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Antigua Guatemala, Guatemala

Strassburg A.,TU DortmundEmil Figge Str. | Kracke F.,TU DortmundEmil Figge Str. | Wenners J.,TU DortmundEmil Figge Str. | Jemeljanova A.,TU DortmundEmil Figge Str. | And 3 more authors.
Macromolecular Bioscience | Year: 2015

Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4-dibromo-2-butene and tetramethyl-1,3-propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40000μg·mL-1. They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50/MIC is more than 20000 for S. epidermidis. Investigations on sequentially prepared PBIs with defined molecular weight Mn and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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