TU Dresden
Physical Review Letters | Year: 2012

Many experiments and simulations of packings of monodisperse hard spheres report a dominance of the face-centered cubic structure in the hexagonally close-packed limit, even though it has no significant energetic or entropic gain over other close-packed configurations. Combining simulations and experiments, we demonstrate that a simple mechanical instability which occurs during the packing process may play an important role in selecting the face-centered cubic structure over other close-packed alternatives. Our argument is supported by detailed quantitative analyses of key configurations in sphere packings and highlights the importance of the packing dynamics. The proposed mechanism is elementary and should therefore play a role in a wide range of sphere systems. © 2012 American Physical Society.

Petrasek Z.,TU Dresden | Suhling K.,King's College London
Optics Express | Year: 2010

We demonstrate that an ultra-fast CMOS camera combined with a photon counting image intensifier can be used to determine photon arrival times well below the exposure time of the camera. We can obtain a time resolution down to around 1% of the exposure time, i.e. of the order of 40 ns with microsecond exposure times. This is achieved by exploiting the invariant phosphor decay of the image intensifier's phosphor screen: Developing a suitable mathematical framework, we show that the relative intensities of the phosphor decay in successive frames following the photon detection uniquely determine the photon arrival time. This approach opens a way to measuring fast luminescence decays in parallel in many pixels. Possible applications include oxygen and ion concentration imaging using probes with luminescence lifetimes in the range of 100 ns to microseconds. © 2010 Optical Society of America.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: Fission-2007-3.1-01 | Award Amount: 6.70M | Year: 2008

Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular disease. In addition, radiation may increase atherosclerotic lesions in the coronary arteries. The aim of this collaborative research project is to elucidate the pathogenesis of early and late alteration in the microcirculation of the heart and of atherosclerotic lesions in arteries after exposure to low radiation doses in comparison to high radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences. To achieve this goal, in vivo as well as ex vivo and in vitro studies will be performed. A central component of the project will be the local irradiation of the heart with subsequent isolation of cardiomyocytes and cardiac endothelial cells to provide all participating groups with the same biological material for further study. In addition, structural, morphological and molecular studies will be complemented by functional assays and imaging methods.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-6.3-2015 | Award Amount: 17.72M | Year: 2016

SELIS is aimed at delivering a platform for pan-European logistics applications by: - Embracing a wide spectrum of logistics perspectives and creating a unifying operational and strategic business innovation agenda for pan European Green Logistics. - Establishing an exceptionally strong consortium of logistics stakeholders and ICT providers, that can leverage EU IP from over 40 projects so as to create proof of concept Common Communication and navigation platforms for pan-European logistics applications in month 18 deployed in 8 living labs (LLs) representing the principal logistics communities. - Establishing a research and innovation environment using the LLs to provide data than can be used for discovery of new insights that will enable continuous value creation supporting the large scale adoption of SELIS. The proposed Shared European Logistics Intelligent Information Space, SELIS, is a network of logistic communities specific shared intelligent information spaces termed SELIS Community Nodes (SCN). SCNs are constructed by individual logistics communities to facilitate the next generation of collaborative, responsive and agile green transportation chains. SCNs link with their participants existing systems through a secure infrastructure and provide shared information and tools for data acquisition and use, according to a cooperation agreement. Connected nodes, provide a distributed common communication and navigation platform for Pan European logistics applications. Each Node decides what information wishes to publish and what information wants to subscribe to. The SELIS Community Node (SCN) concept represents the evolution of a longline of research in this area. The fundamental principle is that it provides a lightweight ICT structure to enable information sharing for collaborative sustainable logistics for all at strategic and operational levels.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 277.40K | Year: 2014

Quantum semiconductor microcavities are structures in which photons can be confined within an area whose size is comparable to the wavelength of light. In this scenario, light-matter interactions can be substantially enhanced. A traditional microcavity is composed of two dielectric or semiconductor Bragg reflectors confining an active area which contains a quantum object such as a quantum well. From the initial observation of strong coupling between photons and excitons in such microcavities, the physics of polaritons has developed very quickly demonstrating such fascinating effects as stimulated scattering and Bose-condensation of polariton; room-temperature polariton lasing, superfluidity, bistability and multistability, soliton formation and many others. Recently it was shown that a localized state of light (Tamm Plasmon) can be formed at the interface between a specially designed Bragg mirror and metallic layer. For decades it was assumed that metallic elements are detrimental to optical coherence and lasing, however the intrinsic properties of the spatial distribution of the electric field of the Tamm Plasmon facilitate optical coherence and lasing in a microcavity with an embedded metallic layer. By coupling a microcavity polariton to a Tamm Plasmon, lateral localization can be achieved, opening the way for polaritonic logic elements and polaritonic circuits. This project is aimed at the design, fabrication and investigation of novel optoelectronic structures: hybrid metallic microcavities. These structures will be used for fabrication of lasers and sources of single photons and entangled photon pairs, polaritonic logic circuits as well as for fundamental studies of microcavity polaritons.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SST.2013.2-1. | Award Amount: 10.93M | Year: 2013

The main scope of this Next Generation Train Control (NGTC) project is to analyse the commonality and differences of required functionality for mainline and urban lines and develop the convergence of both ETCS and CBTC systems, determining the level of commonality of architecture, hardware platforms, and system design that can be achieved. This will be accomplished by building on the experience of ETCS and its standardised train protection kernel, where the different manufacturers can deliver equipment based on the same standardised specifications and by using the experience the suppliers have gained by having developed very sophisticated and innovative CBTC systems around the world The goal is not to develop a system of one size fits all, but to make progress for all railway domains in terms of increasing the commonality in system design and hardware, with various benefits like increasing economies of scale for suppliers, and amongst other things for customers increasing the competition between suppliers, based on standardised functions and interfaces. On top of the synergy of both systems, the NGTC project will aim to apply new technologies to the new train control system. Based on worldwide market driven requirements, NGTC proposes research work on Satellite positioning, the further development of IP based radio communication and a system approach to the moving block concept that is inexistent at the moment. If necessary proposed modifications of the ERTMS message structure will be provided, to make it a scalable solution including urban applications, while maintaining the backward compatibility with the Baseline 3 ETCS message specifications

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.4 | Award Amount: 9.02M | Year: 2008

Trusted Computing (TC) has become meanwhile an established technology for verification and implementation of integrity and security at personal computers. Similar requirements are also needed for embedded computing platforms which have alike trust and security problems due to the increasing complexity and therefore instability of Os and applications as well as connection to the Internet with its security dangers and attacks. Until now the TC standard is mainly targeted for PCs with their large resources of available code space, specific bus interfaces and large computing power which are not available with embedded platforms.\nAs there are a much higher number of embedded computing platforms like PCs in the field, it becomes a necessity to adapt the current TC standard to embedded platforms.\nThe project will make an systematic approach for the development of trusted embedded systems, consisting of hardware platforms with integrated trust components and also work on the necessary trusted operating systems:\n1.Trusted hardware, Trusted Platform Module as VHDL design, which could adapted to different host systems together with processors supporting a trust architecture\n2.Trusted operating systems mainly based on the new virtualisation/hypervisor architecture which are already in use at the PC world. Adapting it to the specific requirements of small platforms and trusted modules\n3.Security layers for implementing easy accessible security mechanisms.\n4.Trusted protocols: Elementary TC protocols like TSS (Host interface API) and TNC (trusted network connect, an advanced secure communication protocol) will be adapted for embedded platforms\n5.Application examples will give us feedback about available trust functionality, application friendliness and user requirements.\nWe will use the results and experience from the project to influence the TC standardisation and prepare for application scenarios like mobile phones, communication, e-commerce, industrial and automotive

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-20-2014 | Award Amount: 3.67M | Year: 2015

The lifetime, reliability, and efficiency of organic light emitting diodes (OLED) are critical factors precluding a number of novel devices from entering the market. Yet, these stability issues of OLEDs are poorly understood due to their notorious complexity, since multiple degradation and failure channels are possible at different length- and timescales. Current experimental and theoretical models of OLED stability are, to a large extent, empirical. They do not include information about the molecular and meso-scales, which prevents their integration into the workflow of the industrial R&D compound design. It is the idea of this project to integrate various levels of theoretical materials characterization into a single software package, to streamline the research workflows in order for the calculations to be truly usable by materials engineers, complementary to experimental measurements. Towards this goal, this project brings together the academic and industrial expertise of the leading experimental and theoretical groups in the field of organic semiconductors.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.1.1-1 | Award Amount: 15.31M | Year: 2010

In recent years, the zebrafish has emerged as a new vertebrate model organism for biomedical research which offers a unique combination of traits: a short generation time, small size and efficient breeding procedures make it the best choice among vertebrates for forward genetic screening and small-molecule screens, including toxicology, while the transparent embryo and larva offers unique opportunities for imaging of cell movement and gene expression in a developing organism. Building on recent advances in the zebrafish field, we will conduct high-throughput phenotyping of at least a thousand regulatory genes relevant for common human diseases, by behavioural assays (for viable mutants), 3D / 4D imaging and expression profiling (including high-throughput sequencing). We will include mutants generated by TILLING and by the new zinc finger nuclease method, as well as mutants from earlier forward-genetics screens. A phenotyping effort of this scale has never been undertaken before in any vertebrate organism. Complementing the study of mutants relevant for neurological disorders, we will produce an atlas of gene expression in the brain, the most comprehensive one in a vertebrate. We will further perform a genome-wide characterisation of regulatory elements of potential disease genes by a combination of bioinformatics and transgenics. Small-molecule screening for mutant rescue or disease-relevant processes will identify candidate drugs and provide insights into gene function. Our increasing knowledge on the regulators and their interactions with regulatory targets will be integrated with knowledge at cellular and organismic level. By capitalising on the virtues of the zebrafish system, this systems biology approach to the regulome will gain unique knowledge complementing ongoing work in mammalian systems, and provide important new stimuli for biomedical research.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2008-1-4-11 | Award Amount: 866.38K | Year: 2009

The nine European Technology Platforms (ETPs) that focus on the Knowledge-Based Bio-Economy (KBBE) join forces in this support action BECOTEPS. The main objectives and the respective activities will be: 1) Achieve closer and more coordinated collaboration between the KBBE ETPs. 2) Develop recommendations for better interaction between KBBE ETP stakeholders along the product chains and the sustainability issue regarding multidisciplinary research, application and policy issues. BECOTEPS will help to link science and application by addressing synergies and gaps i) between the SRAs of the ETPs and ii) with respect to the research preparedness of the scientific community by topical workshops on cross-cutting KBBE issues. The first workshop will address trust and collaboration in the food and feed chain, the second the integration of the non-food chains, and the third cross-cutting sustainability issues. The workshop recommendations on research and policy will be summarised in a White Paper. 3) Encourage discussions among public research initiatives - European and national and between the public and the private research initiatives to foster implementation of the Strategic Research Agendas based on the recommendations developed between the ETPs. In addition, BECOTEPS will promote the KBBE concept with the European Commission, European Parliament and national ministries in the member states including the relevant ERA-NETs. A small number of dissemination events will be held to discuss the KBBE, recommendations from the workshops on implementing cross-cutting issues from the ETPs Strategic Research Agendas (including Lead Markets, SMEs, education and training), and future collaboration.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-14-2014 | Award Amount: 7.23M | Year: 2015

Small Cells, Cloud-Radio Access Networks (C-RAN), Software Defined Networks (SDN) and Network Function Virtualization (NVF) are key enablers to address the demand for broadband connectivity with low cost and flexible implementations. Small Cells, in conjunction with C-RAN, SDN, NVF pose very stringent requirements on the transport network. Here flexible wireless solutions are required for dynamic backhaul and fronthaul architectures alongside very high capacity optical interconnects. However, there is no consensus on how both technologies can be most efficiently combined. 5G-XHaul proposes a converged optical and wireless network solution able to flexibly connect Small Cells to the core network. Exploiting user mobility, our solution allows the dynamic allocation of network resources to predicted and actual hotspots. To support these novel concepts, we will develop: 1) Dynamically programmable, high capacity, low latency, point-to-multipoint mm-Wave transceivers, cooperating with sub-6-GHz systems; 2) A Time Shared Optical Network offering elastic and fine granular bandwidth allocation, cooperating with advanced passive optical networks; 3) A software-defined cognitive control plane, able to forecast traffic demand in time and space, and the ability to reconfigure network components. The well balanced 5G-XHaul consortium of industrial and research partners with unique expertise and skills across the constituent domains of communication systems and networks will create impact through: a) Developing novel converged optical/wireless architectures and network management algorithms for mobile scenarios; b) Introduce advanced mm-Wave and optical transceivers and control functions; c) Support the development of international standards through technical and techno-economic contributions. 5G-XHaul technologies will be integrated in a city-wide testbed in Bristol (UK). This will uniquely support the evaluation of novel optical and wireless elements and end-to-end performance.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: GV-2-2014 | Award Amount: 8.00M | Year: 2015

Innovation in the automotive industry is of pivotal importance for Europeans prosperity. OSEM-EV will provide solutions for better autonomy and predictable range to address todays car buyers concern about electro mobility. Just increasing the battery capacity is not a viable option because the expectation is to have a familiar level of comfort and safe, eco and human oriented mobility at affordable costs. OSEM-EV will translate the foreseen project innovations into a customer value proposition. The highest priority is improved mileage and predictable range without adding further cost and weight. The negative impact of high and low ambient temperatures will be limited. Cars autonomy will be increased due to a reduction of at least 50% of energy used for passenger comfort and at least 30% for component cooling in extreme conditions compared to current FEVs. The consortium will focus on thermal and coupled electro-thermal energy substitution and harvesting and smart energy usage for cooling and heating of the passenger compartment and in-car infrastructure. OSEM-EV goes for novel electro-thermal architectures and control algorithms including thermal insulation, thermal storage, innovative heating and cooling approaches applied to the powertrain (battery, inverter and motor), battery life duration enhancement as a side effect of thermal management, electronic control of energy and power flows, energy efficiency of electrified accessories, energy substitution and harvesting functions. The consortium will take a radical approach, which does not only rely on improving the efficiency of subsystems but also focuses on their interoperability. By creating an electro-thermal network, most of the energy shall be reutilized, no matter if stored in mechanical, electrical or thermal form.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.5.2 | Award Amount: 3.28M | Year: 2010

Clinical trials are increasingly considered to be not only a means for evaluating the effectiveness of new medicine and pharmaceutical formulas but also for experimenting on existing drugs and their appliance to new diseases and disorders. Pharmaceutical companies tend to prefer launching modified versions of existing drugs, which generate generous profits while carrying little risk of rejection. Translation into clinical therapy has to overcome substantial barriers at the preclinical and clinical levels. Thus, bridging basic science to clinical practice comprises a new scientific challenge which can result in successful clinical applications with low financial cost. In the aforementioned context, the results yielding from clinical trials, which are testing the effectiveness of existing drugs and pharmaceutical formulas on diseases other than the ones they are currently treating, are closely dependent on the available data and the patients. The efficacy of such trials requires the pursuit of a number of aspects that need to be addressed ranging from the aggregation of data from various heterogeneous distributed sources (such as electronic health records - EHRs) to the intelligent processing of this data based on the clinical trial-specific requirements for choosing the appropriate patients eligible for recruitment. Within this framework, PONTE aims at providing a platform following a Service Oriented Architecture (SOA) approach that will offer intelligent automatic identification of individuals eligible (concerning their safety and clinical trial efficacy) to participate in clinical trials, as these will be designed and planned through a flexible authoring tool, enabling semantic interoperability of clinical care information systems with clinical research information systems and drug and disease knowledge databases, as well as the appliance of advanced data mining techniques and enhanced learning algorithms.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.2 | Award Amount: 4.05M | Year: 2012

There is a wealth of publicly available data in todays Internet (e.g., Web pages, government law texts, public statistics, media archives, etc.) that can be exploited by large and small companies in various business domains. Storing, processing, and querying such ever increasing amounts of data is becoming a major challenge, and having the capability to do so is a strong asset for the few big companies with sufficient infrastructural resources. For instance, it is not possible for many small companies to mine publicly available content on the Internet because they do not have the means to build, access or store a complete graph of the Web.\nLEADS is based on the premise that, instead of maintaining data in-house in dedicated data centres, it is both economically and ecologically better to store it in a shared infrastructure. Its objective is to build a decentral-ized Data-as-a-Service (DaaS) framework that runs on an elastic collection of micro-clouds. LEADS will provide means to gather, store, and query publicly available data, as well as process this data in real-time. In addition, the public data can be enriched with private data maintained on behalf of a client, and the processing of the real-time data can be augmented with historical versions of the public and private data. The platform will be designed from the ground up to account for privacy, security, energy-efficiency, availability, elastic scalability, and performance considerations. The project will be validated on use-cases involving the crawling of Web data and its exploitation in different application domains.\n\nThe project website will be http://www.leads-project.eu/

The Feel4Diabetes project addresses HCO5-2014: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes. The aim of this project is to develop, implement and evaluate a community-based intervention aiming to create a more supportive social and physical environment to promote lifestyle and behaviour change to prevent type 2 diabetes among families from low and middle income countries and from vulnerable groups in high income countries in Europe. Methods: The PRECEDE-PROCEED Model will provide the theoretical framework for the development, implementation and evaluation of the Feel4Diabetes intervention. The framework has two phases, namely the PRECEDE and PROCEED phase. During the PRECEDE phase, the target population as well as behaviours related to type 2 diabetes and their determinants will be identified. Existing research programs and guidelines for type 2 diabetes prevention, policies, legislation, local infrastructure and human resources will also be recorded. Based on the knowledge gained from this phase, a low-cost and applicable in low-resource settings community-based intervention programme will be developed, with the active engagement of local stakeholders, providing access to the existing infrastructure and human resources wherever feasible. During the PROCEED phase, the intervention will be implemented and its process, impact, outcome, cost-effectiveness and scalability will be evaluated. The results of the intervention will be disseminated, aiming to embed it into policy and practice. Consortium: The Feel4Diabetes multidisciplinary consortium incorporates the necessary expertise on diabetes prevention, behaviours, nutrition, physical activity, policy and health economics. It consists of 10 partners from 7 universities, 1 research institute, 1 advocacy group and a small-medium enterprise, representing European low-middle income, high income and under socioeconomic crisis countries.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.14M | Year: 2013

Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing EU population. The Euroclast consortium (7 academic, 2 private and 1 ass. partner) focuses on osteoclast heterogeneity, a recent insight that poses new fundamental questions best tackled by a multi-partner consortium capable of assembling the sophisticated molecular, genetic and imaging tools required. We will analyze changes in gene and protein expression during osteoclast (trans)differentiation from different precursor cell pools and in various bone sites and relate this to osteoclast activity and sensitivity to therapeutics. The osteoclast resorptive apparatus will be studied using in depth and will define the key enzymatic and molecular machinery to be translated into novel site-specific drug targets or biomarkers. High throughput screening assays for therapeutics and ELISAs for biomarkers will be developed with our private partners. Our multidisciplinary and cross-sectorial approach will improve understanding and treatment of common disorders associated with osteoclast malfunction and train 11 early stage researchers (ESRs) in modern cell and bone biology. We will provide extensive training in generic skills and all ESRs will spend time with our private partners and be seconded to other academic partners to ensure they are well equipped for employment in research and industrial settings. Euroclast will produce an on-line repository for osteoclast protocols, make methodological and scientific advances in osteoclast and bone biology and create a sustainable network of ESRs and senior academics to tackle diseases of bone loss into the future.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-11-2016-2017 | Award Amount: 7.60M | Year: 2017

PACE aims to transform the treatment of patients suffering from critical limb ischemia (CLI), a disease with high medical need, because of limited treatment options and poor outcome by applying a novel, off-the-shelf allogeneic placenta-derived stromal cell product (PLX-PAD). Despite improvements in medical care and revascularization, patients with CLI continue to have a high risk of major amputation (below the knee or higher) and cardiovascular death (1-year amputation-free survival <60%; 10-year mortality 70%). CLI has a strong social impact and its incidence is rising worldwide, including in Europe. The prevalence of CLI in the population aged 6090 years is estimated as 1% (0.51.2%) with male to female ratio around 3:1. We will evaluate the efficacy, tolerability and safety of multiple intramuscular injections of HLA-unmatched allogeneic PLX-PAD for the treatment of CLI patients who are unsuitable for revascularization, in a randomized, double-blind, multicentre, placebo-controlled, parallel group phase II study. The European Medicine Agency (EMA) accepted PLX-PAD as pilot project for the new Adaptive Pathways to Patients to force timely access for patients to the new therapeutic option. The PACE consortium will go beyond the traditional clinical trial endpoints of safety and efficacy, by state-of-the-art characterizing molecular and functional signature of the PLX-PAD product(s), in depth investigating mechanisms-of-action of PLX-PAD therapy, and exploring biomarkers for understanding response/non-response in particular patients (stratification and therapy response markers). PACE partners are world-leading experts in scalable, clinical grade 3D-cell manufacturing approved by authorities, preclinical and clinical cell therapy, and biomarker analyses with well recognized expertise in designing and performing clinical trials, including those with Advanced Therapy Medicinal Products (ATMPs) integrated with in-patient biomarker and mechanistic side-studies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-19-2015 | Award Amount: 3.60M | Year: 2016

Whereas many tools for e-participation have been developed to involve citizens and large stakeholder groups, there are no digital instruments which enable the creative participation of the citizenship on a massive scale. The new co-design environment U_CODE enables communication and collaboration between large numbers of citizen and professional experts. Key novelty is a Public Project Space for non-professional civic users: a highly accessible, low-threshold public interface. For citizens who want to engage actively in the design process, a Project Play Ground is provided which features highly experiential design tools. Second key novelty of U_CODE is a collaboration platform which connects the Project Play Ground to professional urban designers. This Co-design Workspace is a unidirectional exchange hub between public users and professionals. It supports the collection of project relevant information, the generation of initial impulses, and the discussion of propositions in the early phase of the design. Key catalysers for co-design and communication are Moderated Models (MoM) that are exchanged and iterated between professionals and the public until mutual understanding is found. The Moderated Models are derivatives from a cloud-based Project Information Model (PIM) which integrates all project relevant information, including technical data as well as public input. Moderated models are published in the public Project Play Ground as to stimulate feedback e.g. via Social Media. U_CODE will assess the proposals on semantic and emotional level, in order to devise early detection of resistance against projects, and to prevent the build-up of negative public sentiment. U_CODE will enable professional creatives to utilise the publics creativity, to follow public opinions and sentiments, and to derive design intelligence from them. The design and decision making process will be informed and transformed by impulses of citizen experts as a driving force.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.1 | Award Amount: 14.74M | Year: 2008

DOTFIVE is a three-year IP proposal for a very ambitious project focused on advanced RTD activities necessary to move the Silicon/germanium heterojunction bipolar transistor (HBT) into the operating frequency range of 0.5 terahertz (THz) (500 gigahertz GHz) enabling the future development of communication, imaging or radar Integrated Circuits (IC) working at frequencies up to 160 GHz . For a given lithography node bipolar transistors and more recently HBT have always lead the frequency race compared to MOS devices, while offering higher power density and better analogue performances (transconductance, noise, transistor matching).The main objective of this highly qualified consortium is to establish a leadership position for the European semiconductor industry in the area of millimeter wave (mmW) by research and development work on silicon based transistor devices and circuit design capabilities and know-how. SiGe HBT is a key reliable device for applications requiring power > few mW (future MOS limitation) and enabling high density, low cost integration compared to III-V. To achieve the goal DOTFIVE unites a powerful consortium:Seven academic partners for the physics understanding of nanotransistors, simulation, modeling, and characterization (down to few k) of devices; as well as the design and characterization of demonstrator electronic blocks (Low Noise Amplifier, mixers...).Two research institutes in charge of developing novel process modules and transistor structures on silicon wafers, capable of fabricating innovative SiGe HBT concepts.Two industrial companies, capable of producing 250 GHz HBT on silicon, and willing to push their capabilities to 500 GHz by incremental structural and technological improvements utilizing some of the most advanced equipments introduced recently by the CMOS miniaturization race. Two SME capable to deliver to designers, transistor parameter extraction and RF advanced compact models for all the silicon providers above.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2009.3.8 | Award Amount: 3.36M | Year: 2010

The Nanophotonics for Energy Efficiency proposal aims to create a virtual centre of excellence to re-orient and focus nanophotonics research towards the challenges in energy efficient applications. The network will cluster nanophotonic laboratories and research groups in Europe combining their expertise in the development of disruptive approaches to lighting and solar cell technology. The consortium consolidates know-how and resources of 9 different institutions in 6 European countries with complimentary research and development expertise, integrating more than 130 scientists, engineers, technicians and managers in nanophotonics.The project pursues a scientific bottom-up approach to ensure that novel ideas and scientific breakthroughs as well as established proof-of-concepts in academia are promoted along the value chain towards reaching their eventual goal of commercialization. Market and industrial relevance is ensured through the involvement of industry leaders in the Advisory Board. This approach complements the existing top-down, industry-driven projects like e.g. OLED100.eu.The project intends to achieve the overall long-term integration goal by coordinating three main efforts:1.\tRealising a strategy for successful integration: creation of new research clusters and a virtual laboratory network that will lead to the creation of a lasting entity that will exist beyond the duration of this NoE2.\tEstablishing joint research: foster collaborations among the leading groups in nanophotonics for energy efficiency, interchanging knowledge and best practices, and paving the way towards the establishment of common research agendas3.\tSpreading knowledge: education and training specially geared towards young researchers and technicians both on S&T issues as well as on complementary skills like communication, business, entrepreneurial or IPR skills and dissemination towards the scientific community, industry, and the public in general

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.1.1-1 | Award Amount: 18.17M | Year: 2010

The EUCOMMTOOLS Collaborative Project responds to the topic HEALTH.2010.2.1.1-1: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease. EUCOMMTOOLS will provide, in a systematic high-throughput way, genetic tools and resources contributing to the determination of every genes function in any cell type of the entire organism at any given point in time. To contribute to the IKMC goals, EUCOMMTOOLS will establish 250 BAC-CreERT2 transgenic mice allowing inducible conditional gene inactivation in most cell types of the organism at any given point in time. Furthermore, EUCOMMTOOLS will establish 3.500 additional, conditionally targeted mouse ES cells to complete the IKMC resource. In addition, various important technological developments will valorise the EUCOMMTOOLS resources: a genetic toolkit for multipurpose usage of the conditional knockout alleles, and improvements of the Cre-recombinase function. The EUCOMMTOOLS Cre transgenic resource as well as its library of conditionally mutated mouse ES cells enables the establishment of mutant mice world-wide in a standardized, cost-effective and time-saving manner, making mouse mutants more easily available to the wider biomedical research community than possible previously. All EUCOMMTOOLS vectors, mutant ES cells and mice will be displayed via the EUCOMMTOOLS web portal and will be distributed by EuMMCR and EMMA to the scientific community. In general, EUCOMMTOOLS fosters existing European consortia which address mouse functional genomics, mouse mutant phenotyping, and mouse archiving. Taken together, EUCOMMTOOLS will further advance the functional annotation of the entire mouse genome and thereby enhance the understanding of the molecular basis of disease. Furthermore, it will support drug development by SMEs and the pharmaceutical industry.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.97M | Year: 2013

GLOBASOL will develop new concepts, materials and devices for advanced light harvesting and light management for a panchromatic collection of the solar energy and an unprecedented power conversion efficiency. This will be accomplished by integrating in a single device three light-to-electricity converters, exploiting different regions of the solar spectrum based on sensitized mesoscopic solar cells (SMSC), photonic crystals, thermoelectric (TE) cells. The key elements of the project are: 1) new absorbers for SMSC, with a very high conversion efficiency in the UV-vis region; 2) novel photonic materials for the collection/split of the IR spectrum; 3) advanced nanostructured materials for TE conversion of the IR part of the spectrum; 4) radically new architectures for the integrated devices, to increase the total efficiency. The innovative materials will include organometallics, organic dyes and quantum dots as sensitizers, quasi-solid electrolytes, nanostructures and nanowires alloys as well as quantum dots for TE. The devices will be engineered either in tandem arrangements or with optical splitting of the incident radiation, and concentration of the IR fraction to the TE. The targeted power conversion efficiencies are above 15% and 10% for SMSC in high and medium energy spectral regions, respectively, and 6% for TE, to reach a global efficiency above 30%, well beyond the present limits, along with cost-effectiveness and environmental safety. Five Universities and one Research Institution guarantee a scientific and technological multidisciplinary research, based on top level theoretical and experimental approaches. The high degree of knowledge in solid-state physics and chemistry, nanoscience and nanotechnology and engineering of the researchers assures that the new concepts and the objectives proposed will be successfully developed/pursued. A high-tech SME will provide proof-of-concept prototypes to validate the innovative GLOBASOL devices.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.6.5 | Award Amount: 5.15M | Year: 2010

Today, there are largely no communications infrastructure deployments in European medium and low voltage power distribution networks. Powerline communications has a large potential to enable new and intelligent applications to and from the last branch of the distribution grid. However, current powerline communication technologies cannot offer the reliability, quality of service and interoperability that is required for such applications.\n\nDLC\VIT4IP will develop, verify and test a high-speed narrow-band powerline communications infrastructure using the Internet Protocol (IP) which is capable of supporting existing and extending new and multiple communication applications. These shall include the existing power distribution network for novel services in smart electricity distribution networks such as demand side management, control of distributed generation and customer integration.\n\nFrom a communication perspective, the powerline network offers advantages in coverage, costs and availability. On the application side the Internet protocol (IP) suite is an increasingly used protocol stack in many supervisory and control application fields which include the energy sector.\n\nTo efficiently integrate both technologies and achieve the necessary performance and reliability DLC\VIT4IP will extend existing PLC technologies by developing:\n1.\tEfficient transport of the IP(v6) protocol\n2.\tAutomatic measurement, configuration and management\n3.\tSecurity\n4.\tReal-time capabilities\n5.\tChannel models and simulation tools for network planning and design\nModels and the developed system will be tested and verified in a field test.\n\nOutcomes of the project will include a prototype for a high performance communications infrastructure, simulation and planning tools. Testing and conformance rules for application developers and users to choose an appropriate technology for their needs are key driver for end use. Many of these outcomes will be transferred to standardisation.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2009-2-2-01 | Award Amount: 7.98M | Year: 2010

NeuroFAST is a multidisciplinary project, involving ten teams from seven countries, to explore the neurobiology of addiction and eating behaviour and the complex socio-psychological forces that can lead to its dysregulation. These forces include dietary components (including highly palatable foods and alcohol), some of which may have addictive properties, but also cultural and social pressures, everyday stressors, and family-genetic influences on these. The project will provide new data from human studies, including human nutritional studies, that is needed to inform health policy initiatives. This will be underpinned by state-of-the art mechanistic research to establish a solid scientific basis for this advice. The European added value lies in building up the necessary critical mass in several fields of expertise: psychology, epidemiology, human genetics related to eating disorders, human nutrition, eating and addictive behaviour disorders, endocrinology, human brain imaging, together with studies of the basic mechanisms of eating behaviour and addiction, (neuro)endocrine regulators, stress, opiate dependence, and cannabinoid actions. To provide scientific support for European public health policies, a focus will be on a socio-psychological analysis of determinants of food addiction and substance abuse, and of how risk factors like stress in the workplace are driving addictive behaviour. We will establish an evidence base for inter-relationships, linking eating disorder research with obesity research, stress research and addiction research, and involving studies of selected individual food components using novel designed foods with controlled components. In summary, we will use a synergistic combination of controlled laboratory studies, characterization of patient groups, and examination of real-world scenarios based on epidemiological community samples that will be relevant to policy development.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: EeB-ICT-2010.10.2 | Award Amount: 4.65M | Year: 2010

HESMOS will achieve an industry-driven holistic approach for sustainable optimisation of energy performance and emissions (CO2) reduction through integrated design and simulation, while balancing investment, maintenance and reinvestment costs. The objective is to close the gaps between existing intelligent building/facilities data so that complex lifecycle simulation can easily be done in all design, refurbishment and retrofitting phases where the largest energy saving potentials exist. This will be achieved by (1) extending existing BIM, energy simulation and cost calculation tools, so that they can seamlessly exchange the required data, (2) integrating advanced energy simulation tools into the design and FM process, so that BIM-CAD and FM tools can be used as building energy simulator and gap identifier, (3) developing new applications that can visualize building performance in easy to understand way and can quickly display impacts of changed building/space parameters, (4) developing new Cockpit functionality in BIM-CAD on EPBD basis to provide fast feedback of the impact of design parameters on lifecycle energy performance, (5) extending BIM-CAD to model and manage buildings and surrounding areas, and (6) extending BIM-CAD by web services to act as Integrated Virtual Energy Laboratory (IVEL) enabling the study of design and retrofitting alternatives concerning energy performance and total costs. An innovative SOA around the kernel functionality of BIM-based CAD/FM will be applied. Information interoperability will be achieved by enhancing BIM with energy and emissions features to a new sharable eeBIM. Intelligent access methods and a specialised ontology will be developed to enable multi-system integration and management of material, climate and product databases and data from sensor networks and other ICT sub-systems into CAD/FM. An extensive 30-month validation program at 2 PPP projects will be carried out during the project.

Agency: European Commission | Branch: FP7 | Program: JTI-CS | Phase: JTI-CS-2011-1-SGO-02-026 | Award Amount: 291.89K | Year: 2011

The modelling language Modelica and libraries based upon it are excellently suited for model-based design of future aircraft systems, e.g. more electric aircraft or sustainable air-conditioning systems. To enable those design tasks, Modelica Libraries for media models, electromagnetic devices such as transformers and electrical machines and for wavelet analysis shall be developed or extended by a consortium of three partners. XRG Simulation will provide two fluid property models according to the Modelica.Media specification, one model for R134a and one model for humid air. Both models shall be used for complex air conditioning system simulation e.g. of aircraft. Technische Universitt Dresden, where the Modelica.Magnetic.FluxTubes library was originally developed, will extend this library with hysteresis models. Simulation of static (ferromagnetic) and dynamic (eddy current) hysteresis allows for estimation of iron losses in transformers and electrical machines and hence, e.g., for subsequent simulation of heating. In addition, Modelica models of one- and three-phase transformers will be developed. Compared to the simple transformer models already included in the Modelica Standard library, the models to be developed include a transformers magnetic subsystem and hence consider saturation and core losses. The developed hysteresis and transformer models will be validated with in-house measurements. Furthermore, the Modelica.Magnetic library will be extended by electrical machine models based on look-up tables. These models allow for dynamic simulation of machines with saturation and non-linear torque-current-angle characteristics. Technische Universitt Mnchen will develop a Modelica Wavelet library for capture, identification and analysis of processes. This library will allow new signal processing methods for analysis, reconstruction and modelling of signals. That will improve the power quality assessment in physical systems, e.g. in electrical systems of aircraft.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.10.2 | Award Amount: 1.93M | Year: 2011

To maximise the scientific output of a high-performance computing system, different stakeholders pursue different strategies. While individual application developers are trying to shorten the time to solution by optimising their codes, system administrators are tuning the configuration of the overall system to increase its throughput. Yet, the complexity of todays machines with their strong interrelationship between application and system performance presents serious challenges to achieving these goals. The HOPSA project (HOListic Performance System Analysis) therefore sets out to create an integrated diagnostic infrastructure for combined application and system tuning - with the former being under EU and the latter being under Russian responsibility. Starting from system-wide basic performance screening of individual jobs, an automated workflow will route findings on potential bottlenecks either to application developers or system administrators with recommendations on how to identify their root cause using more powerful diagnostic tools. Developers can choose from a variety of mature performance-analysis tools developed by our consortium. Within this project, the tools will be further integrated and enhanced with respect to scalability, depth of analysis, and support for asynchronous tasking, a node-level paradigm playing an increasingly important role in hybrid programs on emerging hierarchical and heterogeneous systems. Using our infrastructure, the scientific output rate of a system will be increased in three ways: First, the enhanced tool suite will lead to better optimisation results, expanding the potential of the codes to which they are applied. Second, integrating the tools into an automated diagnostic workflow will ensure that they are used both (i) more frequently and (ii) more effectively, further multiplying their benefit. Finally, our holistic approach will lead to a more targeted optimisation of the interactions between application and system.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.4 | Award Amount: 3.58M | Year: 2010

Virtualised service platforms and cloud computing hold great promise for delivery of large applications in e-Government. However, to date, the fundamental shared-resource nature of virtualisation technologies has raised legitimate security concerns for Government and other organisations with duties to protect confidential data.\nThe PASSIVE project proposes an improved model of security for such virtualised systems to ensure that:\n*\tadequate separation of concerns (e.g. policing, judiciary) can be achieved even in large scale deployments\n*\tthreats from co-hosted operating systems are detected and dealt with;\n*\tpublic trust in application providers is maintained even in a hosting environment where the underlying infrastructre is highly dynamic\nTo achieve these aims, the consortium proposes:\n*\tA policy-based Secuirty architecture, to allow security provisions to be easily specified, and efficiently addressed.\n*\tFully virtualised resource access, with fine-grained control over device access, running on an ultra-lightweight Virtual Machine Manager.\n*\tA lightweight, dynamic system for authenticaiton of hosts and applications in a virtualised environment.\nIn so doing, PASSIVE will lower the barriers to adoption of virtualised hosting by government users, so that they may acheive the considerable gains in energy effiiciency, reduced capital expenditure and flexibility offered by virtualisation.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.5-1 | Award Amount: 8.51M | Year: 2012

COBWEB will leverage the UNESCO World Network of Biosphere Reserves (WNBR). Concentrating initially on the Welsh Dyfi Biosphere Reserve, we will develop a citizens observatory framework, and then validate the work within the context of the UK National Spatial Data Infrastructure (SDI) and internationally, within the WNBR; specifically, within Greek and German Reserves. The infrastructure we develop will exploit technological developments in ubiquitous mobile devices, crowd-sourcing of geographic information and the operationalising of standards based SDI such as the UK Location Information Infrastructure. It will enable citizens living within Biosphere Reserves to collect environmental information on a range of parameters including species distribution, flooding and land cover/use. A main driver will be the opportunity to participate in environmental governance. Data quality issues will be addressed by using networks of people as sensors and by analysing observations and measurements in real-time combination with authoritative models and datasets. The citizens observatory framework will integrate with evolving INSPIRE compliant national SDIs and allow the fusion of citizen sourced data with reference data from public authorities in support of policy objectives. To maximise impact, COBWEB will work within the processes of the standards defining organisations. Specifically, we will aim to improve the usability of Sensor Web Enablement standards with mobile devices, develop widespread acceptance of the data quality measures we develop and maximise the commercial appeal of COBWEB outputs. The end result we are aiming for is a toolkit and a set of models that demonstrably works in different European countries and which is accepted as a core information system component of the WNBR. Implementations of COBWEB will act as models for how technology may be used to empower citizens associations in environmental decision making.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: Fission-2007-2.2-01 | Award Amount: 10.20M | Year: 2008

Up to now fuel development and qualification has been a long and expensive process essentially based on an empirical approach. European experts currently have an adequate knowledge of conventional fuel manufacturing and its behaviour under operating conditions encountered during 50 years of industrial application and R&D activities. For innovative fuel systems, however, the empirical approach has reached its limit and cannot be easily extrapolated to new materials, new environments, or new operating conditions because the basic underlying mechanisms governing manufacturing, behaviour and performance remain largely poorly understood. One of the challenges for the next years is to supplement the empirical approach by a physically based description of ceramic fuel and cladding materials. To do so, the F-BRIDGE project, which stands for Basic Research for Innovative Fuels Design for GEN IV systems, intends to develop a new approach to fuel development by building a bridge (integration and transfer) between basic research activities and technological applications for the Generation IV fuel-cladding systems. Besides a general approach on ceramic materials, the project will focus on the improvement of a promising composite ceramics concept, the sphere-pac fuel, which exhibit significant advantages for Generation IV. F-BRIDGE aims at: - obtaining data, mechanisms and models from basic research for an improved description of fuel and ceramic cladding materials under irradiation, in a multi-scale approach coupling separate effect experiments and modelling, - ensuring the transfer between basic research and technological issues related to Generation IV systems and illustrating the integration effort through a multi-scale modelling exercise on UO2, - assessing the technological implications of sphere-pac fuels for the GEN IV systems, - ensuring dissemination of results, education and training in the field of R&D on fuel behaviour.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: Fission-2013-2.4.1 | Award Amount: 2.49M | Year: 2013

The strategic objective of NC2I-R is to structure the European public and private R&D capabilities for delivering a nuclear cogeneration demonstrator fully meeting the market needs, in support of the Nuclear Cogeneration European Industrial Initiative. Following the reference EUROPAIRS project and in close collaboration with the ongoing ARCHER project, national projects (e.g. Polish HTRPL, German SYNKOPE), non-EU HTR programs (US, China, South Korea, South Africa) and Generation IV International Forum, NC2I-R will bring a decisive contribution to prepare for a successful, low-risk and rapid European nuclear cogeneration demonstration for Europes industry. To this end, NC2I-R will: 1) Structure the European public and private R&D capacities towards nuclear cogeneration demonstration and identify clearly the status of Europes public and private R&D infrastructures and competences 2) Define the safety requirements to prepare for the future licensing process for a cogeneration demonstrator and limit the associated risk 3) Define clear and consensual specifications for the demonstrator, ensuring its economic viability, its market fit, its future replicability and its safety, in particular of the coupling scheme, and limiting all construction project risks 4) Managing the knowledge from past projects on HTR and nuclear cogeneration with a comprehensive experience feedback in order to identify potential points of attention and success factors 5) Prepare on a joint roadmap paving the way for todays European R&D capacities towards the commissioning of the specified demonstrator and identify potential gaps 6) Prepare for and organise the cooperation with non-European similar programmes to possibly share the demonstrator risk in line with the European interest and to secure EUs leadership position in the global competition for HTR 7) Prepare a smooth and inclusive governance for the future NC2I, engaging all stakeholders including civil society into a wide

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.1.2-3 | Award Amount: 16.09M | Year: 2008

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling stem cell properties and behaviour. Information will be mined from studies in model organisms, but our primary focus is on the paradigmatic mammalian stem cells haematopoietic, epithelial, neural and embryonic. We will compare cellular hierarchy, signalling, epigenetics, dysregulation, and plasticity. Niche dependence, asymmetric division, transcriptional circuitry and the decision between self-renewal and commitment are linked in a cross-cutting work package. A multidisciplinary approach combines transgenesis, real time imaging, multi-parameter flow cytometry, transcriptomics, RNA interference, proteomics and single cell methodologies. SMEs will contribute to the development of enhanced resolution quantitative technologies. A platform work package will provide new computational tools and database resources, enabling implementation of novel analytical and modelling approaches. EuroSyStem will engage with and provide a focal point for the European stem cell research community. The targeted collaborations within the EuroSyStem research project will be augmented by federating European research excellence in different tissues and organisms. We will organise annual symposia, training workshops, summer schools, networking and research opportunities to promote a flourishing basic stem cell research community. This network will foster interaction and synergy, accelerating progress to a deeper and more comprehensive understanding of stem cell properties. In parallel EuroSyStem will develop WEB resources, educational and outreach materials for scientists and the lay community.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.3.1-1 | Award Amount: 6.39M | Year: 2014

Mental disorders affect 38.2% of the EU population. For reducing the associated burden, countries across Europe engage in costly re-organizations of mental health care systems. Reforms focus on one controversial core question: Should systems be functional or integrated? In functional systems, separate staff in different services are in charge of in- and out-patient care (to enhance specialization). In integrated systems, the same staff are responsible across services (to strengthen co-ordination and avoid fragmentation). So far, there is no sound research evidence to inform the debate and far reaching policy decisions. Integrated and functional systems co-exist in some countries. This provides the unique chance to compare the effectiveness of the two systems independently of country specific contexts. We will conduct a large-scale comparison in countries with different traditions, levels of service provision and funding systems of mental health care (Belgium, Germany, Italy, Poland, United Kingdom). We will work as a multi-disciplinary team (psychiatrists, psychologists, nurses, sociologists, public health experts, health economists) and prospectively follow-up more than 5000 patients with major mental disorders over a 9 month period. Across countries, we will compare the effectiveness and cost-effectiveness for clinical and social outcomes (including quality of life), patients health and social needs, safety and quality of care of patients in the two systems. We will also establish how patients and clinicians experience the advantages and limitations of each system, and identify the policies and legislative frameworks determining practice in the two systems. We will produce guidelines for policies specifying in what context and for which patient groups (e.g. older age) functional or integrated systems are preferable, and disseminate these widely (to governments, scientific societies, professional bodies, users and carers organizations).

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-23-2014 | Award Amount: 6.15M | Year: 2015

The evidence base of Internet-based interventions in the prevention and treatment of mental health conditions has rapidly grown in the past decade. Yet many European countries (e.g., Germany, Austria, Switzerland, Great Britain, The Netherlands, Spain) have not implemented these promising approaches into health systems. Individuals with risk conditions or distinct mental health problems interested in using online interventions are often unable to access appropriate and evidence-based online interventions. The aim of this proposal is to establish a comprehensive model of health promotion, risk detection, disease prevention, and treatment facilitation for the most prevalent mental health problems and disorders (depression, anxiety, adjustment disorders, eating disorders/weight management and substance abuse) that assists individuals and mental health professionals in selecting and using evidence-based, online interventions. To reach this aim, the project partners bring together over 30 evidence-based, online interventions spanning the mental health intervention spectrum from universal and targeted prevention, self-help to treatment for the respective conditions applicable to children, adolescents and adults. Following a stakeholder needs survey, the model will be integrated into existing health care and other settings in Germany, Great Britain, Switzerland, Austria, The Netherlands, and Spain by 1. developing valid and economic, online screenings to allocate individuals to interventions, 2. developing technology for a common e-Health intervention platform, 3. developing implementation plans, 4. implementing evidence-based interventions into health care, and 5. evaluating and comparing their feasibility, acceptability, reach, efficacy and (cost)-effectiveness, adoption, and dissemination including moderators of interventions. Our proposal aims at the sustained implementation of the ICare model into health services and collaborations with health care providers across different EU countries.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-3.5-1 | Award Amount: 10.45M | Year: 2008

Outstanding progress has been made in recent years in developing novel structures and applications for direct fabrication of 3D nanosurfaces. However, exploitation is limited by lack of suitable manufacturing technologies. In this project we will develop innovative in-line high throughput technologies based on atmospheric pressure surface and plasma technologies. The two identified approaches to direct 3D nanostructuring are etching for manufacturing of nanostructures tailored for specific applications, and coating. Major impact areas were selected, demonstrating different application fields. Impact Area 1 focuses on structures for solar cell surfaces. Nanostructured surfaces have the potential to improve efficiencies of cells by up to 25% (rel), having dramatic impact on commercial viability. Impact Area 2 focuses on biocidal surface structures. Increasing concerns about infections leading to the conclusion, that only multi-action approaches for control of infection transfer can be effective. We plan to combine such surfaces with 3D nanostructures, which will both immobilise and deactivate pathogenic organisms on surfaces. Impact Area 3 is the direct growth of aligned carbon nanotubes on electrode surfaces. The material is under investigation for use in high load capacitors which are seen as key components for energy storage systems, e.g. for Hybrid Electric Vehicle. Impact Area 4 focuses on tailored interfaces to achieve durable adhesion on polymer surfaces by 3D nanostructuring and coating. Target is to reduce energy consumption by introducing lightweight materials. The N2P partners have been chosen to ensure a strong capability to exploit and disseminate the outcomes. Involved end-user industries represent high market value segments: photovoltaics, aeronautics, automotive, steel. The consortium includes 7 technology leading SMEs and 4 multi-national industries, cooperating with 9 institutes for industrial research and a public body from 8 European countries.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2010.2.5 | Award Amount: 2.12M | Year: 2011

Hydrogen is an important energy carrier as a viable future clean transport fuel. H2-fuelled vehicles are affordable, infrastructure investments are manageable and H2 and electric mobility are required to meet future CO2 emission targets. Plans are made to implement H2-refuelling infrastructure in Germany followed by roll-out over Europe by 2015. Logistically, liquid H2 appears the only viable option to supply the larger stations in the medium term. Without developing a liquefaction capacity, there is a serious risk to H2-infrastructure development and implementation. However, at present liquefaction of H2 is expensive, energy intensive and relatively small scale. Reduction of liquefaction costs via technology development and increased competition is crucial. IDEALHY is an enabling project for viable, economic liquefaction capacity in Europe, to accelerate rational infrastructure investment, and enable the rapid spread of H2-refuelling stations across Europe. The IDEALHY project researches, develops and scales-up data and designs into an optimised design for a generic liquefaction process at a scale of 30-50 te/day, representing a very substantial upscale over proposed and existing LH2-plants. The project also develops a detailed strategic plan for a prospective large-scale demonstration of efficient H2-liquefaction with options for location. The focus is to improve substantially efficiency and reduce capital costs of liquefaction through innovations, including linking LH2 production with LNG terminal operations to make use of available cryogenic temperatures for pre-cooling. Supporting economic and lifecycle assessment of the resulting gains in energy efficiency will be made, together with a whole chain assessment based on near term market requirements. IDEALHY will be undertaken by a partnership comprising world leaders in H2 distribution and liquefaction technologies, research institutes, academic partners and pioneering SME suppliers to the liquefaction indus

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.23M | Year: 2013

LAPASO will provide a unique training opportunity for 15 fellows in a highly interdisciplinary and intersectorial environment with the overarching scientific objective of advancing diagnostics in a wide range of critical medical conditions using advanced microfluidics and nanobiotechnology integration. Microfluidic particle fractionation based on the inherent properties of e.g. cells, microorganisms, organelles offers significant improvements over conventional techniques in terms of ease of handling and usage, speed and reductions in cost. We will consolidate the field at the European level and create a unique comprehensive training program that rests on solid experimental and theoretical foundations. Three leading experimental groups will provide the technological development of microfluidic label-free sorting based on dielectrophoresis, deterministic lateral displacement and acoustophoresis with strong support from leading theorists. The technology will be used to address key medical questions defined by our biomedical collaborators and partners in parasitology, bacteriology and oncology. Three companies are engaged to provide an industrial perspective on our work, specifically from a technological point of view with respect to treatment of infectious disease, advanced fluidics handling and DNA analysis and mass production of devices. To ensure an efficient transfer of knowledge across disciplines and across sectors the work will take place in close collaboration through frequent ESR/ER exchange between the partners. The training of a next generation of researchers will ensure the implementation and dissemination of these powerful novel key techniques to industry and end-users. Through the strong interdisciplinary and intersectorial character of the network, the ESR and ER will receive a uniquely comprehensive training above what a traditional postgraduate training would offer that in turn gives them a strong competitive advantage in both academia and industry.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: EeB.NMP.2013-5 | Award Amount: 11.10M | Year: 2013

eeEmbedded will develop an open BIM-based holistic collaborative design and simulation platform, a related holistic design methodology, an energy system information model and an integrated information management framework for designing energy-efficient buildings and their optimal energetic embedding in the neighbourhood of surrounding buildings and energy systems. A new design control and monitoring system based on hierarchical key performance indicators will support the complex design collaboration process. Knowledge-based detailing templates will allow energy simulations already in the early design phase, and BIM-enabled interoperability grounded on a novel system ontology will provide for a seamless holistic design process with distributed experts, and a seamless integration of simulations in the virtual design office (energy performance, CO2, CFD, control system, energy system, climate change, user behaviour, construction, facility operation), thus extending it to a real virtual design lab. A test period of 12 project months, overlapping the first 42 development months of the project, will provide for real pre-market validation of the system on two real embedded buildings of different types, namely (1) residential or office, and (2) hospital buildings. The development work will be soundly based on 2 business models the business model of the owners and hence the equipment providers and the business model of construction and design companies, and on a set of ISO and industry standard data structures and specifications such as IFC, STEP, CityGML and OWL. A new ontology-based Link Model will provide the bridge between the multiple physical and mathematical models involved in the eeBuilding domain warranting the desired data and services interoperability.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.8 | Award Amount: 12.10M | Year: 2011

The BrainScaleS project aims at understanding function and interaction of multiple spatial and temporal scales in brain information processing. The fundamentally new approach of BrainScaelS lies in the in-vivo biological experimentation and computational analysis. Spatial scales range from individual neurons over larger neuron populations to entire functional brain areas. Temporal scales range from milliseconds relevant for event based plasticity mechanisms to hours or days relevant for learning and development. In the project generic theoretical principles will be extracted to enable an artificial synthesis of cortical-like cognitive skills. Both, numerical simulations on petaflop supercomputers and a fundamentally different non-von Neumann hardware architecture will be employed for this purpose.Neurobiological data from the early perceptual visual and somatosensory systems will be combined with data from specifically targeted higher cortical areas. Functional databases as well as novel project-specific experimental tools and protocols will be developed and used.New theoretical concepts and methods will be developed for understanding the computational role of the complex multi-scale dynamics of neural systems in-vivo. Innovative in-vivo experiments will be carried out to guide this analytical understanding.Multiscale architectures will be synthesized into a non-von Neumann computing device realised in custom designed electronic hardware. The proposed Hybrid Multiscale Computing Facility (HMF) combines microscopic neuromorphic physical model circuits with numerically calculated mesoscopic and macroscopic functional units and a virtual environment providing sensory, decision-making and motor interfaces. The project also plans to employ petaflop supercomputing to obtain new insights into the specific properties of the different hardware architectures.A set of demonstration experiments will link multiscale analysis of biological systems with functionally and architecturally equivalent synthetic systems and offer the possibility for quantitative statements on the validity of theories bridging multiple scales. The demonstration experiments will also explore non-von Neumann computing outside the realm of brain-science.BrainScaelS will establish close links with the EU Brain-i-Nets and the Blue Brain project at the EPFL Lausanne. The consortium consists of a core group of 15 partners with 18 individual groups.Together with other projects and groups the BrainScaelS consortium plans to make important contributions to the preparation of a future FET flagship project. This project will address the understanding and exploitation of information processing in the human brain as one of the major intellectual challenges of humanity with vast potential applications.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: INFRA-2011-3.4. | Award Amount: 1.16M | Year: 2011

The Discover the COSMOS coordination action aims to demonstrate innovative ways to involve teachers and students in eScience through the use of existing e-infrastructures in order to spark young peoples interest in science and in following scientific careers. It aims to support policy development by a) demonstrating effective community building between researchers, teachers and students and empowering the latter to use, share and exploit the collective power of unique scientific resources (research facilities, scientific instruments, advanced ICT tools, simulation and visualisation applications and scientific databases) in meaningful educational activities, that promote inquiry-based learning and appreciation of how science works, b) demonstrating effective integration of science education with e-infrastructures through a monitored-for-impact use of eScience activities, which will provide feedback for the take-up of such interventions at large scale in Europe and c) documenting the whole process through the development of a roadmap that will include guidelines for the design and implementation of effective educational and outreach activities that could act as a reference to be adapted for stakeholders in both scientific research outreach and science education policy.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.8 | Award Amount: 3.67M | Year: 2010

The aim of this project is to transfer the latest advances in plasmonics achieved in the visible to the mid-IR. The main objectives of the project are (1) to look at the fundamental limits and develop new simulation tools for plasmons in the mid-IR, (2) to develop plasmon enhanced surfaces for spectroscopic chemical sensing (SCS), and (3) to use plasmon enhanced surfaces for light harvesting technology. The result of the project will include new software, SCS surfaces for infra-red spectroscopy and smart, cheaper, mid-IR photodetectors. \nThe term plasmonics refers to the investigation, development and application of enhanced electromagnetic properties of metallic (nano-) structures and is starting to find applications in a range of photonic devices such as VCSELs and high speed photodetectors. While the promise of plasmonics photonic components in the visible and NIR is very promising, this project will exploit the huge potential for plasmonics in the IR (i.e. the 1.6-16 m range) that could be truly disruptive.\nIn the mid-IR (a) plasmon losses are much lower than in the visible so the range of possible devices is much larger (b) this area is largely unexplored for applied plasmonics, and (c) IR technology is undergoing a quiet revolution due to key advances such as such room temperature Quantum Cascade Lasers and miniature Fourier transform spectrometers (FTS). This project will help launch the IR revolution by enabling both SCS surfaces and better mid-IR detectors.\nPLAISIR will develop SCS with sensitivity more than 200 times larger than that of a simple surface. This will be combined with microfluidics and integrated into a FTS. The project will work with both InGaAs and HgCdTe photodetectors, by using LHT to improve their noise performance, and tailor their spectral and polarization response. \nThis project includes 4 major actors in fundamental and applied plasmon research, 3 SMEs and an external advisory board made up of strategic end users and key academics

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: NMP-2009-4.0-2 | Award Amount: 2.41M | Year: 2009

For the first time in Europe a real critical mass along the whole value-chain, and in all aspects of the biorefinery concept, will be achieved by the close collaboration of five industry-driven European Technology Platforms, five excellent research partners with complementary expertise, and the International Civil Society Organisation IUCN, who will validate the impact on the global sustainability of the results. The collaboration in this Coordination and Support Action is called Star-COLIBRI, and its main objectives are to promote coordination and work to overcome fragmentation in the field of biorefineries research; to facilitate information exchange and cross-fertilization; to support break-through innovations by speeding up and facilitate industrial exploitation of research results. The Star-COLIBRI project will accomplish these targets by working in two parallel but mutually dependant processes: The first process has longer term objectives and it will provide a framework for collaborations and information exchange, common vision and a roadmap for 2020. It will also directly contribute to policy initiatives such as the European Lead Market Initiative on Bio-Based Products. The second process has shorter term objectives and aims to the immediate support and coordination of ongoing biorefinery research projects with potential high impact. The new strategy developed for this is called StarClustering. Better coordination of national research funding through an ERA-Net Liaisons Office will also be achieved.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-1.2-6 | Award Amount: 3.77M | Year: 2008

Inherited Neuromuscular Diseases (NMD) form a large group of diseases including Limb-Girdle Muscular Dystrophies (LGMD), Congenital Muscular Dystrophies (CMD), Duchenne and Becker Muscular Dystrophies (DMD/BMD), or Charcot-Marie-Tooth disease (CMT). Within a given disease group genetic and clinical heterogeneity is the hallmark. The precise diagnostic of neuromuscular diseases thus requires extensive clinical examination and targeted complementary tests. Additionally, since many of the disease causing mutations are known, molecular and genetic tests are performed to confirm and precise the diagnostic. According to presently available technologies, this is highly complex and time consuming. Thus, many patients remain devoid of genetic confirmation of their disease. More importantly, new cutting edge therapies cannot and will not be possibly envisaged in absence of a precise genetic diagnosis. New molecular diagnosis tools, enabling quick, reliable and cost-effective sequencing of numerous NMD genes are thus required. The development of such tools would allow performing the genetic diagnostic of NMDs patients. DNA chips have the potential to address this issue, in a time and cost effective way. The goal of this project is to i) design and validate a DNA Chip for sequencing genes responsible for LGMDs, CMDs, DMD/BMD, and CMTs, and ii) use the DNA Chip technology to identify new genes/mutations involved in these inherited NMD and increase the molecular diagnosis/patients ratio. This approach will be based on a gene candidate approach. NMD-Chip will thus lead to the development of a novel sensitive and reliable (98%) diagnostic tool, with time and cost effectiveness dedicated to neuromuscular disorders. In total, NMD-Chip, based on human genome knowledge and an advanced read out technology, will give patients an easy access to molecular diagnosis and will thus allow them to benefit from cutting edge therapies which are currently developed.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: Fission-2010-2.3.1 | Award Amount: 10.12M | Year: 2011

In line with the Sustainable Nuclear Energy Technology Platform (SNETP) Strategic Research Agenda (SRA) and Deployment Strategy (DS), the ARCHER project will extend the state-of-the-art European (V)HTR technology basis with generic technical effort in support of nuclear cogeneration demonstration. The partner consortium consists of representatives of conventional and nuclear industry, utilities, Technical Support Organisations, R&D institutes and universities. They jointly propose generic efforts composed of: -System integration assessment of a nuclear cogeneration unit coupled to industrial processes -Critical safety aspects of the primary and coupled system: oPressure boundary integrity oDust oIn-core hot spots oWater and air ingress accident evaluation -Essential HTR fuel and fuel back end R&D oPIE for fuel performance code improvement and validation oBack end research focused on radiolysis -Coupling component development: oIntermediate heat exchanger development oSteam generator assessment -High temperature material R&D: oCompletion of graphite design curves oMaking use of the experience of state of the art metal in conventional industry -Nuclear cogeneration knowledge management, training and communication The activities proposed are imbedded in the international framework via GIF; direct collaboration within the project with international partners from the US, China, Japan, and the republic of Korea; and cooperation with IAEA and ISTC. The proposal is a technical building block supporting nuclear cogeneration as fossil fuel alternative for industry and as such supports a high potential contribution to European energy strategy as defined in the SET-Plan. The results of the proposal will be reported to SNETP, to support the strategic pillar of other uses of nuclear energy, and the establishment of a Nuclear Cogeneration Industrial Initiative, which shall include effective (international) nuclear cogeneration demonstration.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.20M | Year: 2014

Infections associated with dental implants may cause peri-implantitis often resulting in implant loss and impaired function. Recent studies show an alarming increase in the incidence of the infections, while on the other hand the efficacy of the prevailing treatment method is decreasing due to the rising resistance of micro-organisms to antibacterial agents. The SMEs of the NanoTi consortium intend to bring a new titanium implant to the market that possesses the innate capability to resist bacterial infections without the addition of any antibacterial compound. In order to reach this goal the aim of the NanoTi project is to develop nanophase topography on the surface of titanium dental implants that will enable such an effect. This nanophase topography: Reduces the susceptibility of titanium dental implants for infections; Enables the surgical decontamination of implants if infection occurs; Supports bone healing around the dental implant.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-29-2014 | Award Amount: 3.93M | Year: 2015

The overall objective of the PHEBE project is to develop innovative, high-efficiency, blue emitters for white OLEDS, which will create a major breakthrough in the cost performance of OLED lighting. To produce the innovative blue emitters, two new types of molecular systems without rare earth complexes - will be investigated: intramolecular charge transfer systems that enable thermally activated delayed fluorescence (ICT-TADF) intermolecular exciplex charge transfer systems that enable thermally activated delayed fluorescence (Exciplex-TADF) In order to develop the ICT-TADF and Exciplex-TADF based emitters, the following scientific and technical objectives will be targeted: Objective 1: Screen potential ICT-TADF and Exciplex-TADF compounds with theoretical models Objective 2: Synthesise the most promising ICT-TADF and Exciplex-TADF model compounds Objective 3: Characterise and select the best ICT-TADF and Exciplex-TADF synthesised compounds Objective 4: Design white stack units employing the selected TADF based emitter and block materials Objective 5: Design close-to-production OLED lighting panel demonstrators To show the projects overall objective has been achieved, white stack tandem units (2 x 2 cm2 with 90 nm ITO) and OLED lighting panel demonstrators (e.g. 25 cm2 circular panels) - based on the new blue emitters will be produced and tested that meet the performance targets indicated in the H2020 call ICT 29 2014. The PHEBE project will be undertaken by a strong consortium of partners that span the complete value chain for the development and commercialisation of the new, high-efficiency, blue emitters for white OLEDS: OLED lighting research organisations (UDUR, TUD and KTU), OLED component producer (Novaled), and OLED lighting device manufacturer (Astron-FIAMM). Overall, the PHEBE consortium is well-balanced in terms of the number of industrial and academic partners as well as their geographic spread.

Agency: European Commission | Branch: FP7 | Program: ERC-AG | Phase: ERC-AG-PE5 | Award Amount: 1.62M | Year: 2008

Inorganic nanotubes (INT) and particularly inorganic fullerene-like materials (IF) from 2-D layered compounds, which were discovered in the PI laboratory 16 years ago, are now in commercial use as solid lubricants (www.apnano.com) with prospects for numerous applications, also as part of nanocomposites, optical coatings, etc. The present research proposal capitalizes on the leadership role of the PI and recent developments in his laboratory, much of them not yet published. New synthetic approaches will be developed, in particular using the WS2 nanotubes as a template for the growth of new nanotubes. This include, for example PbI2@WS2 or WS2@NbSe2 core-shell nanotubes, which could not be hitherto synthesized. Other physical synthetic approaches like ablation with solar-light, or pulsed laser ablation will be used as well. Nanooctahedra of MoS2 (NbS2), which are probably the smallest IF (hollow cage) structures, will be synthesized, isolated and studied. Extensive ab-initio calculations will be used to predict the structure and properties of the new INT and IF nanoparticles. Cs-corrected transmission electron microscopy will be used to characterize the nanoparticles. In particular, atomic resolution bright field electron tomography will be developed during this study and applied to the characterization of the INT and IF nanoparticles. The optical, electrical and mechanical properties of the newly sythesized INT and IF materials will be investigated in great detail. Devices based on individual nanotubes will be (nano)fabricated and studied for variety of applications, including mechanical and gas sensors, radiation detectors, etc. Low temperature measurements of the transport properties of individual INT and IF will be performed.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.87M | Year: 2013

Organic thin-films constitute a fast growing area of electronic and opto-electronic devices that offer cost-effective and flexible solutions for e.g. improved energy efficiency and energy harvesting. Due to the achievements made during the past decade, the development of such sustainable energy devices has already reached an early commercialization stage, however, in order to further boost their uptake on the market, improvement of device efficiency and lifetime is still needed. Such improvement requires a profound knowledge about fundamental properties of thin-film hybrid interfaces and their implementation in devices a knowledge that is already requested from established and new companies focusing on organic electronic and opto-electronic devices. With this project, we establish a network that trains and educates young researchers within the area of hybrid thin-film interfaces for sustainable energy devices. In order to provide training and education that are of both high quality and of relevance for the market, the research training programmes are in this consortium based on a combination of state-of-the-art research and industrial development and production processes. The consortium consists of 5 full university partners, 1 research organization, 2 full industry partners, 4 associate industry partners and 1 associate research organization. The partners in the consortium are deliberately chosen in order to build up a unique cluster between universities and companies. Such cluster provides the young researchers in the consortium strong competence on 1) state-of-the-art research, 2) innovation and entrepreneurship and 3) large through-put industrial production processes. The training network combines expertise on modeling, thin-film formation, device fabrication and characterization (multidisciplinary aspect) in order to provide solutions for a range of different sustainable energy applications such as thin-film transistors and solar cells (intersectoral aspect).

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.9.1 | Award Amount: 1.86M | Year: 2013

Primary goal of the proposed research action is the development of a novel strategy for hybridizing silicon based photonic devices, exploiting semiconducting carbon nanotubes (CNT) as integrated light source, modulator and detector. Photonics in Information and Communication Technologies is more and more investigated for a broad application domain. These applications require efficient optoelectronic devices to emit, modulate and detect light. To facilitate photonic and electronic convergence, the envisioned approach is based on the silicon platform. However, the definition of optoelectronic devices requires several kinds of materials (Si, Ge and III-V) as silicon is an indirect-gap material with poor electro-optic properties. This project aims at investigating a new and innovative field through the use of CNT in the near infrared wavelength range. The main breakthrough will come from the development of CNT-based optoelectronic components directly co-integrated within a silicon platform to address the major challenges of photonics. Such integration has never been investigated so far and thanks to a joint experimental and theoretical investigation our major goal is to establish the potential of CNT technology for nanophotonics applications. The project reposes on three major cornerstones: (i) A waveguide detector in the 1.3-1.6m wavelength range, (ii) integrated optical modulators using Kerr (electro-refraction) and Stark (electro-absorption) effects and (iii) An integrated electrically pumped optical nanosource. Each of these cornerstones will be a worlds premiere and will constitute a breakthrough. Inherently, this makes it a high risk/high gain yet achievable proposal with a foundational impact both in knowledge and technology for nanophotonics. In a long term vision the establishment of new state of the art and advanced know-how on optoelectronic devices based on CNT will allow developing and addressing a broad range of applications in information technologies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BES-01-2015 | Award Amount: 7.99M | Year: 2016

EU trade, transport, tourism and economic development are directly dependent on open and safe seas and oceans. EUs maritime borders are widely spread including various topologies from open sea to semi-enclosed cabins with islands and islets. This poses great challenges that affect securing maritime border areas. Failing to protect against a wide array of maritime threats and risks may result in these areas becoming arenas for international conflicts, terrorism or organized crime, where smuggling, irregular immigration and drug trafficking are the most common ones. RANGER aims at re-enforcing EU by combining innovative Radar technologies with novel technological solutions for early warning, in view of delivering a surveillance platform offering detection, recognition, identification and tracking of suspicious vessels, capabilities exceeding current radar systems. It will be a platform, consisting of 2 radar technologies, a novel Over-The-Horizon Radar combined with a Multiple Input Multiple Output one implemented exploiting the latest photonics advancements, and an Early Warning System exploiting deep and adaptable machine learning schemes able to Automatically detect radar Targets. It safeguards seamless fitting and interoperability with CISE (enhanced maritime surveillance and cross border SaR operations), through the development of a CISE translation Gateway, exporting on-demand CISE services directly to end-users, by strengthening the information exchange between national authorities and the European Agency. RANGER leverages the experience of its consortium, a balanced blend of technology providers, domain experts and end-users, delivering a cost efficient, environmental friendly solution, abiding to regulations and legislation for the protection of human lives. Two pilot exercises are foreseen to thoroughly assess RANGERs ability to deliver on its promises, enhancing its potential to become a flagship platform for the European Maritime Surveillance industry.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.86M | Year: 2015

The fifth-generation (5G) is coming.Quo vadis 5G?What architectures, network topologies and technologies will define it?Are methodologies to the analysis, design and optimization of current cellular networks still applicable to 5G? 5Gwireless is the first integrated and multi-disciplinary training-through-research network of ESRs and Senior Supervisors fully committed to re-architecting current cellular principles aiming at making 5G a reality, it will define and optimize radically-changing architectures and technologies leading to a wholesale re-thinking of cellular operational principles & architectures, network topologies, transmission technologies and methods to their analysis, design and optimization. It will recruit 15 ESRs having the objective of conducting top-notch research at national, European and international levels.ESRs will receive personalized training and will conduct theoretical and applied research on fundamental challenges to the development of 5G systems and networks. According to the 5G Public-Private Partnership (5GPPP) recently formed by the EU, 5G networks need to be designed, engineered and optimized by relying on innovative technologies capable of providing 1000 times higher capacity and a 90% reduction in energy consumption compared to the status quo.Such a fundamental and radical paradigm-shift in network design and architecture requires cross-sectoral skills&background and can very unlikely be realized by researchers that have not received personalized training on innovative technologies and adequate methodological tools to their analysis.5Gwireless mission is to create a vibrant EU-based training and research environment for young researchers aiming at designing architectures, systems and algorithms for building the 5G cellular network of tomorrow. 5Gwireless is first step in that direction having the long-term target of preparing the first highly-selected & trained class of competent academic researchers and industrial professionals.

Agency: European Commission | Branch: H2020 | Program: BBI-RIA | Phase: BBI.R10-2015 | Award Amount: 5.00M | Year: 2016

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.

Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-14-2015 | Award Amount: 61.99M | Year: 2016

Addressing European Policies for 2020 and beyond the Power Semiconductor and Electronics Manufacturing 4.0 (SemI40) project responds to the urgent need of increasing the competitiveness of the Semiconductor manufacturing industry in Europe through establishing smart, sustainable, and integrated ECS manufacturing. SemI40 will further pave the way for serving highly innovative electronic markets with products powered by microelectronics Made in Europe. Positioned as an Innovation Action it is the high ambition of SemI40 to implement technical solutions on TRL level 4-8 into the pilot lines of the industry partners. Challenging use cases will be implemented in real manufacturing environment considering also their technical, social and economic impact to the society, future working conditions and skills needed. Applying Industry 4.0, Big Data, and Industrial Internet technologies in the electronics field requires holistic and complex actions. The selected main objectives of SemI40 covered by the MASP2015 are: balancing system security and production flexibility, increase information transparency between fields and enterprise resource planning (ERP), manage critical knowledge for improved decision making and maintenance, improve fab digitalization and virtualization, and enable automation systems for agile distributed production. SemI40s value chain oriented consortium consists of 37 project partners from 5 European countries. SemI40 involves a vertical and horizontal supply chain and spans expertise and partners from raw material research, process and assembly innovation and pilot line, up to various application domains representing enhanced smart systems. Through advancing manufacturing of electronic components and systems, SemI40 contributes to safeguard more than 20.000 jobs of people directly employed in the participating facilities, and in total more than 300.000 jobs of people employed at all industry partners facilities worldwide.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-3.4-1 | Award Amount: 7.82M | Year: 2011

The goal of 3D-LightTrans project is to provide groundbreaking, highly flexible and adaptable low-cost technologies for manufacturing of 3D textile reinforced plastic composites (in the following referred to as textile reinforced plastics or TRP), including innovative approaches for the individual processes and its integration in complete manufacturing chains, which will enable to shift them from its current position in cost intensive, small series niche markets, to broadly extended mass product applications, not only in transportation, but also in other key sectors, like health and leisure. To fulfil this goal, 3D-LightTrans manufacturing chains will based on hybrid yarn incorporating thermoplastic matrix material, processed to deep draped multilayer textiles and multifunctional 3D-textile constructions, which will be fixed to dry pre-forms and finally, processed into composites by thermoforming. By integrating these new, innovative process steps with full automation in -nowadays mostly manually performed- complex handling operations, it will be possible to obtain a fully automated and highly adaptable manufacturing chain. 3D-LightTrans will open the way to a totally new concept for the design, manufacturing and application of composites for low-cost mass products in a wide range of sectors. The Consortium brings together multidisciplinary research teams involving five industrial stakeholders from machine tools and machine automation (P-D Glasseiden, Van de Wiele, Lindauer Dornier, Coatema) and several OEM active in the field of processing of flexible materials and composite manufacturing, including Federal Mogul, among others, as well as from the application sector (FIAT and Bentley), and extensive expertise from well known research specialists in the area of materials, production research and technical textiles in particular, like AIT, TU-Dresden and University of Ghent.

Home > Press > Spintronics, low-energy electricity take a step closer: A new class of topological insulators discovered Abstract: Topological insulators are materials that let electric current flow across their surface while keeping it from passing it through their bulk. This exotic property makes topological insulators very promising for electricity with less energy loss, spintronics, and perhaps even quantum computing. EPFL scientists have now identified a new class of topological insulators, and have discovered its first representative material, which could propel topological insulators into applications. The work, which was carried out within the framework of the EPFL-led NCCR Marvel project, is published in Nature Materials. The technological promise of topological insulators has led to an intense search for optimal natural and man-made materials with such properties. Such research combines theoretical work that predicts what properties the structure of a particular material would have. The "candidate" materials that are identified with computer simulations are then passed for experimental examination to see if their topological insulating properties match the theoretical predictions. This is what the lab of Oleg Yazyev at EPFL's Institute of Theoretical Physics has accomplished, working with experimentalist colleagues from around the world. By theoretically testing potential candidates from the database of previously described materials, the team has identified a material, described as a "crystalline phase" of bismuth iodide, as the first of a new class of topological insulators. What makes this material particularly exciting is the fact that its atomic structure does not resemble any other topological insulator known to date, which makes its properties very different as well. One clear advantage of bismuth iodide is that its structure is more ordered than that of previously known topological insulators, and with fewer natural defects. In order to have an insulating interior, a material must have as few defects in its structure as possible. "What we want is to pass current across the surface but not the interior," explains Oleg Yazyev. "In theory, this sounds like an easy task, but in practice you'll always have defects. So you need to find a new material with as few of them as possible." The study shows that even these early samples of bismuth iodide appear to be very clean with very small concentration of structural imperfections. After characterizing bismuth iodide with theoretical tools, the scientists tested it experimentally with an array of methods. The main evidence came from a direct experimental technique called "angle-resolved photoemission spectroscopy". This method allows researchers to "see" electronic states on the surface of a solid material, and has become a key technique for proving the topological nature of electronic states at the surface. The measurements, carried out at the Lawrence Berkeley National Lab, proved to be fully consistent with the theoretical predictions made by Gabriel Autès, a postdoc at Yazyev's lab and lead author of the study. The actual electron structure calculations were performed at the Swiss National Supercomputing Centre, while data analysis included a number of scientists from EPFL and other institutions. "This study began as theory and went through the entire chain of experimental verification," says Yazyev. "For us is a very important collaborative effort." His lab is now exploring further the properties of bismuth iodide, as well materials with similar structures. Meanwhile, other labs are joining the effort to support the theory behind the new class of topological insulators and propagate the experimental efforts. ### This study was carried out within the framework of NCCR Marvel, a research effort on Computational Design and Discovery of Novel Materials, created by the Swiss National Science Foundation and led by EPFL. It currently includes 33 labs across 11 Swiss institutions. The work presented here involved a collaboration of EPFL's Institute of Theoretical Physics and Institute of Condensed Matter Physics with TU Dresden; the Lawrence Berkeley National Laboratory; the University of California, Berkeley; Lomonosov Moscow State University; Ulm University; Yonsei University; Pohang University of Science and Technology; and the Institute for Basic Science, Pohang. The study was funded by the Swiss National Science Foundation, the ERC, NCCR-MARVEL, the Deutsche Forschungsgemeinschaft, the U.S. Department of Energy, and the Carl-Zeiss Foundation. Reference Autès G, Isaeva A, Moreschini L, Johannsen JC, Pisoni A, Mori R, Zhang W, Filatova TG, Kuznetsov AN, Forró L, Van den Broek W, Kim Y, Kim KS, Lanzara A, Denlinger JD, Rotenberg E, Bostwick A, Grioni M, Yazyev OV. A Novel Quasi-One-Dimensional Topological Insulator in Bismuth Iodide β-Bi4I4. Nature Materials 14 December 2015. DOI: 10.1038/nmat4488 For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

News Article | November 22, 2016
Site: www.eurekalert.org

A new color-coding tool is enabling scientists to better track live blood stem cells over time, a key part of understanding how blood disorders and cancers like leukemia arise, report researchers in Boston Children's Hospital's Stem Cell Research Program. In Nature Cell Biology they describe the use of their tool in zebrafish to track blood stem cells the fish are born with, the clones (copies) these cells make of themselves and the types of specialized blood cells they give rise to (red cells, white cells and platelets). Leonard Zon, MD, director of the Stem Cell Research Program and a senior author on the paper, believes the tool has many implications for hematology and cancer medicine since zebrafish are surprisingly similar to humans genetically. People are born with a certain number of blood stem cells and rely on them for life. Various blood disorders and cancers are thought to arise when a mutant clone of an original blood stem cell starts to dominate. But what actually happens with blood stem cells over time has been hard to pin down. "There's significant interest in determining how a stem cell clone expands, what makes one clone dominant, and why that predisposes you to cancer and blood disorders," says Zon. All the colors of the rainbow Zon, with David Traver, PhD, of the University of California at San Diego, first author Jonathan Henninger of Boston Children's and other colleagues, used a specially bred zebrafish called Zebrabow that has multiple copies of genes for red-blue-gene fluorescent protein scattered through its genome. By activating certain enzymes, the team cut the red-blue-green assembly in different ways and in different amounts. This technique yields, in theory, about 80 different colors based on the cell's overall proportions of each fluorescent protein -- each color representing a different clone or variety of blood stem cell. "It's like an RGB television set, where red, blue and green give you the whole spectrum of colors," explains Zon. "In our system, the enzyme cuts out different parts --blue, for example, or green and blue -- so the stem cell will end up a different shade of color. In this way, we were able to mark each stem cell being born with a different color, and then follow the colors through development and see how many stem cells of each color were present in the adult fish." Other scientists have developed tracking systems based on genetic "barcodes." But these require dissecting the cells, so cannot analyze living, circulating cell populations. "Because our system is based on color, we don't have to destroy the cells to analyze their clonality," adds Henninger, a PhD candidate in the Zon Lab. "Rather, we can isolate the cells by color, with the help of computational tools, and then look at what genetic factors are involved in their expansion." A normal blood system tends to have a diversity of clonal stem cell types -- all cells being genetically identical but with different epigenetic changes that affect gene expression. Being able to track how different clonal populations develop has many implications for medicine. For example, leukemia and myelodysplastic disorders (in which certain kinds of blood cells aren't made or don't mature properly) are thought to arise from a clone of an original stem cell that went amok and began replicating in great numbers. But until now, this has been hard to analyze, since no one knew how many blood stem cells we start out with. Based on the zebrafish data, Henninger and Zon estimate that blood stem cells make up about 20 percent of all blood cell progenitors at the time they are formed. That provides a starting point for exploring, for example, why and how a particular blood stem cell clone may begin to expand as people age, posing a risk for leukemia, or how cancer chemotherapy can sometimes transform tumor cells. "Within a tumor, you can get clones of cells that become resistant to chemotherapy, and that's what kills the person," Zon explains. "The questions are, 'what makes a clone take off and start to behave differently than the rest? How is clonal diversity regulated?'" Similarly, the knowledge could also help improve bone marrow transplant for a variety of childhood and adult disorders. "When you do a bone marrow transplant, only certain clones of stem cells take," Zon explains. "This is important because these clones are driving development of an entire blood system, based on a finite number of cells." To test this out, the team irradiated the Zebrabow fish, damaging their blood cells, then watched as their blood systems recovered, using their color coding system. "We saw that a smaller number of clones were dominant," Zon says. "This suggests there are some 'good' cells that are help people regenerate a healthy blood system." Zon and his team are now rushing to put genes that are mutated in humans with clonal expansion, and that predispose to leukemia, into the Zebrabow fish. Zon hopes the experiments will reveal how the dominant clones expand, and ultimately become cancerous. Zon and Henninger are also affiliated with the Division of Hematology/Oncology at Boston Children's Hospital and Dana-Farber Cancer Institute. The study was supported by the Howard Hughes Medical Institute, the National Institutes of Health (F31HL126338, R01-DK074482, F32DK752433, R01-HL04880, P01-HL032262, 5P30-DK49216, 5R01-DK53298, 5U01-HL10001, R24-DK09276), the Deutsche Forschungsgemeinschaft (SFB655), the TU Dresden and the European Union (Zf Health), and an MPN Research Foundation Grant. Zon is a founder and stockholder of Fate, Inc. and Scholar Rock. Boston Children's Hospital is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including seven members of the National Academy of Sciences, 11 members of the Institute of Medicine and 10 members of the Howard Hughes Medical Institute comprise Boston Children's research community. Founded as a 20-bed hospital for children, Boston Children's today is a 404-bed comprehensive center for pediatric and adolescent health care. Boston Children's is also the primary pediatric teaching affiliate of Harvard Medical School. For more, visit our Vector and Thriving blogs and follow us on our social media channels: @BostonChildrens, @BCH_Innovation, Facebook and YouTube.

News Article | December 22, 2016
Site: www.eurekalert.org

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner in the German Center for Diabetes Research, which has now been published in 'Nature'. The study shows that a high BMI leads to epigenetic changes at nearly 200 loci of the genome - with effects on gene expression. While our genes do not change in the course of life, our lifestyle can directly influence their surroundings. Scientists speak here of the epigenome (Greek epi: over, outside of, around), which refers to everything that happens on or around the genes. Up to now there has not been much research on how the epigenome is altered as a result of being overweight. "This issue is particularly relevant because an estimated one and a half billion people throughout the world are overweight," said first author Dr. Simone Wahl of the Research Unit Molecular Epidemiology (AME) at Helmholtz Zentrum München, "especially considering that being overweight can have adverse consequences and lead to diabetes and diseases of the cardiovascular and metabolic systems." For this reason, the international research team led by Dr. Christian Gieger and Dr. Harald Grallert of the AME (as well as Jaspal Kooner and John Chambers of Imperial College London) examined possible correlations between body mass index (BMI) and epigenetic changes.* Using state-of-the-art technology, the team carried out the world's largest study so far on the subject. The scientists examined the blood samples of over 10,000 women and men from Europe. A large proportion of these were inhabitants of London of Indian ancestry, who according to the authors are at high risk for obesity and metabolic diseases. In a first step with 5,387 samples **, the research team identified 207 gene loci that were epigenetically altered dependent on the BMI. They then tested these candidate loci in blood samples of an additional 4,874 subjects and were able to confirm 187 of these***. Further studies and long-term observations also indicated that the changes were predominantly a consequence of being overweight - not the cause. "In particular, significant changes were found in the expression of genes responsible for lipid metabolism and substrate transport, but inflammation-related gene loci were also affected," said group leader Harald Grallert. From the data, the team was also able to identify epigenetic markers that could predict the risk of type 2 diabetes. "Our results allow new insights into which signaling pathways are influenced by obesity", said Christian Gieger, head of the AME. "We hope that this will lead to new strategies for predicting and possibly preventing type 2 diabetes and other consequences of being overweight." Next, within the framework of translational research in the German Center for Diabetes Research, the researchers want to investigate in detail how the epigenetic changes affect the expression of the underlying genes. * Specifically, the team investigated the methylation patterns, i.e. the presence or absence of methyl groups on the DNA. By means of high-throughput measurements, these methylation patterns can now be investigated relatively quickly and on a large scale. ** Among others from the Augsburg KORA study, the London LOLIPOP study and a part of the EPICOR study population from Italy *** Some of these have also been confirmed in adipose tissue, indicating that changes in gene regulation in disease-relevant tissues are also visible in the blood. Helmholtz Zentrum München has extensive expertise in the field of genetic and epigenetic causal research on metabolic diseases: As recently as July 2016, the researchers were involved in the world's largest genetic study on type 2 diabetes, which was likewise published in the renowned journal Nature. Link to press release: https:/ Furthermore, already in March 2016 scientists of Helmholtz München showed that diet-induced obesity and diabetes can be passed on epigenetically to the offspring via both oocytes and sperm. Link to related press release: https:/ Wahl, S. et al. (2016): Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, doi:10.1038/nature20784 http://www. The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members. http://www. The Research Unit of Molecular Epidemiology (AME) analyses population-based cohorts and case studies for specific diseases, using genomics, epigenomics, transcriptomics, proteomics, metabolomics and functional analyses. The aim of this research unit is to decipher the molecular mechanisms of complex diseases like type 2 diabetes or obesity. The unit administers the biological specimen repository of the Department of Epidemiology and stores the samples for national and international projects. http://www. The Institute of Epidemiology II (EPI II) focuses on the assessment of environmental and lifestyle risk factors which jointly affect major chronic diseases such as diabetes, heart disease and mental health. Research builds on the unique resources of the KORA cohort, the KORA myocardial infarction registry, and the KORA aerosol measurement station. Aging-related phenotypes have been added to the KORA research portfolio within the frame of the Research Consortium KORA-Age. The institute's contributions are specifically relevant for the population as modifiable personal risk factors are being researched that could be influenced by the individual or by improving legislation for the protection of public health. http://www. Research at the Institute of Genetic Epidemiology (IGE) focuses on planning, realization and analysis of projects regarding the identification of genetic factors responsible for complex traits. This involves application, further development and implementation of a variety of statistical methods to address specific aspects such as rare genetic variants, mitochondrial DNA, gene-gene and gene-environment interactions, family studies, and the handling of population structures. The elucidation of disease-relevant genetic factors as well as their inclusion into models of disease risk provides the basis of individualized approaches to treatment or prevention. http://www. The Institute of Human Genetics (IHG) at the Helmholtz Zentrum München and the Technical University of Munich: The Institute is concerned with identifying genes associated with disease and characterizing their functions. The main aim of the research projects is to develop disease-related genetic variation in humans and mice as well as to develop chromosome analysis techniques and new methods for dealing with specific issues in the sphere of pre- and post-natal diagnostics and tumor cytogenetics. http://www. The German Center for Diabetes Research (DZD) is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes. Members are Helmholtz Zentrum München - German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Medical Center Carl Gustav Carus of the TU Dresden and the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard-Karls-University of Tuebingen together with associated partners at the Universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich. http://www.

News Article | November 7, 2016
Site: www.eurekalert.org

Certain proteins in the blood of children can predict incipient type 1 diabetes, even before the first symptoms appear. A team of scientists at the Helmholtz Zentrum München, partners in the German Center for Diabetes Research (DZD), reported these findings in the Diabetologia journal. The work was based on two large studies that are intended to explain the mechanisms behind the development of type 1 diabetes (BABYDIAB and BABYDIET*). The study participants are children who have a first-degree relative with type 1 diabetes and who consequently have an increased risk of developing the disease due to the familial predisposition. This autoimmune process does not develop from one day to the next, however: Often the young patients go through longer asymptomatic preliminary stages that see the formation of the first antibodies against the child's own insulin-producing cells in the pancreas; these are the so-called autoantibodies. Biomarkers that indicate whether and when this is the case and how quickly the clinical symptoms will appear could significantly improve the treatment of patients at-risk. A team of scientists, led by Dr. Stefanie Hauck, head of the Research Unit Protein Science and the Core Facility Proteomics, and Prof. Dr. Anette-G. Ziegler, Director of the Institute of Diabetes Research (IDF) at the Helmholtz Zentrum München, analyzed blood samples from 30 children with autoantibodies who had developed type 1 diabetes either very rapidly or with a very long delay. The researchers compared the data with data on children who displayed neither autoantibodies nor diabetes symptoms. In a second step with samples from another 140 children, the researchers confirmed the protein composition differences that they found in this approach. "Altogether, we were able to identify 41 peptides** from 26 proteins that distinguish children with autoantibodies from those without," reports Dr. Christine von Toerne, a scientist in the Research Unit Protein Science who shared first authorship of the work with Michael Laimighofer, a doctoral candidate in Jan Krumsiek's junior research group at the Institute of Computational Biology. Striking in their evaluations: A large number of these proteins are associated with lipid metabolism. "Two peptides -- from the proteins apolipoprotein M and apolipoprotein C-IV -- were particularly conspicuous and were especially differently expressed in the two groups," von Toerne adds. In autoantibody-positive children, it was furthermore possible to reach a better estimate of the speed of the diabetes development using the peptide concentrations of three proteins (hepatocyte growth factor activator, complement factor H and ceruloplasmin) in combination with the age of the particular child. The researchers are confident that the protein signatures they have discovered will be helpful as biomarkers for future diagnostics. "The progression of type 1 diabetes into a clinical disease takes place over a period of time that varies from individual to individual and that at this time is insufficiently predictable," explains Prof. Ziegler. "The biomarkers that we have identified allow a more precise classification of this presymptomatic stage and they are relatively simple to acquire from blood samples." * The BABYDIAB study, which was established in 1989 as the world's first diabetes prospective birth cohort, is a pioneering study in the field of type 1 diabetes pathogenesis research. More than 1650 children of parents with type 1 diabetes have been observed since their birth, or for a period of 25 years. The objective of the BABYDIAB study is to determine when islet autoantibodies first appear, which genetic factors and environmental factors influence their development, and which characteristics of the autoantibodies are most strongly associated with the development of type 1 diabetes. The participants in the study are reexamined every three years by means of blood samples and questionnaires. The BABYDIET is examining the influence of food containing gluten on the development of type 1 diabetes. Of the 2,441 children included in the two studies, so far 124 have developed a precursor to diabetes. 82 of these meanwhile display a clinical disease (as of November 2014). ** Peptides are molecules that, like proteins, are constructed from amino acids. However, they are smaller and to some extent result as fragments during protein breakdown. The transition is therefore relatively fluid. The study was financed by the Juvenile Diabetes Research Foundation (JDRF), which has headquarters in the USA. The number of new cases of type 1 diabetes each year continues to rise. New immunotherapeutic approaches aim at stopping this development. A precise assessment of the individual stage of disease development is an important criterion for the targeted use of new treatments. The described study shows that children already display proteomic changes in the blood during the presymptomatic stage. This information allows a better assessment of the time until clinical manifestation of the disease. Recently scientists in the Protein Science Research Unit were also able to identify biomarkers for the precursor to type 2 diabetes: https:/ Von Toerne, C. & Laimighofer, M. et al. (2016): Peptide serum markers in islet autoantibody-positive children. Diabetologia, doi: 10.1007/s00125-016-4150-x http://link. The presence of certain proteins in blood samples can predict incipient type 1 diabetes. The researchers identify these in their measurements using so-called peptide peaks (see selection in red). Source: Helmholtz Zentrum München The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members. http://www. The independent Research Unit Protein Science (PROT) investigates the composition of protein complexes and their integration into cellular processes and protein networks. One focus is the analysis of the interaction of genetic variance and environmental factors in neurodegenerative and metabolic diseases. The aim of this research is to identify biological systems and disease-associated disorders on a systemic level, thus contributing to a molecular understanding of diseases. http://www. The Core Facility Proteomics is an instrumental analysis platform at the Helmholtz Zentrum München. It provides interested research groups with access to comprehensive proteome analyses conducted with highly sensitive mass spectrometers. The portfolio ranges from technical and scientific consultation during project design and sample preparation to the development of optimized analysis methods to actual sample measurement and data evaluation. The Institute of Diabetes Research (IDF) focuses on the pathogenesis and prevention of type 1 diabetes and type 2 diabetes and the long-term effects of gestational diabetes. A major project is the development of an insulin vaccination against type 1 diabetes. The IDF conducts long-term studies to examine the link between genes, environmental factors and the immune system for the pathogenesis of type 1 diabetes. Findings of the BABYDIAB study, which was established in 1989 as the world's first prospective birth cohort study, identified risk genes and antibody profiles. These permit predictions to be made about the pathogenesis and onset of type 1 diabetes and will lead to changes in the classification and the time of diagnosis. The IDF is part of the Helmholtz Diabetes Center (HDC). http://www. The German Center for Diabetes Research (DZD) is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes. Members are Helmholtz Zentrum München - German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Medical Center Carl Gustav Carus of the TU Dresden and the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard-Karls-University of Tuebingen together with associated partners at the Universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich. https:/

News Article | February 16, 2017
Site: www.eurekalert.org

The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists at the German Diabetes Center (Deutsches Diabetes-Zentrum, DDZ) and the Helmholtz Center in Munich (HMGU) have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. The results of the study provide information on the earliest changes in the metabolism of the liver that in the long term lead to fatty liver disease in overweight persons as well as in those with type 2 diabetes. In the current issue of the "Journal of Clinical Investigation", DZD researchers working at the German Diabetes Center, in conjunction with the Helmholtz Center in Munich and colleagues from Portugal, published a scientific investigation conducted on healthy, slim men, who were given at random a flavored palm oil drink or a glass of clear water in a control experiment. The palm oil drink contained a similar amount of saturated fat as two cheeseburgers with bacon and a large portion of French fries or two salami pizzas. The scientists showed that this single high-fat meal sufficed to reduce the insulin action, e.g. cause insulin resistance and increase the fat content of the liver. In addition, changes in the energy balance of the liver were proven. The observed metabolic changes were similar to changes observed in persons with type 2 diabetes or non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common liver disease in the industrial nations and associated with obesity, the so-called "metabolic syndrome," and is associated with an increased risk in developing type 2 diabetes. Furthermore, NAFLD in advanced stages can result in severe liver damage. "The surprise was that a single dosage of palm oil has such a rapid and direct impact on the liver of a healthy person and that the amount of fat administered already triggered insulin resistance", explained Prof. Dr. Michael Roden, scientist, Managing Director and Chairman at the DDZ and the German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD). "A special feature of our study is that we monitored the liver metabolism of people with a predominantly non-invasive technology, e.g. by magnetic resonance spectroscopy. This allows us to track the storage of sugar and fat as well as the energy metabolism of the mitochondria (power plants of the cell)." Thanks to the new methods of investigation, the scientists were able to verify that the intake of palm oil affects the metabolic activity of muscles, liver and fatty tissue. The induced insulin resistance leads to an increased new formation of sugar in the liver with a concomitant decreased sugar absorption in the skeletal muscles - a mechanism that makes the glucose level rise in persons afflicted with type 2 diabetes and its pre-stages. In addition, the insulin resistance of the fatty tissue causes an increased release of fats into the blood stream, which in turn continues to foster the insulin resistance. The increased availability of fat leads to an increased workload for the mitochondria, which can in the long term overtax these cellular power plants and contribute to the emergence of a liver disease. The team of Prof. Roden suspects that healthy people, depending on genetic predisposition, can easily manage this direct impact of fatty food on the metabolism. The long-term consequences for regular eaters of such high-fat meals can be far more problematic, however. This paper is promoted by the Federal Ministry of Health, the Ministry for Innovation, Science and Research of the state of North Rhine-Westphalia, the Federal Ministry for Education and Research (Deutsches Zentrum für Diabetesforschung e.V.), as well as the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), the German Diabetes Society (DDG) and the Schmutzler Foundation. Elisa Álvarez Hernández, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrab? de Angelis and Michael Roden, Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance, J Clin Invest. 2017, January 23, 2017. doi:10.1172/JCI89444. The German Diabetes Center (DDZ) is the German reference center for diabetes. The goal is to contribute to the prevention, early detection, diagnosis and treatment of diabetes mellitus. At the same time, the research center aims at improving the epidemiological data situation in Germany. DDZ is in charge of the multi-center German Diabetes Study. It is the point of contact for all players in the health sector. In addition, it prepares scientific information on diabetes mellitus and makes it available to the public. DDZ is part of "Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz" (WGL) and is a partner of the German Center for Diabetes Research (DZD e.V.). The German Center for Diabetes Research (DZD) is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim is to develop novel strategies for personalized prevention and treatment of diabetes. Members are Helmholtz Zentrum München - German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Medical Center Carl Gustav Carus of the TU Dresden and the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard-Karls-University of Tuebingen together with associated partners at the Universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich. The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members

Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-15-2015 | Award Amount: 65.27M | Year: 2016

The EU has set the stage to empower semiconductor manufacturing in Europe being one of the key drivers for innovation and employment and creator for answers to the challenges of the modern society. Aim of IoSense is to boost the European competitiveness of ECS industries by increasing the pilot production capacity and improving Time-to-Market for innovative microelectronics, accomplished by establishing three fully connected semiconductor pilot lines in Europe: two 200mm frontend (Dresden and Regensburg) and one backend (Regensburg) lines networking with existing highly specialized manufacturing lines. Focus is the availability of top innovative, competitive sensors and sensor systems Made in Europe for applications in Smart Mobility, Society, Energy, Health and Production. Today competitors are already involved in the development of sensor systems for applications in the emerging Internet of Things. But there is a significant gap between those forces and the capabilities to bring ideas into the high volume market fast enough. IoSense will close this gap by providing three modular flexible pilot lines being seamless integrated in the IoT value crating networks and ready to manufacture each kind of sensor system prototypes. IoSense will increase the manufacturing capacity of sensor/MEMS components in the involved pilot lines by factor of 10 while reducing manufacturing cost and time by 30%. IoSense is designed to enable focused development work on technological and application oriented tasks combining with market orientation. Design to Market Needs will be accomplished by customer involvement, embedding all required functionality besides sensors. Finally, the time for idea-to-market for new sensor systems is intended to be brought down to less than one year. As a result, semiconductor manufacturing will get a new boost in Europe enabling the industry with competitive solutions, securing employment and providing answers to the upcoming challenges in the IoT era.

News Article | December 2, 2016
Site: www.eurekalert.org

TU Dresden's team of researchers was one of the three finalists, and managed to successfully prevail over their competitors. "For the first time in the history of this award ceremony, a team in the field of civil engineering has been honoured. This shows how important our research and our endeavours are, that aim at bringing about the absolutely necessary paradigm shift in the field of civil engineering and driving it towards more resource efficiency and sustainability", states Professor Manfred Curbach, Director of the Institute of Concrete Structures and spokesman of the winning team. The "Deutscher Zukunftpreis" of the Federal President is one of the most important science awards in Germany. TU Dresden's rector Professor Hans Müller-Steinhagen is exceptionally pleased: "Congratulations! This is a great success for the three professors, for the Technische Universität Dresden, and also for Dresden as a hub for science and research. With this award, scientists of our university have succeeded in making trendsetting innovations comprehensible, and thus convincing the distinguished German Future Award jury for the second time since 2011, starting with an idea and fundamental research leading all the way to market introduction." The three researchers developed a novel composite material that relies on the use of carbon instead of steel reinforcement. Carbon is four times lighter and can yet its bearing capacity is six times larger than steel. The innovative potential composite material's is huge. In comparison to reinforced concrete, carbon concrete is more resistant and at the same time more durable because no oxidisation is taking place. Construction compounds and buildings can be constructed thinner while valuable resources such as water and sand are conserved. In addition, the material allows for filigree forms and a broad range of applications. By implementing carbon concrete, more than 50 per cent of material can be saved. This correlates with a decrease in energy consumption and CO² emissions. In the development process however, all details must be taken into consideration. Components made from carbon concrete enable a combination with additional functionalities such as insulation, heating, or supervising of buildings. Carbon concrete cannot only be implemented in the field of new constructions but is also suitable for the reinforcement of already existing buildings. The expected lifetime of buildings, bridges, and poles can be considerably increased by applying a thin layer of carbon concrete. As early as 2006, old buildings throughout Germany and the world are reinforced using this procedure, e.g. a shopping centre in Prague or huge silos such as the sugar silo in Uelzen. The building material carbon concrete therefore not only is an innovation for Dresden but is gaining in importance worldwide. The German Federal Ministry of Education and Research saw the importance of the carbon concrete technology and funds the C³ - Carbon Concrete Composite association, established in 2014, with up to 43 million Euros. The C³ is an interdisciplinary network consisting of more than 150 associates from the areas of economy, science, and organisations who jointly advance the market introduction of this innovative material. Title: C³ - Project Patron: Federal Ministry of Education and Research Time period: Sept. 2013 - 2020 Consortium leader: TU Dresden, Insitute of Concrete Structures Head: Prof. Dr.-Ing. E.h. Manfred Curbach Contact: Dr. Ing. Frank Schladitz Project partners: Consortium of over 150 companies, associations and institutions

Elstner M.,Karlsruhe Institute of Technology | Seifert G.,TU Dresden
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2014

This paper reviews the basic principles of the density-functional tight-binding (DFTB) method, which is based on density-functional theory as formulated by Hohenberg, Kohn and Sham (KSDFT). DFTB consists of a series of models that are derived from a Taylor series expansion of the KS-DFT total energy. In the lowest order (DFTB1), densities and potentials are written as superpositions of atomic densities and potentials. The Kohn-Sham orbitals are then expanded to a set of localized atom-centred functions, which are obtained for spherical symmetric spin-unpolarized neutral atoms self-consistently. The whole Hamilton and overlap matrices contain one- and two-centre contributions only. Therefore, they can be calculated and tabulated in advance as functions of the distance between atomic pairs. The second contributions to DFTB1, the DFT double counting terms, are summarized together with nuclear repulsion energy terms and can be rewritten as the sum of pairwise repulsive terms. The second-order (DFTB2) and third-order (DFTB3) terms in the energy expansion correspond to a selfconsistent representation, where the deviation of the ground-state density from the reference density is represented by charge monopoles only. This leads to a computationally efficient representation in terms of atomic charges (Mulliken), chemical hardness (Hubbard) parameters and scaled Coulomb laws. Therefore, no additional adjustable parameters enter the DFTB2 and DFTB3 formalism. The handling of parameters, the efficiency, the performance and extensions of DFTB are briefly discussed. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Borrell V.,and oUniversidad Miguel Hernandez | Calegari F.,TU Dresden
Neuroscience Research | Year: 2014

In the last few years, several studies have revisited long-held assumptions in the field of brain development and evolution providing us with a fundamentally new vision on the mechanisms controlling its size and shape, hence function. Among these studies, some described hitherto unforeseeable subtypes of neural progenitors while others reinterpreted long-known observations about their cell cycle in alternative new ways. Most remarkably, this knowledge combined has allowed the generation of mammalian model organisms in which brain size and folding has been selectively increased giving us the means to understand the mechanisms underlying the evolution of the most complex and sophisticated organ. Here we review the key findings made in this area and make a few conjectures about their evolutionary meaning including the likelihood of Martians conquering our planet. © 2014 The Authors.

Hajishengallis G.,University of Pennsylvania | Chavakis T.,TU Dresden
Trends in Immunology | Year: 2013

Leukocyte recruitment is a central immune process. Multiple factors have been described to promote leukocyte infiltration into inflamed tissues, but only recently has evidence for endogenous negative modulators of this inflammatory process emerged. The discovery of several locally produced modulators has emerged into a new field of endogenous inhibitors of leukocyte extravasation. Recent findings from several inflammatory disease models show that tissues can self-regulate the recruitment of inflammatory cells, suggesting that local tissues may have a greater 'regulatory say' over the immune response than previously appreciated. Here, we propose that locally produced modulators of leukocyte recruitment may represent local homeostatic mechanisms that tissues and organs may have evolved for protection against the destructive potential of the immune system. © 2012 Elsevier Ltd.

Sezgin E.,TU Dresden | Sezgin E.,Max Planck Institute of Molecular Cell Biology and Genetics | Kaiser H.-J.,Max Delbrück Center for Molecular Medicine | Baumgart T.,University of Pennsylvania | And 3 more authors.
Nature Protocols | Year: 2012

The observation of phase separation in intact plasma membranes isolated from live cells is a breakthrough for research into eukaryotic membrane lateral heterogeneity, specifically in the context of membrane rafts. These observations are made in giant plasma membrane vesicles (GPMVs), which can be isolated by chemical vesiculants from a variety of cell types and microscopically observed using basic reagents and equipment available in any cell biology laboratory. Microscopic phase separation is detectable by fluorescent labeling, followed by cooling of the membranes below their miscibility phase transition temperature. This protocol describes the methods to prepare and isolate the vesicles, equipment to observe them under temperature-controlled conditions and three examples of fluorescence analysis: (i) fluorescence spectroscopy with an environment-sensitive dye (laurdan); (ii) two-photon microscopy of the same dye; and (iii) quantitative confocal microscopy to determine component partitioning between raft and nonraft phases. GPMV preparation and isolation, including fluorescent labeling and observation, can be accomplished within 4 h. © 2012 Nature America, Inc. All rights reserved.

Volotka A.V.,TU Dresden | Volotka A.V.,Saint Petersburg State University | Plunien G.,TU Dresden
Physical Review Letters | Year: 2014

A systematic investigation of the nuclear polarization effects in one- and few-electron heavy ions is presented. The nuclear polarization corrections in the zeroth and first orders in 1/Z are evaluated to the binding energies, the hyperfine splitting, and the bound-electron g factor. It is shown that the nuclear polarization contributions can be substantially canceled simultaneously with the rigid nuclear corrections. This allows for new prospects for probing the QED effects in a strong electromagnetic field and the determination of fundamental constants. © 2014 American Physical Society.

von Dawans B.,Albert Ludwigs University of Freiburg | Kirschbaum C.,TU Dresden | Heinrichs M.,Albert Ludwigs University of Freiburg
Psychoneuroendocrinology | Year: 2011

Psychological stress is an ubiquitous challenge across human cultures affecting mental and physical health. Recent evidence indicates that performance tasks combining elements of socio-evaluative threat and uncontrollability elicit reliable stress responses. The Trier Social Stress Test (TSST) is the most frequently used psychological protocol in stress research; however, to date it has only been available in a single-subject version. In particular, there is an increasing need in several emerging research fields such as stress research or social neurosciences for a standardized research tool to expose relatively large groups of subjects to controlled simultaneous stress. In search of a laboratory stressor that allows simultaneous stress exposure in a group format, we exposed a total of 25 healthy male participants to the Trier Social Stress Test for Groups (TSST-G; public speaking and mental arithmetic tasks in front of a panel of two evaluators in groups of six participants) and a specific control condition. Results showed that the TSST-G induced significant increases in cortisol, heart rate, and psychological stress responses. The TSST-G provides a novel, effective, and economical protocol for experimental paradigms requiring simultaneous stress induction in multiple participants. © 2010 Elsevier Ltd.

Tress W.,Linköping University | Tress W.,TU Dresden | Inganas O.,Linköping University
Solar Energy Materials and Solar Cells | Year: 2013

Adjusting the work function of the two electrodes to the energy levels of the intrinsic active materials of an organic solar cell is crucial for a good device performance. Often, injection barriers (in combination with selective contacts blocking one charge carrier species) caused by a misaligned metal work function or extraction barriers resulting from insulating intentional or unintentional interlayers between metal and active layers, result in a decrease in fill factor seen in the extreme case in S-shaped current-voltage (J-V) characteristics. To avoid this S-kink, it is essential to identify its origin, desirably applying a simple experimental method. We propose an approach based on analyses of current-voltage data as a function of illumination intensity. A normalization of the J-V curves at the saturated photocurrent reveals distinctive features for each type of barrier. We apply the method to planar heterojunction small-molecule and bulk heterojunction polymer solar cells with oxidized metal electrode or plasma-treated active layer and explain the theory with a drift-diffusion model. © 2013 Elsevier B.V.

Tress W.,TU Dresden | Tress W.,Linköping University | Corvers S.,TU Dresden | Leo K.,TU Dresden | Riede M.,TU Dresden
Advanced Energy Materials | Year: 2013

The role of drift and diffusion as driving forces for charge carrier extraction in flat heterojunction organic solar cells is examined at the example of devices showing intentional S-shaped current-voltage ( J-V ) characteristics. Since these kinks are related to energy barriers causing a redistribution of the electric fi eld and charge carrier density gradients, they are suitable for studying the limits of charge extraction. The dynamics of this redistribution process are experimentally monitored via transient photocurrents, where the current response on square pulses of light is measured in the ? s to ms regime. In combination with drift-diffusion simulation data, we demonstrate a pile-up of charge carriers at extraction barriers and a high contribution of diffusion to photocurrent in the case of injection barriers. Both types of barrier lead to S-kinks in the J-V curve and can be distinguished from each other and from other reasons for S-kinks (e.g. imbalanced mobilities) by applying the presented approach. Furthermore, it is also helpful to investigate the driving forces for charge extraction in devices without S-shaped J-V curve close to open circuit to evaluate whether their electrodes are optimized. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ummels M.,German Aerospace Center | Baier C.,TU Dresden
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Probabilistic model checking mainly concentrates on techniques for reasoning about the probabilities of certain path properties or expected values of certain random variables. For the quantitative system analysis, however, there is also another type of interesting performance measure, namely quantiles. A typical quantile query takes as input a lower probability bound p ∈ ]0,1] and a reachability property. The task is then to compute the minimal reward bound r such that with probability at least p the target set will be reached before the accumulated reward exceeds r. Quantiles are well-known from mathematical statistics, but to the best of our knowledge they have not been addressed by the model checking community so far. In this paper, we study the complexity of quantile queries for until properties in discrete-time finite-state Markov decision processes with nonnegative rewards on states. We show that qualitative quantile queries can be evaluated in polynomial time and present an exponential algorithm for the evaluation of quantitative quantile queries. For the special case of Markov chains, we show that quantitative quantile queries can be evaluated in pseudo-polynomial time. © 2013 Springer-Verlag.

Schwager H.,TU Dresden | Schwager H.,Albert Ludwigs University of Freiburg
Proceedings. Biological sciences / The Royal Society | Year: 2013

Branching in columnar cacti features morphological and anatomical characteristics specific to the subfamily Cactoideae. The most conspicuous features are the pronounced constrictions at the branch-stem junctions, which are also present in the lignified vascular structures within the succulent cortex. Based on finite-element analyses of ramification models, we demonstrate that these indentations in the region of high flexural and torsional stresses are not regions of structural weakness (e.g. allowing vegetative propagation). On the contrary, they can be regarded as anatomical adaptations to increase the stability by fine-tuning the stress state and stress directions in the junction along prevalent fibre directions. Biomimetic adaptations improving the functionality of ramifications in technical components, inspired, in particular, by the fine-tuned geometrical shape and arrangement of lignified strengthening tissues of biological role models, might contribute to the development of alternative concepts for branched fibre-reinforced composite structures within a limited design space.

Zhang D.-B.,University of Minnesota | Zhang D.-B.,Beijing Computational Science Research Center | Seifert G.,TU Dresden | Chang K.,CAS Institute of Semiconductors
Physical Review Letters | Year: 2014

We present, for the first time, an atomic-level and quantitative study of a strain-induced pseudomagnetic field in graphene nanoribbons with widths of hundreds of nanometers. We show that twisting strongly affects the band structures of graphene nanoribbons with arbitrary chirality and generates well-defined pseudo-Landau levels, which mimics the quantization of massive Dirac fermions in a magnetic field up to 160 T. Electrons are localized either at ribbon edges forming the edge current or at the ribbon center forming the snake orbit current, both being valley polarized. Our result paves the way for the design of new graphene-based nanoelectronics. © 2014 American Physical Society.

Baek S.-H.,Leibniz Institute for Solid State and Materials Research | Efremov D.V.,Leibniz Institute for Solid State and Materials Research | Ok J.M.,Pohang University of Science and Technology | Kim J.S.,Pohang University of Science and Technology | And 4 more authors.
Nature Materials | Year: 2015

A fundamental and unconventional characteristic of superconductivity in iron-based materials is that it occurs in the vicinity of two other instabilities. In addition to a tendency towards magnetic order, these Fe-based systems have a propensity for nematic ordering: a lowering of the rotational symmetry while time-reversal invariance is preserved. Setting the stage for superconductivity, it is heavily debated whether the nematic symmetry breaking is driven by lattice, orbital or spin degrees of freedom. Here, we report a very clear splitting of NMR resonance lines in FeSe at T nem = 91 K, far above the superconducting T c of 9.3 K. The splitting occurs for magnetic fields perpendicular to the Fe planes and has the temperature dependence of a Landau-type order parameter. Spin-lattice relaxation rates are not affected at T nem, which unequivocally establishes orbital degrees of freedom as driving the nematic order. We demonstrate that superconductivity competes with the emerging nematicity. © 2015 Macmillan Publishers Limited. All rights reserved.

Franze K.,University of Cambridge | Janmey P.A.,University of Pennsylvania | Guck J.,University of Cambridge | Guck J.,TU Dresden
Annual Review of Biomedical Engineering | Year: 2013

Biological cells are well known to respond to a multitude of chemical signals. In the nervous system, chemical signaling has been shown to be crucially involved in development, normal functioning, and disorders of neurons and glial cells. However, there are an increasing number of studies showing that these cells also respond to mechanical cues. Here, we summarize current knowledge about the mechanical properties of nervous tissue and its building blocks, review recent progress in methodology and understanding of cellular mechanosensitivity in the nervous system, and provide an outlook on the implications of neuromechanics for future developments in biomedical engineering to aid overcoming some of the most devastating and currently incurable CNS pathologies such as spinal cord injuries and multiple sclerosis. Copyright © 2013 by Annual Reviews.

Grunwaldt J.-D.,Karlsruhe Institute of Technology | Schroer C.G.,TU Dresden
Chemical Society Reviews | Year: 2010

X-Ray microscopic techniques are excellent and presently emerging techniques for chemical imaging of heterogeneous catalysts. Spatially resolved studies in heterogeneous catalysis require the understanding of both the macro and the microstructure, since both have decisive influence on the final performance of the industrially applied catalysts. A particularly important aspect is the study of the catalysts during their preparation, activation and under operating conditions, where X-rays have an inherent advantage due to their good penetration length especially in the hard X-ray regime. Whereas reaction cell design for hard X-rays is straightforward, recently smart in situ cells have also been reported for the soft X-ray regime. In the first part of the tutorial review, the constraints from a catalysis view are outlined, then the scanning and full-field X-ray microscopy as well as coherent X-ray diffraction imaging techniques are described together with the challenging design of suitable environmental cells. Selected examples demonstrate the application of X-ray microscopy and tomography to monitor structural gradients in catalytic reactors and catalyst preparation with micrometre resolution but also the possibility to follow structural changes in the sub-100 nm regime. Moreover, the potential of the new synchrotron radiation sources with higher brilliance, recent milestones in focusing of hard X-rays as well as spatiotemporal studies are highlighted. The tutorial review concludes with a view on future developments in the field of X-ray microscopy that will have strong impact on the understanding of catalysts in the future and should be combined with in situ electron microscopic studies on the nanoscale and other spectroscopic studies like microRaman, microIR and microUV-vis on the macroscale. © 2010 The Royal Society of Chemistry.

Previati G.,Polytechnic of Milan | Kaliske M.,TU Dresden
International Journal of Fatigue | Year: 2012

In this paper, the fatigue life of pneumatic tires is investigated with particular focus on the phenomenon of belt separation. This phenomenon yields the propagation of fatigue cracks in the rubber separating the belts; not the separation of the rubber at the interfaces with the belts. Cracks at the belts edges are related among others to the high stress concentration due to the very different stiffness of the two materials. A steady-state rolling finite element model of the full tire is used to evaluate the stress and strain fields in the rubber at the edges of the belts. Suitable life predictors are defined and computed for the identification of the zones with a higher expectation of failure. For the evaluation of crack propagation in the bulk rubber material between different belts, in principle, two different approaches are employed associated with crack nucleation and crack growth. The two approaches are applied to the study of crack propagation in a truck tire and the results of different predictors are compared to crack propagation found in a real tire. © 2011 Elsevier Ltd. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 4.68M | Year: 2009

FACETS-ITN is a research and training network involving partners from 11 universities and research centres, 3 industrial companies and 1 semi-industrial research centre from 6 European countries. It combines competencies in neurobiology, computational neuroscience, information science, physics and electrical engineering. The scientific goal is to experimentally and theoretically explore the structure and the computational principles of biological neural circuits using in-vitro and in-vivo neurobiological experiments as well as analytical approaches, model building and simulation techniques. The concepts of learning and plasticity will be of particular importance. Based on the input from biology and modelling it is expected to prepare the grounds for novel hardware based computing devices that make use of such principles. Such devices will be built and operated in the form of large scale demonstrators as part of the research plan. Within the training network 21 selected Ph.D. students will be integrated into an existing international research environment and receive a strongly interdisciplinary training. The training comprises an intense exchange and visiting programme, specific training workshops for all scientific areas covered as well as in non-scientific key competencies.. This training concept will enhance their original academic education in order to cope with the challenges of this diverse international research environment. The proposed training programme will be closely coupled to existing research projects as well as graduate programmes of participating universities. It will create a sustained infrastructure based on web-based learning as well as on scientific interdisciplinary networks and the intersectional exchange with industry. The community building among Ph.D. students from different disciplines will include students from other projects, in particular the current FACETS integrated project and its planned successor.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.4.2-3 | Award Amount: 15.68M | Year: 2010

The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental factors are probably involved in this profound transformation process in the atria. Therefore, we believe that progress in the diagnostics, prevention and treatment of AF requires highly integrative research from the molecule to bedside and from specific signaling pathways and electrophysiological mechanisms to population based studies. A consortium was formed providing this variety of expertises and has identified central research objectives for improvements in AF prevention and therapy. In 5 work packages focusing on basic research, new biomarkers for AF and therapeutic targets will be identified. We will study mechanisms of conduction disturbances in the atria, explore new ion channel targets for treatment of AF, identify specific alterations in the atria depending on the underlying heart disease, and evaluate beneficial effects of organ-protective compounds. Within two clinically oriented work packages the clinical application of these findings will be tested. The predictive value of diagnostic tools like serum biomarkers, 3D reconstruction of atrial conduction patterns based on high resolution body surface ECGs, and echocardiographic markers will be studied in large scale population studies. The new therapeutic targets will be explored in smaller prove-of-principle clinical trials (substrate oriented ablation, new pharmacological targets, and local gene delivery).

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.2.2-1 | Award Amount: 13.07M | Year: 2012

As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chronic disease are urgently needed and will have an outstanding impact on public health as a whole. Among the most promising interventions that meet these requirements are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The DO-HEALTH will close this knowledge gap in a large 3-year multi-centre clinical trial that will establish long-term efficacy and safety data for the 3 interventions in the prevention of age-related diseases in seniors. The DO-HEALTH trial will enrol 2152 community-dwelling men and women aged 70 and older, when chronic diseases increase substantially. The randomized-controlled trial will test the individual and the combined benefit of 2000 IU vitamin D/day, 1 g of omega-3 fatty acids/day and a simple home exercise program in an efficient factorial trial design. DO-HEALTH will establish evidence in 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, glucose tolerance, gastro-intestinal symptoms, mental and oral health, quality of life, and mortality. Follow-up will be in-person, in 3-monthly intervals (4 clinical visits and 9 phone calls). DO-HEALTH will further assess the comparative effectiveness of the interventions by evaluating reasons why or why not seniors adhere to them, and will assess their cost-benefit in a health economic model based on documented health care utilization and observed incidence of chronic disease.

Agency: European Commission | Branch: H2020 | Program: ECSEL-RIA | Phase: ECSEL-06-2015 | Award Amount: 38.85M | Year: 2015

The goal of the PRIME project is to establish an open Ultra Low Power (ULP) Technology Platform containing all necessary design and architecture blocks and components which could enable the European industry to increase and strengthen their competitive and leading eco-system and benefit from market opportunities created by the Internet of Things (IoT) revolution. Over 3 years the project will develop and demonstrate the key building blocks of IoT ULP systems driven by the applications in the medical, agricultural, domestics and security domains. This will include development of high performance, energy efficient and cost effective technology platform, flexible design ecosystem (including IP and design flow), changes in architectural and power management to reduced energy consumption, security blocks based on PUF and finally the System of Chip and System in Package memory banks and processing implementations for IoT sensor node systems. Developped advanced as 22nm FDSOI low power technologies with logic, analog, RF and embedded new memory components (STT RAM and RRAM) together with innovative design and system architecture solutions will be used to build macros and demonstrate functionality and power reduction advantage of the new IoT device components. The PRIME project will realize several demonstrators of IoT system building blocks to show the proposed low power wireless solutions, functionality and performance of delivered design and technology blocks. The consortium semiconductor ecosystem (IDMs, design houses, R&D, tools & wafer suppliers, foundries, system/product providers) covers complementarily all desired areas of expertise to achieve the project goals. The project will enable an increase in Europes innovation capability in the area of ULP Technology, design and applications, creation of a competitive European eco-system and help to identify market leadership opportunities in security, mobility, healthcare and smart cost competitive manufacturing.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-25-2015 | Award Amount: 4.54M | Year: 2016

The interest for developing smart systems based on interconnected objects is growing fast (50 billion objects connected in 2020). The main components of Internet of Things (IoT) devices are autonomous battery-operated smart embedded systems comprising communication circuits, sensors, computing/processing devices and storage. The key requirements are ultra-low power, high processing capabilities, fast/dense storage, wireless communication, heterogeneous integration, and autonomy. The different functions are so far implemented in separate chips/technologies, which is a bottleneck in terms of costs and miniaturization. To tackle the key issues of monolithic heterogeneous integration, fast yet low power processing, high integration density, fast yet low power storage, the goal of the GREAT STREP project is to co-integrate multiple functions like sensors (Sensing), RF receivers (Communicating) and logic/memory (Processing/Storing) together within CMOS by adapting the STT-MTJs (Magnetic devices) to a single baseline technology. This lead to a unique STT-MTJ cell technology called Multifunctional Standardized (MTJ) Stack (MSS), paving the way to 2.5D self-integrated heterogeneous architectures . The major outputs of GREAT are the technology and the architecture platform for IoT SoCs which provides better integration of embedded & mobile communication systems and a significant decrease of their power consumption. Based on the STT unique set of performances (non-volatility, high speed, infinite endurance and moderate read/write power), GREAT will achieve the same goal as heterogeneous integration of devices but in a much simpler way. The project final objectives are: fabrication of an advanced MSS technology test chip jointly with a system-level simulation and design of a representative M2M IoT platform integrating MSS. The consortium is composed of 9 EU partners led by CEA and of an Advisory Board comprising leaders in IP solutions, IoT, and mobile technologies.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 203.40K | Year: 2011

A recent innovation in materials modeling has been the phase field crystal model. Instead of a phenomenological phase field variable the quantity of interest is the atomic number density. This formulation has made it possible to incorporate the kinetics of phase transformations with properties of solids that arise due to their periodic structure. This includes elastic strain, topological defects, vacancy diffusion and polycrystalline grain boundary interactions. The appealing feature of the phase field crystal model is its connection with classical density functional theory, which allows material specific simulations on diffusive time scales, orders of magnitude larger than classical molecular dynamics. Our mission is to foster international cooperation in phase field crystal modeling and serve as a platform for addressing global challenges in materials science by using the phase field crystal approach. Applications of interest are self-assembly of quantum dots in thin film growth and fluid-structure interactions in microfluidics. We involve participants from diverse sectors, regions and science and engineering disciplines which have already proven to be able to work together efficiently.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-3.3-1 | Award Amount: 3.74M | Year: 2010

COPING presents a child-centred research strategy covering four European countries, the UK, Germany, Romania and Sweden, which will identify the characteristics of children with imprisoned parents, their resilience, and their vulnerability to mental health problems. This group of children are exposed to triple jeopardy through break-up of the family, financial hardship, and extremes of stigma and secrecy, leading to adverse social and educational repercussions. None of the four countries so far recognises the extreme disadvantage experienced by these young people. Support available, for example, in accessing prisons and participating in prison visits is extremely variable and mainly provided through non-governmental organisations. Support for imprisoned parents, whose moral authority is diminished through their incarceration, is equally inconsistent. The COPING research strategy places the clearest emphasis on knowledge obtained directly from children and young people. The project will commission surveys of 200 children in each country aged 11-16 with an imprisoned parent, using the Strengths and Difficulties Questionnaire and the Rosenberg Self-Esteem Scale, to ascertain coping strategies and mental health problems for these young people, which will be compared with normative population samples. Smaller groups of children and parents will be involved in in-depth qualitative interviews to explore the impact of parental imprisonment and support services available in greater detail. Interventions to support these families will be comprehensively mapped. Children will play a prominent role in disseminating research results to policy makers and professional bodies Impacts of the COPING research will include improvements in information about this group of children; step changes in Government and public awareness about their plight; potential new legislation; and improvements in prison regimes to enable effective contact and visits for children to imprisoned

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-21-2015 | Award Amount: 3.29M | Year: 2016

The future energy system is challenged by the intermittent nature of renewables and requires therefore several flexibility options. Still, the interaction between different options, the optimal portfolio and the impact on environment and society are unknown. It is thus the core objective of REFLEX to analyse and evaluate the development towards a low-carbon energy system with focus on flexibility options in the EU to support the implementation of the SET-Plan. The analysis are based on a modelling environment that considers the full extent to which current and future energy technologies and policies interfere and how they affect the environment and society while considering technological learning of low-carbon and flexibility technologies. For this purpose, REFLEX brings together the comprehensive expertise and competences of known European experts from six different countries. Each partner focusses on one of the research fields techno-economic learning, fundamental energy system modelling or environmental and social life cycle assessment. To link and apply these three research fields in a compatible way, an innovative and comprehensive energy models system (EMS) is developed, which couples the models and tools from all REFLEX-Partners. It is based on a common database and scenario framework. The results from the EMS will help to understand the complex links, interactions and interdependencies between different actors, available technologies and impact of the different interventions on all levels from the individual to the whole energy system. In this way, the knowledge base for decision-making concerning feasibility, effectiveness, costs and impacts of different policy measures will be strengthened, which will assist policy makers and support the implementation of the SET-Plan. Stakeholders will be actively involved during the entire project from definition of scenarios to dissemination and exploitation of results via workshops, publications and a project website.

Agency: European Commission | Branch: H2020 | Program: ECSEL-RIA | Phase: ECSEL-01-2015 | Award Amount: 33.04M | Year: 2015

The REFERENCE project aims to leverage a European leading edge Radio Frequency (RF) ecosystem based on RF Silicon On Insulator (SOI) disruptive technology, perceived as the most promising to address performance, cost and integration needs for RF Front End Modules (FEMs)s. The project targets to develop over the next 3 years, innovative solutions from material, engineered substrates, process, design, metrology to system integration capable to address the unresolved 4G\ requirements for RF FEMs (data rate >1Gb/s) and pave the way to 5G. The R&D and demonstration actions include: Development of innovative RFSOI substrates for 4G\ / 5G Move to 300 mm diameter Development of 4G\ / 5G RF-SOI devices with 2 major European foundries : analog in 200 mm 130nm technology, RF digital by combining RFSOI and FDSOI in 300 mm at 22nm; Innovative design for 4G\ /5G (analog and RF digital), Integration of several 4G\ FEM components on the same chip and demonstration System in Package Technology (SiP). 3 applications are investigated : Cellular / Iot : 4G\ RFSOI FEM demonstrator at SiP device level Automotive : 4G\ RF-SOI demonstrator at SiP device level Aviation: RF-SOI high data rate wireless communication module at system level; targeting a new frequency band for aeronautic. The project is executed within 5 European countries, by on a strong and complementary and well balanced consortium, 6 large industrial companies (world leaders in material, foundries, aeronautics), 4 SMEs and a network of world class level and major European public research institutes and academics. It clearly aims to develop industrial solutions enabling European leadership and production. Through this technology disruption, REFERENCE project addresses major thrusts for smart mobility, smart society, semiconductor processes, equipments, design technology and smart systems implementation, and support the societal challenges of smart transport, as well as secure and innovative society.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2010-1.2-3 | Award Amount: 5.29M | Year: 2011

The NanoHiTEC project is focused on planar thermo-electric converters based on super-lattice quantum wells, which have shown on laboratory scale already a figure of merit ZT > 4 for a wide temperature range. The optimization of BiTe based layer systems as well as Si/SiGe and B4C/B9C lattices will be combined with the development of low cost/high throughput industrial deposition processes for multilayers. Direct p-n-junctions at the hot side of the converter promise further increase in performance and long term stability of the devices, but also simplified fabrication. As technologies for improved material performance multilayered nanowires and sintered nanopowders will be investigated. A central point of NanoHiTEC is the optimization of the passive components (thermal and electrical contacts, substrates) and of new geometries for the layout of planar converters to maximize the system efficiency. In this field particular emphasis is given to the heat flow into the hot and out of the cold side of the active elements where actual devices show the most efficiency loss. The developments in the project are backed by partners experienced in the qualification of thermo-electric materials and devices. Besides the parameters defining the thermoelectric performance - measured in a wide range of temperatures, pressures and magnetic fields - the microstructure, dopant distribution and the inner potentials will be investigated by scanning microscopy and TEM (holography). A major part of the project is the simulation of electronic and phononic properties based on the material microstructure. Intense interaction of theoretical work and characterization results of fabricated systems will pave the way for further enhanced material efficiency and better producibility. A main target is the integration in automotive applications where the high efficiency of superlattice systems over a broad temperature range promises good adaptation to the varying conditions in vehicles.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.13 | Award Amount: 11.87M | Year: 2011

For the past thirty years, the need for ever greater supercomputer performance has driven the development of many computing technologies which have subsequently been exploited in the mass market. Delivering an exaflop (or 10^18 calculations per second) by the end of this decade is the challenge that the supercomputing community worldwide has set itself. The Collaborative Research into Exascale Systemware, Tools and Applications project (CRESTA) brings together four of Europes leading supercomputing centres, with one of the worlds major equipment vendors, two of Europes leading programming tools providers and six application and problem owners to explore how the exaflop challenge can be met. CRESTA focuses on the use of six applications with exascale potential and uses them as co-design vehicles to develop: the development environment, algorithms and libraries, user tools, and the underpinning and cross-cutting technologies required to support the execution of applications at the exascale. The applications represented in CRESTA have been chosen as a representative sample from across the supercomputing domain including: biomolecular systems, fusion energy, the virtual physiological human, numerical weather prediction and engineering.\n\nNo one organisation, be they a hardware or software vendor or service provider can deliver the necessary range of technological innovations required to enable computing at the exascale. This is recognised through the on-going work of the International Exascale Software Project and, in Europe, the European Exascale Software Initiative. CRESTA will actively engage with European and International collaborative activities to ensure that Europe plays its full role worldwide. Over its 39 month duration the project will deliver key, exploitable technologies that will allow the co-design applications to successfully execute on multi-petaflop systems in preparation for the first exascale systems towards the end of this decade.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.27M | Year: 2017

SECRET is a collaborative European Training Network (ETN) committed to create an excellent educational training platform; that is multi-disciplinary and intersectoral in nature, for Early Stage Researchers (ESRs) in the field of wireless communications and networking. In this dynamic field, the challenges are always evolving and more stringent in line with market expectation, and socio-economical requirements. The chapter of 4G (4th Generation) of mobile systems is finally coming to an end, with waves of 4G systems deployed over Europe and worldwide. 4G systems provide a universal platform for broadband mobile services at any time, any place and anywhere. However, mobile traffic is still growing at an unprecedented rate and the need for more sophisticated broadband services is still further pushing the limits on current standards to provide even tighter integration between wireless technologies and higher speeds. The increase in number of mobile devices and traffic, the change in the nature of service and device, along with the pressure on operation and capital costs, and energy efficiency are all continuously putting stringent limits on the requirement of the design of mobile networks. It is widely accepted that incremental enhancements of current networking paradigm will not achieve or come close to meeting the requirements of networking by 2020 . This has led to the need of a new generation of mobile communications: the so-called 5G. The interests of stakeholders and academic researchers are now focused on 5G paradigm. Although 5G systems are not expected to penetrate the market till 2020, the evolution towards 5G is widely accepted to be the convergence of internet services with existing mobile networking standards leading to the commonly used term mobile internet over heterogeneous networks (HetNets), with very high connectivity speeds. This proposal aims to narrow the gap between current networking technologies and the foreseen requirements of future 2

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 5.28M | Year: 2010

In current wireless communications, radio spectrum and infrastructure are typically used such that interference is avoided by exclusive allocation of frequency bands and employment of base stations. SAPHYRE will demonstrate how equal-priority resource sharing in wireless networks improves spectral efficiency, enhances coverage, increases user satisfaction, leads to increased revenue for operators, and decreases capital and operating expenditures.SAPHYRE represents a consortium that spans the entire chain from spectrum regulatory aspects, networking, physical layer to hardware implementation. The vision of SAPHYRE is to: (i) show how voluntary sharing of physical and infrastructure resources enables a fundamental, order-of-magnitude-gain in the efficiency of spectrum utilisation; (ii) develop the enabling technology that facilitates such voluntary sharing; (iii) and determine the key features of a regulatory framework that underpins and promotes such voluntary sharing.SAPHYREs main objectives are conceptually described as:1. SAPHYRE will analyse and develop new self-organising physical layer resource (spectrum, spatial coexistence) sharing models by a generalised cross-layer and cross-disciplinary approach.2. SAPHYRE will propose and analyse efficient co-ordination mechanisms which require only small intervention (to counteract selfish, malicious users). In particular in sharing scenarios, incentive based design is applied in order to reduce regulatory complexity.3. SAPHYRE will develop a framework for infrastructure sharing to support quality of service with sufficiently wide carrier bandwidths and competition between different operators.Therefore, modern and novel physical layer techniques, including network and interference aware modulation/ coding, multi-antenna, spatial scheduling, multi-hop, relay co-operative transmission which lead to high spectral efficiency are developed.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 3.53M | Year: 2015

High Performance Computing (HPC) has become a major instrument for many scientific and industrial fields to generate new insights and product developments. There is a continuous demand for growing compute power, leading to a constant increase in system size and complexity. Efficiently utilizing the resources provided on Exascale systems will be a challenging task, potentially causing a large amount of underutilized resources and wasted energy. Parameters for adjusting the system to application requirements exist both on the hardware and on the system software level but are mostly unused today. Moreover, accelerators and co-processors offer a significant performance improvement at the cost of increased overhead, e.g., for data-transfers. While HPC applications are usually highly compute intensive, they also exhibit a large degree of dynamic behaviour, e.g., the alternation between communication phases and compute kernels. Manually detecting and leveraging this dynamism to improve energy-efficiency is a tedious task that is commonly neglected by developers. However, using an automatic optimization approach, application dynamism can be detected at design-time and used to generate optimized system configurations. A light-weight run-time system will then detect this dynamic behaviour in production and switch parameter configurations if beneficial for the performance and energy-efficiency of the application. The READEX project will develop an integrated tool-suite and the READEX Programming Paradigm to exploit application domain knowledge, together achieving an improvement in energy-efficiency of up to 22.5%. Driven by a consortium of European experts from academia, HPC resource providers, and industry, the READEX project will develop a tools-aided methodology to exploit the dynamic behaviour of applications to achieve improved energy-efficiency and performance. The developed tool-suite will be efficient and scalable to support current and future extreme scale systems.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-14-2014 | Award Amount: 8.17M | Year: 2015

The mmMAGIC (Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications) project will develop and design new concepts for mobile radio access technology (RAT) for mm-wave band deployment. This is envisaged as a key component in the 5G multi-RAT ecosystem and will be used as a foundation for global standardization. The project will thus enable ultrafast mobile broadband services for mobile users, supporting UHD/3D streaming, immersive applications and ultra-responsive cloud services. The consortium brings together major infrastructure vendors (Samsung, Ericsson, Alcatel-Lucent, Huawei, Intel, Nokia), major European operators (Orange, Telefonica), leading research institutes and universities (Fraunhofer HHI Institute, CEA-LETI, IMDEA Networks, Universities Aalto, Bristol, Chalmers and Dresden), measurement equipment vendors (Keysight Technologies, Rohde & Schwarz) and one SME (Qamcom). To complement its strong industry leadership and academic excellence, the project has an Advisory Board drawn from major European telecommunications regulators in Germany, France, Finland, Sweden and the UK. A new radio interface, including novel network management functions and architecture components will be proposed, taking as guidance 5G PPPs KPI and exploiting the use of novel adaptive and cooperative beam-forming and tracking techniques to address the specific challenges of mm-wave mobile propagation. The project will undertake extensive radio channel measurements in the 6-100 GHz range, and will develop and validate advanced channel models that will be used for rigorous validation and feasibility analysis of the proposed concepts and system, as well as for usage in regulatory and standards fora. The ambition of the project is to pave the way for a European head start in 5G standards, including 3GPP, and to secure essential IPRs to European industry, strengthening European competitiveness.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: PEOPLE-2007-3-1-IAPP | Award Amount: 831.56K | Year: 2008

Legionella are an important health and environment issue. Regular outbreaks of Legionellosis in certain cases causing the disease of patients show the dangerousness and reality of an infection risk. A significant number of Legionella contaminations are related to industrial complexes where cooling towers present a high Legionella risk. The bacteria colonize the water of these cooling towers and in some cases they are transported outside by the exhaust steam and may thus cause infections. The Vesicount project focuses on Legionella in cooling towers and public health constituting the main industrial and community risk issue. Current difficulties in Legionella detection and treatment arise because the bacteria are sometimes contained in protozoa vesicles where they grow and multiply. The vesicles do not appear with classic detection methods. Also they are able to protect Legionella from deleterious action of disinfectants and biocides. Vesicount project is intended as a long term industry-academia-cooperation concerning research for, firstly, indisputable methods detecting digestives vesicles transported and freed by typical protozoa containing Legionella inside of the industrial cooling towers and, secondly, for efficient ways of eliminating them in a healthy and reliable way. The university partners contribute to this project by offering specialized research experience and the industrial partner by bringing in his field experience. Secondments, recruitments and knowledge transfer between the partners will give the necessary frame to this 4 year cooperation aiming at the establishment of a new Legionella detection and treatment standard.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2013.4-2.;AAT.2013.1-1. | Award Amount: 5.83M | Year: 2013

Virtual prototyping (VP) is a key technology for environmental friendly and cost effective design in the aircraft industry. However, the underlying analysis and simulation tools (for loads, stresses, emissions, noise), are currently applied with a unique set of input data and model variables, although realistic operating conditions are a superposition of numerous uncertainties under which the industrial products operate (uncertainties on operational conditions, on geometries resulting from manufacturing tolerances, numerical error sources and uncertain physical model parameters). Major new developments in this new scientific area of Uncertainty Management and Quantification (UM and UQ) and Robust Design methods (RDM) are needed to bridge the gap towards industrial readiness, as the treatment of uncertainties enables a rigorous management of performance engagements and associated risks. This is the main objective of the UMRIDA project, which has the following action lines: Address major challenges in UQ and RDM to develop and apply new methods able to handle large numbers of simultaneous uncertainties, generalized geometrical uncertainties in design and analysis within a turn-around time acceptable for industrial readiness in VP systems. To respond to the validation requirements of UQ and RDM, a new generation of database, formed by industrial challenges (provided by the industrial partners), and more basic test cases, with prescribed uncertainties, is proposed. The methods developed will be assessed quantitatively towards the industrial objectives on this database, during the project and at two open workshops. The gained experience will be assembled in a Best Practice Guide on UQ and RDM. It is anticipated that the UMRIDA project will have a major impact on most of the EU objectives for air transport, by enabling design methods to take into account uncertainty based risk analysis.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.3-8 | Award Amount: 3.83M | Year: 2008

CEED3 (Collaborative European Effort to Develop Diabetes Diagnostics) has as its central objective, the development of diagnostic tools to differentiate specific subgroups of diabetic patients to allow individualisation of patient care. CEED3 will achieve this by integrating basic science findings from animal models, cell studies, and large scale genetic studies with clinical observations and testing of patients phenotype. The development of diabetes diagnostic tools will involve a clearly defined process of discovery of potential novel genetic and non-genetic biomarkers, validation within test and population based data samples, development of a clinical application and then dissemination of this application. The areas of focus for the diabetes diagnostics will be three areas where there is potential for considerable improvement in care and reduction in the burden of diabetes: the identification of patients with specific subgroups of monogenic diabetes, the identification of non diabetic and diabetic subjects with initial pancreatic beta-cell dysfunction at high risk of rapidly deteriorating glycaemia and the detection of diabetic patients at increased risk of vascular complications. For each of these patient groups the identification of the subgroups will result in improved clinical care by allowing treatment to be tailored for the individual patient. Therefore, the goal of this proposal is to make a rapid translation from scientific discoveries to improved care for diabetic patients. CEED3 has assembled the best researchers, clinical samples and technical expertise in Europe to realise this goal.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2007. | Award Amount: 1.68M | Year: 2008

HEREPLUS will: 1) involve coordination among epidemiologists, biostatisticians, environmental scientists, GIS specialists in order to realize the full potential of GIS technology in environmental health research; 2) develop risk maps relating to human health, and O3 and PM concentrations using the ArcGis approach, taking into account existing and validated epidemiological models, for selection of important and problematic large European urban areas such as Rome, Madrid, Dresden, Athens; 3) improve the knowledge of the potential role of different urban vegetation types for mitigating the O3 and PM pollution levels, and provide best practices regarding the selection of no-VOCs emitting species and management of large green areas located in different neighbouring urban areas; 4) furnish guidelines for municipal managers and administrators deputed to establish urban-environmental measures which combine risk maps, urban vegetation as a sink for ozone and PM, and minimization of sanitary costs, all based on results and knowledge achieved by the project activities as a whole. These guidelines will take the form of best practices recommendations and designs for municipal laws that may be used as a base-line for municipal administrations; 5) disseminate guidelines and best practice indications at a European level, through international workshops and a conclusive report. Specific cardio-respiratory disease, such as asthma, bronchitis, COPD exacerbation, ischemic heart disease, and the morbidity and mortality for these diseases, associated to O3 and PM, will be considered in HEREPLUS. HEREPLUS will produce the above mentioned risk maps starting from pre-existent environmental and health data, by development of new epidemiological and statistical approach, also in support for the implementation of Global Earth Observation System of Systems (GEOSS) initiative and the Environment and Health Action Plan.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.5-02 | Award Amount: 3.93M | Year: 2012

In BIOCLEAN project, novel and robust microorganisms (aerobic and anaerobic bacteria, and fungi) able to extensively degrade polyethylene (PE), polypropylene (PP), polystyrol (PS) and polyvinyl chloride (PVC) polymers and plastics will be isolated from actual-site aged plastic wastes obtained from several European marine and terrestrial sites, composting facilities and landfills, and obtained via tailored screenings from existing European collections of microbes. Robust enzymes able to fragment the target plastics with the production of valuable chemicals and building blocks will be obtained from the selected microbes and enzyme collections. Untreated and physically/chemically pre-treated PE, PS, PP and PVC polymers and plastics will be employed in such isolation/ screening activities, and an integrated methodology, relying on advanced analytical methods (determining plastics physicochemical changes and breakdown products resulting from biological attack), and tailored enzymatic, microbiological and ecotoxicological methods, will be adopted for the characterization of actual industrial relevance of the obtained microbes and enzymes. Physical and chemical pretreatments improving biodegradability of target plastics will be identified and transferred on the pilot scale. The most promising microbial cultures and enzymes will be exploited in the development of pilot scale, slurry or solid-phase bioprocesses for the bioremediation and controlled depolymerization, respectively, of target pretreated plastics and in the set up of tailored bioaugmentation protocols for enhancing plastic waste biodegradation in marine water systems, composting and anaerobic digestor facilities. The processes developed will be assessed for their economical and environmental sustainability. Field scale validation of the most promising bioaugmentation protocols in a composting and a marine site and attempts to develop a plastic pollution reduction strategy for the Aegean Sea have been planned too

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.6 | Award Amount: 3.88M | Year: 2012

Achievement of ever higher levels of integration in microelectronics will eventually require a radical shift from the field-effect transistor (FET) based paradigm to a revolutionary approach to computing. Quantum-dot Cellular Automata (QCA) is an alternative vision to binary computing since no current flow is required to encode binary information, and has been considered one of the most promising post-Moore alternatives.Implementation and miniaturization of QCA at the molecular level offer important advantages, including the perspective of room temperature operation, an essential step for industrial exploitation. However, the small sizes of the building blocks lead also to severe challenges when addressing the single elementary units.The present proposal specifically addresses the basic requirements to implement molecular QCA-inspired Networks, namely the measurement of the electrostatic interaction between a forced molecule (input) and its neighbour; the investigation of the propagation of a signal in a longer row of molecule (binary line); the implementation and testing of a majority gate.In particular we will address the following topics:\n-Pattern the molecules in controlled positions,\n-Contact the single molecules to force the state (inputs) and apply the clock (outputs)\n-Set up of a sensitive read-out system to discriminate among the two logic states of the molecule.\n-Understand the precise conformation and positioning of the molecules in the built system.\n-Evaluate the impact of non-idealities with respect to classical QCA on computation.\nState of the art research and development of activities in the field of molecular scale architectures for unconventional computation will be undertaken during the research programme, to reach the envisioned projects objectives and to develop a technology for the development of QCA computing in Europe. We expect our results to build a solid starting point for the development of a novel unconventional computational paradigm.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.1 | Award Amount: 8.96M | Year: 2012

Nowadays manufacturing ICT platforms provide a number of useful tools, including sensors, wireless networks, mobile devices, MES, ERP and information management systems, support shop-floor and back-office personnel in a series of activities. However, there is a long way to go before the huge amount of information gathered and generated by such ICT systems is presented in a manner that can truly speed up production processes, enable immediate reaction to issues and shortcomings.\n-\tInformation distribution usually neglects different user roles in a typical production facility. The information source is not aware of the role of the information receiver and thus fails at delivering the required subset.\n-\tIn many cases information infrastructure fails to successfully aggregate and manage data from factory-wide sensor networks as well as from various data sources such as MES or ERP, analyse such data and deliver it in a context-based manner to different users.\n-\tCognitive load, especially of shop-floor operators working under harsh conditions, is not properly addressed during information distributing.\n-\tUser Interfaces are often too complex and require much too effort to follow and use effectively either in harsh shop-floor environment or in back-office.\nSense&React project envisages overcoming the above mentioned issues via:\n\tThe use of customised, role-specific user interfaces provided through mobile devices in order to support the shop-floor personnel with the adequate amount of information also considering the cognitive load when performing certain operations.\n\tThe development of new information structures and information flow approaches so as to optimise the load of information presented to the different users at the shop-floor.\n\tDevelopment and application of factory-wide optimization methods that utilize real-time data, such as personnel, asset or part location data in order to optimize production performance, energy efficiency and safety.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.1 | Award Amount: 4.82M | Year: 2013

Innovative components and systems based on nano-engineered semiconductor, magnetic or insulating materials will be the driving force for the micro- and nano-electronics industry of the 21st century. For telecommunications systems, but also for data storage and Automation, Control and Security applications, alternative More than MOORE paths to systems are provided by nano-scale microwave spintronics components due to (i) their unique spin polarized transport properties that appear only at nanoscale dimensions (<100nm lateral, and 2-5 nm vertical), (ii) their unique (multifunctional) microwave properties including signal generation, processing and detection and (iii) their compatibility with CMOS technology. Going beyond previous fundamental research on spintronics devices, this project will target technological breakthroughs not only to generate, but also to process (mix, modulate, synchronise) and to detect microwave frequencies. Based on innovative spin transfer devices, four discrete systems will be developed that address bottlenecks of current technologies: A Wireless Telecommunications 1: Ultrawideband frequency synthesis provided by spintronics microwave components with novel circuit design on CMOS for realization of an adapted phase locked loop; B Wireless Telecommunications 2: Ultrafast frequency detection using frequency discriminating level detection; C Data storage: Novel dynamic readout schemes for detecting frequency shifts implemented for realization of high data rate read heads; D Automation control & security : Broad bandwidth, high slew rate proximity sensor based on frequency generation and modulation capabilities.\nThe broader objective is to bring the device level knowledge acquired in the past years by the partners towards systems as a first crucial step towards industrialization, warranting the leading position not only of European research but also of European industry in microwave spintronics.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.3.3-1.;AAT.2010.4.1-1. | Award Amount: 5.73M | Year: 2011

Ditching analysis is requested for large transport aircraft by EASA. The respective requirements are specified under CS 25.801 Ditching. They are primarily devoted to a minimisation of risks for immediate injuries and the provision of fair chances for an evacuation. A significant part of average air travel is over water and historically a planned or unplanned water-landing event occurs grossly speaking every 5 years. This proposal directly addresses areas Aircraft Safety and Aircraft Development Cost. The primary outcome of the SMAES project will be advanced methodologies and simulation tools to support aircraft development from pre-project phase to certification. These will enhance future innovation in aircraft design through ensuring that innovative designs are compliant with safety requirements The key developments addressed in the work programme are: 1. Improved models for the calculation of ditching loads including both analytical and detailed fluid dynamics models. Inclusion of the effects of the complex flow physics in ditching is critical to prediction of ditching loads. 2. Reliable and predictive aircraft models for structural behaviour under dynamic fluid loads. 3. Demonstration of the methods on representative future aircraft design concepts. The consortium brings together aircraft manufacturers, analysis software developers, research organisations and universities. Together the partners form a strong team covering the required expertise in aircraft design, numerical methods and simulation, ditching analysis and supporting experimental methods to achieve the project objectives.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: NMP.2013.4.0-4 | Award Amount: 1.25M | Year: 2013

The objective of this project is to regroup a cluster of private and academic laboratories supported by key manufacturers from both aeronautic, automotive and railway sectors in order to investigate the possibility to benchmark specific composites : from the aeronautics. Depending on the application targeted, the cluster will be able to take advantage of the mutual return on experiment in order to identify the safety requirements for the new materials and detect the most suitable range of composite material. From automotive process: able to produce the composite parts in order to develop the final structure at acceptable cost, keeping rentability of composite industry. From Railways process : for the standards and norms, which are harmonized at the European level The scientific focus of the MADMAX project is the joint effort concentrating on those scientific and technical items with interdisciplinary topics: material science, interactive materials, simulation, composites and sensoring for : - Development of high performance functionalized materials to 3D complex preforms - Development of automonous system to monitor the composites structures, incorporation of sensors inside the preforms - Development of standards to qualify the composites and the durability - Development of model for fundamental understanding of the structure/property relationship with advanced simulation tools The ultimate goals is to insure the the development of highly innovative textile processes and high performance flexible materials with significant improvement of mechanical behavior and integrated functions, e.g. structural health monitoring and self-healing for composites structures.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.71M | Year: 2015

In response to the increasing problem of water shortage, the reuse of treated urban wastewater is considered the most suitable and reliable alternative for sustainable water management and agricultural development. In spite of the benefits associated with this practice, major concerns currently exist, related to the adverse effects regarding chemical and biological contaminants of emerging concern such as antibiotics and mobile antibiotic resistance elements such as antibiotic resistant bacteria and resistance genes. These are now considered as a serious public health problem by various international organizations and the European Commission, because of their spread in the environment, the food chain, drinking water, etc. To tackle these problems, scientists with an interdisciplinary research/training background are urgently needed. This ETN will train a new generation of ESRs to address the risks associated with such contaminants and wastewater reuse. Innovative chemical, microbiological, toxicological and modelling tools, and novel process engineering will form the scientific and training core of their innovative research projects and training. The project will contribute to understanding the fate and transmission of antibiotics and resistance from wastewater to the environment and humans, through soil, ground/surface water and crops. Relevant ELVs will be determined, essential for the development and implementation of regulatory frameworks. This project directly tackles these aspects, by bringing together a multidisciplinary research team, with the private sector, and policy makers and through communication activities towards stakeholders and the wider public.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2009. | Award Amount: 8.60M | Year: 2010

EO2HEAVEN contributes to a better understanding of the complex relationships between environmental changes and their impact on human health. The project will monitor changes induced by human activities, with emphasis on atmospheric, river, lake and coastal marine pollution. EO2HEAVEN will follow a multidisciplinary and user-driven approach involving public health stakeholders who will work closely with technology and service providers in both the earth observation and in-situ environmental monitoring domain. The result of this collaboration will be the design and development of a GIS based upon an open and standards-based Spatial Information Infrastructure (SII) envisaged as a helpful tool for research of human exposure and early detection of infections. The key factors of the EO2HEAVEN system will be 1) an enhanced integration of remotely sensed and in-situ environmental measurements, and 2) the development of models to relate these environmental data to exposure and health data. Both factors will directly address current goals of GEOSS such that the resulting system will be integrated into the GEOSS infrastructure after successful validation already during the course of the project. Throughout the life span of the project the stakeholder requirements from three different use cases (in Europe and Southern Africa) will be assessed and the technical solutions proposed by EO2HEAVEN will be evaluated through an iterative process, thus ensuring that the solutions can be applied on a global scale. EO2HEAVEN will specify and implement the SII as an open architecture based upon international standards and adaptive geospatial Web services in alignment with the large-scale initiatives INSPIRE and GMES. The SII will include bridging capabilities at the syntactic and semantic levels to and between environmental and health systems. Ongoing and recently completed research projects in the ICT, environmental and health domains will be studied and used in an integrative approach.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.61M | Year: 2014

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines and the associated European training needs provide the foundation for the MEL-PLEX ETN. MEL-PLEX aims to understand the network-level and multi-scale regulation of disease-relevant signalling in melanoma through a combination of quantitative biomedical and computational research approaches that go significantly beyond the current state-of-the-art. Coordinated by the RCSI Centre for Systems Medicine, MEL-PLEX will train 15 early stage researchers through a highly interdisciplinary and intersectoral research training programme. MEL-PLEX comprises 11 beneficiaries and 7 partner organisations from 11 countries, including European and international leaders in personalised melanoma therapy, melanoma systems biology and cancer systems medicine. MEL-PLEX aims to (i) achieve an unmatched depth of molecular and mechanistic disease understanding, (ii) will exploit this knowledge to develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iii) will provide superior and clinically relevant tools and biomarker signatures for personalising and optimising melanoma treatment. The MEL-PLEX ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans across biology, medicine and mathematics, that can navigate confidently between clinical, academic and private sector research environments, and that have developed an innovative and creative mindset to progress research findings towards applications.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.2 | Award Amount: 14.01M | Year: 2012

TREASORES will demonstrate the production of large area organic electronics using high throughput manufacturing technologies based on roll-to-roll (R2R) wet deposition processes. In particular, by developing large area (>1m2) transparent conducting barrier foils which will be used for the production of flexible organic light-emitting devices (OLED), light-emitting electrochemical devices (LEC) and flexible organic photovoltaics (OPV). This industry-driven project is a sustainable approach towards low cost production of organic thin film optoelectronic devices using low-temperature (<180C) fabrication methods.\nTREASORES has a comprehensive, systematic approach including the fabrication of three 3 substrate and barrier layers, 4 novel transparent electrode layers, high-performance devices (Eff. >25 lm/W for OLED and LEC; Eff.>5%) made from organic semiconductors as well as reliable encapsulation (LEC lifetime>5000h, OLED lifetime >10000h). Testing, reliability validation and disposal issues are an integral part of the project. A key objective is to demonstrate the scale-up of novel flexible, transparent (Tr>90%) and conductive (R< 10/square) substrates to replace the widespread use of indium tin oxide (ITO). To keep production costs low (190 < /m2), roll-to-roll processes will be applied all the way from the manufacturing of components to devices. Emphasis will be given to organic semiconductors that have proven to be efficient and stable on the laboratory scale. Scale-up of device area (>100cm2) to high throughput production (web speed >1m/min.) without degradation of performance or yield is a key objective of the project. Flexible encapsulation foils shall use the most advanced barrier materials and will be made available in large enough surface area to be compatible with prototype device fabrication on a pilot scale.\nExploitation is ensured by the participation of manufacturers concerned with OLED, LEC and OPV devices, by the clear pathway from laboratory development to pilot production (using the same processes) and by the extensive experience of the academic partners in collaborating with industry.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 3.85M | Year: 2013

DIWINE considers wireless communication in a dense relay/node scenario where WNC (Wireless Network Coding) messages are flooded via dense massively air-interacting nodes in the self-contained cloud while the PHY air-interface between the terminals (sources/destinations) and the cloud is simple and uniform. A complex infrastructure cloud creates an equivalent air-interface to the terminal, which is as simple as possible.Source and destination air-interfaces are completely cloud network-structure-blind. The cloud has its own self-contained organising and processing capability. This concept facilitates energy-efficient, high-throughput and low-latency network communication performed directly at the PHY layer, which is capable of operating in complicated, dense, randomly defined network topologies and domains.The applications of the DIWINE paradigm are generic, being relevant to complex systems ranging from intelligent transport systems to healthcare and even machine-type communication in wireless networks. However, in order to exhibit practical, highly focused and high impact results, DIWINE concentrates on two core application/demonstration cases: i) smart metering networks and ii) critical industrial monitoring and control applications. To this end, DIWINE algorithms and theoretical technology will be integrated into two industrial proof-of-concept demonstration platforms targeting the aforementioned applications. Both of these applications require low-latency, dense networking solutions and are sure to be integral to future European policy and society as evidenced by recent European Commission initiatives such as EUROPE 2020.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 172.80K | Year: 2010

Protein-protein interactions are keys to executing important cellular functions. We hypothesize that gain or loss of protein-protein interactions plays important roles in carcinogenesis. We propose a network-based approach to biomarker discovery that uses protein-protein interactions and regulatory transcriptional networks. We will use prostate cancer and gliomas as models. Prostate cancer is the most common form of cancer and the leading cause of cancer death among men in the developed countries. Glioblastoma multiforme (GBM) is the most common and most aggressive type of primary brain tumor and it GBM accounts for 52% of all primary brain tumor cases. Novel markers and therapeutic targets are still needed for these two cancers. We will be focusing on the androgen receptor protein-protein network in prostate cancer and TGF-beta mediated network in gliomas. Protein interactions will be extracted by text mining, from databases, and from structural data on protein complexes. To identify transcription factors and their targets in human, ChIP-Chip and ChIP-Seq experiments will be carried out. The resulting networks serve as a scaffold on which data of deregulated proteins derived from microarray and next-generation sequencing of patient cancer samples will be mapped. The perturbed subnetwork will be visualized with a new method that identifies and highlights network motifs and modules. Promising biomarker candidates will be further examined and validated experimentally. Where possible, candidates will be modelled using protein structural data on protein-protein complexes, providing the basis to design ligands that occupy binding sites in order to disrupt cancer-relevant interactions. Our proposal is highly innovative. We expect to identify key nodal points in the network, to which protein-protein interactions can be disrupted as a way to perturb or interfere with the network. These key nodal points will serve both as biomarkers and therapeutic targets.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.9.7 | Award Amount: 9.19M | Year: 2013

The PAMS project will explore all scientific and technological aspects of the fabrication of planar atomic and sub-molecular scale electronic devices on surfaces of Si:H, Ge:H, AlN, CaCO3 (calcite) and CaF2 with atomic scale precision and reproducibility. The sub-nanoscale devices will be made by combining ultra-precise Scanning Tunnelling Microscopy (STM) and non-contact-Atomic Force Microscopy (NC-AFM) atomic and molecular manipulation, including hydrogen extraction from passivated surfaces, controlled local doping and on-surface chemical synthesis of molecular devices and wires by coupling of precursors.\nPAMS will develop new solutions to reliably address sub-nanometer scale devices from the human scale by developing a new generation of low-temperature interconnection and manipulation machines comprising four STM/NC-AFM heads with sub- precision, allowing for contacting nanopads connected to dangling bond nanowires, doped silicon nanowires or molecular nanowires. Understanding and optimization of the electronic structures of these nanowires and of the contacts between the various components of the planar device will be one of the central objectives. The atomic and molecular devices will include dangling bond circuitries, functionalized by coupling with organic molecules, and controlled by remote alteration of molecular states by local band bending; alternatively multi-branch polyaromatic logical gates will be synthesized and addressed by up to four nanowires.\nPAMS will address the novel theoretical challenges posed by these planar devices. Accordingly, new methodological tools will be developed, allowing for a multiscale description (using from first-principles to empirical force-fields) of the structural, electronic and transport properties of such atomic and molecular devices, as well as their fabrication and characterization. These new theoretical tools will ultimately permit us to optimize the design and synthesis of atomic and molecular gates.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.5.3 | Award Amount: 5.08M | Year: 2012

Pre-approval clinical trials cannot possibly ensure that a drug will not have disastrous side effects once it arrives on the market. Post-approval safety data gathering was put in place to address this problem, but as implemented, it has not proven to be as effective as hoped. This is due to the fact that, current post market safety studies largely depend on the submission of spontaneous case reports where underreporting is a major problem. The need for a proactive approach is apparent, where safety data from multiple sources are actively monitored, linked and analyzed. Effective integration and utilization of electronic health records (EHR) can help to improve post-market safety activities on a proactive basis. There are prototype studies to monitor EHRs for simplifying ADE reporting, and also for signal detection by screening multiple EHRs, however these tools are directly built on top of EHR/EMR systems through proprietary interfaces. It is apparent that the promise of proactive, continuous monitoring of multiple sources cannot be achieved through such proprietary integrations. To facilitate wide scale proactive post market safety studies, there is a need for a new capacity enabling accessing the data locked in multiple different heterogonous EHR systems. In SALUS project, we aim to provide a standard-based interoperability framework that will enable execution of safety studies for mining and analyzing real-time patient data in communication with disparate heterogeneous EHR systems. SALUS will provide:\n\tFunctional interoperability profiles enabling exchange of EHRs\n\tSemantic interoperability solutions enabling meaningful interpretation of the exchanged EHRs\n\tSecurity and Privacy mechanisms ensuring EHRs are shared in an ethical and safe way\n\tA novel framework for open-ended temporal pattern discovery for safety studies on top of EHR Systems\n\tImplementation of high potential use cases enabling secondary use of EHRs for post market safety studies

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 3.94M | Year: 2008

Gas flows in microsystems are of great interest for various applications that touch almost every industrial field. This diversity is typified through the following examples: fluidic microactuators for active control of aerodynamic flows, vacuum generators for extracting biological samples, mass flow and temperature micro-sensors, pressure gauges, micro heat-exchangers for the cooling of electronic components or for chemical applications, micropumps and microsystems for mixing or separation for local gas analysis, mass spectrometers, vacuum and dosing valves. The main characteristic of gas microflows is their rarefaction, the level of which often requires a modelling both by continuous and molecular approaches. The role played by the interaction between the gas and the wall becomes essential and is generally badly known. Numerous models of boundary conditions are currently in confrontation and require an empirical adjustment strongly dependent on the micro manufacturing techniques. On the other hand, the experimental data are fragmentary and difficult to confront. Most of them do not address heat transfer and gas mixtures issues. The proposed network has been built from several existing collaborati